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11 results about "Candida parapsilosis" patented technology
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Candida parapsilosis is a fungal species of yeast that has become a significant cause of sepsis and of wound and tissue infections in immunocompromised people. Unlike Candida albicans and Candida tropicalis, C. parapsilosis is not an obligate human pathogen, having been isolated from nonhuman sources such as domestic animals, insects and soil. C. parapsilosis is also a normal human commensal and it is one of the fungi most frequently isolated from human hands. There are several risk factors that can contribute to C. parapsilosis colonization. Immunocompromised individuals and surgical patients, particularly those undergoing surgery of the gastrointestinal tract, are at high risk for infection with C. parapsilosis. There is currently no consensus on the treatment of invasive candidiasis caused by C. parapsilosis, although the therapeutic approach typically includes the removal of foreign bodies such as implanted prostheses and the administration of systemic antifungal therapy. Amphotericin B and Fluconazole are often used in the treatment of C. parapsilosis infection.
Candida parapsilosis producing 3-methylthiopropanol and application thereof
The application belongs to the field of microorganism and fermentation engineering, and provides a Candida magnoliae with high yield of 3-methylthiopropanol, and the preservation number is CGMCC NO. 23668. The Candida magnoliae can be used for producing 3-methylthiopropanol, the yield can reach 3.16 g / L, and the ethanol tolerance is high, and can be applied in the wine making, condiment and food additive industries.
Owner:BEIJING TECH & BUSINESS UNIV
Preparation method of candida parapsilosis auxiliary fermentation sausage
The invention discloses a Candida parapsilosi GDMCC 66465 strain capable of automatically separating and preserving breeds and being used for sausage fermentation and an application method of the Candida parapsilosi GDMCC 66465 strain, and belongs to the field of food microorganisms. The bacterium is screened from Xuanwei hams, can be used for cooperatively fermenting sausages with lactobacillus plantarum, and can be used for remarkably promoting degradation of muscle protein and selective hydrolysis of triglyceride to strengthen the flavor of the hams. GC-IMS detection shows that the content of key flavor substances such as aldehydes and ketones in the finished sausage is remarkably increased, and the flavor score is increased by 30% or above compared with that of a control group. Genome sequencing analysis shows that the strain has no pathogenic risk and is a potential strain suitable for industrial production of fermented meat products.
Owner:NANJING AGRICULTURAL UNIVERSITY
Use of larch mushroom acid in the preparation of antifungal drugs
This invention discloses the application of larvicin or its pharmaceutical salt in the preparation of antifungal drugs. The structure of larvicin is shown below. This invention discovers an effective antifungal compound with pharmaceutical potential: larvicin. The compound larvicin of this invention exhibits clear antifungal activity against pathogenic fungi such as *Candida albicans*, *Candida auris*, *Candida tropicalis*, *Candida parapsilosis*, *Candida krusei*, *Cryptococcus neoformans*, *Trichophyton mentagrophytes*, and *Trichophyton rubrum*, with a minimum inhibitory concentration (MIC). 90 The range is 2–8 μg / mL.
Owner:THE NAVAL MEDICAL UNIV OF PLA
Carbonyl reductase mutant, coding gene and application of carbonyl reductase mutant in synthesis of 4-tert-butylcyclohexanol
The invention discloses a carbonyl reductase mutant, a coding gene and application of the carbonyl reductase mutant in synthesis of 4-tert-butylcyclohexanol, and belongs to the technical field of bioengineering. The carbonyl reductase mutant is obtained by carrying out amino acid mutation on short-chain dehydrogenase from escherichia coli K12 with an amino acid sequence shown as SEQ ID NO.1 or carrying out amino acid mutation on medium-chain dehydrogenase from candida parapsilosis with an amino acid sequence shown as SEQ ID NO.2. Compared with wild type carbonyl reductase, the carbonyl reductase mutant provided by the invention has higher enzyme activity, cis-4-tert-butyl cyclohexanol or trans-4-tert-butyl cyclohexanol can be prepared by taking 4-tert-butyl cyclohexanone as a substrate, the product yield is high, no by-product is generated, and the carbonyl reductase mutant has a very good industrial application prospect.
