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Water soluble triazole compound and synthesis method thereof
ActiveCN101824002ABroad spectrum antifungalGood water solubilityOrganic active ingredientsAntimycoticsAntifungalSolubility
The invention discloses a water soluble triazole compound and a synthesis method thereof. The water soluble triazole compound has a structure as shown in Formula Ia, Formula Ib, Formula Ic or Formula Id, wherein R1 is a group in Formula II. The compound of the invention is formed by adding a new group on the structural basis of a broad-spectrum, high-efficiency antifungal compound discovered in the present clinical application and new drug development process to increase the water solubility and reduce the toxicity, is a derivate of the triazole antifungal drug, and has the characteristics of broad antifungal spectrum, high antifungal activity, good safety and the like.
Owner:NANJING HUAWE MEDICINE TECH DEV
Triazole alcohol antifungal compounds with nitrogen-containing side chains, preparation method thereof and application thereof
InactiveCN102311399AStrong antifungal effectLow toxicityOrganic active ingredientsAntimycoticsAntifungalSide effect
The invention relates to the technical field of medicines. Present antifungal medicines which have problems of large side effect, narrow antimicrobial spectrum, easy generation of the drug resistance and the like cannot satisfy clinical treatment needs. The invention provides novel triazole alcohol antifungal compounds with high efficiency, low toxicity and wide spectrum and pharmaceutically acceptable salts thereof. The compounds are 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(nitrogen-containing side chain substituted)-2-propanol compounds, and the general structure of the compounds is shown in the specification. The invention also provides a preparation method of the compounds and an application of the compounds in the preparation of antifungal medicines.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Novel triazolols antifungal compound, preparation method and application thereof
InactiveCN101357906AStrong antifungal effectBroad spectrum antifungalOrganic active ingredientsAntimycoticsHydrobromideChemical structure
The invention relates to the medical technical field, in particular to a new triazole alcohols antifungal compound and salts thereof with the following chemical structure formula and a preparation method and the application thereof; R1 is selected from n-propyl, isopropyl or butyl; R2 is selected from alkyl or halogen; the salts include hydrochloride, hydrobromide and methane sulphonate. The compound has strong antifungal activity on various fungi in shallow parts and deep parts. Compared with the antifungal medicines used in the existing clinical applications, the compound has the advantages of high efficiency, low toxicity, broad antifungal spectrum, and the like, and can be used for preparing new antifungal medicines.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Triazole alcohol derivative and preparation method and application thereof
ActiveCN106336383ALow toxicityBroad spectrum antifungalOrganic active ingredientsAntimycoticsChemical structureAntifungal drug
The invention relates to a triazole alcohol derivative and a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is as shown in the formula I. The invention also provides salt of the compound, a pharmaceutical composition, a preparation method and application. The compound of the invention has strong antifungal activity, has advantages of low toxicity and wide antimicrobial spectrum, and can be used for preparation of antifungal drugs.
Owner:YANGTZE RIVER PHARM GRP CO LTD
Triazole alcohol derivative, preparation method and application thereof
ActiveCN104817508ALow toxicityBroad spectrum antifungalOrganic active ingredientsAntimycoticsPropanolAntifungal drug
The invention relates to a triazole alcohol derivative, a preparation method and application thereof. The triazole alcohol derivative is a 2-(2, 4-difluorophenyl)-3-(1-substituted-1H-1, 2, 3-triazole-4-yl)-1-(1H-1, 2, 4-triazole-1yl)-2-propanol compound. The invention also provides a salt of the compound, a pharmaceutical composition, a preparation method and application thereof. The compound provided by the invention has strong antifungal activity, and has the advantages of low toxicity, broad antibacterial spectrum and the like, and can be used for preparation of antifungal drugs.
