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Insecticidal composition capable of being compounded with macrolide compound

An insecticidal composition and technology of macrolides, applied in the field of disease control compositions, can solve the problem that insecticides have no insecticidal effect, and achieve the effects of less resistance, high work efficiency, and excellent antibacterial activity

Inactive Publication Date: 2017-06-13
新昌县赛因斯生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the application of macrolides is in the field of body antibiotics, but there is no method with good deworming effect in insecticides

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A kind of suspension concentrate of the pesticidal composition compounded with macrolide compound:

[0021] Telithromycin 5g, emamectin emamectin 1g, butylparaben 3g, ethylene glycol 2g, xanthan gum 6g, silicone oil 1g, make up the remaining water to 100g, mix other additives, mix evenly by high-speed shearing, add Telithromycin and emamectin benzoate are ground in a ball mill for 2-3 hours, so that the particle diameter is below 5mm, and the above-mentioned suspending agent of the insecticidal composition containing telithromycin and emamectin benzoate of the present invention is obtained preparation. Butylparaben can enhance the insecticidal effect of telithromycin and emamectin benzoate, and at the same time delay the emergence of drug resistance.

[0022] Telithromycin 15g, emamectin benzoate 2g, butylparaben 6g, ethylene glycol 3g, xanthan gum 8g, silicone oil 1g, make up the remaining water to 100g, mix other additives, mix evenly by high-speed shearing, add Tel...

Embodiment 2

[0024] A water emulsion of an insecticidal composition compounded with a macrolide compound:

[0025] Telithromycin 10g, emamectin 1g, polyoxyethylene fatty alcohol ether 4g, dichloromethane 3g, sodium citrate 4g, ethylene glycol 3g, silicone oil 1g, xanthan gum 5g, water to make up to 100g. Add the original drug telithromycin and emamectin benzoate, solvent, emulsifier, and co-solvent together to dissolve into a uniform oil phase; mix some water, antifreeze, antimicrobial and other pesticide adjuvants together into a uniform water phase; while stirring at high speed in the reactor, add the oil phase to the water phase, slowly add water until the phase inversion point is reached, turn on the shearing machine for high-speed shearing, and add the remaining water, shearing for about half an hour , forming an oil-in-water emulsion. That is, the water emulsion of the insecticidal composition containing telithromycin and emamectin emamectin is prepared.

Embodiment 3

[0027] A water-dispersible granule of an insecticidal composition compounded with a macrolide compound:

[0028] Telithromycin 2g, emamectin 10g, butylparaben 6g, saponin powder 6g, citric acid 2g, white carbon black 74g. Mix telithromycin, emamectin benzoate, butylparaben, saponin powder, citric acid and white carbon black evenly, pulverize with an ultra-fine airflow mill, knead, and then add it to a fluidized bed granulation dryer for granulation. After granulation, drying and sieving, the water-dispersible granules of the above-mentioned insecticidal composition containing telithromycin and emamectin emamectin salt of the present invention are obtained through sampling analysis.

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PUM

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Abstract

The invention relates to feed and in particular relates to an insecticidal composition capable of being compounded with a macrolide compound. Specifically, the insecticidal composition contains active ingredients A and B, and the balance of aids, composition components and auxiliary components needed in the process of preparing related formulations of pesticides, wherein the active ingredient A is selected from novel telithromycin, and the active ingredient B is selected from emamectin benzoate. The compound composition experiment discovers that an obvious synergistic effect can be achieved between the two active ingredients, the insecticidal efficiency is greatly improved, and compared with that of a single agent, the pest control effect of the insecticidal composition disclosed by the invention is generally improved by about 10-15%. Moreover, the fast-acting property is greatly improved, the lasting period is long, the repeated usage frequency and dosage of the pesticides are less, the agricultural cost is reduced, and the environmental pollution is alleviated.

Description

technical field [0001] The invention relates to a disease control composition, in particular to an insecticidal composition compounded with a macrolide compound. Background technique [0002] Macrolide antibiotics play an important role in the treatment of infectious diseases in various clinical departments. At present, the problem of drug-resistant bacteria in the world is becoming more and more serious. Using chemical methods to modify the structure of macrolide compounds has obtained several types of compounds with good antibacterial activity against drug-resistant bacteria, such as ketolides, acylactones and 4-carbamate compounds. [0003] In order to solve the problem of serious infections caused by drug-resistant strains, it is urgent to develop new antibiotics that are effective against drug-resistant bacteria. It is generally believed that the 3-position cladinose of erythromycin A is an essential group for antibacterial activity, and its hydrolysis will cause a de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01P1/00A01P3/00A01P7/00
CPCA01N43/90A01N2300/00
Inventor 周建波张媛媛
Owner 新昌县赛因斯生物科技有限公司
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