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70 results about "Teicoplanin" patented technology

Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. It is a semisynthetic glycopeptide antibiotic with a spectrum of activity similar to vancomycin. Its mechanism of action is to inhibit bacterial cell wall synthesis.

Production method of high-purity teicoplanin

The invention provides a method for making high-purity teicoplanin. The method comprises the following stages that: stage a, gel chromatography and macropore fractionation by adsorption of a teicoplanin crude product solution are carried out so as to obtain a teicoplanin crude product solution; stage b, active carbon decoloring, ultrafiltration, nanofiltration and crystallization of the teicoplanin crude product solution are carried out so as to obtain high-purity teicoplanin. The method furthest increases the production efficiency of teicoplanin, thereby realizing the industrialization of high-purity teicoplanin.
Owner:ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY

Method of producing teicoplanin

ActiveUS20050245481A1Inexpensive and safe methodCheap methodAntibacterial agentsBiocideActivated carbonMicroorganism
Disclosed is a method of producing teicoplanin. The method includes purifying teicoplanin from a culture broth, obtained by culturing microorganisms capable of producing teicoplanin by a porous adsorption resin under selective elution conditions and recovering highly pure teicoplanin using activated carbon and / or ultrafiltration. In this regard, the method can further include ultrafiltration as pre-treatment before the culture broth is adsorbed into the porous adsorption resin so as to increase the purity of teicoplanin.
Owner:DONG KOOK PHARMA CO LTD

Preparation method of single teicoplanin components

The invention relates to a preparation method of single teicoplanin components, which belongs to the field of preparation of medicaments with microbial ingredients. The method comprises the following steps of: decolorizing teicoplanin fermentation liquor through macroporous decolorizing resin, and absorbing the teicoplanin fermentation liquor through macroporous adsorption resin, then desorbing the teicoplanin fermentation liquor, and concentrating the teicoplanin fermentation liquor to obtain a crude teicoplanin extract including the six components of TA2-1, TA2-2, TA2-3, TA2-4, TA2-5 and TA3-1; and dissolving the crude extract in water, and performing chromatographic separation on the dissolved crude extract through polymer microspheres to obtain the six single components, namely TA2-1, TA2-2, TA2-3, TA2-4, TA2-5 and TA3-1, of teicoplanin with high purity. According to the separation method of the single teicoplanin components, the novel chromatography media-polymer microspheres are adopted to simultaneously separate the six single components from the crude teicoplanin extract; and the method is simple in technology, can be used for disposing a large quantity of samples, consumes less solvent, can be used for preparing the single teicoplanin components in a large scale, and provides samples for intensive study on pathology, toxicology and the like of the single teicoplanin components.
Owner:NCPC NEW DRUG RES & DEV

New lactic bacteria useful as probiotics

InactiveUS20080063666A1Pleasant flavorHealthy digestion and intestineBiocideBacterial antigen ingredientsDiseaseAmpicillin
An isolated strain of Enterococcus faecalis GALT deposited under number C E C T 7121 of the group of lactic bacteria is disclosed, which is capable of surviving and colonizing the gastrointestinal tract of humans and / or animals and showing beneficial probiotic activity for the health of humans and animals. The strain E. faecalis GALT and / or a culture supernatant and / or metabolites thereof shows no in vitro multiresistance to antibiotics of common use in human clinics as glycopeptides, such as vancomycin, teicoplanine; carbapenemes, such as impipenem, meropenem; and ampicillin. The strain E. faecalis GALT contains no red blood cell-destroying hemolysins of human, ovine and equine origin; and it does not produce any gelatinase, DNase and decarboxylases. The strain E. faecalis GALT is useful for the preparation of a composition intended for the treatment and / or prophylaxis of disorders associated with colonization by pathogenic microorganisms of the gastrointestinal tract; for use as a regulator of the immune response in human and animals, as well as for the preparation of a composition. The invention is also directed to methods and uses of the strain E. faecalis GALT.
Owner:ALLENDE MIGUEL ANGEL GARCIA

Teicoplanin p-chlorophenyl isocyanate chiral stationary phase filling and method for preparing same