Owner:YANGTZE RIVER PHARM GRP CO LTD
Substituted triazolone benzyl amine triazole antifungal compounds and method for preparing same
InactiveCN1699351AStrong antifungal effectLow toxicityOrganic active ingredientsAntimycoticsAntifungalTriazole antifungals
The invention relates to a substituted triazolone benzyl amine triazole antifungal compound, i.e. 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[N-methyl-N-(2-substituted-2H-1,2,4-triazol-3-one-4-yl) benzylaminoformyl]-2-propanols compounds, their salts and their preparation process. The compounds has very strong antimycotic effect.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Tricyclic isoxazole derivative, preparation method thereof and application
ActiveCN107311995AGood antifungal activityBroad spectrum antifungalOrganic active ingredientsAntimycoticsAntifungal drugsGeometric isomer
The invention discloses a tricyclic isoxazole derivative, belongs to the technical field of medicines, and provides a compound with a general formula (1) as shown in the specification, a geometrical isomer of the compound or pharmaceutically acceptable salt, hydrates, solvates and prodrugs of the compound and preparation methods of the salt, the hydrates, the solvates and the prodrugs. The compound has good antifungal activity for various superficial and deep fungi and the advantages of high efficiency, low toxicity, wide antifungal spectrum and the like as compared with existing clinically-applied antifungal drugs, and the compound can be used for preparing antifungal drugs.
Owner:SHENYANG PHARMA UNIVERSITY
Azole antifungal compound and preparation method and application thereof
InactiveCN103265538AGood antifungal activityBroad spectrum antifungalOrganic active ingredientsAntimycoticsTriazoleNitryl
The present invention relates to a novel triazole alcohol compound. The triazole alcohol compound has a following chemical structural formula as shown in a chemical structure in the specification, wherein X is CH=CH or O; R is selected from alkyl, halogen, alkoxy or nitryl. The invention has the advantages that: the compound has good antifungal activity for various superficial and deep fungi, has the advantages of high efficiency, low toxicity and wide antifungal spectrum compared with conventional clinical applied antifungal drugs, and can be used in the preparation of antifungal drugs. The compound is simple in the preparation method, high in yield, and good in antifungal effect, and a novel compound is provided for the preparation of antifungal drugs.
Owner:NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
Novel azole antifungal compound and preparation method and application thereof
InactiveCN102796080AStrong antifungal activity against deep fungiBroad spectrum antifungalOrganic active ingredientsAntimycoticsAntifungal drugPhenyl group
The invention provides a novel azole antifungal compound. According to the azole antifungal compound, a structural general formula is shown in the specification, wherein X is hydroxyl, Ar is 2,4-difluoro phenyl, and R is selected from hydrogen, alkyl, halogen, cyano-group, nitryl, amino or alkoxy and can be positioned at the ortho-position, meta-position or para-position of a benzene ring and can be mono-substituted or multi-substituted; the alkyl has 1 to 4 carbon atoms; the halogen is selected from F, Cl, Br and I; the amino is selected from -NH2, one or two aminos substituted by the alkyl and cyclic amino; and the alkoxy is selected from methoxyl, ethyoxyl and tert-butyl oxygroup. The invention also provides a method for preparing the compound and application of the compound to preparation of antifungal medicines. Compared with the conventional antifungal medicines which are applied clinically, the azole antifungal compound has the advantages of high antifungal activity on invasive fungi, high efficiency, low toxicity, broad spectrum and the like; and the method is simple and high in yield, and the prepared compound has a good antifungal effect.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Novel triazole antifungal compound and salt thereof
InactiveCN101768126AStrong antifungal effectBroad spectrum antifungalOrganic active ingredientsAntimycoticsMethane sulfonateLeaving group
The invention relates to technical field of medicine, in particular to novel azole antifungal compound and salt thereof and the application, wherein, X presents hydroxyl or straight-chain ester group or branch-chain ester group with 1-6 carbon atoms and the ester group with easily-leaving group; Y presents substituent group on aromatic ring; M presents propargyl group or cyanomethyl; P presents various substituent groups on benzene ring, the substituent positions can be different positions on aromatic ring, mono substitution, or polysubstitution combined by the substituent groups; Z presents C or N atom; if Z presents Z atom, the position can be different positions on ring, and can be mono substitution, or polysubstitution; n is equal to 0-5; the salt comprises hydrochloride, nitrate, hydrobromide or methane sulfonate. The advantages of the invention are as follows: the compound provided by the invention has strong antifungal activity, low toxicity, and wide antifungal spectrum, and can be used for preparing novel antifungal drugs.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
2, 4, 4-trisubstituted dihydrooxazole derivative and application thereof
ActiveCN111848600AGood antifungal activityBroad spectrum antifungalOrganic active ingredientsAntimycoticsDrugs synthesisPharmaceutical medicine
The invention belongs to the technical field of drug synthesis, and relates to 2, 4, 4-trisubstituted dihydrooxazole derivatives, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, preparation methods of the 2, 4, 4-trisubstituted dihydrooxazole derivatives and the pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, and an application of the 2, 4, 4-trisubstituted dihydrooxazole derivatives and the prodrugs thereof as drugs for treating various diseases caused by fungal infection. The general formula of the 2, 4, 4-trisubstituted dihydrooxazole derivative and the stereoisomer or the pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof is shown as (I), wherein MBG, X, Y, M and R1 are shown in the claims and the specification. .
