90 results about "Norfloxacino" patented technology

The invention discloses an antibacterial moisture-absorption softening agent and a preparation method thereof. The preparation method comprises the following preparation steps: 1, preparing a softener; the preparation method comprises the following steps: S1, reacting toluene diisocynate with polyethylene glycol in a solvent to generate an intermediate I; s2, reacting the intermediate I with tetramethyldipropylenetriamine in an inert gas atmosphere to generate an intermediate II; s3, carrying out reaction on the hydrogen-containing silicone oil, allyl polyoxyethylene ether and allyl epoxy terminated polyoxyethylene ether in a solvent and a catalyst to generate modified silicone oil; and S4, carrying out a reaction on the modified silicone oil and a norfloxacin aqueous solution in a solvent, then adding the intermediate II into a reactant, carrying out a reaction for a period of time, and removing impurities to obtain the antibacterial moisture-absorption softening agent.

The invention relates to a preparation method and application of an electrochemical sensor for detecting norfloxacin in water, a boron-doped diamond (BDD) electrode is modified by adopting a multi-walled carbon nanotube and gold nanoparticles, and the sensitivity of the electrode is enhanced; and preparing a layer of molecular imprinting film on the surface of a boron-doped diamond (BDD) electrode by taking norfloxacin as an imprinting molecule and adopting an electrochemical in-situ electropolymerization technology, so as to improve the specificity of the electrode and construct an electrochemical sensor for detecting norfloxacin in water. The MIP / AuNPs / MWCNTs / BDD electrode is immersed into norfloxacin buffer solutions with different concentrations for 10 min, and then a differential pulse method DPV is used for testing to obtain a peak current and concentration corresponding relation curve; therefore, the selectivity of the electrode is improved, and the influence of other interfering substances is reduced. Meanwhile, the sensitivity and the stability of the electrode are enhanced, and trace substances are detected.

The present invention belongs to the field of biotechnology, and specifically relates to the use of the CD630_27900 gene in reducing the tolerance of Clostridium difficile. Knocking out the CD630_27900 gene can reduce the tolerance of Clostridium difficile to acidic environments and antibiotics and reduce its cytotoxicity; the sequence of the CD630_27900 gene is shown in SEQ ID NO.1; the antibiotics include ampicillin, metronidazole, amoxicillin, vancomycin, norfloxacin, cefoxitin, clindamycin and kanamycin. The research results of the present invention suggest that the CD630_27900 gene can be used as a target for inhibiting the drug resistance and reducing the toxicity of Clostridium difficile, providing a new idea for the treatment of Clostridium difficile infection (CDI).

The invention discloses a preparation method and application of UiO-66 / MWCNTs-COOH / SA composite gel microspheres, and belongs to the technical field of composite material preparation. The preparation method comprises the following steps: mixing a zirconium source, terephthalic acid, carboxylated multi-walled carbon nanotubes, a solvent and glacial acetic acid, and heating for reaction to obtain a UiO-66 / MWCNTs-COOH composite material; adding sodium alginate according to a certain proportion, and cross-linking the SA-UC gel microspheres with the sodium alginate to form SA-UC composite gel microspheres. The SA-UC composite gel microspheres have high adsorption capacity on quinolone antibiotics, are easier to carry out solid-liquid separation, and have the advantages of high recycling rate and good recycling performance. In addition, when the SA-UC composite gel microspheres adsorb norfloxacin in solutions with different ionic strengths, the adsorption capacity can still reach about 90%, and the anti-ionic interference capability is high.

The embodiment of the invention provides a Fe3O4 (at) COF electrochemical sensor based on a covalent organic framework, and a preparation method and application thereof. The electrochemical sensor comprises a base electrode with the surface modified with a solid film; the solid film is a Fe3O4 (at) COF composite material; the Fe3O4-coated COF composite material comprises an inner core formed by ferroferric oxide with a porous structure and a COF shell layer attached to the surface of the inner core, the COF shell layer is a covalent organic framework layer formed by copolymerization of an aromatic aldehyde compound and a polyamino aromatic compound. According to the Fe3O4 (at) COF electrochemical sensor based on the covalent organic framework, the preparation method and the application provided by the invention, quinolone antibiotic molecules such as norfloxacin and the like can be detected, and the detection limit can reach 1.927 * 10 <-13 > mol / L; and the method can be widely applied to detection of quinolone antibiotics such as norfloxacin in milk and environmental water samples.

