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Polyrhachis vicina extractive and antifungal medical purpose thereof

A technology of imitating spiny ants and extracts, which is applied in the field of medicine, can solve the problems of poor metabolic properties and physical and chemical properties, poor curative effect of systemic infection, difficulty in satisfying research and development samples, etc., and achieves convenient raw material sources and industrialization prospects Clear, huge social and economic benefits

Inactive Publication Date: 2014-03-19
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although new antifungal drugs have expanded antibacterial spectrum, they have poor metabolic properties and physical and chemical properties, low water solubility, and poor bioavailability; patients need a high-fat diet to facilitate drug absorption, or take expensive special preparations to take effect; for Cyclodextrin added to increase water solubility also poses a greater threat to those with renal insufficiency
[0005] Triazole antifungal drugs, no matter the first generation or the second generation, have poor curative effect on systemic infections caused by filamentous fungi; and although new echinocandin antifungal drugs have certain curative effects on such diseases, they still face challenges. The biggest problem is: there is no oral dosage form, only limited to injection (and limited to hospital use), so it is quite inconvenient for patients to use
However, bulldog ants (Myrmecia nigriscapa and similar species) are special insects in Australia, and are not distributed in other countries and regions; and the collection of metapleurins is to stimulate living bulldog ants to secrete antibiotic-like active substances from the metapleural glands , therefore, it is difficult to meet the large number of samples required for further research and development

Method used

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  • Polyrhachis vicina extractive and antifungal medical purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 : One of the preparation processes of the extract of Pseudomonas spinosa

[0023] The crude drug used in this example was purchased from the local Chinese medicinal material market in Lincang City, Yunnan Province, and was identified as a dried product of Pseudomonas spiny ants by Professor Yang Zizhong of the National and Local Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Yunnan Province.

[0024] 1.1 Take 400.0 mg of dried Pseudomonas spinosa, soak and extract in 100, 80, and 60 ml of 75% ethanol solution at room temperature for three times, the extraction time is 18, 12, and 8 hours respectively, filter out the soaking solution, and combine and extract liquid, concentrated under reduced pressure, and recovered the solvent. The worms after extraction were dried naturally.

[0025] 1.2 Use a tissue homogenizer to grind and homogenize the parasites that have been soaked and extracted under Item 1.1 and ...

Embodiment 2

[0026] Example 2 : The second preparation process of the extract of Pseudomonas spp.

[0027] The crude drug used in this example was purchased from the local Chinese medicinal material market in Lincang City, Yunnan Province, and was identified as a dried product of Pseudomonas spiny ants by Professor Yang Zizhong of the National and Local Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Yunnan Province.

[0028] 2.1 Take 400.0 mg of dried Pseudomonas spinosa extract, soak it in 75% methanol solution at room temperature and extract three times, the dosage of each 75% methanol solution is 60 ml, the extraction time is 24, 12, 6 hours respectively, filter Take out the soaking solution, concentrate under reduced pressure, and recover the solvent. The worms after extraction were dried naturally.

[0029] 2.2 Use a tissue homogenizer to grind and homogenize the parasites that have been soaked and extracted under Item 2.1 and t...

Embodiment 3

[0030] Example 3 : Detection of antifungal activity of the extract of Pseudomonas spp.

[0031] With reference to the standardized antifungal susceptibility test method proposed by the National Committee for Clinical Laboratory Standards (NCCLS), the extract (1) and the extract (2 ) in vitro antifungal activity.

[0032] 3.1 Fungal standard strain:

[0033] Candida albicans ATCC76615 (CS3): Provided by PLA Second Medical University.

[0034] Candida albicans ATCC90029 (5-FC drug-resistant strain): Provided by the Clinical Laboratory Center of the Ministry of Health of Beijing Hospital.

[0035] Candida albicans 98001: Provided by Wuhan Culture Collection Center.

[0036] 3.2 Reagents:

[0037] 3.2.1 Sabouraud dextrose agar medium (sabouraud dextrose agar): product of Guangdong Kai Microbiology Technology Co., Ltd.

[0038] 3.2.2 Yeast extract: repackaged by Haishenggong Bioengineering Technology Service Co., Ltd.

[0039] 3.2.3 Three azamorphine propanesulfonic acid (3...

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Abstract

The invention relates to a Polyrhachis vicina extractive and antifungal medical purpose thereof. Specifically, the invention relates to a traditional Chinese medicine Polyrhachis vicina extractive with function of controlling fungal infection diseases, and a preparation method and medical purpose thereof in preparation of antifungal drugs. The Polyrhachis vicina extractive provided by the invention is prepared by organic solvent immersion and extraction on dried bodies of Polyrhachis vicina. The extractive has significant activity on inhibiting the growth of Candida albicans, and can be prepared into tablets, granules, capsules, pills, an oral liquid, dripping pills, a coating agent, an external liniment, a film agent, an ointment, a spraying agent, an injection, a transdermal patch and an aerosol, and used in the preparation of medicines, daily chemical products or medical devices for prevention and treatment of fungal infections.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular, the present invention relates to an extract of Pseudomonas ant with antifungal activity and a preparation method thereof, a pharmaceutical composition containing the extract and its use in the preparation of drugs for preventing and treating fungal infections the use of. Background technique [0002] With the development of medical science, various new drugs and new technologies such as broad-spectrum antibiotics, hormones, various catheter intubation techniques, chemotherapy, transplantation and other medical methods are widely used, as well as HIV infection and tumors, causing the human immune system to be gradually The number of cases of destruction is increasing year by year, which leads to an increasing incidence of mycoses caused by deep fungal infections; on the other hand, with the widespread use of human antibiotics and clinical antifungal drugs, traditional antib...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P31/10
Inventor 张成桂赵荣华李成功赵昱杜一民
Owner DALI UNIV
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