Compound telithromycin nanoemulsion oral liquid and preparation method thereof

Abstract

The invention discloses compound telithromycin nanoemulsion oral liquid. The grain size of the oral liquid ranges from 1nm to 100nm, the compound telithromycin nanoemulsion oral liquid is prepared by raw materials including, by mass percent, from 35 to 45% of surface active agent, from 1 to 5% of cosurfactant, from 4 to 12% of oil phase, from 1 to 3.5% of telithromycin, from 0.1 to 0.3% of bromhexine hydrochloride and the balance deionized water, and the sum of the mass percents of the raw materials is 100%. The telithromycin is the first and the uniquely listed ketolide medicine in the worldat present, and has broad-spectrum antibiotic activity, lower selective drug resistance and cross drug resistance with other ketone antibiotics; and after the telithromycin is compatible with the bromhexine hydrochloride, a high treatment effect in terms of treating respiratory tract infection is realized. Compound telithromycin nanoemulsion remarkably increases activities of two types of medicines, is high in safety, simple in preparation and low in energy consumption, can be produced in a batch manner without special equipment, and has a wide market prospect in the field of medicine.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of the ketolide antibiotic telithromycin, in particular to a transparent and stable oil-in-water compound spiramycin nanoemulsion oral liquid and a preparation method thereof. Background technique [0002] Telithromycin (Telithromycin) is the first antibacterial drug in the semi-synthetic macrolide-lincosamide-streptomycin B (MLSB) family. It belongs to the ketolide antibiotic and is resistant to macrolides. Designed for sexual respiratory pathogens. It has broad-spectrum antibacterial activity, low selective drug resistance and cross-resistance with other ketone antibiotics. Similar to macrolides, this type of compound acts by interfering with the synthesis of bacterial proteins, but the biggest difference is that the binding force of telithromycin to wild-type ribosomes is about 10 times stronger than that of erythromycin and clarithromycin And 6 times, it has good c...

AI Technical Summary

Problems solved by technology

Bromhexine hydrochloride is slightly soluble in water, can only be used orally, the drug absorption rate is low, the dissolution rate is unstable, and it is inconvenient to use for those who have difficulty swallowing or children

Images