The utility model provides a mixing device for norfloxacin production, which belongs to the technical field of norfloxacin production and comprises a tank support, a mixing tank and a tank cover, a mixing motor is arranged at the top of the mixing tank, a first feed inlet is arranged on one side of the mixing motor, a second feed inlet is arranged on the other side of the mixing motor, and a coupler is arranged below the mixing motor. A plurality of connecting blocks are vertically arranged on the surface of the mixing roller; a mixing plate is arranged in front of the connecting blocks; brush rollers are arranged in front of the mixing plate; first rotating shafts are arranged in the brush rollers; the mixing motor can be started to enable the mixing shaft to rotate, then the mixing roller drives the connecting block to rotate, then the mixing plate performs stirring and mixing, the brush roller is matched with the first rotating shaft to perform rotary scraping on the upper part, the middle part and the lower part of the inner wall of the tank body, and the lengthened brush roller performs scraping cleaning on positions which cannot be cleaned by the brush roller.

The utility model provides a norfloxacin material drying device, which belongs to the technical field of pharmaceutical production equipment, and comprises an outer box and an inner box, the outer box is provided with a drying mechanism for heating the inner box, the drying mechanism comprises a heating assembly and a circulating assembly, and the inner box is provided with a stirring mechanism for assisting the drying mechanism in heating; the heating assembly comprises a storage table arranged on the outer box and heating pipes circularly arranged in the outer box; water is injected into the outer box, necessary heat is provided for the heating pipe through the electric heater, the heating pipe heats water in the outer box and heats the inner box, then materials in the inner box are heated through heat transfer, and hot water in the outer box is contained in the hollow rotating shaft and pumped through the water pump. According to the norfloxacin drying device, heating work of norfloxacin materials in the inner box is achieved, circulating heat supply of the norfloxacin materials is achieved through hot water in the outer box and hot water in the rotating shaft, the norfloxacin materials are subjected to heat radiation sufficiently, sufficient drying is achieved, and the drying efficiency is improved.

The application belongs to the technical field of photocatalysis, and discloses application of peroxymonosulfate assisted g-C3N4 / CoOOH composite photocatalyst in degrading norfloxacin; g-C3N4 is prepared by taking melamine as raw material, then g-C3N4 is added in the preparation of CoOOH to carry out compounding, and g-C3N4 / CoOOH catalyst is prepared by a plurality of hydrothermal methods; g-C3N4 and CoOOH construct heterojunction to improve the electron transfer capacity, have good energy band structure, greatly improve the photocatalytic degradation capacity, and have excellent activation peroxymonosulfate (PMS) capacity, which is used for exciting PMS to generate ·SO4 2‑ , and is used for degrading norfloxacin, has good degradation effect, and has stronger degradation activity.

The embodiment of the present application provides a Fe3O4@COF electrochemical sensor based on a covalent organic framework, a preparation method and application, the electrochemical sensor comprises: a base electrode which is surface-modified with a solid film; the solid film is a Fe3O4@COF composite material; the Fe3O4@COF composite material comprises: a core formed by a porous structure of Fe3O4 and a COF shell layer attached to the surface of the core; the COF shell layer is a covalent organic framework layer formed by copolymerization of aromatic aldehyde compounds and polyamino aromatic compounds. The Fe3O4@COF electrochemical sensor based on the covalent organic framework, the preparation method and the application can detect quinolone antibiotic molecules such as norfloxacin, and the detection limit can reach 1.927*10 ‑ 13 mol / L; and can be widely applied to the detection of quinolone antibiotics such as norfloxacin in milk and environmental water samples.

The present application relates to the technical field of catalyst, especially to application of soluble alkali metal sulfide secondary activation PMS in degradation of norfloxacin, and provides a reducing agent-soluble alkali metal sulfide for improving reaction efficiency of Fe(II) / PMS homogeneous catalytic system. The reducing agent and the Fe(II) / PMS homogeneous catalytic system can efficiently degrade norfloxacin, no iron mud is generated in the reaction process, it is green and environment-friendly, the pH use range is relatively wide, the initial required Fe(II) dosage in the system is small, the pollutant treatment cost is reduced, and it is beneficial to large-scale popularization and application.

