95 results about "Clindamycin Hydrochloride" patented technology

The invention discloses a method for synthesizing clindamycin phosphate, which comprises the following steps of: performing ketal protection reaction on clindamycin hydrochloride alcoholate at the temperature of between 2.0 below zero and 2.0 DEG C under the action of acetone and phosphorus oxychloride to form propylidene clindamycin; and performing esterification, hydrolysis, adsorption, washing, deabsorption, concentration, coarse crystallization, decoloration, refining and drying to obtain the finished product of clindamycin phosphate. Because a new catalyst 4-dimethylaminopyridine participates in the esterification in the rection system, the phosphorylating reaction is performed completely, and the conversion rate of raw materials is improved. Meanwhile, due to the secondary crystallization method, the problems of poor color grade and poor powder solubility are solved, and the operating conditions are mild and simple. By adopting triethylamine to replace partial pyridine, the esterification is pushed forwards; the reaction period is shortened; and importantly, related impurities in the finished product and the production cost are reduced, and the content is improved.

The invention relates to compound emulsifiable paste for treating acne and a preparation method thereof, in particular to a medicament for treating acne and a preparation method thereof. The compound emulsifiable paste solves the problems of long treatment course and skin oxidation, dim skin and formation of color spots in the healing process in the conventional medicament for treating the acne. The compound emulsifiable paste is prepared from clindamycin hydrochloride, metronidazole, vitamin A, vitamin C, an emulsifying agent, stearic acid, albolene, glycerol monostearate, lanolinum, glycerol and purifying water. The preparation method comprises the following steps of: adding the vitamin A into uniform solution prepared from the stearic acid, the albolene, the glycerol monostearate and the lanolinum to obtain an oil phase; dissolving the glycerol and the emulsifying agent into the purifying water, adding the clindamycin hydrochloride, the metronidazole and the vitamin C, and stirring uniformly to obtain a aqueous phase; and adding the oil phase into the aqueous phase, stirring, homogenizing and standing the mixture to obtain the compound emulsifiable paste for treating the acne. The treatment period of the compound emulsifiable paste is between 14 and 24 days, skin is bright and clean after healing, and the compound emulsifiable paste can treat the acne, seborrheic dermatitis, acne rosacea and folliculitis.

The invention relates to a process for synthesizing clindamycin phosphate. The process comprises the following steps: 1) ketal reaction, wherein clindamycin hydrochloride alcoholate is used as a basic raw material to prepare a 3.4-clindamycin condensation compound through selective hydroxyl protection; and 2) phosphatidic reaction, wherein the 3.4-clindamycin condensation compound is used as a raw material, phosphorus oxychloride is used as a phosphatidic agent, and anhydrous potassium carbonate is used as an acid binding agent to complete the phosphatidic reaction under double actions of esterification catalyst dimethylamino pyridine and phase-transfer catalyst benzyl triethyl ammonium chloride, and a target compound, namely the clindamycin phosphate, can be obtained through hydrolysis deprotection. The process has the advantages that: 1, the process has simple method and practical application; 2, the content of pyridine/triethylamine in wastewater of phosphatidic reacting process can be controlled, so that the pressure of high COD wastewater drainage can be greatly reduced; and 3, the weight yield reaches over 95 percent, and the product quality fulfills the requirement of WS1-(X-322)-2003Z.

The invention relates to a process for synthesizing new clindamycin hydrochloride. The process comprises the following steps of: 1) finishing chlorination reaction by using lincomycin hydrochloride as a basic raw material and using low-C halogenated hydrocarbon as a solvent; 2) finishing hydrolysis reaction of sodium hydroxide in an aqueous phase by using a product obtained in the step 1), and demixing the solution to obtain clindamycin free alkali; and 3) in a solvent system of acetone, performing salt forming reaction on the clindamycin free alkali obtained in the step 2) and hydrochloric acid, and crystallizing the reaction product to obtain the clindamycin hydrochloride. The invention has the advantages that: 1, the process is simple; 2, the process reduces one-step chemical reaction on chemical unit reaction; 3, the process reduces one raw material and one intermediate on materials and intermediate links; and 4, the yield of the product is greatly improved, the epimer clint content of impurities is reduced by 80 percent, the process has high yield, and the yield is improved by over 5 percent compared with a four-step method.

