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Use of rhizoma paridis chinensis for preparing antifungal drug

An antifungal drug, the technology of Bitouqi, which is applied in the field of medicine, can solve the problems that the antifungal effect of Bitouqi has not been seen.

Active Publication Date: 2018-11-09
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, at present, there is no report on the antifungal effect of Pianitouqi at home and abroad.

Method used

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  • Use of rhizoma paridis chinensis for preparing antifungal drug
  • Use of rhizoma paridis chinensis for preparing antifungal drug
  • Use of rhizoma paridis chinensis for preparing antifungal drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0018] 1. The effect of Piantoqi on different fungi

[0019] 1. Test drug

[0020] Part 7: Bought from Delkang Pharmaceutical Chain Store (the fourth chain store of Huai Ya).

[0021] Fluconazole: sigma company, batch number 036M4709V.

[0022] Dimethylsulfoxide (DMSO): Tianjin Tianli Chemical Reagent Co., Ltd.

[0023] All reagents were stored at -20°C. Before the experiment, the drug was taken out and placed in a 35°C incubator to melt, mixed well, and pharmacodynamic tests were carried out respectively.

[0024] 2. Strains

[0025] Strains used, including:

[0026] 1) Sensitive strains: sensitive Candida albicans (SC5314), Candida parapsilosis (22019) and Cryptococcus neoformans (32609);

[0027] 2) Drug-resistant strains: drug-resistant Candida albicans (103), drug-resistant Candid...

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PUM

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Abstract

The invention discloses use of rhizoma paridis chinensis for preparing an antifungal drug, belonging to the technical field of medicines. In-vitro cell experiments show that rhizoma paridis chinensishas different levels of antifungal effects and even fungus-killing effect to drug-resistant candida albicans 103, candida albicans SC5314, cryptococcus neoformans, candida krusei, candida parapsilosis, candida glabrata and candida tropicalis and therefore can be taken as the antifungal drug. According to the use, new use of rhizoma paridis chinensis is opened up, rhizoma paridis chinensis is usedfor preparing the antifungal drug, and a new candidate drug is provided for the treatment of fungal infection. Currently, drugs with wide antifungal spectrums and fungus-killing activity on clinic arevery few, and a new way is provided for the clinical and efficient treatment of infection of fungi and even drug-resistant fungi by virtue of the characteristics of wide antifungal spectrums and fungus-killing activity of rhizoma paridis chinensis under the conditions that clinical fungus drug resistance becomes common increasingly and the drug resistance level becomes serious increasingly.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the use of mitocephalus seven in the preparation of antifungal drugs. Background technique [0002] Piantouqi is one of the seven medicines of Qinling Mountains. It is the dried root and rhizome of SmilacinajaponicaA.Gray and Smilacina henryi(baker).WangTang, a perennial herb of the genus Liliaceae. It has the effects of invigorating qi and kidney, expelling wind and dampness, promoting blood circulation and regulating menstruation. It can be used to treat rheumatism and bone pain, nervous headache, mastitis, irregular menstruation, carbuncle, furuncle, swollen poison and bruises and other diseases. [0003] But at present, there is no report on the antifungal effect of Pitacean seven at home and abroad. Contents of the invention [0004] The purpose of the present invention is to provide the application of Mitoseven in the preparation of antifungal drugs. [00...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P31/10
CPCA61K36/896A61K2236/15A61K2236/333A61K2236/51A61P31/10
Inventor 刘伟张子悦乔欣悦
Owner SHAANXI UNIV OF SCI & TECH
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