The invention belongs to the technical field of coordination polymers, and particularly relates to a zinc coordination polymer as well as a preparation method and application thereof in fluoroquinolone antibiotic detection. The structural formula of the zinc coordination polymer is [Zn (mu3-L ') (H2O)] n, wherein L' 2-is generated by hydrolyzing 5-((4 '-cyanobenzyl) oxygen) isophthalic acid (H2L) in the reaction process. The zinc coordination polymer is prepared by the following steps: adding Zn (NO3) 2.6 H2O and 5-((4 '-cyanobenzyl) oxygen) isophthalic acid into a mixed solvent containing acetonitrile and water, and carrying out solvothermal reaction. The zinc coordination polymer has a one-dimensional structure, has good fluorescence selectivity detection performance on fluoroquinolone antibiotics in an aqueous solution, such as ofloxacin, levofloxacin and norfloxacin, and can be used as a fluorescence sensor for efficiently detecting the fluoroquinolone antibiotics.

The invention belongs to the field of antibiotic detection, and relates to detection of norfloxacin (NOR). The invention provides a Luminol-Eu-NCDs ratiometric fluorescent probe as well as a preparation method and application of the Luminol-Eu-NCDs ratiometric fluorescent probe. According to the application, a novel ratiometric fluorescence sensor is constructed through covalent linkage of Luminol-Eu self-assembled and synthesized by AIE and NCDs derived from Listeria monocytogenes. The Luminol-Eu NPs with the AIE effect overcomes the fluorescence quenching characteristic of a traditional fluorophore in a high concentration or aggregation state, so that the reference fluorescence brightness of fluorescence analysis is greatly improved. In addition, due to the introduction of the Luminol-Eu NPs, the sensitivity and the accuracy of NOR detection can also be improved. On the basis, a simple ratio fluorescence sensor with high selectivity is developed, and the ratio fluorescence sensor is used for detecting NOR residues in a milk sample.

This invention provides a post-processing device for boron chelates used in norfloxacin production, comprising a mixing tank, a stirring rod rotatably mounted inside the mixing tank, and a wall scraping assembly on the outer side of the stirring rod. The wall scraping assembly includes a fixed frame mounted on the outer side of the stirring rod, a mounting base detachably mounted on the outer side of the fixed frame, a telescopic component mounted inside the mounting base, and a scraper at the end of the telescopic component. This invention allows the stirring rod to rotate via a drive component, simultaneously causing the fixed frame and the telescopic component on the outer side of the fixed frame to be scraped and cleaned against the inner wall of the mixing tank under centrifugal force. This avoids excessive material adhering to the inner wall of the mixing tank, which would lead to uneven mixing and unnecessary waste of material. Furthermore, the detachable mounting base allows for easy disassembly, cleaning, and maintenance of the mounting base and scraper, greatly reducing the difficulty of scraper maintenance.

The invention discloses a norfloxacin-europium sensor array for identifying physiological phosphate and monitoring ATP (adenosine triphosphate) hydrolysis as well as a preparation method and application of the norfloxacin-europium sensor array. The sensor array comprises at least two sensing units with different norfloxacin-europium ion molar concentration ratios, the sensing unit is obtained by mixing and self-assembling a norfloxacin solution and a europium ion solution. Based on direct self-assembly of cheap norfloxacin (NF) and Eu < 3 + > ions, five physiologically crucial phosphates can be effectively distinguished, and ATP hydrolysis can be monitored. By adjusting the concentration of Eu < 3 + >, a multiple recognition mechanism is established, and target PPs can be completely distinguished with the accuracy of 100%.

The invention relates to a method for adjusting the norfloxacin removal performance of ferrate based on buffer salts, and belongs to the technical field of novel pollutant environmental protection, and the method mainly comprises the following steps: preparing different types of buffer salts, and calculating the norfloxacin removal rate to evaluate the norfloxacin removal performance of ferrate in different buffer systems.

The application discloses a preparation method and application of a fluorescence-enhanced probe for rapidly detecting moxifloxacin and norfloxacin, and belongs to the technical field of rapid antibiotic detection. The fluorescence-enhanced probe is prepared from p-aminosalicylic acid and L-cysteine by a hydrothermal method, and the optimal preparation process is that the p-aminosalicylic acid and the L-cysteine with a mass ratio of 4:1 are dissolved in anhydrous ethanol, and then heated at 200 DEG C for 14 hours. Moxifloxacin and norfloxacin can significantly enhance the fluorescence intensity of the fluorescence probe at 520 nm and 460 nm, respectively, and have a good linear relationship with the concentration. The application has the advantages of simple operation, low cost, rapid detection, high sensitivity, high selectivity, wide detection range and low detection limit, and can realize on-site rapid detection of moxifloxacin and norfloxacin in water and milk.

