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This medication is used with other medications to treat active tuberculosis (TB) of the lungs. It may also be used with another medication (isoniazid) to prevent active TB infections in people who are infected with the bacteria (people with positive TB skin test).
A rifabutin microsphere thermosensitive gel and its preparation method
This invention relates to the field of pharmaceutical technology and proposes a rifapentine microsphere thermosensitive gel and its preparation method. The rifapentine microsphere thermosensitive gel includes rifapentine microspheres and a thermosensitive gel matrix. The rifapentine microspheres comprise a continuous aqueous phase and an oil phase dispersed in the aqueous phase. The oil phase includes rifapentine, an emulsifier, and vegetable oil. The aqueous phase includes glycerol and water. The emulsifier consists of poloxamer and lecithin in a mass ratio of 5:4~6. The rifapentine microsphere thermosensitive gel provided by this invention has good encapsulation efficiency and drug loading, solving the problems of insufficient encapsulation efficiency and drug loading in existing rifapentine microsphere thermosensitive gels.
Owner:HEBEI MEDICAL UNIVERSITY +1