Owner:SHENYANG PHARMA UNIVERSITY
Application of formononetin in preparation of aspergillus fumigatus resistant medicament
InactiveCN103585143AGood antifungal activityBroad spectrum antifungalOrganic active ingredientsAntimycoticsAntifungal drugsAspergillus fumigatus
The invention relates to application of formononetin in aspergillus fumigatus prevention. The technical scheme of the invention provides application of the formononetin in preparation of a fungus infectious disease medicament. The fungus is aspergillus fumigatus. The compound in the invention is high in antifungal activity to various funguses on both the superficial part and the deep part. Compared with the conventional clinically applied antifungal medicament, the formononetin has the advantages of high efficiency, low toxicity, large antifungal spectrum and the like and can be used for preparing antifungal medicaments.
Owner:苏州市马尔泰新材料有限公司
Triazole alcohol derivative, and preparation method and application thereof
ActiveCN111018839ALow toxicityBroad spectrum antifungalAntimycoticsOrganic chemistryAntifungalBenzene
The invention relates to a triazole alcohol derivative, and a preparation method and an application thereof. The chemical structure of the triazole alcohol derivative is represented by formula I, A inthe formula I represents a benzene ring or a substituted benzene ring, and the substituent group of the substituted benzene ring can be located at each position of the benzene ring, is monosubstituted or polysubstituted, and is selected from: a) halogen which is F, Cl, Br or I; b) an electron-withdrawing group, wherein the electron withdrawing group is a cyano group, a nitro group or a trifluoromethyl group; c) a C1-4 low alkyl group or a halogen-substituted low alkyl group; and d) a C1-4 low alkoxy group or a halogen-substituted low alkoxy group. The compound has the advantages of high antifungal activity, low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal medicines.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Bacillus velezensis as well as fermentation method and application
ActiveCN112126601AEnhanced inhibitory effectBroad spectrum antifungalBiocideBacteriaBiotechnologyPathogenic bacteria
The invention discloses bacillus velezensis XW0513 with a preservation number of CGMCC No.20474. The bacillus velezensis has an antifungal capability. The bacillus velezensis disclosed by the invention has an obvious inhibition effect on pathogenic fungi including botrytis cinerea, root rot fungi, fusarium oxysporum f.sp cucumerinum, fusarium moniliforme, pyricularia grisea, magnaporthe oryzae andaspergillus flavus, and is wide in antifungal spectrum. The bacillus velezensis has no antibacterial effect on pathogenic bacteria. It is shown that the strain XW0513 has a relatively good inhibitioneffect on various pathogenic fungi.
Owner:TIANJIN UNIV
Water-soluble triazole antifungal compound
ActiveCN101575320ABroad spectrum antifungalGood water solubilityOrganic active ingredientsAntimycoticsSolubilityAntifungal
The invention belongs to the field of pharmaceutical preparations, in particular discloses a water-soluble triazole antifungal compound and a preparation method thereof. The water-soluble triazole antifungal compound has a structural formula like a formula Ia, a formula Ib or a formula Ic, wherein R1 is a group of a formular II. The compound is formed by inducing a new group on a structural basis of a broad-spectrum and high-efficiency antifungal compound in the processes of clinical application and new drug development so as to improve the water solubility of the compound and lower the toxicity, is used as a prodrug of triazole antifungal medicaments and has the advantages of wide antifungal spectrum, strong antifungal activity resistance, good safety, and the like.
