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Summary of Antituberculosis medications. Rifampicin, also known as rifampin, is an antibiotic used to treat a number of bacterial infections. This includes tuberculosis, leprosy, and legionella, among others.
Method for determining bedaquiline concentration in blood serum
ActiveRU2865302C1Fluoroacetic acidAntituberculosis drug
FIELD: pharmacology.SUBSTANCE invention can be used to determine the concentration of an anti-tuberculosis drug in blood serum. The method for determining the concentration of bedaquiline in the blood serum in patients with tuberculosis or mycobacteriosis is that whole blood samples are centrifuged at 3000 rpm for 20 minutes, then the blood plasma is collected in sterile 1.5 mL Eppendorf tubes, then 900 mcL of acetonitrile are added to 300 mcL of plasma and centrifuged at 13500g for 15 minutes, then 1 mL of the supernatant is transferred to a chromatographic vial and make the assay by UHPLC MS / MS using an Athena UHPLC C18, 1.8 mcM, 120A, 2.1×100 mm chromatography column, when using an aqueous solution containing 5 g / L of ammonium acetate, 25 ml / L of concentrated acetic acid, 2 ml / L trifluoroacetic acid as mobile phase A and 100% acetonitrile as mobile phase B, the concentration of bedaquiline is determined using a pre-plotted calibration curve.EFFECT: determination of bedaquiline in human blood plasma in a time not exceeding 6 minutes.1 cl, 9 dwg, 6 tbl
Owner:FEDERALNOE GOSUDARSTVENNOE BYUDZHETNOE UCHREZHDENIE NATSIONALNYJ MEDITSINSKIJ ISSLEDOVATELSKIJ TSENTR FTIZIOPULMONOLOGII I INFEKTSIONNYKH ZABOLEVANIJ MINISTSTVA ZDRAVOOKHRANENIYA ROSSIJSKOJ FEDERATSII (FGBU NMITS FPI MINZDRAVA ROSSII)
Composition comprising hypoxia-inducible factor prolyl hydroxylase inhibitor and antituberculosis drug, and use thereof
PCT designated stageWO2026130409A1Antibacterial agentsBlood disorderAntituberculosis drugTreating tuberculosis
A composition comprising a hypoxia-inducible factor prolyl hydroxylase inhibitor and an antituberculosis drug, and a use thereof in the preparation of medicines or health care products for preventing and treating chronic inflammatory anemia and infections. The obtained medicines or health care products can alleviate chronic inflammatory anemia caused by interference from mycobacterium tuberculosis, and can be used for treating tuberculosis.
Owner:GUANGZHOU EIGHTH PEOPLES HOSPITAL GUANGZHOU MEDICAL UNIV