The invention provides Kineococcus G2 and application of the Kineococcus G2 in preparation of a pigment with antioxidant activity, the Kineococcus new strain G2 is CCTCC No. M20242602, the strain is spherical, the size is 1.0 * 1.5 mu m, the optimal growth temperature is 30-37 DEG C, the pH value is 7.0-9.0, and the salt concentration is 1.0%-2.0%. The strain G2 is not sensitive to bacitracin, ciprofloxacin and norfloxacin, and is sensitive to novobiocin, polymyxin, gentamicin, piperacillin, ofloxacin, erythromycin, streptomycin, kanamycin, rifampicin, ampicillin, vancomycin, carbenicillin, chloramphenicol, tetracycline, penicillin, cefoperazone, oxacillin, amoxicillin and neomycin. Pigment generated by fermentation of the G2 strain has good antioxidant activity, and when the concentration is 10 micrograms / mL, the scavenging activity on DPPH is 25.00%, the scavenging activity on hydroxyl radicals is 80.58%, and the iron ion reducing capacity is 1.57, which are all higher than those of contrast beta-carotenoid. The application of the new Kineococcus strain G2 can lay a foundation for the research of antioxidant drugs such as medical treatment and health care product development.

The invention relates to a ratio type rare earth functionalized covalent organic framework fluorescent probe as well as a preparation method and application thereof. The fluorescent probe comprises a covalent organic framework and rare earth ions, the covalent organic framework comprises a first connector and a second connector; the first connector is 3, 3 ''-dihydroxy-[1, 1 ': 4', 1''-terphenyl]-4, 4 ''-dialdehyde, and the second connector is 3, 3''-dihydroxy-[1, 1 ': 4', 1 ''-terphenyl]-4, 4''-dialdehyde; the rare earth ions are scandium ions. The prepared fluorescent probe can detect enrofloxacin, norfloxacin and pefloxacin in the environment, and compared with other fluorescent probes, the fluorescent probe has higher resistance to changes of external environmental factors, and the recognition result is more accurate and reliable; and the preparation method is simple, high in product yield and suitable for batch production and application.

The invention discloses a cucurbit [5] uril-based framework material as well as a preparation method and application thereof, and belongs to the crossing field of supramolecular chemistry and functional materials. The preparation method comprises the following steps: dissolving potassium salt and cucurbit [5] uril in distilled water; then adding a 3, 3 '-disulfo-[1, 1'-biphenyl]-4, 4 '-dicarboxylic acid ligand, and stirring to obtain a mixed solution; the mixed solution is subjected to a heating reaction, then cooling, filtering and drying are conducted, and the cucurbit [5] uril-based framework material is obtained, and the chemical formula is C396H360K18N180O198S18. Through coordination of an organic ligand containing a sulfonic acid group and metal ions, in combination with non-covalent interaction of hydrogen bonds, Van der Waals force and the like, and through optimal regulation and control of a material ratio, pH and temperature, a honeycomb three-dimensional porous framework structure with high stability is successfully constructed. By utilizing the fluorescence characteristic and the structural characteristic, the efficient recognition of Fe < 3 + > and Pb < 2 + > heavy metal ions and norfloxacin antibiotics in a water body can be realized. The problems that in the prior art, when heavy metal ions and antibiotics in water are detected, operation is tedious, and cost is high are solved.

The invention discloses an AuNPs@CTS@NiCo2O4 composite material, a preparation method and an application thereof, comprising the following steps: step 1: reducing chloroauric acid with sodium citrate to obtain nano-gold; step 2: adding NiCo2O4 to chitosan to obtain a NiCo2O4 dispersant, wherein the mass ratio of NiCo2O4 to chitosan is 1:1; step 3: fully mixing and dispersing the NiCo2O4 dispersant obtained in step 2 and the nano-gold solution obtained in step 1 to obtain the AuNPs@CTS@NiCo2O4 composite material, wherein the mass ratio of chloroauric acid to NiCo2O4 is 1:25; the composite material is used to prepare an electrochemical sensor for detecting norfloxacin, and the prepared sensor has a low LOD (0.0077 nM) and a wide linear range (0.02-1.09 nM); and the sensor has good selectivity, good anti-interference and good stability.

