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32 results about "Telithromycin" patented technology
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This medication is a ketolide antibiotic used to treat a type of pneumonia caused by bacteria.
Method for improving erythrocin yield through inactivation saccharopolyspora erythraea SACE_3446 gene
The invention discloses a method for improving erythrocin yield through a negative control gene SACE_3446 on an inactivation saccharopolyspora erythraea chromosome. Saccharopolyspora erythraea is used for producing erythrocin. The erythrocin and derived drugs of the erythrocin such as clarithromycin, azithromycin and telithromycin are used widely in clinic. Erythrocin high-producing strain screening is very important in industrial production. The erythromycin biosynthesis negative control gene SACE_3446 is screened from a saccharopolyspora erythraea TetR family. Compared with erythrocin yield of an original strain, deletion mutants of the saccharopolyspora erythraea SACE_3446 is improved remarkably, the erythrocin is returned to low yield after gene complementation of the SACE_3446, and therefore the SACE_3446 gene is a erythromycin biosynthesis negative control gene. The inactivation saccharopolyspora erythraea SACE_3446 gene can improve the erythrocin yield through a genetic engineering way. Due to the fact that erythromycin biosynthesis gene control is a network system, upstream and downstream control factors acted by SACE_3446 control factors can be found by using the SACE_3446 as an object. The erythrocin yield can also be improved by changing upstream or downstream control factor genes of the saccharopolyspora erythraea SACE_3446 control factors.
Owner:ANHUI UNIVERSITY
Method for preparing macrolides half-synthesized antibiotics telithromycin
InactiveCN1800198AReduce manufacturing costImprove securityAntibacterial agentsOrganic active ingredientsPotassium thiocyanateHexamethylenetetramine
The invention discloses a new method for preparing macrolides semi-synthesizing antibiotic tallysomycin. The mother core part uses 6-methoxy bristacin as raw material, which is dewatered on the effect of the base after dewatering, acylating, re-etherification and oxidant, and then it reacts with the carbonyl diimidazole to obtain the intermediate (VI); the lateral chain part uses 3-acetyl pyridine as raw material and is hydrolyzed after bromide and reacting with the hexamine, then it ringed with the potassium sulfocyanide and reacts with the N-(4-bromide butyl)-phthalimide on base condition after the effect of diluted nitric acid and then it is hydrazinolysized to obtain the lateral chain (XIII); the intermediate (VI) reacts with the lateral chain (XIII) to synthesize the tallysomycin.
Owner:CHINA PHARM UNIV
Novel ketolide compound and preparation method and application thereof
InactiveCN101792473ANovel structureHigh activityAntibacterial agentsOrganic active ingredientsAntibacterial activityMacrolide resistance
The invention discloses a ketolide compound similar with the telithromycin antibiotic. The compound has a structural formula as the accompanying drawing. The compound of the invention belongs to a third generation erythromycin analogue antibiotic, has novel structure and stronger activity than the macrolide antibiotic used clinically, has good antibacterial activity on the drug-resistance bacteria by the primary research and has great industrialization prospect.
Owner:JINAN UNIVERSITY
Porphyromonas gingivalis culture medium for tartar specimens
InactiveCN103789390AImprove separation rateReliable detectionMicrobiological testing/measurementPorphyromonas gingivalisHemin
The invention discloses a Porphyromonas gingivalis culture medium for tartar specimens and a preparation method thereof. The invention is characterized in that every 1000ml of culture medium contains malt extract, egg white, hemin solution, vitamin K1 ethanol solution, magnesium citrate, agar, synercid, telithromycin, linezolid, asparagine and the balance of distilled water. The preparation method of the optimal formula comprises the following steps: dissolving the malt extract, egg white, hemin, agar, magnesium citrate, calcium citrate tetrahydrate, synercid, garlic press juice and L-cysteine in a rhizoma polygonati boiling solution, evenly mixing, adding water to the constant volume, sterilizing and packaging. Compared with the prior art, the culture medium has the characteristics of high detection reliability and high Porphyromonas gingivalis separation rate.