Owner:NANJING HUAWE MEDICINE TECH DEV
Antifungal compound of substitution benzyl triazole alcohols
InactiveCN1539830AStrong antifungal effectBroad spectrum antifungalOrganic active ingredientsAntimycoticsPropanolAntifungal
An antifungus compound 1-(1H-1,2,4-triazole-1-yl)-2-(2,4- difluorophenyl)-3-[N-methyl-N-(4-substituted amino) benzylamino]-2-propanol and its salts, and its preparing process are disclosed. Its advantages are high curative effect, low poison and broad spectrum.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
A kind of azole antifungal compound and its preparation method and application
InactiveCN103265538BGood antifungal activityBroad spectrum antifungalOrganic active ingredientsAntimycoticsAlcoholAntifungal drug
The present invention relates to a novel triazole alcohol compound. The triazole alcohol compound has a following chemical structural formula as shown in a chemical structure in the specification, wherein X is CH=CH or O; R is selected from alkyl, halogen, alkoxy or nitryl. The invention has the advantages that: the compound has good antifungal activity for various superficial and deep fungi, has the advantages of high efficiency, low toxicity and wide antifungal spectrum compared with conventional clinical applied antifungal drugs, and can be used in the preparation of antifungal drugs. The compound is simple in the preparation method, high in yield, and good in antifungal effect, and a novel compound is provided for the preparation of antifungal drugs.
Owner:NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
Beta-azoles-phenyl ketone derivative and application thereof
ActiveCN109485607AGood antifungal activityBroad spectrum antifungalOrganic active ingredientsAntimycoticsAntifungal drugStereoisomerism
The invention belongs to the technical field of pharmaceutical synthesis, and provides a beta-azoles-phenyl ketone derivative shown as a general formula, stereoisomers of the beta-azoles-phenyl ketonederivative or pharmaceutically acceptable salt, hydrates, solvate or pro-drugs of the beta-azoles-phenyl ketone derivative and methods for preparing the stereoisomers or the pharmaceutically acceptable salt, the hydrates, the solvate or the pro-drugs. Definition of an A, a B, an R1, an R2, an R3 and an X is given in an instruction book. The beta-azoles-phenyl ketone derivative, the stereoisomersor the pharmaceutically acceptable salt, the hydrates, the solvate or the pro-drugs and the methods have the advantages that compounds are high in inhibitory activity for superficial and deep fungi, are high in activity, low in toxicity and broad in antibacterial spectrum as compared with clinically used antifungal drugs and can be used for preparing antifungal drugs, and the like.
Owner:SHENYANG PHARMA UNIVERSITY
Triazole alcohol antifungal compound with side chain containing piperidine oxadiazole as well as preparation method and application thereof
InactiveCN104356125AStrong antifungal effectLow toxicityOrganic chemistryFungicidesChemical structureAntifungal drugs
The invention relates to the technical field of medicine, and provides a class of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-((piperidine oxadiazole side chain substituted))-2-propanol compound, which comprises cis-trans-isomers of the compound and any mixture of these forms or medical salts thereof. The chemical structure of the compound is as shown in a formula (I) in the Specification. The invention further provides a preparation method of the compound, and an application in the preparation of an antifungal drug. Antifungal experiments show that the compound has excellent antifungal effect for various shallow and deep funguses; compared with an existing antifungal drug such as fluconazole in clinical application, the compound has the advantages of high efficiency, low toxicity and wide antifungal spectrum, and can be used for preparing new antifungal drugs.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Application of 7-hydroxy-4'-methoxyisoflavone in antifungal medicament
InactiveCN103565794AGood antifungal activityBroad spectrum antifungalOrganic active ingredientsAntimycoticsAntifungalDisease
The invention relates to application of 7-hydroxy-4'-methoxyisoflavone in an antifungal medicament. The technical scheme is the application of 7-hydroxy-4'-methoxyisoflavone in preparing medicaments for treating fungus infected diseases, wherein the fungus is candida albicans. The compound has an excellent antifungal activity on various superficial and deep funguses, has the advantages of high activity, low toxicity, broad antifungal spectrum and the like when being compared with an antifungal medicament in existing clinical application, and can be used for preparing antifungal medicaments.
