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Macrolide antibiotics sodium hyaluronate eye transfer system

A macrolide and antibiotic technology, applied in the field of macrolide antibiotic ophthalmic delivery system, can solve the problems of limiting the application of MA drugs, difficult eyelid blinking, limited synergistic effect and the like

Inactive Publication Date: 2006-08-09
无锡康福特药物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

See Chinese patent CN14100071A, Wu Wenyao, Wang Ling. Azithromycin ophthalmic gel. However, synthetic polymers lack biocompatibility and have the characteristics of Newtonian fluids, that is, the viscosity increases with the increase of concentration but is not affected by shear force When the viscosity reaches a certain level, it will make the eyelids difficult to blink and high concentration will often irritate the sensitive eye tissue, making the eyes intolerable
In addition, the synergistic effect produced by synthetic polymers is also very limited. When the liquid reaches a certain viscosity, even if the concentration of the polymer is increased, the drug effect will not be enhanced.
The above factors limit the application of MA drugs in ophthalmology

Method used

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  • Macrolide antibiotics sodium hyaluronate eye transfer system
  • Macrolide antibiotics sodium hyaluronate eye transfer system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Prescription: (based on 100ml eye drops)

[0057] Azithromycin 1g

[0058] Sodium Hyaluronate (SH) 1g

[0059] Hydrochloric acid amount

[0060] Sodium chloride appropriate amount

[0061] Benzalkonium Chloride 0.005g

[0062] Appropriate amount of sodium hydroxide

[0063] Add water for injection to 100ml

[0064] Process: Dissolve 1g of sodium hyaluronate in about 40ml of water for injection. Take an appropriate amount of hydrochloric acid to dissolve azithromycin, adjust the pH to 6.0-7.0 with sodium hydroxide, add benzalkonium chloride and sodium chloride therein, and stir evenly. Mix the two solutions together, add water for injection to 100ml, and stir well. Sterilize by filtration with a 0.25um membrane, pack in aliquots, and obtain.

Embodiment 2

[0066] Prescription: (based on 100ml eye drops)

[0067] Clarithromycin 1g

[0068] Sodium Hyaluronate (SH) 1g

[0069] Hydrochloric acid amount

[0070] Sodium chloride appropriate amount

[0071] Benzalkonium Chloride 0.005g

[0072] Appropriate amount of sodium hydroxide

[0073] Add water for injection to 100ml

[0074] Process: Dissolve 1g of sodium hyaluronate in about 40ml of water for injection. Take an appropriate amount of hydrochloric acid to dissolve clarithromycin, adjust the pH to 6.0-7.0 with sodium hydroxide, add benzalkonium chloride and sodium chloride therein, and stir evenly. Mix the two solutions together, add water for injection to 100ml, and stir well. Sterilize by filtration with a 0.25um membrane, pack in aliquots, and obtain.

Embodiment 3

[0076] Prescription: (based on 100ml eye drops)

[0077] Erythromycin 1g

[0078] Sodium Hyaluronate (SH) 1g

[0079] Hydrochloric acid amount

[0080] Sodium chloride appropriate amount

[0081] Benzalkonium Chloride 0.005g

[0082] Appropriate amount of sodium hydroxide

[0083] Add water for injection to 100ml

[0084] Process: Dissolve 1g of sodium hyaluronate in about 40ml of water for injection. Take an appropriate amount of hydrochloric acid to dissolve erythromycin, adjust the pH to 6.0-7.0 with sodium hydroxide, add benzalkonium chloride and sodium chloride therein, and stir evenly. Mix the two solutions together, add water for injection to 100ml, and stir well. Sterilize by filtration with a 0.25um membrane, pack in aliquots, and obtain.

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PUM

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Abstract

This invention relates to an eye use transmission system of macrolide type antibiotic hyaluronic acid natrium. The goal of this invention is to provide a macrolide type antibiotic eye use medicine preparation with carrier is hyaluronic acid or its salt. It is used to cure germ eye region infection. The macrolide type antibiotic in this invention includes antibiotic that has 14 yuan,15yuan, 16yuan large ring construction features , for example, natural antibiotic bring by streptomycete erythromycin, josamycin, spiramycin, medemycin etc. and semisynthesis derivant from by structure modification of natural antibiotic, such as roxithromycin, azithromycin, clarithromycin, rokitamycin, telithromycin.

Description

technical field [0001] The invention is a macrolide antibiotic ophthalmic delivery system with hyaluronic acid and its salt as the carrier. technical background [0002] Macrolide Antibiotics (Macrolide Antibiotics, English abbreviation: MA) is a class of weakly basic antibiotics produced by Streptomyces. ring. [0003] MA is widely used clinically. It mainly acts on the 50S subunit of the sensitive sclerotin body, inhibits RNA synthesis, hinders the process of bacterial transpeptide, and thus inhibits the synthesis of bacterial proteins. It is a quiescent antibacterial agent. Because of its good antibacterial effect, it is widely used in the treatment of infectious diseases in various clinical departments, and is one of the most widely used antibacterial drugs in clinical practice. The first generation is natural varieties, such as erythromycin, josamycin, midecamycin, spiramycin, etc.; the second generation is semi-synthetic products, such as roxithromycin, azithromycin,...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K31/7048A61K31/7052A61P31/04
Inventor 涂家生吴建梅银春
Owner 无锡康福特药物科技有限公司
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