The invention relates to alpha-
aryl alanine compounds and a preparation method thereof. Alpha-
aryl alanine compounds shown as general formulas (I) and (II) are racemate, wherein R1, R2 and R3 shown as general formulas (I) and (II) are expressed as
hydrogen atoms,
halogen atoms, hydroxyl, substituted or non-substituted
alkyl, alkenyl, alkoxy,
aryl, aryl
alkyl,
alkyl or aryl acyl; R4 is expressed as the
hydrogen atoms, formoxyl, acetyl, trifluoro-acetyl, benzoyl, phthaloyl, triphenylmethyl, carbobenzoxy, trimethyl
silicon carbethoxy, benzyl, 2,4-dimethoxy benzyl, p-methoxy benzyl and diphenyl phosphoryl; and R5 is expressed as the
hydrogen atoms, methyl or ethyl. The invention has the advantages that a novel method for preparing the alpha-aryl
alanine compounds, which is low in cost of raw materials, mild in
reaction conditions and high in yield is provided, and the alpha-aryl alanine compounds can be used as a synthetic intermediate of
a peptide deformylase
enzyme (PDF) inhibitor.