InactiveCN1994557AEasy to prepareChiral recognition is not affectedOther chemical processesTriethoxysilaneElectrical polarity
The invention relates to a carbanilate group carbanilate group chirality fixed phase stuff and relative production, wherein it uses silica gel as carrier; the carrier and 3-propyl triethoxysilicane to process silanization reaction; activates the carrier and distant arm; bonds silica carrier and peptide macrocyclic antibiotics, processes derivation with carbanilate group. The inventive fixed phase stuff has high chirality recognize ability and high stability to be used in any spectrum conditions. The invention can separate glutacid in reverse flow phase, to separate the salbutamolum in polar flow phase.
Owner:ZHEJIANG UNIV

Separating and purifying method for obtaining highly pure teicoplanin

The invention discloses a separating and purifying method for obtaining highly pure teicoplanin. The method comprises the following steps: removing solids in a teicoplanin fermenting liquid through using a microfiltration membrane, and concentrating an obtained teicoplanin-containing micro-filtrate through a nanofiltration membrane to obtain a teicoplanin concentrate; carrying out adsorption elution of the concentrate through a macroporous adsorption resin twice to obtain a highly pure teicoplanin eluate; carrying out nanofiltration concentration of the eluate, adding a protein precipitating agent acetone to the concentrate for precipitating proteins of the concentrate, and filtering for removing the proteins to obtain a filtrate; adding active carbon to the filtrate for decoloring, and filtering to obtain a decolored liquid; and adding acetone to the decolored liquid, carrying out low temperature crystallization, and carrying out vacuum drying of obtained crystals to obtain finally obtained highly pure teicoplanin having a purity of above 96%. The method has the advantages of low cost, high separation purity of teicoplanin, and suitableness for the commercial production.
Owner:江苏海阔生物医药有限公司

Methods for producing an oralsuspension of teichoplanin or teichoplanin analogs

A stable suspension of teicoplanin and one or more pharmaceutically acceptable additives and method for preparation wherein the teicoplanin is mixed with an aqueous or non aqueous suspension base and pharmaceutically acceptable additives and wherein the teicoplanin is milled to obtain a homogeneously dispersed suspension.
Owner:MAHER ILLYA KEITH

Preparation method of high-purity teicoplanin

The invention relates to a preparation method of high-purity teicoplanin, which comprises the following steps: dissolving a crude teicoplanin product in water or a buffer salt solution, adding the sample to a chromatographic column filled with nano polymer microspheres, carrying out gradient analysis with a polar solvent / water mixed liquid to obtain a teicoplanin analysis solution in which the proportion of the components and impurities are satisfactory, decolorizing with activated carbon or resin, nanofiltering, desalting, concentrating, crystallizing, filtering, drying and the like to obtain the high-purity controllable-proportion teicoplanin fine powder. The method provided by the invention has the advantages of simple technique, high sample processing capacity and low solvent consumption, and can be used for large-scale preparation of medicinal teicoplanin fine powder.
Owner:NCPC NEW DRUG RES & DEV

Method for separating and measuring Palonosetron hydrochloride and optical isomers thereof

ActiveCN101661019AQuantitative determination of contentComponent separationSolid sorbent liquid separationOrganic solventGlycopeptide
The invention relates to a method for separating and measuring content of Palonosetron hydrochloride and optical isomers thereof by high performance liquid chromatography, which is characterized in that: a chromatographic column packing material used in the high performance liquid chromatography is macrocyclic glycopeptides and teicoplanin bonded silica gel, and a mobile phase consists of aqueoussolution of triethylamine and organic solvent.
Owner:CHONGQING HUAPONT PHARMA

Method for detecting antibacterial agent in serum by ultra-high performance liquid chromatography-tandem mass spectrometry technology

The invention discloses a method for detecting an antibacterial agent in serum by an ultra-high performance liquid chromatography-tandem mass spectrometry technology. The antibacterial agent containssulbactam (SBT), imipenem (IPN), linezolid (LNZ), melopenem (MPN), moxifloxacin (MXC), piperacillin (PRC), tigecycline (TGC), cefoperazone (CFZ), vancomycin (VCM) and teicoplanin (TCL). The method comprises the steps: detecting the content of the antibacterial drug in the pretreated serum by adopting an ultra-high performance liquid chromatography tandem mass spectrometry method, quantifying by utilizing a mass spectrometry isotope internal standard method, establishing a calibration curve by taking the concentration ratio of a standard substance to an internal standard substance as an X axisand the peak area ratio of the standard substance to the internal standard substance as a Y axis, and calculating the concentration of a target drug in the serum. According to the method, the pretreatment process is simple, the sensitivity is high, the specificity is high, separation and detection of the antibacterial agent are completed within 5 min, and a reliable detection method is provided for monitoring the treatment concentration of the antibacterial agent clinically.
Owner:南京品生医学检验实验室有限公司