Owner:武改莲
Applications of azithromycin and telithromycin in anti-Ebola virus infection
ActiveCN105362284AClear securityDrug metabolism properties are clearOrganic active ingredientsAntiviralsAnti virusAzithromycin
The present invention discloses applications of azithromycin and telithromycin in anti-Ebola virus infection, wherein the applications comprise applications of azithromycin or / and telithromycin in prevention or treatment of Ebola virus infection or combined applications of azithromycin or / and telithromycin and other anti-virus drugs.
Owner:INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
Medicament for curing ague completely
InactiveCN101181639AImprove securityPlay a role in preventioOrganic active ingredientsAntiparasitic agentsAzithromycinMedicine
The invention relates to a medicine for curing and radically curing malaria. The weight parts of the components are: 1 to 5 parts of arteannuin ramification and 5 to 100 parts of large ring lactone antibiotic. The arteannuin ramification can be any artesunate medicine, such as arteannuin, artesunate, artemether or dihydro-arteannuin. The large ring lactone antibiotic can be first, second or third generation large ring lactone antibiotic, such as erythrocin, azithromycin, telithromycin and kui erythrocin. The medicine of the invention is low in poison, safe, rapid in effect, high sufficient and can radically cure malaria, which solves the problem that the after-combustion rate and the recurerence rate of the arteannuin ramification medicine is high after curing malaria; furthermore, the invention is high in medicine safety and has the functions of preventing, curing and blocking spreading of malaria, which is not only suitable for the common malaria infected area, but also more suitable for the infected area with multiple drug fastness malaria, thereby being very safe and effective to the children and pregnant women patients.
Owner:GUANGXI ZHUANG AUTONOMOUS REGION CENT FOR DISEASE CONTROL & PREVENTION
Macrolide antibiotics sodium hyaluronate eye transfer system
InactiveCN1814299AInvestigate the stay situationAntibacterial agentsOrganic active ingredientsRoxithromycinClarithromycin
This invention relates to an eye use transmission system of macrolide type antibiotic hyaluronic acid natrium. The goal of this invention is to provide a macrolide type antibiotic eye use medicine preparation with carrier is hyaluronic acid or its salt. It is used to cure germ eye region infection. The macrolide type antibiotic in this invention includes antibiotic that has 14 yuan,15yuan, 16yuan large ring construction features , for example, natural antibiotic bring by streptomycete erythromycin, josamycin, spiramycin, medemycin etc. and semisynthesis derivant from by structure modification of natural antibiotic, such as roxithromycin, azithromycin, clarithromycin, rokitamycin, telithromycin.
Owner:无锡康福特药物科技有限公司
Porphyromonas gingivalis culture medium for tartar specimen
InactiveCN102703568AImprove separation rateReliable detectionMicrobiological testing/measurementPorphyromonas gingivalisHemin
The invention discloses a porphyromonas gingivalis culture medium for a tartar specimen and preparation method. The porphyromonas gingivalis culture medium is characterized in that a formula for preparing 1000ml of the culture medium comprises malt soaking powder, egg white liquid, chlorhematin solution, vitamin K1 ethanol solution, citric acid magnesium, agar, co-killing element, telithromycin, linezolid, asparagines and balanced distilled water which are 1000ml. Optimized formula preparation method is obtaining the malt soaking powder, the egg white liquid, the chlorhematin, the agar, the citric acid magnesium, calcium citrate tetrahydrate, the co-killing element, garlic squeezed juice, L-semi cystine to be soluble in rhizoma polygonati poaching liquid, evenly mixing, enabling volume tobe constant, sterilizing and conducting split charging. Compared with the prior art, the porphyromonas gingivalis culture medium has the advantage sof being reliable in detection and high in separation rate of porphyromonas gingivalis.
Owner:候素君
Novel process for the preparation of telithromycin
InactiveUS20080051352A1High yieldEasy to operateBiocideSugar derivativesTelithromycinMedicinal chemistry
Owner:ALEMBIC LTD
Novel polymorphs of erythromycin compound
The present invention relates to novel polymorphs of Telithromycin designated as Form I, II and III and its process for preparation. Also it provides Telithromycin with at least 99% purity.
