2 results about "Sparfloxacin" patented technology

The invention discloses a garnet nucleus carbon quantum dot fluorescent probe, a preparation method thereof and an application of the fluorescent probe in rapid detection of sparfloxacin. Green and environment-friendly waste garnet nucleus is selected as a carbon source, ammonium sulfate and europium nitrate are used as dopants, and DNW CDs with good luminescence stability and high solubility are synthesized through a one-step hydrothermal method; the method is used for rapidly detecting the content of sparfloxacin in an actual sample, resource recycling can be achieved while the residual level of sparfloxacin in food is monitored, and environmental pollution is reduced.

The present disclosure provides a gene delivery nanoparticle, and its preparation and application, pertaining to the technical field of biomedicine. In the preparation method, 2-((tert-butoxycarbonyl)amino)ethyl methacrylate as monomer, mPEG5k-RAFT as macromolecular chain transfer agent and azobisisobutyronitrile as initiator are subjected to reversible addition-fragmentation chain transfer polymerization in dimethylformamide, dialysis and freeze-drying to obtain an intermediate; the intermediate is dissolved in dichloromethane, added with trifluoroacetic acid and reacted to yield polyethylene glycol-poly(aminoethyl methacrylate); sparfloxacin is dissolved in a hydrochloric acid solution, and added with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, N-hydroxysuccinimide and a solution of polyethylene glycol-poly(aminoethyl methacrylate) in dimethyl sulfoxide to produce a mixture; the mixture is subjected to dialysis and freeze-drying to obtain the final product polyethylene glycol-poly(sparfloxacin), which is placed in an aqueous solution to allow self-assembly, thereby forming the desired nanoparticle.