Antibiotic coating of porous body, its prepn. and application

The invention describes an antibiotic coating for porous bodies and its use. Into the porous system of non-metallic porous bodies and of metallic porous bodies, a coating made of at least one antibiotic salt that is hardly soluble in water or in an aqueous environment from the group of the netilmicin laurate, the netilmicin myristate, the netilmicin dodecyl sulfate, the sisomicin laurate, the sisomicin myristate, the sisomicin dodecyl sulfate, the gentamicin laurate, the gentamicin myristate, the clindamycin laurate, the amikacin laurate, the amikacin myristate, the amikacin dodecyl sulfate, the kanamycin laurate, the kanamycin myristate, the kanamycin dodecyl sulfate, the tobramycin laurate, the tobramycin myristate, the tobramycin dodecyl sulfate, the ciprofloxacin myristate, the vancomycin dodecyl sulfate, the vancomycin laurate, the vancomycin myristate, the vancomycin teicoplanin and the clindamycin teicoplanin is introduced. The antibiotically coated, porous bodies are used as implants.
Owner:HERAEUS MEDICAL

Purification method of high-purity teicoplanin refined powder

The invention provides a purification method of high-purity teicoplanin refined powder, which comprises the following steps: centrifuging a teicoplanin fermentation liquid under alkaline conditions to remove solids in the fermentation liquid, regulating the filtrate to a neutral state, adsorbing and eluting with a macroporous adsorbent resin to obtain a teicoplanin eluate with the concentration of 65% above, and filtering by gel chromatography to obtain a 80% teicoplanin eluate; concentrating the eluate, adding acetone to precipitate, and centrifuging to obtain a milk white teicoplanin crude product; and dissolving the crude product with a right amount of water, adding the sample to a chromatographic column filled with reversed phase silica gel, carrying out gradient elution with an acetonitrile-water mixed solution to obtain a high-purity teicoplanin eluate, adding activated carbon for decolorization, filtering, cooling to precipitate, removing the residual impurities, adding acetone to the clear solution to completely precipitate, and carrying out infrared drying on the wet product to obtain the teicoplanin pure product. The method has the advantages of simple technique, reliable quality, high purity of the teicoplanin refined powder and controllable single-component content, and is suitable for industrial large-scale production of high-purity teicoplanin.
Owner:FUJIAN INST OF MICROBIOLOGY

Method for separating and purifying teicoplanin

The invention provides a method for separating and purifying teicoplanin. The method specifically comprises the following steps: filtering a teicoplanin fermentation liquid by means of a ceramic membrane; performing macroporous adsorption resin column chromatography; performing cation exchange resin column adsorption, and performing elution; performing nanofiltration on the eluate, and performing concentration; performing reverse chromatographic resin column adsorption, and performing elution; performing activated carbon decolorization; performing nanofiltration on the decolorization liquid, and performing concentration; performing ultrafiltration, performing nanofiltration, and performing concentration; and performing freeze-drying. The method overcomes the defects of the existing teicoplanin extraction technology, and improves the purity of the teicoplanin.
Owner:鲁南新时代生物技术有限公司

Medicinal composition for treating complex infection and preparation method of medicinal composition

The invention relates to a medicinal composition for treating complex infection and a preparation method thereof. The medicinal composition is characterized by comprising an active ingredient selected from one of glycopeptides antibacterial drugs of telavancin, dalbavancin, oritavancin, vancomycin, teicoplanin or a pharmaceutically acceptable salt thereof, and also comprising polyene and echinocandin type antifungal agents, and being prepared into a freeze-dried powder injection by adopting a conventional process. The medicinal composition provided by the invention realizes combined application of the antibacterial drugs and the antifungal agents, can simultaneously give play to an antibacterial infection effect and an antifungal infection effect, and is convenient for clinical use.
Owner:SHENZHEN JYMED TECH

