Chitosan quaternary ammonium salt hydrogel antibacterial dressing and preparation method thereof

The technology of chitosan quaternary ammonium salt and organosilicon quaternary ammonium salt is applied in the fields of medical science and bandages, which can solve the problems of poor broad-spectrum natural antibacterial agent, high cost of inorganic antibacterial agent, unsatisfactory treatment effect, etc. Superior sterilization, avoid toxic side effects, combined with the effect of enhanced bacteriostatic ability

Inactive Publication Date: 2018-05-01
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] All these antibacterial agents have defects in varying degrees during use: the cost of inorganic antibacterial agents is high, and the antibacterial effect is slow; organic antibacterial agents are often irritating to the skin, have low safety, and poor antibacterial durability; natural antibacterial agents The agent has poor broad-spectrum and is unstable to light, heat and chemicals
However, the existing methods and products are often unsatisfactory in terms of therapeutic effect

Method used

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  • Chitosan quaternary ammonium salt hydrogel antibacterial dressing and preparation method thereof
  • Chitosan quaternary ammonium salt hydrogel antibacterial dressing and preparation method thereof
  • Chitosan quaternary ammonium salt hydrogel antibacterial dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A chitosan quaternary ammonium hydrogel antibacterial dressing, said chitosan quaternary ammonium hydrogel antibacterial dressing is made from the following raw materials in parts by weight: 0.1 part of chitosan quaternary ammonium salt, 0.1 part of organosilicon quaternary ammonium salt 1 part, 1 part of cellulose derivative, 5 parts of glycerin, 80 parts of purified water.

[0034] The degree of deacetylation of the chitosan quaternary ammonium salt is 90%; the molecular weight range of the chitosan quaternary ammonium salt is 20,000.

[0035] The cellulose derivative is sodium carboxymethyl cellulose.

[0036] The silicone quaternary ammonium salt includes dimethyl hexadecyl [3-(trimethoxysilyl) propyl] ammonium chloride.

[0037] A kind of preparation method of chitosan quaternary ammonium hydrogel antibacterial dressing, comprises the steps:

[0038] 1) Take chitosan quaternary ammonium salt, organosilicon quaternary ammonium salt, cellulose derivatives, glycerin...

Embodiment 2

[0042] A chitosan quaternary ammonium hydrogel antibacterial dressing, the chitosan quaternary ammonium hydrogel antibacterial dressing is made from the following raw materials in parts by weight: 5 parts of chitosan quaternary ammonium salt, 5 parts of organosilicon quaternary ammonium salt parts, 8 parts of cellulose derivatives, 20 parts of glycerin, and 120 parts of purified water.

[0043]The degree of deacetylation of the chitosan quaternary ammonium salt is 98%; the molecular weight range of the chitosan quaternary ammonium salt is 300,000.

[0044] The cellulose derivative is methyl cellulose.

[0045] The organosilicon quaternary ammonium salt is dimethyleicosyl[3-(trimethoxysilyl)propyl]ammonium chloride.

[0046] A kind of preparation method of chitosan quaternary ammonium hydrogel antibacterial dressing, comprises the steps:

[0047] 1) Take chitosan quaternary ammonium salt, organosilicon quaternary ammonium salt, cellulose derivatives, glycerin and purified wat...

Embodiment 3

[0051] A kind of chitosan quaternary ammonium hydrogel antibacterial dressing, said chitosan quaternary ammonium hydrogel antibacterial dressing is made from the following raw materials in parts by weight: 1.5 parts of chitosan quaternary ammonium salt, 1.5 parts of organosilicon quaternary ammonium salt 2 parts of dandelion extract, 3 parts of cellulose derivatives, 10 parts of glycerin, 90 parts of purified water.

[0052] The preparation method of described dandelion extract comprises the steps:

[0053] Take the dandelion medicinal material and grind it through a 40-mesh sieve, add 50% ethanol aqueous solution 11 times the volume of the medicinal material, soak for 2 hours, heat and reflux for extraction for 2.5 hours, filter to obtain a filtrate, and add 50% of the volume of 6 times the weight of the medicinal residue to the medicinal residue. Continue to reflux the ethanol aqueous solution for 2 hours, filter to obtain the secondary filtrate, combine the primary filtrate...

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Abstract

The invention relates to a chitosan quaternary ammonium salt hydrogel antibacterial dressing and a preparation method thereof, and belongs to the field of biomedicine. The chitosan quaternary ammoniumsalt hydrogel antibacterial dressing is prepared from the following raw materials in parts by weight: 0.1-5 parts of a chitosan quaternary ammonium salt, 0.1-5 parts of an organosilicon quaternary ammonium salt, 1-8 parts of a cellulose derivative, 5-20 parts of glycerol and 80-120 parts of purified water. The chitosan quaternary ammonium salt hydrogel antibacterial dressing provided by the invention has a good antibacterial effect, stability and a wide application range, and has a good therapeutic effect on wound healing.

Description

technical field [0001] The invention relates to a chitosan quaternary ammonium hydrogel antibacterial dressing and a preparation method thereof, belonging to the field of biomedicine. Background technique [0002] The antibacterial agents currently used in the market mainly include three categories: inorganic antibacterial agents, organic antibacterial agents and natural antibacterial agents. Inorganic antibacterial agents mainly include metal ion type and photocatalytic type. Metal ion type includes silver series, zinc series and copper series. ) is fixed on the surface of porous materials such as fluorspar and silica gel to make antibacterial agents; the photocatalytic type is mainly anatase nano-TiO2, and its bactericidal ability comes from its photocatalytic activity. Organic antibacterial agents have been researched and developed relatively early in European and American countries, and there are many varieties. They are traditional antibacterial agents. Currently, quat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0057A61L26/0066A61L26/008A61L2300/208A61L2300/232A61L2300/30A61L2300/404C08L5/08C08L1/286
Inventor 张聪车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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