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3 results about "Echinocandin" patented technology
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Echinocandins are a new class of antifungal drugs that inhibit the synthesis of β-glucan in the fungal cell wall via noncompetitive inhibition of the enzyme 1,3-β glucan synthase. The class has been termed the "penicillin of antifungals," along with the related papulacandins, as their mechanism of action resembles that of penicillin in bacteria. β-glucans are carbohydrate polymers that are cross-linked with other fungal cell wall components, equivalent to bacterial peptidoglycan. Caspofungin, micafungin, and anidulafungin are semisynthetic echinocandin derivatives with clinical use due to their solubility, antifungal spectrum, and pharmacokinetic properties.
Echinocandin compounds, pharmaceutical compositions thereof, and uses thereof
Owner:SHANGHAI INST OF PHARMA IND CO LTD +1
Echinocandin drug impurity compound, preparation method therefor and use thereof
PCT designated stageWO2026102990A1Peptide preparation methodsBiological testingEchinocandinSide chain
Provided are a novel echinocandin drug impurity compound, a preparation method therefor, and the use thereof. Compared with the structure of drug micafungin, the echinocandin drug impurity compound has one more hydrophobic acyl side chain. The method comprises first dissolving a side chain active ester in a solvent, adding a basic catalyst, and then adding an appropriate amount of a FR179642 compound for reaction. The provided high-purity echinocandin drug impurity can be applied to quality control of the echinocandin drug as a reference standard for establishing analysis methods.
Owner:SHANGHAI TECHWELL BIOPHARMACEUTICALS CO LTD
Pharmaceutical composition comprising echinocandin analog and preparation method for pharmaceutical composition
The present disclosure provides a pharmaceutical composition comprising an echinocandin analog and a preparation method for the pharmaceutical composition. Specifically, the present disclosure provides a pharmaceutical composition, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a solubilizer, and a buffer. The composition has excellent stability.
Owner:JIANGSU HENGRUI MEDICINE CO LTD