Application of teicoplanin to resisting Ebola virus

ActiveCN104873954AGood antiviral effectInhibition of the phenomenon of infection of 293T cellsAntiviralsSaccharide peptide ingredientsViral entry into host cellEbola virus
The invention provides application of teicoplanin to resisting Ebola virus. The teicoplanin can inhibit the envelope protein GP of Ebola virus. The envelope protein GP is the Zaire envelope protein of Ebola virus breaking out in 2014. The teicoplanin can inhibit Ebola virus from entering host cells and acting in host cells.
Owner:SUN YAT SEN UNIV

Method of producing teicoplanin

Disclosed is a method of producing teicoplanin. The method includes purifying teicoplanin from a culture broth, obtained by culturing microorganisms capable of producing teicoplanin by a porous adsorption resin under selective elution conditions and recovering highly pure teicoplanin using activated carbon and / or ultrafiltration. In this regard, the method can further include ultrafiltration as pre-treatment before the culture broth is adsorbed into the porous adsorption resin so as to increase the purity of teicoplanin.
Owner:DONG KOOK PHARMA CO LTD

Specific primer combination and probe combination for detecting four glycopeptide drug resistance genes in enterococcus bacteria and application thereof

The invention discloses a specific primer combination and a probe combination for detecting four glycopeptide drug resistance genes vanA, vanB, vanD and vanM in enterococcus bacteria, comprising a primer combination for specific amplification of four glycopeptide drug resistance genes and further comprising specific probes for detecting the four glycopeptide drug resistance genes. A method for detecting the four glycopeptide drug resistance genes by using the specific primer and probe combinations is further provided. The combinations have high specificity and coverage, can be used not only for detecting the drug resistance genes vanA, vanB, vanD and vanM in human infected samples but also for suggesting resistance degree to vancomycin and teicoplanin, and provides a reference basis for clinical anti-infective therapy medication. At the same time, the development of glycopeptides drug resistance is monitored. The combinations can also be used for monitoring the distribution and transfer of the four glycopeptide drug resistance genes in animal and environmental samples.
Owner:ZHEJIANG UNIV

Isotonic composition used for improving stability of teicoplanin for injection and preparation method of isotonic composition

The invention provides an isotonic composition used for improving the stability of teicoplanin for injection and a preparation method of the isotonic composition. The isotonic composition comprises 0.1 g of the teicoplanin, 0.2 g of sodium chloride and / or glucose and 0.4 g of water for injection, wherein the pH value of the composition is 7.0-8.0. The isotonic composition used for improving the stability of the teicoplanin for injection can effectively improve the clarity, the stability is equivalent to that of a teicoplanin composition for injection only containing sodium chloride, and the isotonic composition can be stored at room temperature.
Owner:ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY

Separation and purification method of high-purity teicoplanin

The invention provides a separation and purification method of high-purity teicoplanin, which comprises the steps of taking teicoplanin coarse powder as a raw material, sequentially conducting absorption, water washing, low-concentration low alcohol washing, water washing and high-concentration low alcohol elution with an aluminum oxide chromatographic column, then conducting nanofiltration concentration, decoloration, refined filtration and crystallization on an effluent, and obtaining pure teicoplanin. The method is easy and simple to operate and low in cost, and is suitable for industrial production, the obtained teicoplanin is high in purity, and the product quality complies with the EP (European Pharmacopoeia) standard.
Owner:NCPC NEW DRUG RES & DEV

Preparation method, product and application of teicoplanin-functionalized gold nanoparticles

The invention discloses a preparation method, a product and an application of teicoplanin-functionalized gold nanoparticles. The preparation method comprises the following steps: mixing teicoplanin, chloroauric acid and water into a solution, adjusting the pH value of the solution with alkali till the pH value of the solution is in a range of 10-14 and the solution is brown, performing a stirring reaction at the temperature of 20-25 DEG C for 0.5-24 h till the solution becomes dark red, and performing dialysis to remove unreacted teicoplanin or chloroauric acid to obtain the teicoplanin-functionalized gold nanoparticles. According to the method, teicoplanin and chloroauric acid are subjected to a one-pot mixing reaction. The teicoplanin molecular structure contains hydroxyl and amino, which can be directly used as a stabilizer and reductant in the reaction. The method is quite simple and easy to operate. The teicoplanin-functionalized gold nanoparticles has better gram positive bacteria resistance performance than teicoplanin, and can be applied to the field of biological medicine.
Owner:SOUTHWEST UNIVERSITY

