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Vaginal mucosa antibacterial gel and preparation method thereof

A gel and mucosal technology, applied in the field of gynecological gel and its preparation, can solve the problems of destroying vaginal acid-base balance and flora balance, and achieve the maintenance of vaginal microecological balance, improvement of vaginal cleanliness, and good treatment effect of effect

Active Publication Date: 2018-12-25
HEILONGJIANG ACAD OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the technical problem of destroying the acid-base balance and flora balance in the vagina while treating inflammation in the existing gynecological gel, and to provide a preparation method of vaginal mucosa antibacterial gel

Method used

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  • Vaginal mucosa antibacterial gel and preparation method thereof
  • Vaginal mucosa antibacterial gel and preparation method thereof
  • Vaginal mucosa antibacterial gel and preparation method thereof

Examples

Experimental program
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Effect test

specific Embodiment approach 1

[0016] Specific embodiment one: In this embodiment, each unit of vaginal mucosa antibacterial gel contains 0.1 g of Sophora japonica extract, 0.2 g of Chinese rose extract, 0.03 g of carbomer, 0.5 g of Tween 80, 1 g of glycerin, and poloxa Mu 188 0.1g and methylparaben added in an amount of 0.1% of the total mass of the vaginal mucosa antibacterial gel.

specific Embodiment approach 2

[0017] Specific embodiment two: the difference between this embodiment and specific embodiment one is that the preparation method of vaginal mucosa antibacterial gel is carried out according to the following steps:

[0018] 1. Weigh 1g of Sophora japonica extract, 2g of Chinese rose extract, 0.3g of carbomer, 5g of Tween 80, 10g of glycerin, and 188.1g of poloxamer;

[0019] 2. Thoroughly grind 1 g of poloxamer 188 and 1 g of Sophora japonica extract to obtain a grinding mixture, mix 10 g of glycerin, 5 g of Tween 80 and 20 ml of purified water and stir well, add the grinding mixture and 2 g of Chinese rose extract, Stir evenly to obtain a suspension;

[0020] 3. Weigh 0.3g of carbomer, add 20g of purified water until it swells completely, and obtain a swelling solution;

[0021] 4. Add the suspension to the swelling solution, and then add 0.1% methylparaben in an amount equal to the total mass of the vaginal mucosa antibacterial gel to obtain the vaginal mucosa antibacterial...

Embodiment 1

[0024] Embodiment 1: adopt simple Sophora japonica extract (other ingredients are unchanged) to make gel:

[0025] 1. Weigh 1g of Sophora japonica extract, 0.3g of carbomer, 5g of Tween 80, 10g of glycerin, 0.1g of poloxamer 188 and 0.1% of methylparaben.

[0026] 2. Fully grind 1 g of Poloxamer 188 and 1 g of Sophora japonica extract for later use, mix 10 g of glycerin, 5 g of Tween 80 and 20 ml of purified water and stir well, add the grinding mixture to it, and stir evenly to obtain a suspension;

[0027] 3. Weigh 0.3g of carbomer, add 20g of purified water until it swells completely, and obtain a swelling solution;

[0028] 4. Add the suspension to the swelling solution, and then add 0.1% methylparaben to obtain the product.

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Abstract

The invention relates to a vaginal mucosa antibacterial gel and a preparation method thereof, aiming to solve the technical problem that conventional gynecological gels are easy to damage acid and alkali balance and microbial flora balance in the vagina when used for treatment on inflammation. The vaginal mucosa antibacterial gel comprises extract of Fructus Sophorae, extract of Rosa chinensis, Carbomer, Tween 80, glycerol, poloxamer 188 and methylparaben. The preparation method includes the steps of firstly, weighing the raw material respectively; secondly, mixing glycerol, Tween 80 and purified water uniformly, and then adding in poloxamer 188, extract of Fructus Sophorae and extract of Rosa chinensis; thirdly, weighing 0.3 g of Carbomer, adding in 20 g of purified water until completelyswelling to obtain a swelling solution; fourthly, adding a suspension solution into the swelling solution, and then adding in methylparaben to obtain the product. The gel keeps acid and alkali balance in the vagina without damaging the microbial flora balance therein when used for treatment of female vaginal inflammation, that is to say, the gel can achieve good treatment effect while avoiding damages to micro-ecology of the vagina.

Description

technical field [0001] The invention relates to a gynecological gel and a preparation method thereof. Background technique [0002] Vaginitis, or inflammation of the vagina, is a group of conditions that cause vulvovaginal symptoms such as itching, burning, irritation, and abnormal discharge. Due to the characteristics of anatomical tissue, the vagina of normal healthy women has a natural defense function against the invasion of pathogens. For example, the closure of the vaginal opening, the close contact of the front and rear walls of the vagina, the hyperplasia of vaginal epithelial cells and keratinization of surface cells under the influence of estrogen, and the balance of vaginal pH balance inhibits the reproduction of pathogens that adapt to alkaline, while the cervical mucus appears Alkaline, when the natural defense function of the vagina is destroyed, pathogens are easy to invade, leading to vaginal inflammation. Under normal circumstances, there are aerobic bacte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61K9/06A61P15/00A61P31/02A61P31/04A61P31/10A61P15/02
CPCA61K9/0034A61K9/06A61K36/489A61K36/738A61K47/32A61P15/00A61P15/02A61P31/02A61P31/04A61P31/10A61K2300/00
Inventor 王伟明霍金海李梦雪刘华石潘五九韩德强
Owner HEILONGJIANG ACAD OF TCM
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