Owner:ALEMBIC LTD
Process for the production of telithromycin
InactiveUS20110040078A1Economical and simpleLow costSugar derivativesTelithromycinMedicinal chemistry
The present invention relates to a process for the preparation of erythromysin derivatives, in particular telithromycin of formula (I) and its pharmaceutically acceptable salts, providing the isolated intermediates in crystalline form of superior stability and purity.
Owner:WOLF SIEGFRIED +1
Azithromycin and roxithromycin derivatives as senolytic drugs
PendingCN113164504AAntibacterial agentsTetracycline active ingredientsFibroblast cell lineTelithromycin
This disclosure describes the use of azithromycin, roxithromycin, and telithromycin, including derivatives thereof, as senolytic drugs. BrdU was used to induce senescence in model human fibroblast cell lines. Also disclosed are methods for screening compounds for senolytic activity. The SRB assay was used to measure cell viability through protein content. Azithromycin roxithromycin, and telithromycin, clinically-approved pharmaceuticals, were found to be senolytic drugs. However, the closely-related parent compound, erythromycin, showed no senolytic activity. Azithromycin strongly induced both aerobic glycolysis and autophagy in human fibroblasts, but showed bi-phasic effects including on mitochondrial oxygen consumption rates with inhibitory activity at 50 muM and stimulatory activity at 100 muM. The xCELLigence real-time assay system showed that azithromycin preferentially targets senescent cells, removing approximately 97% (nearly a 25-fold reduction in senescent cells).
Owner:LUNELLA BIOTECH INC
Semi-synthesis method for preparing antibiotic telithromycin
InactiveCN101235063AHigh yieldImprove qualitySugar derivativesBulk chemical productionAbomacetinSide chain
The invention relates to a semi-synthetic method for preparing a new antibiotic as telithromycin (I), belonging to pharmacy technical field, which comprises using self-manufactured Fe-V-Ti-ZSM-5 of 3-(2-mercaptoglyoxaline-4-radical) pyridine and hydrogen dioxide solution catalysis oxidization desulfhydro method to prepare high-purity side chain key intermediate compound (II), reacting the compound (II) with abomacetin decorated mother ring (III) protected by benzoyl, removing protective radical (benzoyl) to obtain telithromycin. The preparation method has mild conditions, high product yield and eliminated column chromatography separation purification replaced by simple recrystallization purification, to reduce device investment and reduce cost with simple operation and support for industrial production.
Owner:CHENGDU WINS CHEM
Novel acylide derivative and preparing method thereof
InactiveCN104961785AHigh antibacterial activityGood anti-drug-resistant bacteria activityAntibacterial agentsSugar derivativesResistant bacteriaOrganic acid
The invention provides a novel acylide derivative which has a general formula I or a general formula II or which is an acceptable salt or ester composed of a compound having the general formula I or the general formula II and an inorganic acid or organic acid. The novel acylide derivative according to the embodiment has a novel structure and has excellent antibacterial activity on clinically common sensitive bacteria and drug resistant bacteria, and part of compounds of the novel acylide derivative are as good as or better than telithromycin in inhibitory and bactericidal activity. The existing knowledge about the structure-activity relation of acylides is broken through, the novel acylide derivative having bactericidal activity is provided and is as good as the telithromycin in the market in activity, and the novel acylide derivative is easy to industrially produce. Researches show that targets of the acylides acting on bacterial ribosomes are different from those of ketolides. In total, compared with the prior ketolides having defects, the novel acylide derivative has better market prospect in resisting drug resistant bacteria.
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY
Method for preparing macrolides half-synthesized antibiotics telithromycin
InactiveCN100424089CReduce manufacturing costImprove securityAntibacterial agentsOrganic active ingredientsPotassium thiocyanateHexamethylenetetramine
The invention discloses a new method for preparing macrolides semi-synthesizing antibiotic tallysomycin. The mother core part uses 6-methoxy bristacin as raw material, which is dewatered on the effect of the base after dewatering, acylating, re-etherification and oxidant, and then it reacts with the carbonyl diimidazole to obtain the intermediate (VI); the lateral chain part uses 3-acetyl pyridine as raw material and is hydrolyzed after bromide and reacting with the hexamine, then it ringed with the potassium sulfocyanide and reacts with the N-(4-bromide butyl)-phthalimide on base condition after the effect of diluted nitric acid and then it is hydrazinolysized to obtain the lateral chain (XIII); the intermediate (VI) reacts with the lateral chain (XIII) to synthesize the tallysomycin.
