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Preparation process of sarafloxacin hydrochloride soluble powder

A sarafloxacin hydrochloride, preparation technology, applied in non-active ingredient medical preparations, medical preparations containing active ingredients, powder delivery, etc., can solve the limitations, low bioavailability of soluble powder, poor water solubility, etc. question

Inactive Publication Date: 2020-07-07
XIAN CHANGSHENG ANIMAL HEALTH PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Sarafloxacin hydrochloride fluoroquinolones have broad antibacterial spectrum and strong antibacterial activity, and have good killing effect on Gram-positive bacteria, negative bacteria, anaerobic bacteria, mycoplasma and chlamydia, and can be used to prevent and treat various bacteria diseases, but the water solubility of sarafloxacin hydrochloride is poor, and the bioavailability of the soluble powder is low, which greatly limits its application, so we propose a preparation process of sarafloxacin hydrochloride soluble powder

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The present embodiment proposes a kind of preparation technology of sarafloxacin hydrochloride soluble powder, comprises the following steps:

[0019] S1: Select sarafloxacin hydrochloride, then use a nano jet mill to pulverize sarafloxacin hydrochloride into a superfine powder of more than 1000 mesh, and then use a nanometer measuring instrument to obtain sarafloxacin hydrochloride superfine powder of 1-100nm;

[0020] S2: Select β-cyclodextrin, add β-cyclodextrin into the ball mill, and add water twice the weight of β-cyclodextrin to the ball mill at the same time, and the ball mill grinds the β-cyclodextrin and water inside it Evenly, then add sarafloxacin hydrochloride superfine powder of 1 times the weight of β-cyclodextrin to the ball mill, set the internal reaction temperature of the ball mill to 40°C, and after the ball mill is fully ground for 30 minutes, a pasty mixture is obtained;

[0021] S3: The ball mill described in S2 performs decompression drying on th...

Embodiment 2

[0025] The present embodiment proposes a kind of preparation technology of sarafloxacin hydrochloride soluble powder, comprises the following steps:

[0026] S1: Select sarafloxacin hydrochloride, then use a nano jet mill to pulverize sarafloxacin hydrochloride into a superfine powder of more than 1000 mesh, and then use a nanometer measuring instrument to obtain sarafloxacin hydrochloride superfine powder of 1-100nm;

[0027] S2: Select β-cyclodextrin, add β-cyclodextrin into the ball mill, and add water 6 times the weight of β-cyclodextrin to the ball mill, and the ball mill grinds the β-cyclodextrin and water inside it Evenly, then add 3 times the weight of β-cyclodextrin superfine powder of sarafloxacin hydrochloride into the ball mill, the internal reaction temperature of the ball mill is set to 50 ° C, after the ball mill is fully ground for 105 minutes, a pasty mixture is obtained;

[0028] S3: The ball mill described in S2 performs decompression drying on the pasty mix...

Embodiment 3

[0032] The present embodiment proposes a kind of preparation technology of sarafloxacin hydrochloride soluble powder, comprises the following steps:

[0033] S1: Select sarafloxacin hydrochloride, then use a nano jet mill to pulverize sarafloxacin hydrochloride into a superfine powder of more than 1000 mesh, and then use a nanometer measuring instrument to obtain sarafloxacin hydrochloride superfine powder of 1-100nm;

[0034] S2: Select β-cyclodextrin, add β-cyclodextrin into the ball mill, and add water 10 times the weight of β-cyclodextrin to the ball mill, and the ball mill grinds the β-cyclodextrin and water inside it uniform, then add 1 to 5 times the weight of β-cyclodextrin superfine powder of sarafloxacin hydrochloride into the ball mill, set the internal reaction temperature of the ball mill to 60°C, and after the ball mill is fully ground for 180 minutes, a pasty mixture is obtained;

[0035] S3: The ball mill described in S2 performs decompression drying on the pas...

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Abstract

The invention discloses a preparation process of sarafloxacin hydrochloride soluble powder. The preparation process comprises the following steps: firstly sequentially crushing and detecting selectedsarafloxacin hydrochloride, so as to obtain sarafloxacin hydrochloride ultrafine powder with a diameter of 1nm-100nm; then adding selected beta-cyclodextrin into a ball mill, sequentially adding a certain amount of water and a certain amount of the sarafloxacin hydrochloride ultrafine powder to obtain a pasty mixture, carrying out reduced pressure drying on the pasty mixture, and detecting the pasty mixture by virtue of an X-ray diffractometer; and finally, uniformly mixing a sarafloxacin hydrochloride B-cyclodextrin inclusion compound with glucose fine powder, so as to obtain the sarafloxacinhydrochloride soluble powder. The sarafloxacin hydrochloride B-cyclodextrin inclusion compound is prepared by virtue of a nanometer ultrafine powder technique and a beta-cyclodextrin inclusion technique, and the sarafloxacin hydrochloride soluble powder is prepared from the sarafloxacin hydrochloride B-cyclodextrin inclusion compound, so that the water solubility of the sarafloxacin hydrochloridesoluble powder is increased by 90 folds or above, the bioavailability is increased, and the drug stability is enhanced.

Description

technical field [0001] The invention relates to the field of preparation of sarafloxacin hydrochloride soluble powder, in particular to a preparation process of sarafloxacin hydrochloride soluble powder. Background technique [0002] Sarafloxacin hydrochloride fluoroquinolones have broad antibacterial spectrum and strong antibacterial activity, and have good killing effect on Gram-positive bacteria, negative bacteria, anaerobic bacteria, mycoplasma and chlamydia, and can be used to prevent and treat various bacteria diseases, but the water solubility of sarafloxacin hydrochloride is poor, and the bioavailability of the soluble powder is low, which greatly limits its application. Therefore, we propose a preparation process of sarafloxacin hydrochloride soluble powder. Contents of the invention [0003] Based on the technical problems existing in the background technology, the present invention proposes a preparation process of sarafloxacin hydrochloride soluble powder. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/69A61K47/26A61K31/496A61P31/04
CPCA61K9/145A61K9/146A61K31/496A61K47/6951A61P31/04
Inventor 郭尊武朱永刚
Owner XIAN CHANGSHENG ANIMAL HEALTH PRODS
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