Fructose injection of antibiotic medicine

A technology of antibiotics and injections, applied in the field of medicine, can solve problems such as reducing the scope of use, and achieve the effects of quick onset, convenient use, and expanded use scope

Inactive Publication Date: 2018-11-02
WEIHAI HAOTONG MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For drugs used by injection, especially antibiotic glucose injection drugs, glucose solution is used as a drug carrier, which is oxidized into carbon dioxide and water in the body, and at the same time supplies energy, or is stored in the form of glycogen, which has the functions of detoxification, The role of liver protection, which

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1. lomefloxacin hydrochloride fructose injection

[0024] Take an appropriate amount of fructose and add it to an appropriate amount of water for injection to dissolve completely, then add an appropriate amount of activated carbon for needles, stir well, adjust the pH value to 4-4.5 with hydrochloric acid solution, keep it warm at 90°C for 30 minutes, filter while hot to remove the activated carbon; Add an appropriate amount of lomefloxacin hydrochloride to the above fructose filtrate, add water for injection to the full amount, stir evenly, seal the jar with fine filter, sterilize by autoclaving at 115°C for 30 minutes, test and inspect, and pack.

[0025] In the above preparation process, activated carbon is used to adsorb pyrogens and decolorize, and activated carbon is not a component of the injection; in addition, injections with different concentrations can be prepared by controlling the dosage of lomefloxacin hydrochloride and fructose, for example, eac...

Embodiment 2

[0027] Embodiment 2. Ornidazole fructose injection

[0028] Weigh 5 grams of ornidazole and add about 900 ml of water for injection to dissolve, add 50 grams of fructose, stir until completely dissolved, adjust the pH value to about 4.5 with dilute hydrochloric acid, add 0.05% activated carbon for needles, and keep warm for 15 minutes at about 50 ° C. Decarbonize and filter while it is hot, add water for injection to 1000ml, measure the content and pH value of the solution, then fine filter with a 0.45 micron microporous membrane, fill and seal in a 100ml infusion bottle with nitrogen, and sterilize by hot pressing at 115°C 30 minutes, each bottle contains 0.5g ornidazole, 5.0g

[0029] The ornidazole fructose injection consists of ornidazole, fructose, hydrochloric acid, nitrogen and water, wherein the hydrochloric acid and nitrogen are additives, which are respectively pH regulator and protective gas.

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PUM

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Abstract

The invention relates to fructose injection of an antibiotic medicine. The fructose injection of the antibiotic medicine consists of antibiotics, fructose and water and also comprises proper additives, wherein the antibiotics comprise gatifloxacin, levofloxacin, ciprofloxacin, pazufloxacin, fleroxacin, sparfloxacin, moxifloxacin, pefloxacin, rufloxacin, lomefloxacin, norfloxacin, caderofloxacin, azithromycin, telithromycin, ornidazole, secnidazole, tinidazole, metronidazole, clindamycin, lincomycin, fluconazole, etimicin, netilmicin, amikacin as well as medicinal acid addition salt, esterification compounds, derivatives and the like; the fructose injection is prepared from the antibiotics; the advantages that the injection is convenient to use and takes effect rapidly are achieved; and compared with the glucose injection, the fructose injection is easier to absorb and utilize, more suitable for antisepsis and anti-inflammation, energy supply and body liquid supplementation of patientssuffering from diabetes, heart diseases and liver diseases, and enlarges the use range.

Description

technical field [0001] The invention belongs to the field of medical technology, and relates to a series of fructose injection injection medicines of antibiotic medicines. Background technique [0002] Injection is a type of liquid injection. Drugs enter human blood vessels, tissues or organs directly in liquid form. Drugs are absorbed quickly and act quickly. They are very suitable for rescuing critically ill patients and patients who are not suitable for oral administration. [0003] Antibiotics are antimicrobial drugs widely used clinically, especially antibiotic injection drugs. In clinical use, glucose or sodium chloride solution is often used as a carrier for injection with antibiotic drugs, such as levofloxacin lactate glucose injection, Oxen Nitazole Sodium Chloride Injection, etc. In addition to regulating osmotic pressure, the glucose and sodium chloride in the injection can also correct the disturbance of water and electrolytes in the body, and regulate the acid-...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K9/08A61K47/26A61P31/04
CPCA61K9/08A61K9/0019A61K45/00A61K47/26
Inventor 姚辉涛刘凡磊
Owner WEIHAI HAOTONG MEDICAL SCI & TECH
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