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Application of formononetin in preparation of aspergillus fumigatus resistant medicament

A technology of formononetin and Aspergillus fumigatus is applied in the directions of antifungal agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve good antifungal activity and broad antifungal spectrum.

Inactive Publication Date: 2014-02-19
苏州市马尔泰新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there is no report about the application of formononetin in infectious diseases

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  • Application of formononetin in preparation of aspergillus fumigatus resistant medicament
  • Application of formononetin in preparation of aspergillus fumigatus resistant medicament

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Embodiment 1

[0011] The specific implementation manners provided by the present invention will be described in detail below.

[0012] (1) Experimental method: conventional in vitro antibacterial test method (see: Antimicrob Agents Chemother 1995,39(5):1169 for details)

[0013] 1. Materials and Methods

[0014] (1) The compound to be tested in the present invention: formononetin, also known as formononetin (7-hydroxy-4'-methoxy isoflavone), its molecular formula is C 16 h 12 o 4 , the molecular weight is 268.26.

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Abstract

The invention relates to application of formononetin in aspergillus fumigatus prevention. The technical scheme of the invention provides application of the formononetin in preparation of a fungus infectious disease medicament. The fungus is aspergillus fumigatus. The compound in the invention is high in antifungal activity to various funguses on both the superficial part and the deep part. Compared with the conventional clinically applied antifungal medicament, the formononetin has the advantages of high efficiency, low toxicity, large antifungal spectrum and the like and can be used for preparing antifungal medicaments.

Description

technical field [0001] The invention relates to the application of a compound, in particular to the application of formononetin in Aspergillus fumigatus. Background technique [0002] Fungal infectious diseases are divided into four categories according to the parts of the fungus that invade the human body: superficial mycosis, skin mycosis, subcutaneous tissue mycosis and systemic mycosis; the former two are collectively called superficial mycosis, and the latter two are also called For deep mycoses. Fungal infectious diseases are divided into the following types according to different fungi: Candida albicans infectious disease, Candida parapsilosis infectious disease, Candida glabrata infectious disease, Cryptococcus neoformans infectious disease, plaster Microsporum infectious disease, Trichophyton rubrum infectious disease, Aspergillus fumigatus infectious disease. [0003] In recent years, with the wide application of broad-spectrum antibiotics, corticosteroids and im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P31/10
Inventor 朱明华
Owner 苏州市马尔泰新材料有限公司
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