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Antibiotic coating of porous body, its prepn. and application

An antibiotic, hole-shaped technology, applied in the direction of non-active ingredient medical preparations, active ingredient-containing medical preparations, coatings, etc.

Inactive Publication Date: 2004-03-10
HERAEUS MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In conclusion, it can be said that so far there is no method for creating antibiotic coatings on the surface of interconnected pore systems, such coatings are composed of Netilmicin, Sisomicin, Composed of slightly water-soluble organic salts of Kanamycin, Amikacin, Vancomycin and Clindamicin, they are in the pores of the coating The water-soluble salts and water-soluble fatty acid salts of netilmicin, sisomicin, kanamycin, amikacin, vancomycin and clindamycin and / or salts of alkyl sulfates synthesized

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 80 mg of gentamicin sulfate (Ak 628) was dissolved in 1.92 g of double distilled water (solution 1). Another 75 mg of sodium laurate was dissolved in 1 g of a 50% water-ethanol mixture (solution 2). In the pores of the square phosphate glass, drop the pre-made solution 1. The test subject blotted solution 1 dry. The water present in the pores is then separated by drying through anhydrous calcium chloride. Subsequently, the prepared solution 2 was dropped into the pores of the dried phosphate glass. Then pass through anhydrous calcium chloride to dry the sample until the mass is constant.

Embodiment 2

[0036] 80 mg of clindamycin hydrochloride was dissolved in 1.92 g of double distilled water (solution 1). Another 20 mg of sodium laurate was dissolved in 1 g of water (solution 2). First, drop the prepared solution 1 into the pores of the square phosphate glass. The test subject blotted solution 1 dry. The moisture present in the pores is then dried and separated by anhydrous calcium chloride. As the prepared solution 2 is dropped into the pores of the dried phosphate glass. Finally, the specimen was dried with anhydrous calcium chloride until the mass was constant.

Embodiment 3

[0038] 80 mg of kanamycin sulfate was dissolved in 1.92 g of double distilled water (solution 1). Another 93 mg of sodium laurate was dissolved in 1 g of a 50% water-ethanol mixture (solution 2). First, drop the prepared solution 1 into the pores of the square phosphate glass. The test subject blotted solution 1 dry. The moisture present in the pores is then dried and separated by anhydrous calcium chloride. As the prepared solution 2 is dropped into the pores of the dried phosphate glass, the test body is finally dried with anhydrous calcium chloride until the mass is constant.

[0039] The amounts of antibiotic and sodium laurate added are measured by weight.

[0040] Amount of antibiotic added [mg]

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PUM

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Abstract

The invention describes an antibiotic coating for porous bodies and its use. Into the porous system of non-metallic porous bodies and of metallic porous bodies, a coating made of at least one antibiotic salt that is hardly soluble in water or in an aqueous environment from the group of the netilmicin laurate, the netilmicin myristate, the netilmicin dodecyl sulfate, the sisomicin laurate, the sisomicin myristate, the sisomicin dodecyl sulfate, the gentamicin laurate, the gentamicin myristate, the clindamycin laurate, the amikacin laurate, the amikacin myristate, the amikacin dodecyl sulfate, the kanamycin laurate, the kanamycin myristate, the kanamycin dodecyl sulfate, the tobramycin laurate, the tobramycin myristate, the tobramycin dodecyl sulfate, the ciprofloxacin myristate, the vancomycin dodecyl sulfate, the vancomycin laurate, the vancomycin myristate, the vancomycin teicoplanin and the clindamycin teicoplanin is introduced. The antibiotically coated, porous bodies are used as implants.

Description

technical field [0001] The invention relates to an antibiotic coating of an interconnected porous body and its preparation method and application. The antibiotic-coated porous bodies are used in human and veterinary medicine as implants for bone defects and sometimes soft tissue defects. In addition, the antibiotic coating on the inner surface of the pore system provides continuous release of antibiotics for several days, allowing effective control of bacterial infection within the area of ​​the bone defect and / or soft tissue defect being treated, especially for commonly used antibiotics. resistant bacteria. Background technique [0002] Skeletal defects are relatively common in human and veterinary medicine, especially bone diseases due to fistulas, comminuted fractures, and tumors. Various infections of the bone tissue are often observed in open comminuted fractures. Treatment of this skeletal defect is achieved with suitable implants. In recent years, porosity implant...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K9/14A61K9/16A61K31/7036A61K31/7056A61K47/10A61K47/12A61L27/54A61L27/56
CPCA61L2300/406A61L27/54A61L27/56A61P23/00A61P31/04
Inventor S·福格特M·施纳贝尔劳赫K-D·库恩
Owner HERAEUS MEDICAL
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