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Applications of nicotinamide as antifungal drug synergist

The technology of an antifungal drug, nicotinamide, is applied in the field of medicine to achieve the effect of treating fungal infection, important clinical application value, and enhancing effect

Active Publication Date: 2017-02-15
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report that nicotinamide can be used as a synergist for antifungal drugs such as azoles, echinocandins or polyenes

Method used

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  • Applications of nicotinamide as antifungal drug synergist
  • Applications of nicotinamide as antifungal drug synergist
  • Applications of nicotinamide as antifungal drug synergist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: The effect of combined use of nicotinamide and fluconazole on different clinical fungal strains

[0022] Materials and Method

[0023] 1. Reagent:

[0024] Nicotinamide: American sigma reagent company (the same below).

[0025] Fluconazole: American sigma reagent company (the same below).

[0026] Dimethyl sulfoxide: China National Pharmaceutical (Group) Shanghai Chemical Reagent Company.

[0027] Nicotinamide was prepared with a culture medium to prepare a mother liquor with a concentration of 200 mg / ml, and fluconazole was prepared with dimethyl sulfoxide to prepare a mother liquor with a concentration of 6.4 mg / ml. The test drug was stored at -20°C. Before the experiment, the drug storage solution was taken out and placed in a 35°C incubator to melt, mix well, and conduct pharmacodynamic tests respectively.

[0028] 2. Strains:

[0029] Clinical strains of Candida albicans, Candida tropicalis and Cryptococcus neoformans were provided by the Fungi Room of Shanghai Chan...

Embodiment 2

[0057] Example 2: The effect of combined use of nicotinamide and voriconazole on different clinical fungal strains

[0058] Materials and Method

[0059] 1. Reagent:

[0060] Nicotinamide: American sigma reagent company (the same below).

[0061] Voriconazole: American sigma reagent company (the same below).

[0062] Dimethyl sulfoxide: China National Pharmaceutical (Group) Shanghai Chemical Reagent Company.

[0063] Nicotinamide was prepared with culture broth to prepare a mother liquor with a concentration of 200 mg / ml, and voriconazole was prepared with dimethyl sulfoxide to prepare a mother liquor with a concentration of 6.4 mg / ml. The test drug was stored at -20°C. Before the experiment, the drug storage solution was taken out and placed in a 35°C incubator to melt, mix well, and conduct pharmacodynamic tests respectively.

[0064] 2. Strains:

[0065] Candida albicans, Candida tropicalis and Cryptococcus neoformans were provided by the Fungus Room of Shanghai Changhai Hospital and c...

Embodiment 3

[0074] Example 3: The effect of combined use of nicotinamide and caspofungin on different clinical fungal strains

[0075] Materials and Method

[0076] 1. Reagent:

[0077] Nicotinamide: American sigma reagent company (the same below).

[0078] Caspofungin: American sigma reagent company (the same below).

[0079] Dimethyl sulfoxide: China National Pharmaceutical (Group) Shanghai Chemical Reagent Company.

[0080] Nicotinamide was prepared with a culture broth to prepare a mother liquor with a concentration of 200 mg / ml, and caspofungin was prepared with dimethyl sulfoxide to prepare a mother liquor with a concentration of 0.2 mg / ml. The test drug was stored at -20°C. Before the experiment, the drug storage solution was taken out and placed in a 35°C incubator to melt, mix well, and conduct pharmacodynamic tests respectively.

[0081] 2. Strains:

[0082] Candida albicans, Candida tropicalis and Cryptococcus neoformans were provided by the Fungus Room of Shanghai Changhai Hospital and co...

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Abstract

The invention belongs to the technical field of medicine, and more specifically provides applications of nicotinamide in preparing an antifungal drug synergist. Novel applications of nicotinamide are provided; nicotinamide is capable of reducing dosages of antifungal drugs such as azoles, echinocandins, and polyenes as an antifungal drug synergist, and reducing toxic and side effect of drugs, especially fluconazole, voriconazole, caspofungin, and amphotericin B, accordingly. Nicotinamide is capable of recovering the effect of antifungal drugs on drug resistance funguses as a antifungal drug synergist, treating fungal infection especially drug resistance fungus infection effectively, reducing drug toxicity, and reducing economic burden of patients in drug therapy; and in addition, nicotinamide is capable of improving the effect of antifungal drugs on candida tropicalis and cryptococcus neoformans, and possesses high clinical application value.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to the new use of nicotinamide as an antifungal drug synergist. Background technique [0002] In recent years, invasive fungal infection has become one of the important death factors in intensive care units (ICUs) in many countries. However, there are relatively few types of antifungal drugs that can be used clinically, with large toxic and side effects, and clinically resistant strains are continuously isolated and reported, which makes the treatment of fungal infections facing more and more severe challenges. Antifungal drugs such as azoles, echinocandins and polyenes are commonly used clinically antifungal drugs that can effectively treat deep and superficial fungal infections, such as fluconazole and voriconazole in azoles; Caspofungin in bacteriocins; Amphotericin B in polyenes, etc. However, as the clinically drug-resistant strains become more and more common, the dosage has to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61P31/04A61K31/455
CPCA61K31/455A61K45/06A61K2300/00
Inventor 朱臻宇曹颖瑛廖泽彬董怀怀朱逸菲李玲王韵柴逸峰姜远英
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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