The invention discloses a preparation method and application of a metal Co-doped catalyst InBO3. The method comprises the following steps: dissolving InCl3. 4H2O, CoCl2. 6H2O, boric acid and citric acid in water, heating until the solution is in a sol-gel state, foaming, sintering in a muffle furnace for two times after foaming, washing with deionized water for three times, and drying to obtain In1-xCoxBO3. The catalyst In1-xCoxBO3 prepared by the method can be used for activating persulfate to degrade norfloxacin and catalyzing benzyl alcohol oxidation, and has a good catalytic effect and stable catalytic properties.

The utility model discloses a norfloxacin composition preparation device, which comprises a mixing tank, a bottom table, a stirring and wall scraping mechanism, an anti-overload mechanism and a spring adjusting mechanism, the stirring and wall scraping mechanism comprises a stirring motor, a stirring shaft, stirring blades, a cross beam and a wall scraping plate, the anti-overloading mechanism comprises an anti-overloading pipe, an anti-overloading rod, an anti-overloading groove, an extending frame, a moving block, a moving groove and an anti-overloading spring, the spring adjusting mechanism comprises a directional sleeve, an adjusting ring, a matching plate, a matching groove, a sliding block, a supporting spring and a fixing frame, and a wall scraping plate makes contact with the inner wall of the mixing tank, so that material residues on the inner wall of the mixing tank can be effectively scraped; the anti-overloading stirring tank has the advantages that the anti-overloading stirring tank is simple in structure and convenient to use, non-uniform mixing caused by adhesion of materials to the tank wall in the mixing process is avoided, mixing efficiency is improved, the anti-overloading mechanism can play an automatic protection role when the stirring motor or the stirring shaft is overloaded, a stirring system is prevented from being damaged due to overloading, and the service life of the anti-overloading stirring tank is effectively prolonged.

The invention discloses iron-cobalt modified biochar as well as a preparation method and application thereof, and belongs to the technical field of organic pollutant treatment, the iron-cobalt modified biochar can remove norfloxacin through an adsorption effect, and can activate peroxymonosulfate to generate sulfate free radicals, so that the norfloxacin is degraded through an advanced oxidation process. Fe and Co on the surface of Co-Fe-BC are used as catalysts, the energy threshold of sulfate free radicals generated by persulfate decomposition can be reduced, and the activation rate of persulfate is increased. The generated sulfate free radicals have high oxidation-reduction potential, can attack norfloxacin molecules in a non-selective manner, and initiate free radical chain reaction through hydrogen atom picking or an electron transfer mechanism, and finally, norfloxacin is mineralized into harmless small molecular substances, such as carbon dioxide and water. The process not only effectively removes norfloxacin, but also reduces the generation of disinfection by-products, and improves the safety of water quality.

The invention provides amphiphilic resorcinol calixarene based on guanidino carbonyl pyrrole functionalization and a nano particle containing the amphiphilic resorcinol calixarene. Firstly, nanoparticles are constructed on the basis of amphiphilic resorcinol calixarene, then antibiotic norfloxacin is entrapped in the nanoparticles, and binary nanoparticles with a synergistic antibacterial effect are prepared and are used for efficient antibiosis. The nanoparticles show excellent synergistic antibacterial effect and biocompatibility under the condition that the concentration is far lower than the minimum inhibitory concentration of subjects and guests, and the problem of drug resistance of bacteria is avoided to the greatest extent due to the use of low-dose antibiotics.

The invention relates to the field of electrochemical degradation of antibiotic wastewater, in particular to an Ag-loaded MOFs modified TiOnanorod conductive glass electrode and a preparation process thereof.The preparation method comprises the steps that firstly, FTO conductive glass is subjected to mixed solution ultrasonic cleaning, hydrothermal growth and muffle furnace calcination annealing, and a TiONRs electrode is prepared; carrying out solvothermal reaction and vacuum drying to obtain a Fe, Ti M 'MOFs / TiONRs electrode; and finally, carrying out adsorption-ultraviolet light reduction to obtain the Ag (at) Fe, Ti M 'MOFs / TiONRs electrode. The preparation method is simple and convenient, few in reagent and low in cost; the TiO nanorod grows firmly and is compact in structure; the applied bias voltage is low, 70.62% of 10 mg / L norfloxacin can be degraded under 1.0 V for 120 min, the norfloxacin degradation rate is high, and the electrode stability is good.