Owner:ZHEJIANG UNIV
Multiple qPCR (quantitative polymerase chain reaction) detection reagent for detecting superficial fungal disease pathogens
PendingCN121109646AMicrobiological testing/measurementMicroorganism based processesMolecular diagnosticsFungus Diseases
The invention discloses a multiple qPCR (quantitative polymerase chain reaction) detection reagent for detecting pathogens of a superficial fungal disease. The multiple qPCR detection reagent comprises specific primers and probes for detecting trichophyton rubrum, epidermophyton flocculent, microsporum canine, trichophyton beard, candida parapsilosis, candida albicans, malassezia furfur and gliocladium breviculare, wherein the specific primers and the probes are used for detecting trichophyton rubrum, epidermophyton flocculent, microsporum canine, trichophyton beard, candida parapsilosis; according to the invention, different fluorescently-labeled probes are utilized to add specific primers and probes of multiple pathogens into a reaction system to detect multiple targets at the same time, and the method has the advantages of good specificity, high sensitivity, high detection speed, capability of detecting multiple pathogens at the same time, rapidness, simplicity, convenience and economy; a convenient method is provided for rapid detection of superficial fungal disease pathogens, and the kit has important significance in epidemiological research, clinical early molecular diagnosis and the like.
Owner:KUNMING UNIV OF SCI & TECH
A plant essential oil composition having anti-candida activity and a preparation method and application thereof
This invention discloses a plant essential oil composition with anti-Candida activity and its preparation method, which consists of a heavy oil component of Sichuan pepper and a light oil component of dried ginger in a volume ratio of 1:8 to 2:1. Research in this invention has found that, after specific volume ratios, particularly when the heavy oil component of Sichuan pepper or the light oil component of dried ginger is in a volume ratio of 1:8, it exhibits a synergistic effect against Candida albicans, Candida tropicalis, and Candida glabrata; when the heavy oil component of Sichuan pepper or the light oil component of dried ginger is in a volume ratio of 2:1, it exhibits a very good synergistic effect against Candida parapsilosis. This invention allows the heavy oil component of Sichuan pepper and the light oil component of dried ginger to be formulated into an anti-Candida drug in a specific volume ratio.
Owner:NINGXIA MEDICAL UNIV
Detection, differentiation and identification of yeast of genus Candida, microbiological methods and tools therefor
The present invention relates to microbiological methods and media dedicated for the non-denaturing detection, differentiation and / or identification of Candida spp. Yeasts, in particular Candida auricula, Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis and Candida krusei. The invention more specifically relates to a method for identifying a yeast of the genus Candida, optionally present in a biological sample, comprising the steps of: culturing the yeast to be identified on or in a culture medium comprising:-a nutritional ingredient capable of allowing the development and growth of a yeast of the genus Candida; and-an alpha-glucosidase inducer and, optionally, an alpha-glucosidase repressor; -an acid phosphatase inducer and a phosphatase repressor; a-N-acetyl-beta-glucosaminase inducer, and a method for producing the same; and-detecting any alpha-glucosidase, acid phosphatase and / or N-acetyl-beta-glucosaminase activity expressed by said yeast; and-identifying the species to which said yeast belongs, based on the activity of alpha-glucosidase, acid phosphatase and / or N-acetyl-beta-glucosaminase actually expressed by said yeast.
