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Netilmicin sulfate injection and preparing method

A technology of netilmicin sulfate and injection, applied in medical preparations containing active ingredients, drug delivery, antibacterial drugs, etc., can solve problems such as regardless of technical effects

Active Publication Date: 2015-12-16
成都天台山制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Regardless of the technical effects of these powder injections, the high production process cost of freeze-dried powder injections is not commensurate with this cheap drug

Method used

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  • Netilmicin sulfate injection and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0174] Embodiment 1: preparation netilmicin sulfate injection

[0175] formula:

[0176] Netilmicin sulfate 50,000 U,

[0177] Anhydrous sodium sulfite 3mg,

[0178] L-cysteine ​​0.4mg,

[0179] Edetate Disodium 0.2mg, and

[0180] Water for injection, appropriate amount, added to 1ml.

[0181] Preparation method:

[0182] (1) Add cysteine ​​and netilmicin sulfate raw materials to water for injection with a preparation volume of 20% (water temperature below 40°C, the same below), stir to dissolve them, and add 0.2% injection for injection to the liquid medicine Activated carbon, stirred and adsorbed for 30 minutes, filtered;

[0183] (2) Add sulfite and edetate to the water for injection with a preparation amount of 20%, stir to dissolve it, add 0.2% activated carbon for needles to the liquid, stir and absorb for 30 minutes, and filter;

[0184] (3) Mix the medicinal solution obtained in step (1) and step (2), add water for injection of 50% of the preparation amount, mi...

Embodiment 2

[0186] Embodiment 2: preparation netilmicin sulfate injection

[0187] formula:

[0188] Netilmicin sulfate 20,000 U,

[0189] Anhydrous sodium sulfite 8mg,

[0190] L-cysteine ​​0.2mg,

[0191] Edetate Disodium 0.6mg, and

[0192] Water for injection, appropriate amount, added to 1ml.

[0193] Preparation method:

[0194] (1) Add cysteine ​​and netilmicin sulfate raw materials to water for injection with a preparation volume of 20% (water temperature below 40°C, the same below), stir to dissolve them, and add 0.2% injection for injection to the liquid medicine Activated carbon, stirred and adsorbed for 30 minutes, filtered;

[0195] (2) Add sulfite and edetate to the water for injection with a preparation amount of 20%, stir to dissolve it, add 0.2% activated carbon for needles to the liquid, stir and absorb for 30 minutes, and filter;

[0196] (3) Mix the medicinal solution obtained in step (1) and step (2), add water for injection of 50% of the preparation amount, mi...

Embodiment 3

[0198] Embodiment 3: preparation netilmicin sulfate injection

[0199] formula:

[0200] Netilmicin sulfate 100,000 U,

[0201] Anhydrous sodium sulfite 2mg,

[0202] L-cysteine ​​1mg,

[0203] Edetate Disodium 0.1mg, and

[0204] Water for injection, appropriate amount, added to 1ml.

[0205] Preparation method:

[0206] (1) Add cysteine ​​and netilmicin sulfate raw materials to water for injection with a preparation volume of 20% (water temperature below 40°C, the same below), stir to dissolve them, and add 0.2% injection for injection to the liquid medicine Activated carbon, stirred and adsorbed for 30 minutes, filtered;

[0207] (2) Add sulfite and edetate to the water for injection with a preparation amount of 20%, stir to dissolve it, add 0.2% activated carbon for needles to the liquid, stir and absorb for 30 minutes, and filter;

[0208] (3) Mix the medicinal solution obtained in step (1) and step (2), add water for injection of 50% of the preparation amount, mix...

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Abstract

The invention relates to a netilmicin sulfate injection and a preparing method. Particularly, the netilmicin sulfate injection is prepared from netilmicin sulfate, sodium sulfite or sodium hydrogen sulfite, cysteine, edetate disodium or sodium calcium edentate and water for injection. The invention further relates to the preparing method for the netilmicin sulfate injection. The prepared netilmicin sulfate injection has one or more excellent characteristics described in the description.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical engineering, and in particular relates to a netilmicin sulfate product and a preparation method thereof, in particular to a netilmicin sulfate injection and a preparation method thereof. Background technique [0002] Netilmicin Sulfate (NTM), a new generation of semi-synthetic aminoglycoside antibiotics introduced in 1994, works by inhibiting the normal protein synthesis of sensitive microorganisms. Netilmicin sulfate has been included in the 2010 and 2015 editions of "Chinese Pharmacopoeia". The chemical structural formula, molecular formula and molecular weight of netilmicin sulfate are as follows: [0003] [0004] (C 21 h 41 N 5 o 2 ) 2 ·5H 2 SO 4 1441.54 [0005] Netilmicin sulfate is O-3-deoxy-4-C-methyl-3-methylamino-β-L-arabinosyl (1—>4)-O-[2,6 diamino- 2,3,4,6-Tetradeoxy-α-D-glyceryl-4-enhexopyranosyl-(1—>6)]-2-deoxy-N 3 - Ethyl-L-Streptavidin Sulfate. The raw ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/7048A61P31/04
Inventor 方专吴国庆陈娟张莲莲王敬江威赵东明
Owner 成都天台山制药股份有限公司
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