Application of Netilmicin sulfate in preparation of eye drops

A technology of netilmicin sulfate and eye drops, applied in medical preparations containing active ingredients, antibacterial drugs, organic active ingredients, etc., can solve problems such as low side effects and ophthalmic diseases without the use of netilmicin sulfate , to achieve a non-irritating effect

Inactive Publication Date: 2004-06-09
TIANJIN PHARMA GROUP XINZHENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Netilmicin sulfate has the advantages of good curative effect and low side effects, but so far netilmicin sulfate has not been used in ophthalmic diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The preparation process of the present invention: take sodium acetate, boric acid, sodium bisulfite, disodium edetate, β-cyclodextrin, benzyl alcohol, and povidone K30 and dissolve them in water for injection, add water to the full amount, add 0.01 % 767 activated carbon for needles, stirred for 30 minutes, then decarbonized by filtration through a 0.45 μm microporous membrane; sterilized by flowing steam at 100°C for 30 minutes, and left to cool for later use. Under aseptic operation, add netilmicin sulfate, shake well, pass the intermediate inspection and filter through a 0.22 μm microporous membrane, and then sub-package to obtain the product.

[0018] Specific steps:

[0019] (1) Clean the plastic eye drop bottle, sterilize it by circulating steam at 100°C for 20 minutes, and set it aside;

[0020] (2) Dissolve sodium acetate, boric acid, sodium bisulfite, disodium edetate, β-cyclodextrin, benzyl alcohol, and povidone K30 in water for injection and add to the full ...

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PUM

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Abstract

The present invention belongs to a preparation process of eye drops with obvious curative effect for curing keratitis due to pseudomonas and infective ophthalmopathies due to gram-negative bacteria, pseudomonas aeruginosa and other bacteria. Said eye drops preparation is of netilamicin sulfate which is used as main raw material and adding chemical inhibitor, antioxidation synergist, preservative, pH regulating agent, isoosmotic regulating agent, stabilizing agent and solvent as auxiliary material.

Description

technical field [0001] The invention relates to a preparation process of medicine for treating ophthalmic diseases, in particular, an eye drop is mainly prepared by using netilmicin sulfate together with auxiliary materials. Background technique [0002] At present, in clinical ophthalmic medicine, antibiotic chemicals have an absolute advantage. According to statistics, 80% to 90% of patients who visit ophthalmology clinics have outer eye infections. Topical administration is the main way of ophthalmic medicine, because local administration can not only make the concentration of the liquid medicine in the lesion part higher and maintain it for a long time, but also can greatly save medicine and reduce systemic side effects. Eye drops are the most commonly used topical drug formulation in ophthalmology. Among the eye drops for the treatment of eye inflammation, aminoglycosides, macrolides, quinolones, etc. are widely used clinically, and aminoglycosides have good permeabil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61P27/02A61P31/04
Inventor 余世春
Owner TIANJIN PHARMA GROUP XINZHENG
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