Owner:苏州市马尔泰新材料有限公司
Triazole alcohol derivative as well as preparation method and application thereof
ActiveCN110845486ALow toxicityBroad spectrum antifungalOrganic active ingredientsAntimycoticsMethyl groupCarbon atom
The invention relates to a triazole alcohol derivative as well as a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is shown as a formula I, R1 represents a benzene ring or a substituted benzene ring, and substituent groups of the substituted benzene ring can be located at all positions of the benzene ring, can be mono-substituted or multi-substituted, and can be selected from a) halogen which is F and Cl; b) an electron withdrawing group which is cyano or trifluoromethyl; c ) a lower alkyl of 1-4 carbon atoms or a halogen substituted loweralkyl; and d) lower alkoxy of 1-4 carbon atoms or halogen substituted lower alkoxy. The compound of the invention has strong antifungal activity, has the advantages of low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal drugs.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Application of formononetin in cryptococcus neoformans
InactiveCN103565790AGood antifungal activityBroad spectrum antifungalOrganic active ingredientsAntimycoticsAntifungalDisease
The invention relates to application of formononetin in cryptococcus neoformans. The technical scheme of the invention is the application of formononetin in preparing medicaments for treating antifungal infected diseases, wherein the fungus is cryptococcus neoformans. The compound has an excellent antifungal activity on various superficial and deep funguses, has the advantages of high activity, low toxicity, broad antifungal spectrum and the like when being compared with an antifungal medicament in existing clinical application, and can be used for preparing antifungal medicaments.
Owner:苏州市马尔泰新材料有限公司
Application of formononetin in antifungal medicaments
InactiveCN103565793AGood antifungal activityBroad spectrum antifungalOrganic active ingredientsAntimycoticsAntifungal drugsMedicine
The invention relates to application of formononetin in antifungal medicaments. The technical scheme of the invention is the application of formononetin in preparing medicaments for treating antifungal infected diseases, wherein the fungus is candida glabrada. The compound has an excellent antifungal activity on various superficial and deep funguses, has the advantages of high activity, low toxicity, broad antifungal spectrum and the like when being compared with an antifungal medicament in existing clinical application, and can be used for preparing antifungal medicaments.
Owner:苏州市马尔泰新材料有限公司
Triazole alcohol antifungal compound with piperidine oxadiazole side chain and preparation method for compound and application of compound
ActiveCN105384734AStrong antifungal effectLow toxicityAntimycoticsOrganic chemistryDitazoleAntifungal drug
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Phosphoramido pyridine derivative, and preparation method, medical composition and application thereof in antifungal agent
InactiveCN102796139AStrong inhibitory activityBroad spectrum antifungalOrganic active ingredientsAntimycoticsOxygen atomChemical property
The invention provides a phosphoramido pyridine derivative represented by a structural formula (I) and salt thereof. In the formula, R1 represents a hydrogen atom, a halogen atom, cyano, amino, R4-NH-, R5-O-, C1-6 alkyl, hydroxyl C1-6 alkyl, C1-6 alkoxy or C1-6 alkoxy C1-6 alkyl; R4 represents C1-6 alkyl, hydroxyl C1-6 alkyl or C1-6 alkoxy C1-6 alkyl; R5 represents C1-6 alkyl or C1-6 alkoxy C1-6 alkyl; R2 and R3 are selected from a hydrogen atom, C1-6 alkyl or C1-6 alkoxy, or R2 and R3 form a C3-8 ring; and X represents a single bond, methylene, an oxygen atom, a sulphur atom, -CH2O-, -OCH2-, -NH-, -CH2NH-, -NHCH2-, -CH2S- or -SCH2-. The invention also provides a preparation method of the phosphoramido pyridine derivative and the salt thereof, a medical composition using the phosphoramido pyridine derivative and the salt thereof as the active ingredient, and application thereof in the preparation of antifungal medicaments. Compared with the conventional clinically applied antifungal medicaments, the compound has the advantages of high efficiency, low toxicity, wide antifungal spectrum, high physical and chemical property, fine in-vivo antifungal activity and the like.
Owner:姜远英
Triazole aromatic alcohol heterocyclic ether derivative and preparing method and application thereof
InactiveCN105237513ALow toxicityBroad spectrum antifungalOrganic active ingredientsAntimycoticsAntifungal drugFluconazole
The invention relates to a triazole aromatic alcohol heterocyclic ether derivative and the preparing method and application thereof, and particularly provides the general structure, crystal form, pharmaceutically acceptable inorganic acid salt or organic acid salt, aquo-complex, and solvate or prodrug of the triazole aromatic alcohol heterocyclic ether derivative. In-vitro and in-vivo bacteriostasis experiments prove that the compound has remarkable activity in inhibiting human body pathomycete candida albicans, candida parapsilosis, cryptococcus neoformans, candida glabrata, aspergillus fumigates, gypseous microsporum and trichophyton rubrum, and the activity is higher than that of fluconazole. Furthermore, the compound has the advantages of being low in toxicity, wide in antifungal spectrum and the like, and therefore the compound can be used for preparing antifungal drugs.
