The invention mainly discloses a
chemical preparation method of
sarafloxacin hydrochloride. The method comprises the steps of: performing heat-perservation refluxing on 7-chloro-6-fluoro-1-p-fluoro phenyl-1,4-oxoquinoline-3-
carboxylic acid (as shown in formula I in the specification) and
piperazine which are used as raw materials in a
solvent for 10 hours, and recovering the
solvent and the
piperazine after reaction; adding water, then adding a
sodium hydroxide solution to regulate a pH value to not less than 13, filtering, adding salt into filtrate, filtering, and adding acid in the filtrate to regulate the pH value to 7.0-7.3 to obtain a wet
crystal product of
sarafloxacin (as shown in a formula II in the specification); and then, adding the wet product of the
sarafloxacin (as shown in the formula II in the specification) into 85%
ethanol, heating for refluxing, adding
hydrochloric acid as a
reagent, regulating a pH value to 2-2.5, and cooling and crystallizing to obtain the sarafloxacin
hydrochloride (as shown in a formula III in the specification). The
chemical preparation method disclosed by the invention has the advantages of easiness for
solvent recovery, environment friendliness, high yield 3-5% higher than that of other methods, low cost about 10% lower than that of other methods, high product purity and the like.