Teicoplanin purifying method

The invention provides a teicoplanin purifying method. The purifying method includes steps of orderly performing resin gathering, resin purification, film concentration, and spraying drying operations on teicoplanin fermentation liquor. Compared with the prior art, polarity macroporous adsorbing rein is combined with a medium-sized polarity chromatography resin with uniform grain diameter, thus the product yield is high and decoloring effect is good; the spraying drying technology avoids the massive use of acetone, so that environment is protected, cost is reduced and problem of residue of organic solvent in the prior art can be further avoided; the ratio of every component of the teicoplanin obtained through the purifying method can meet standard, the purifying process is high-efficient and convenient, the preparation amount is big; the teicoplanin purifying method is applicable to industrial production.
Owner:FUJIAN INST OF MICROBIOLOGY

HPLC method for quick teicoplanin fermentation liquor unit detection

The invention discloses an HPLC method for quick teicoplanin fermentation liquor unit detection. The method comprises the following steps: processing teicoplanin fermentation liquor with alkali, performing ultrasonography, performing centrifugation for two times, enabling clear liquor to pass a filtration film at one step, and then placing the filtrated liquor on a machine to be detected and analyzed, wherein a high-performance liquid chromatograph (HPLP) is mainly equipped with a reversed-phase C18 column; a detector is an ultraviolet detector; a mobile phase is an ammonium acetate solution and an acetonitrile buffer solution for gradient elution, and data is collected and analyzed at a condition of 277 nm. The detection method provided by the invention is simple, convenient and fast, and is high in sensitivity and good in accuracy.
Owner:鲁南新时代生物技术有限公司

Culture medium for producing teicoplanin by using actinoplanes and culture method

The invention relates to a culture medium for producing teicoplanin by using actinoplanes and a culture method. The culture medium comprises a seed culture medium and a fermentation culture medium. Byusing a culture medium recipe and the culture method provided by the invention, the teicoplanin fermentation unit can be improved; the fermentation period can be shortened; the fermentation cost canbe reduced; the environment influence on raw and auxiliary material sources is reduced to the maximum degree; the sufficient supply of raw and auxiliary materials is ensured; and the stable and efficient production of the teicoplanin is realized.
Owner:宁夏泰瑞制药股份有限公司

Teicoplanin purifying method

The invention discloses a teicoplanin purifying method. The method comprises the following steps: cooling a teicoplanin fermentation liquid to 5-10 DEG C, adjusting the pH value of the teicoplanin fermentation liquid to 11-12, and carrying out ceramic membrane filtration to obtain a ceramic membrane filtrate; adjusting the pH value of the ceramic membrane filtrate by using hydrochloric acid, carrying out first stage resin column adsorption on the adjusted filtrate, and collecting obtained eluate; adding purified water to dilute the eluate, carrying out second stage resin column adsorption on the diluted eluate, eluting the diluted eluate with purified water, eluting the diluted eluate with methanol, and collecting obtained eluate; adding purified water to dilute the eluate, and concentrating the eluate by using a nanofiltration membrane; and carrying out active carbon decolorizing, crystallizing and drying: decolorizing the obtained nanofiltration concentrate by using active carbon, adding acetone used as a crystallization solvent, crystallizing the decolorized concentrate, and drying obtained crystals to obtain fine teicoplanin powder with the teicoplanin purity of 95% or above and the total yield of 60% or above. The purifying method has he advantages of high purity, high recovery rate and safety.
Owner:沁浩膜技术(厦门)有限公司

Production technology of high-purity teicoplanin

The present invention provides a production technology of high-purity teicoplanin. The production technology comprises the following steps: 1) a slant culture medium, a seed culture medium and a fermentation culture medium are prepared; 2) fermentation liquid is prepared; 3) an eluent is prepared; and 4) a finished product is obtained. Mg2+ can improve activity of glucose oxidase of actinoplanaceae cells, Fe3+ can promote growth of live bacteria and formation of endospores, and the Mg2+ and Fe3+ produce an active center through a synergistic action, effectively conduct catalytic fermentation and increase yield of the teicoplanin.
Owner:JIANGSU JIUYANG BIOLOGICAL PHARMA
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