Owner:王倩
Microbial organic compound fertilizer and production process thereof
InactiveCN112898082AAdaptableBroad spectrum antifungalBio-organic fraction processingExcrement fertilisersRice strawBacillus amyloliquefaciens
The invention relates to the technical field of crop fertilizers, and in particular, relates to a microbial organic compound fertilizer. The formula of the microbial organic compound fertilizer comprises the following raw materials in parts by weight: 500 to 600 parts of cow dung, 400 to 500 parts of pig manure, 300 to 400 parts of sheep manure, 100 to 200 parts of chicken manure, 0.6 to 6 parts of a livestock and poultry manure decomposition agent, 300 to 400 parts of rice straw, 300 to 400 parts of wheat straw, 0.16 to 0.8 part of a straw decomposition agent, 100 to 200 parts of a functional additive, 0.1 to 0.4 part of bacillus amyloliquefaciens, 0.1 to 0.4 part of bacillus subtilis, 50 to 70 parts of chitosan and 50 to 70 parts of cellulose. The invention also provides a production process of the microbial organic compound fertilizer. Under the action of bacillus amyloliquefaciens and bacillus subtilis, the plant disease and insect pest resistance of crops can be improved.
Owner:银川瑞海陈技术咨询服务有限公司
Water soluble triazole compound and synthesis method thereof
ActiveCN101824002BBroad spectrum antifungalGood water solubilityOrganic active ingredientsAntimycoticsSolubilityAntifungal
The invention discloses a water soluble triazole compound and a synthesis method thereof. The water soluble triazole compound has a structure as shown in Formula Ia, Formula Ib, Formula Ic or Formula Id, wherein R1 is a group in Formula II. The compound of the invention is formed by adding a new group on the structural basis of a broad-spectrum, high-efficiency antifungal compound discovered in the present clinical application and new drug development process to increase the water solubility and reduce the toxicity, is a derivate of the triazole antifungal drug, and has the characteristics ofbroad antifungal spectrum, high antifungal activity, good safety and the like.
Owner:NANJING HUAWE MEDICINE TECH DEV
A novel azole antifungal compound and its preparation method and application
InactiveCN102796080BStrong antifungal activity against deep fungiBroad spectrum antifungalOrganic active ingredientsAntimycoticsAntifungalOrtho position
The invention provides a novel azole antifungal compound. According to the azole antifungal compound, a structural general formula is shown in the specification, wherein X is hydroxyl, Ar is 2,4-difluoro phenyl, and R is selected from hydrogen, alkyl, halogen, cyano-group, nitryl, amino or alkoxy and can be positioned at the ortho-position, meta-position or para-position of a benzene ring and can be mono-substituted or multi-substituted; the alkyl has 1 to 4 carbon atoms; the halogen is selected from F, Cl, Br and I; the amino is selected from -NH2, one or two aminos substituted by the alkyl and cyclic amino; and the alkoxy is selected from methoxyl, ethyoxyl and tert-butyl oxygroup. The invention also provides a method for preparing the compound and application of the compound to preparation of antifungal medicines. Compared with the conventional antifungal medicines which are applied clinically, the azole antifungal compound has the advantages of high antifungal activity on invasive fungi, high efficiency, low toxicity, broad spectrum and the like; and the method is simple and high in yield, and the prepared compound has a good antifungal effect.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Triazole alcohol derivatives, and preparation method and application thereof
InactiveCN110885323ALow toxicityBroad spectrum antifungalAntimycoticsOrganic chemistryAlkaneAntifungal drug
The invention relates to triazole alcohol derivatives, and a preparation method and application thereof. The chemical structures of the derivatives are shown as a formula I shown in the specification,wherein R represents a structure shown in the specification or a structure shown in the specification; R1 and R2 may individually represent a hydrogen atom, alkyl, aryl, aralkyl, or cycloalkyl; substituents may be located at various positions of the benzene ring in a mono- or poly-substituted manner; the substituents and R3 are selected from: a) a halogen which is F or Cl, b) an electron withdrawing group which is cyano or trifluoromethyl, c) C1-C4 lower alkyl or halogen-substituted C1-C4 lower alkyl, and d) C1-C4 lower alkoxy or halogen-substituted C1-C4 lower alkoxy. The compounds of the invention have strong antifungal activity, have the advantages of low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal drugs.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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