50 results about "Micafungin" patented technology

The invention discloses a pharmaceutical composition containing an annular polypeptide compound micafungin of formula (I), or its salt and trehalose as a stabilizer. The pharmaceutical composition provided by the invention has good stability.

The invention relates to a method for preparing a pharmaceutical intermediate, in particular to a method for synthesizing and purifying a micafungin intermediate. The method comprises the following steps: subjecting a compound II to a carboxylic acid group acylation reaction to obtain a compound III, subjecting the compound III and a compound IV to a condensation reaction, and carrying out crystallization purification to obtain a high-purity micafungin intermediate I. The preparation method provided by the invention has the advantages of simple process, cheap reagents, low solvent consumption, greatly reduced production cost, and higher purity and yield of products, and easy realization in industrial production.

The invention discloses a saccharomyces cerevisiae strain with excellent autolysis resistance, and belongs to the field of molecular biology and microbiology. The strain is preserved in China General Microbiological Culture Collection Center (CGMCC) on September 1, 2014, the Preservation No. is CGMCC No. 9628, and the preservation address is Institute of Microbiology at the Chinese Academy of Sciences, at No.3, Courtyard No.1, Beichen West Road, Chaoyang District, Beijing. Compared with original strains, the thickness of cell walls of the strain is doubled, the strain can tolerate a starvation culture for 24 h in a mixture of 50 ng / mL of micafungin, 8% of ethanol, 0.4 M NaCl and sterile water, and autolysis simulation experiment data and scanning electron microscope results (60 h) show that the autolysis of recombinant strains is superior to that of original strains. The strain disclosed by the invention provides a new thought for the better control and utilization of an autolysis phenomenon of saccharomyces cerevisiae, and the obtained strain has a good application value in the aspects of improving the properties such as flavor, foam stability and the like of beer.

The invention relates to a solid phase-liquid phase full synthetic method for preparing micafungin. The method comprises that Fmoc-P-CTC resin serves as a carrier, a solid phase polypeptide synthetic method is adopted to gradually couple amino acid with an Fmoc protecting group from the C end to the N end, and then the protecting group is deprived through splitting, intramolecular reaction and liquid phase condensation to obtain the micafungin. The method is high in yield, brings convenience to aftertreatment and provides a new thinking way for industrial scale production of the micafungin.

The invention discloses a preparation method of immobilized cyclic lipopeptide deacylase. A cyclic lipopeptide deacylase solution is directly mixed with a porous hydrophily enzyme carrier without purification, one or more kinds of organic solutions and inorganic salt are added, and then the immobilized cyclic lipopeptide deacylase is obtained. The invention further discloses application of the method in industrial production of micafungin parent nucleuses and anidulafungin parent nucleuses. The preparation method is simple in technology, enzyme purification equipment is omitted, the recovery rate of enzyme activities is obviously increased in the immobilization process, and immobilized enzymes can be repeatedly used. The enzyme method for converting micafungin and anidulafungin intermediates has higher concentration of reaction substrates when compared with a fermentation conversion method, a few product impurities are generated, and the conversion efficiency is high.

The invention discloses a high-purity micafungin or a salt thereof, and a preparation method and an application thereof. The content of a residual organic solvent in the micafungin or the salt thereofis lower than 1.8%. Air with a certain humidity is introduced into a drying box during preparation,, a raw material containing micafungin or the salt thereof is put into the drying box, and the raw material a water system undergo vacuum drying, and when the humidity of the drying box reaches 70% or above, air introduction is stopped. The preparation method has the advantages of mild conditions, simple operation process, high yield, good stability and convenient transportation of the product, great reduction of the technological operation difficulty coefficient, and reduction of the productioncost. The micafungin or the salt thereof can be used for preparing medicines for preventing or treating diseases caused by fungal infection.

The invention relates to a solid phase-liquid phase full synthetic method for preparing micafungin. The method comprises that Fmoc-P-CTC resin serves as a carrier, a solid phase polypeptide synthetic method is adopted to gradually couple amino acid with an Fmoc protecting group from the C end to the N end, and then the protecting group is deprived through splitting, intramolecular reaction and liquid phase condensation to obtain the micafungin. The method is high in yield, brings convenience to aftertreatment and provides a new thinking way for industrial scale production of the micafungin.

The invention belongs to the technical field of medicines, and in particular relates to an anti-infection micafungin freeze-drying composition and a preparation method thereof. The anti-infection micafungin freeze-drying composition mainly consists of active components micafungin, mannitol, meglumine and a pH adjusting agent. The anti-infection micafungin freeze-drying composition provided by the invention is stable in quality and free of conspicuous light degradation phenomenon after being diluted, so that convenience can be brought to clinical medical operators to prepare medicines, and use security to patients can be improved.

The invention discloses a preparation method for a micafungin precursor compound by using a Coleophoma sp. fermentation culture. The method comprises the following steps: carrying out filtration, digestion, resin adsorption, desorption, condensation and the like on the Coleophoma sp. fermentation culture so as to obtain a crude extract of FR901379; and carrying out further purification on the crude extract of the FR901379 by using silica gel chromatography so as to obtain a micafungin precursor compound FR901379 product with high purity. The invention has the following advantages: resin adsorption and silica gel chromatography are used to extract and separate the FR901379 in the method to prepare the micafungin precursor compound FR901379 with high purity, and the method is simple and feasible and is suitable for industrial production.

The present invention provides simple, cost effective, rapid, and scalable at industrial scale and provide high purity and yield of Echinocandin-type compounds at low cost as compared to prior art. Moreover the process allows for the removal of impurities by using economical salt-adsorbent complex and provide highly purified Echinocandin type compounds which is highly improved in terms of purity and sufficient for further processing to obtain an active pharmaceutical ingredient such as, the antifungals caspogungin, anidulafungin, and micafungin.

The present invention provides a medicinal composition containing micafungin or a pharmaceutically acceptable salt thereof and trehalose as a stabilizing agent.

The invention discloses a liquid pharmaceutical composition containing echinocandin antifungal agent micafungin, wherein the pharmaceutical composition containing carbohydrate as a stabilizer. The pharmaceutical composition provided by the invention has good stability.

The present invention relates to an improved process for the preparation of Micafungin.

The invention discloses a pharmaceutical composition of micafungin or its salt. The composition uses polysaccharide or monosaccharide or a mixture thereof as excipient and may contain an appropriate amount of pH regulator. The stability and potential safety of the pharmaceutical composition provided by the invention are superior to the existing preparations.