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Application of phenylbutyric acid combined with triazole antifungal drugs and its products

A technology of combined application of antifungal drugs, applied in the field of medicine, can solve problems such as increased drug resistance, achieve the effects of enhancing antibacterial activity, expanding the scope of application, and reducing the amount of medication

Active Publication Date: 2017-11-10
QIANFOSHAN HOSPITAL OF SHANDONG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide an application of phenylbutyric acid combined with triazole antifungal drugs and its products in order to overcome the current problem of fungal infection and the increase in the resistance rate of triazole antifungal drugs

Method used

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  • Application of phenylbutyric acid combined with triazole antifungal drugs and its products
  • Application of phenylbutyric acid combined with triazole antifungal drugs and its products
  • Application of phenylbutyric acid combined with triazole antifungal drugs and its products

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Embodiment Construction

[0034] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0035] Embodiment Phenylbutyric acid and triazole antifungal drugs combined antifungal action determination

[0036] 1. Materials

[0037] 1.1 Drugs and reagents

[0038] Fluconazole (FLC), Meilun Biological Co., Ltd.;

[0039] Voriconazole (VRC), Meilun Biological Co., Ltd.;

[0040] Itraconazole (ITC), Meilun Biological Co., Ltd.;

[0041] Phenylbutyric acid (PBA): Shaoyuan Chemical Technology (Shanghai) Co., Ltd.;

[0042] CHROMagar Candida Chromogenic Medium, Zhengzhou Bosai Biological Engineering Co., Ltd.;

[0043] TTC-Sapauer agar, Hangzhou Tianhe Microbiological Reagent Co., Ltd.;

[0044] Yeast paste, Beijing Aoboxing Biotechnology Co., Ltd.;

[0045] Peptone, Beijing Aoboxing Biotechnology Co., Ltd.;

[0046] Glucose, Sinopharm Chemical Reagent Co., Ltd.;

[0047] Agar powder, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[00...

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Abstract

The invention discloses the application of the composition of benzenebutanoic acid and a triazole antifungal drug and an antifungal product. Static and dynamic combined antifungal activity, on drug-resisting candida albicans (CA), of the composition of the triazole antifungal drug and benzenebutanoic acid is researched. When PBA is combined with FLC, ITC and VRC, the antimicrobial activity of the triazole antifungal drug on drug-resisting CA can be improved, a synergic antifungal effect can be realized, the drug resistance of drug-resisting CA on the triazole antifungal drug can be reversed, and a research direction is provided for development of new drugs and new application of old drugs. For CA (MIC>=512 mug / ml) resistant to FLC, ITC and VRC, minimal inhibitory concentration can be reduced remarkably through drug combination, over 80% fungi can be killed through combination of PBA of 32 mug / ml and FLC of 1 mug / ml, combination of PBA of 32 mug / ml and ITC of 0.125 mug / ml, and combination of PBA of 16 mug / ml and VRC of 0.25 mug / ml, and the effect is better as concentration becomes higher.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of phenylbutyric acid combined with triazole antifungal drugs and the products thereof. Background technique [0002] With the increase of patients with acquired immunodeficiency syndrome and the wide application of broad-spectrum antibacterial drugs, the development of medical technologies such as organ transplantation technology and catheter technology, the morbidity and mortality of invasive fungal infections are also increasing year by year. The morbidity and fatality rate of bacteria reached 40%, occupying the fourth place in the hospital acquired bloodstream infection. Among them, Candida albicans (Candida albicans, CA) is a common isolate in clinical fungal infections, usually treated with azole antifungal drugs fluconazole (Fluconazole, FLC), voriconazole (Voriconazole, VRC), itraconazole azole (Itraconazole, ITC) treatment. As a safe, effective and che...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4196A61K31/496A61K31/506A61K31/192A61P31/10
CPCA61K31/192A61K31/4196A61K31/496A61K31/506A61K2300/00
Inventor 孙淑娟张柳平李涛时银萍赵霞
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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