Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sarafloxacin hydrochloride solution as well as preparation method and application thereof

A technology of sarafloxacin hydrochloride and solution, which is applied in the direction of pharmaceutical formulations, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor solubility and poor stability, and achieve good solubility, good The effect of stability and simple preparation process

Pending Publication Date: 2021-12-21
FOSHAN STANDARD BIO TECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, the present invention proposes a kind of sarafloxacin hydrochloride solution and its preparation method and application, to improve the problems of poor stability and poor solubility existing in the existing sarafloxacin hydrochloride solution

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sarafloxacin hydrochloride solution as well as preparation method and application thereof
  • Sarafloxacin hydrochloride solution as well as preparation method and application thereof
  • Sarafloxacin hydrochloride solution as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A kind of sarafloxacin hydrochloride solution, in the sarafloxacin hydrochloride solution of every 100g, comprise the sarafloxacin hydrochloride of 5.473g, the ethanolamine of 15g, the propylene glycol of 10g, the polyoxyethylene octylphenol ether-10 of 5g, the di Methyl sulfoxide, 20g of purified water, an appropriate amount of saturated sodium hydroxide solution, an appropriate amount of hydrochloric acid solution and the rest of ethanol. Wherein the volume concentration of ethanol is 95%.

[0045] The preparation method of above-mentioned sarafloxacin hydrochloride solution is:

[0046] (1) sarafloxacin hydrochloride is mixed with purified water, then mixed with 10g of ethanol and ethanolamine, propylene glycol, polyoxyethylene octylphenol ether-10, dimethyl sulfoxide to obtain the first mixture;

[0047] (2) The first mixture is mixed with sodium hydroxide solution to a pH value of 10.7; then mixed with hydrochloric acid solution to a pH value of 9.5-10.5 to obtain...

Embodiment 2

[0050] A kind of sarafloxacin hydrochloride solution, in the sarafloxacin hydrochloride solution of every 100g, comprise the following components: 2.737g of sarafloxacin hydrochloride, 20g of ethanolamine, 10g of propylene glycol, 5g of polyethylene glycol 400, 2.5g of Dimethyl sulfoxide, 15g of purified water, an appropriate amount of saturated sodium hydroxide solution, an appropriate amount of hydrochloric acid solution and the rest of ethanol. Wherein, the volume concentration of ethanol is 95%.

[0051] The preparation method of above-mentioned sarafloxacin hydrochloride solution is:

[0052](1) sarafloxacin hydrochloride and purified water are mixed, then mixed with 10g of ethanol and ethanolamine, propylene glycol, polyethylene glycol 400, dimethyl sulfoxide to obtain the first mixture;

[0053] (2) The first mixture is mixed with sodium hydroxide solution to a pH value of 10.7; then mixed with hydrochloric acid solution to a pH value of 9.5-10.5 to obtain the second m...

Embodiment 3

[0056] A kind of sarafloxacin hydrochloride solution, in the sarafloxacin hydrochloride solution of every 100g, comprise the sarafloxacin hydrochloride of 1.095g, the ethanolamine of 10g, the propylene glycol of 30g, the dimethyl sulfoxide of 1g, the purified water of 15g, appropriate amount Sodium hydroxide solution, an appropriate amount of hydrochloric acid solution, and the balance of ethanol. Wherein, the volume concentration of ethanol is 95%.

[0057] The preparation method of above-mentioned sarafloxacin hydrochloride solution is:

[0058] (1) sarafloxacin hydrochloride and purified water are mixed, then mixed with ethanol and ethanolamine, propylene glycol, polyethylene glycol 400, dimethyl sulfoxide of 5g, get the first mixture;

[0059] (2) The first mixture is mixed with sodium hydroxide solution to a pH value of 10.7; then mixed with hydrochloric acid solution to a pH value of 9.5-10.5 to obtain the second mixture; record the usage amount X of sodium hydroxide so...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of veterinary preparations, and particularly relates to a sarafloxacin hydrochloride solution as well as a preparation method and application thereof. The sarafloxacin hydrochloride solution comprises the following components of, sarafloxacin hydrochloride, ethanolamine, a stabilizer, dimethyl sulfoxide, water and ethanol. According to the sarafloxacin hydrochloride solution, through the interaction of the ethanolamine, the dimethyl sulfoxide and the stabilizer, the sarafloxacin hydrochloride solution can still keep better stability after being placed in a high-temperature and high-humidity environment for 6 months, can be arbitrarily diluted with water according to a dilution ratio of 1:1 to 1:1000, keeps a non-discoloring, clear and transparent state, and shows better solubility. The sarafloxacin hydrochloride solution provided by the invention also has the advantages of simple preparation process, easy realization of industrial production and the like.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to a sarafloxacin hydrochloride solution and a preparation method and application thereof. Background technique [0002] Sarafloxacin hydrochloride is a third-generation fluoroquinolone broad-spectrum antibacterial drug specially used for animals. It has strong antibacterial activity and has antibacterial effects on Gram-negative bacteria, Gram-positive bacteria and mycoplasma, especially Escherichia coli , Salmonella, Klebsiella, Proteus, Pasteurella multocida, Campylobacter and other enterobacteria have shown good antibacterial properties, and are currently mainly used for livestock and poultry digestive system, respiratory system, and urinary tract infections caused by sensitive bacteria and treatment of mycoplasmosis. [0003] Sarafloxacin hydrochloride is almost slightly soluble in water and ethanol, and only 0.1g of sarafloxacin hydrochloride ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/08A61K31/496A61K47/10A61K47/20A61K47/18A61P31/04
CPCA61K31/496A61K9/08A61K47/10A61K47/20A61K47/18A61P31/04
Inventor 黎剑坤刘肖娟王振兴赵一阳谭志坚符德文
Owner FOSHAN STANDARD BIO TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com