Owner:CHINA PHARM UNIV
Fructose injection of antibiotic medicine
InactiveCN108721625AEasy to useSuitable for useAntibacterial agentsPharmaceutical delivery mechanismFluconazoleNorfloxacin
The invention relates to fructose injection of an antibiotic medicine. The fructose injection of the antibiotic medicine consists of antibiotics, fructose and water and also comprises proper additives, wherein the antibiotics comprise gatifloxacin, levofloxacin, ciprofloxacin, pazufloxacin, fleroxacin, sparfloxacin, moxifloxacin, pefloxacin, rufloxacin, lomefloxacin, norfloxacin, caderofloxacin, azithromycin, telithromycin, ornidazole, secnidazole, tinidazole, metronidazole, clindamycin, lincomycin, fluconazole, etimicin, netilmicin, amikacin as well as medicinal acid addition salt, esterification compounds, derivatives and the like; the fructose injection is prepared from the antibiotics; the advantages that the injection is convenient to use and takes effect rapidly are achieved; and compared with the glucose injection, the fructose injection is easier to absorb and utilize, more suitable for antisepsis and anti-inflammation, energy supply and body liquid supplementation of patientssuffering from diabetes, heart diseases and liver diseases, and enlarges the use range.
Owner:WEIHAI HAOTONG MEDICAL SCI & TECH
Compound telithromycin nanoemulsion oral liquid and preparation method thereof
InactiveCN102499936AIncrease fat solubilityReduce intakeAntibacterial agentsOrganic active ingredientsActive agentTherapeutic effect
The invention discloses compound telithromycin nanoemulsion oral liquid. The grain size of the oral liquid ranges from 1nm to 100nm, the compound telithromycin nanoemulsion oral liquid is prepared by raw materials including, by mass percent, from 35 to 45% of surface active agent, from 1 to 5% of cosurfactant, from 4 to 12% of oil phase, from 1 to 3.5% of telithromycin, from 0.1 to 0.3% of bromhexine hydrochloride and the balance deionized water, and the sum of the mass percents of the raw materials is 100%. The telithromycin is the first and the uniquely listed ketolide medicine in the worldat present, and has broad-spectrum antibiotic activity, lower selective drug resistance and cross drug resistance with other ketone antibiotics; and after the telithromycin is compatible with the bromhexine hydrochloride, a high treatment effect in terms of treating respiratory tract infection is realized. Compound telithromycin nanoemulsion remarkably increases activities of two types of medicines, is high in safety, simple in preparation and low in energy consumption, can be produced in a batch manner without special equipment, and has a wide market prospect in the field of medicine.
Owner:NORTHWEST A & F UNIV
Prevention and cure chemical agent for sisal hemp mealybug
The invention discloses a prevention and cure chemical agent for sisal hemp mealybug. The chemical agent is prepared from the following raw materials in parts by weight: 1 to 2 parts of kaolin, 0.5 to1.6 parts of konjac glucomannan, 4 to 8 parts of sepiolite, 0.2 to 0.4 part of vegetable oil, 3 to 6 parts of calcium acetate, 4 to 8 parts of potassium dihydrogen phosphate, 2 to 4 parts of biological surfactant, 6 to 15 parts of fungus concentrate, 3 to 5 parts of fatty alcohol-polyoxyethylene ether, 2 to 6 parts of alkyl polyoxyethylene ether, 1 to 3 parts of sucrose fatty acid ester, 0.5 to 1.6 parts of r-amino butyrate, and 0.2 to 0.6 part of telithromycin. After being sprayed, the chemical agent is adhered onto the surface of mealybug, the components of the chemical agent such as the biological surfactant, fatty alcohol-polyoxyethylene ether, alkyl polyoxyethylene ether and the like can damage the shell of the mealybug, so that active ingredients such as the fungus concentrate can enter the body of the mealybug so as to kill the mealybug, and the killing effect is good; and the konjac glucomannan, the kaolin and the sepiolite in the chemical agent wraps the fungus concentrate, so that the chemical effect period can be prolonged.
