This invention provides a soluble
solid dosage form of
sarafloxacin hydrochloride and its preparation method, belonging to the field of
pharmaceutical technology. The soluble
solid dosage form of
sarafloxacin hydrochloride of this invention comprises the following components in parts by weight: 10 parts
sarafloxacin hydrochloride, 6-15 parts soluble
phosphate, 2-10 parts stabilizer, and 65-82 parts
diluent; wherein the stabilizer is tetrasodium ethylenediaminetetraacetate or
ethylenediaminetetraacetic acid; and the
diluent is at least one selected from
anhydrous glucose,
sucrose,
lactose, and
maltodextrin. The soluble
solid dosage form of sarafloxacin hydrochloride of this invention has good water
solubility; even at high concentrations (5000 ppm), the solution remains relatively clear, making it less likely to
cause blockage of drinking water pipelines when administered to
livestock farms; furthermore, it is suitable for preparing solutions with different water qualities, and no special requirements are needed for
water quality during clinical use.