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Method for preparing colon targeted pill of tilmicosin used for poultry and livestock

A technology of tilmicosin and colon targeting, which is applied in pill delivery, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems that have not yet been retrieved for invention patents, and achieve good therapeutic effects

Inactive Publication Date: 2007-05-30
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] No patents have been retrieved for the invention of this drug in the field of veterinary drug targeted preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: the preparation method of tilmicosin colon targeting pill

[0041] 1. Drugs, excipients and reagents

[0042] Tilmicosin API, Eudragit S100, triethyl citrate, blank pellets 40 mesh, HPMC 15MPa.S, 10MPa.S, 5MPa.S, 95% ethanol.

[0043] 2. Instruments and equipment

[0044] EPL-1 fluidized bed, 78HW-1 magnetic stirrer, J-11 stirrer

[0045] 3. Preparation method

[0046] 1. Place 900 g of blank pellets in a fluidized bed, and coat the drug layer, retardation layer, time lag layer and pH-sensitive film in sequence according to the following methods and processes.

[0047](1) Coating of the main drug

[0048] Preparation of coating solution: 100 g of tilmicosin was dissolved in 1000 ml of 50% ethanol.

[0049] Coating conditions:

[0050] Material temperature: 40°C Air outlet temperature: 40°C Liquid supply hose inner diameter: 2mm

[0051] Air inlet temperature: 48°C Liquid supply speed: 20r / min Spray gun diameter: 1.2mm

[0052] Induced air flow: 38H...

Embodiment 2

[0073] Embodiment 2: The medicine of the present invention can be used for the treatment of Gram-positive bacteria and negative bacteria, mycoplasma, spirochete etc. all have inhibitory effect, have stronger antibacterial effect to Actinobacillus pleuropneumoniae, Pasteurella, mycoplasma than tylosin active. It is mainly used for pneumonia and mycoplasma disease caused by Actinobacillus pleuropneumoniae, Pasteurella, and Mycoplasma. It is used to prevent and treat pleuropneumonia and pneumonia caused by Actinobacillus and Pasteurella in pigs; the administration method is mixed feed administration, 2285-4570g per ton of feed for pigs, and the cure rate can reach more than 85% when used continuously for 5 days.

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PUM

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Abstract

The invention relates to Tilmicosin colon-targeting pills which comprise Netilmicin as the main ingredient, and blank pellets are employed. The medicinal layer comprises 8% retarding layer of hexadecyl alcohol, 2% retarding layer of HPMC, 15% pH responsive film of acrylic resin S100. The prepared colon-targeting pills are of retarding-and-pH responsive combined type which can achieve the positioned medicinal release on the animal's colons, the curative effects for localized infection and general infection can be improved substantially.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and relates to a tilmicosin colon-targeted pill for treating diseases caused by bacterial infection in livestock and poultry. Background technique [0002] With the continuous improvement of the scale and intensification of livestock and poultry breeding, various problems in breeding also follow. Some diseases caused by bacteria and mycoplasma often occur in livestock and poultry. For the above-mentioned situation, the current method of treating this type of disease is mainly to control this type of disease with antibiotics. In terms of human medicine, there is a colon-targeted drug delivery system (OCDDS), which is a targeted preparation that releases drugs in the colon. Oral colon-targeted drug delivery system is a research hotspot recently. It is a new preparation for localized drug release in the colon through oral administration to achieve local or systemic treatment. The colon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/20A61P31/04
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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