Owner:DAXIN SCI & TECH INFORMATION RES INST
Fructose injection of antibiotic drug
InactiveCN106668862AEasy to useSuitable for useAntibacterial agentsPharmaceutical delivery mechanismFluconazoleNorfloxacin
The invention provides a fructose injection of an antibiotic drug. The injection is composed of antibiotics, fructose and water. The injection also can contain proper additives. The antibiotic comprise gatifloxacin, levofloxacin, ofloxacin, ciprofloxacin, pazufloxacin, fleroxacin, sparfloxacin, moxifloxacin, pefloxacin, rufloxacin, lomefloxacin, norfloxacin, caderofloxacin, azithromycin, telithromycin, ornidazole, secnidazole, tinidazole, metronidazole, clindamycin, lincomycin, fluconazole, etimicin, netilmicin, amikacin and medicinal acid additive salts, esterified compounds, derivatives and the like. The antibiotics are prepared into the fructose injection. Besides the advantages of convenience in use and quickness to take effect of the injection, compared with a gluconic infection, the injection provided by the invention is more easily absorbed and utilized, is more suitable for preventing bacteria and diminishing inflammation, supplying energy and supplementing body fluids for patients with diabetes, heart disease and liver disease, so that the application range of the injection is expanded.
Owner:威海恒基伟业信息科技发展有限公司
Method of preparing ketolide macrolide antibiotics
InactiveCN106928294AAvoid generatingHigh reaction yieldSugar derivativesSugar derivatives preparationSide chainButt joint
The invention discloses a method of preparing ketolide macrolide antibiotics. The method of preparing ketolide macrolide antibiotics comprises the following steps: S1, performing a reaction on a side chain with triphosgene to generate isocyanate; S2, performing butt-joint of isocyanate obtained in the step 1 with isocyanate and performing cyclization to generate an oxazolone compound; and S3, removing a hydroxyl protective group from the oxazolone compound obtained in the step 2 to obtain telithromycin. The method disclosed by the invention does not use an unstable carbonyl imidazole intermediate, so that impurities of macrolide structures are prevented from being generated, and relatively high reaction yield and better product purity are obtained.
Owner:上海启雁实业有限公司
Method for preparing porphyromonas gingivalis culture medium for plaque specimens
InactiveCN103243045BImprove separation rateReliable detectionBacteriaMicroorganism based processesBiotechnologyEgg protein
Owner:胡希勇
Application of telithromycin in anti-ebola-virus infection
ActiveCN109700823AClear securityDrug metabolism properties are clearOrganic active ingredientsAntiviralsAzithromycinAnti virus
Owner:INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
Compound telithromycin nanoemulsion oral liquid and preparation method thereof
InactiveCN102499936BIncrease fat solubilityReduce intakeAntibacterial agentsOrganic active ingredientsActive agentTherapeutic effect
The invention discloses compound telithromycin nanoemulsion oral liquid. The grain size of the oral liquid ranges from 1nm to 100nm, the compound telithromycin nanoemulsion oral liquid is prepared by raw materials including, by mass percent, from 35 to 45% of surface active agent, from 1 to 5% of cosurfactant, from 4 to 12% of oil phase, from 1 to 3.5% of telithromycin, from 0.1 to 0.3% of bromhexine hydrochloride and the balance deionized water, and the sum of the mass percents of the raw materials is 100%. The telithromycin is the first and the uniquely listed ketolide medicine in the worldat present, and has broad-spectrum antibiotic activity, lower selective drug resistance and cross drug resistance with other ketone antibiotics; and after the telithromycin is compatible with the bromhexine hydrochloride, a high treatment effect in terms of treating respiratory tract infection is realized. Compound telithromycin nanoemulsion remarkably increases activities of two types of medicines, is high in safety, simple in preparation and low in energy consumption, can be produced in a batch manner without special equipment, and has a wide market prospect in the field of medicine.
Owner:NORTHWEST A & F UNIV
Amorphous telithromycin compound
The present invention relates to stable amorphous 3-De[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]erythromycin (telithromycin), methods for the preparation thereof, the use of stable amorphous telithromycin in the treatment of bacterial infections and to pharmaceutical compositions comprising stable amorphous telithromycin.