The invention discloses a conjugated microporous polymer and application thereof in treatment of norfloxacin. The conjugated microporous polymer has visible light responsiveness, shows excellent photocatalytic degradation performance to norfloxacin under visible light irradiation, has a degradation rate exceeding 80% in actual water, and shows very high compatibility to complex water quality factors such as a wide pH range, common competitive ions and humic acid. When the dosage of the catalyst is reduced to 0.02 g / L, 95% of norfloxacin can still be degraded in a system of 1000 mL, and the industrial application potential of the norfloxacin in low-dosage and large-volume accumulated water treatment is shown. Meanwhile, the material has excellent cycling stability, the degradation rate is still kept to be 76% or above after the material is continuously used for five times, and the material has remarkable cost advantage and popularization prospect in advanced treatment of industrial wastewater by combining high efficiency and reusability of the material.

The invention discloses a sulfur-doped bi-metal cobalt cerium oxide Fenton-like catalyst and a preparation method and application thereof.The sulfur-doped bi-metal cobalt cerium oxide Fenton-like catalyst is a sulfur-doped cobalt cerium composite oxide, and in the sulfur-doped bi-metal cobalt cerium oxide Fenton-like catalyst, the Co element content is 20-24 wt%, the Ce element content is 50-56 wt%, the O element content is 20-22 wt%, and the balance is a carrier. The content of the S element is 1-4 wt%. According to the sulfur-doped bimetallic cobalt cerium oxide Fenton-like catalyst disclosed by the invention, peroxyacetic acid is activated to generate organic oxygen free radicals, and 90.5% of moxifloxacin can be degraded within 15 minutes; and the composite material has a good degradation effect on pollutants of polycyclic aromatic compounds such as ofloxacin, gatifloxacin, norfloxacin, tetracycline, o-nitrophenol, naproxen and the like.

The present invention discloses a functionalized isoquinolone and quinolone compounds and an efficient transition-metal-free approach for the synthesis of the same. The invention provides a highly functionalized isoquinolones from the reaction of dimethyl-2-((phenylamino)methylene) malonate with aryne precursors under mild. The reaction proceeds through insertion of aryne into the C−C σ-bond, which offers a novel and practical entry to access a wide range of isoquinolones with enhanced yields. The substrate scope is broad as the process can stands a variety of functional groups and the application of the developed process has been demonstrated in the total synthesis of antimalarial agent SJ000101247. Also, the highly functionalized quinolones are also useful in the synthesis of floxacins based compounds and derivatives e.g. ciprofloxacin, norfloxacin, G003967, etc.

The invention discloses norfloxacin degrading bacteria as well as an immobilized material and application thereof, and belongs to the field of water treatment. The invention firstly provides a norfloxacin degrading bacterium Pedobacter sp.KHR607 which is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number is CCTCC M 2025139; the strain has a good removal effect on norfloxacin. According to the invention, an embedding technology is further adopted, the strain is prepared into an immobilized material, and the embedded immobilized material has wider pH adaptability and adaptability to high-concentration norfloxacin, and has a better application prospect in the treatment of wastewater containing norfloxacin.

The invention belongs to the field of food safety detection, and particularly relates to a norfloxacin visual ratio fluorescence detection method based on an integrated detection device and application of the norfloxacin visual ratio fluorescence detection method. The integrated detection device provided by the invention comprises a filtering module and a detection module, the filtering module comprises a first container as well as modified sodium alginate hydrogel and glass wool which are filled in the first container; the modified sodium alginate hydrogel comprises a sodium alginate matrix and polyvinyl alcohol doped in the sodium alginate matrix; the detection module comprises a second container and a sodium alginate hydrogel bead which is filled in the second container and comprises a probe; the probe comprises a copper nano-cluster which is coordinated with terbium ions and modified by dithioerythrine. The integrated detection device provided by the invention is simple to operate and reliable in result, realizes rapid detection and visual response of norfloxacin, and has very high practicability and wide applicability.