Owner:BIOMERIEUX SA
A beta-1, 6-glycosidic bond hydrolytic enzyme and application thereof in traditional Chinese medicine resources
The application discloses a beta-1, 6-glycosidic bond hydrolytic enzyme and application thereof in traditional Chinese medicine resources. The method screens a key gene sequence with a function of hydrolyzing beta-1, 6-glycosidic bond from a Candida parapsilosis L7 genome, and names the key gene sequence as CoExg1. A gene engineering bacterium capable of efficiently heterologously expressing CoExg1 is constructed by using a molecular cloning technology. After fermentation and enzyme production, an enzyme catalytic reaction system is established, and a traditional Chinese medicine active molecule in mogroside V is directionally converted, beta-1, 6-glycosidic bonds in different regions of a substrate structure are selectively hydrolyzed, and therefore, efficient and phased synthesis of different products such as sianoside I and mogroside IIIE is realized. In addition, CoExg1 can also hydrolyze beta-glycosidic bonds in the structures of icariin and lupeol, and directionally synthesize icariin II and lupeol, thereby providing important technical support for high-value utilization of traditional Chinese medicine resources and quality improvement and efficiency enhancement of traditional Chinese medicine glycosides.
Owner:NANJING UNIV OF TRADITIONAL CHINESE MEDICINE
Microbial leavening agent for increasing flavor of ham and application thereof
The invention discloses a microbial leavening agent for increasing ham flavor and application thereof, and is characterized in that the microbial leavening agent is at least one of candida parapsilosis and penicillium angustifolium, and the viable count in candida parapsilosis powder and penicillium angustifolium powder is not less than 1 * 10 < 6 > CFU / g or 1 * 10 < 8 > CFU / mL. Further, the microbial leavening agent is prepared by mixing candida parapsilosis yeast powder and penicillium angustifolium powder according to the mass ratio of (1-2): (1-2), and the microbial leavening agent is added into normal-temperature pure water to be stirred and mixed to be uniform, so that a zymophyte solution is obtained; and uniformly spraying 50-300ml of the zymophyte liquid on the surface of the ham after air drying is finished according to the surface area of each square meter of the ham, and then placing the ham in a fermentation warehouse for fermentation for 2-4 months to obtain the flavored ham with meat fat fragrance, mellow fragrance and fresh fragrance. The fat fragrance, the mellow fragrance and the fresh fragrance of the dry-cured ham meat are obviously improved.
Owner:BEIJING TECH & BUSINESS UNIV
Primer probe group and kit for multiplex fluorescent PCR (Polymerase Chain Reaction) and / or multiplex quantitative digital PCR detection of five candida
PendingCN121472467AMicrobiological testing/measurementMicroorganism based processesMultiplexC. tropicalis
The invention belongs to the technical field of in-vitro molecular detection of pathogenic microorganisms, and particularly provides a primer probe group and a reagent for multiple fluorescent PCR (Polymerase Chain Reaction) and / or multiple quantitative digital PCR detection of five candida. The primer probe group comprises specific primer pairs and corresponding probes aiming at candida albicans, candida tropicalis, candida glabrata, candida parapsilosis and candida krusei. Based on the unified combination, two compatible detection paths are established: five-target synchronous qualitative detection can be realized by adopting a multiple fluorescent PCR (Polymerase Chain Reaction) method, and five-target absolute quantitative analysis can also be realized by adopting a multiple quantitative digital PCR method; the two methods can be applied independently or jointly. Through verification, the primer probe group has high specificity; the sensitivity is excellent, and DNA extracted from a clinical sample can be directly detected. The method is simple in detection process and short in time consumption, and an efficient and reliable molecular detection solution is provided for early differential diagnosis and precise medication of clinical invasive candidiasis.
Owner:HANGZHOU DILAN BIOTECHNOLOGY CO LTD
Method for producing hydroquinone
The purpose of the present invention is to provide a method for producing hydroquinone that involves an enzyme that can convert p-hydroxybenzoic acid into hydroquinone at higher efficiencies than the 4-hydroxybenzoate 1-hydroxylase possessed by Candida parapsilosis strain CBS604. This purpose is achieved, for example, by a method for producing hydroquinone, the method comprising a step for obtaining hydroquinone by reacting p-hydroxybenzoic acid with a 4-hydroxybenzoate 1-hydroxylase derived from Spathaspora passalidarum.
Owner:BIOPHENOLICS INC