Owner:SANDOZ AG
Insecticidal composition capable of being compounded with macrolide compound
InactiveCN106818792AStrong antibacterial activityEffective controlBiocideDead animal preservationEmamectin benzoateMacrolide resistance
The invention relates to feed and in particular relates to an insecticidal composition capable of being compounded with a macrolide compound. Specifically, the insecticidal composition contains active ingredients A and B, and the balance of aids, composition components and auxiliary components needed in the process of preparing related formulations of pesticides, wherein the active ingredient A is selected from novel telithromycin, and the active ingredient B is selected from emamectin benzoate. The compound composition experiment discovers that an obvious synergistic effect can be achieved between the two active ingredients, the insecticidal efficiency is greatly improved, and compared with that of a single agent, the pest control effect of the insecticidal composition disclosed by the invention is generally improved by about 10-15%. Moreover, the fast-acting property is greatly improved, the lasting period is long, the repeated usage frequency and dosage of the pesticides are less, the agricultural cost is reduced, and the environmental pollution is alleviated.
Owner:新昌县赛因斯生物科技有限公司
Macrolide antibiotics sodium hyaluronate eye transfer system
InactiveCN100408046CInvestigate the stay situationAntibacterial agentsOrganic active ingredientsRoxithromycinMacrolide resistance
This invention relates to an eye use transmission system of macrolide type antibiotic hyaluronic acid natrium. The goal of this invention is to provide a macrolide type antibiotic eye use medicine preparation with carrier is hyaluronic acid or its salt. It is used to cure germ eye region infection. The macrolide type antibiotic in this invention includes antibiotic that has 14 yuan,15yuan, 16yuan large ring construction features , for example, natural antibiotic bring by streptomycete erythromycin, josamycin, spiramycin, medemycin etc. and semisynthesis derivant from by structure modification of natural antibiotic, such as roxithromycin, azithromycin, clarithromycin, rokitamycin, telithromycin.
Owner:无锡康福特药物科技有限公司
Amorphous Telithromycin Compound
The present invention relates to stable amorphous 3-De[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]erythromycin (telithromycin), methods for the preparation thereof, the use of stable amorphous telithromycin in the treatment of bacterial infections and to pharmaceutical compositions comprising stable amorphous telithromycin.
Owner:SANDOZ AG
Control agent for sisal mealybug
Owner:DAXIN SCI & TECH INFORMATION RES INST
Potentiation of antibiotic activity by a novel cationic peptide, spr741
This disclosure provides a method of potentiating the efficacy of certain antibiotics by administering a therapeutically effect amount of the antibiotic in combination with SPR741. In certain embodiments the antibiotic is retapamulin, telithromycin, or aztreonam. The disclosure also provides a method of treating a bacterial infection by administering SPR741 in combination with a second antibioticand pharmaceutical compositions comprising SPR741 and a second antibiotic.
Owner:我希望增效剂公司
Fructose injection of antibiotic drug
InactiveCN109953943AEasy to useSuitable for useAntibacterial agentsOrganic active ingredientsFluconazoleSupplement use
A fructose injection of an antibiotic drug comprises antibiotics, fructose and water and can contain proper additives. The antibiotics comprise gatifloxacin, levofloxacin, ofloxacin, ciprofloxacin, pazufloxacin, fleroxacin, sparfloxacin, moxifloxacin, pefloxacin, rufloxacin, lomefloxacin, norfloxacin, cadrofloxacin, azithromycin, telithromycin, ornidazole, secnidazole, tinidazole, metronidazole, clindamycin, lincomycin, fluconazole, etimicin, netilmicin, amikacin as well as pharmaceutical acid added salts, esters and derivatives thereof. The antibiotics are prepared into the fructose injection, beside injection advantages of being convenient to use and taking effect quickly, compared with glucose injections, the injection is easier to absorb and utilize and more suitable for antisepsis andanti-inflammation, energy supply and body fluid supplement use for patients suffering from diabetes, heart disease and hepatopathy, and the use range of the injection is enlarged.
Owner:李芳凯
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