Provided is the application of a compound in anti-
coronavirus. The application is the application of a compound or a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of a pharmaceutically acceptable salt thereof, or a
crystal form thereof in the preparation of an anti-
coronavirus preparation, wherein the compound is selected from one or more of
gossypol acetic acid, mecobalamin,
ertapenem, chaetocidin,
netilmicin sulfate, sennoside A and
ellagic acid. In the application, the compound can effectively inhibit
coronavirus RNA-dependent
RNA polymerase (RDRP), thereby inhibiting the proliferation of coronavirus and being applied to anti-coronavirus. The inhibition effect is strong, the cost is low, and the required
dose is small, and the compound can be effectively used in anti-coronavirus.