The invention discloses an adapalene clindamycin hydrochloride compound gel preparation and a preparation method thereof. The preparation contains 0.08 to 0.12 percent of adapalene and 0.8 to 1.2 percent of clindamycin hydrochloride according to the weight percentage. The preparation method for the adapalene clindamycin hydrochloride compound gel comprises the steps of: preparing a gel matrix, swelling, sterilizing, dissolving the adapalene and the clindamycin hydrochloride into the gel matrix respectively, and using triethanolamine to adjust the pH value to form the steady gel. The product can effectively treat acne.

The invention discloses a method for preparing clindamycin hydrochloride. The method comprises the following steps of: a) adding purified water into a chloroformic solution of clindamycin hydrochloride alcohol complex and washing; b) adding purified water into the washed organic phase, dripping hydrochloric acid to adjust PH value to be 2 to 3, standing and layering; c) adding activated carbon into a water phase obtained through separation and decoloring, and filtering; d) adsorbing filtrate by using a resin, and washing by using deionized water; e) desorbing by using methanol of which the mass concentration is more than 95 percent; f) concentrating a desorption solution under reduced pressure; g) adding acetone into concentrated dried materials, and stirring at the temperature of between 55 and 58 DEG C until the solution is clarified; h) dripping hydrochloric acid to adjust PH value to be 2 to 2.5; and i) reducing temperature to 0 to 5 DEG C, performing suction filtration under negative pressure to obtain web powder, washing by using iced acetone, and after suction filtration, drying to obtain the clindamycin hydrochloride. According to the method, the step of alcohol complex crystallization in the conventional process is eliminated; the process is simplified; production cost is reduced; and the weight yield and the quality of the whole batch of clindamycin hydrochloride are improved simultaneously.

The invention discloses a clindamycin hydrochloride injection and a preparation method thereof. The preferred preparation formulation is injection and lyophilized powder. The clindamycin hydrochloride injection composition consists of clindamycin hydrochloride as an active ingredient and moderate buffer salt. The solvent of the invention is only water for injection and has no any other organic solvents, and the lyophilized powder does not contain excipients. The clindamycin hydrochloride injection has the advantages that: firstly, the formula is simple, the species of excipients are few, and the excipients belong to the medicinal injection grade, are commonly used medicinal excipients, meet the requirements of intravenous injection medication of human bodies, and greatly reduce the risk of potential adverse reaction in clinical use; secondly, the product quality is very stable, the long-term 2-year experiment shows that the product quality has a little change, so that the product can meet the needs of industrialized mass production.

The invention discloses a clindamycin hydrochloride palmitate capsule and the preparation method. Each capsule contains clindamycin hydrochloride palmitate with a content equal to 35 to 300 milligram of clindamycin hydrochloride. The capsule also contains pharmaceutical excipients such as diluent, disintegrant, solubilizer and seed coating agents. The invention produces granules by dry granulating method, wraps the granules with moisture proof agricultural film, and performs the process of capsule loading. The invention solves the problems of easy moisture absorbing, caking and breaking of capsule shell caused by moisture absorbing. The invention also solves the problems with the product that the formulation is unitary and only granules and dispersible tables are provided, enriches the formulation of the capsule, offers patients with more choices of formulation and the compliance is good. Due to the addition of solubilizer, the clindamycin hydrochloride palmitate is stripped more rapidly and the bioavailability of the invention is enhanced. And the invention adopts the process of moisture proof agricultural film wrapping after dry granulating method, so the activity of the clindamycin hydrochloride palmitate is preserved better, the effect of the drug is better and the drug is much safer; thereby the invention is fit for industrial production.

The invention discloses an integrated treatment process for clindamycin hydrochloride production wastewater. The process comprises the following steps: performing triple-effect evaporation and concentration on the clindamycin hydrochloride production wastewater, performing centrifugal separation, feeding coarse salts produced by centrifugal separation into a salt refining workshop, collecting the mother solution to be used for extracting phosphate, and repeatedly performing dissolution, evaporation and centrifugal separation on the coarse salts in the salt refining workshop, thereby obtaining high-purity chlorine salts; washing by ethanol, thereby obtaining the finished chlorine salts; collecting the produced mother solution to be used for extracting phosphate; performing evaporation and concentration on the phosphate mother solution, centrifuging and washing, thereby obtaining the phosphate; rectifying the scrubbing solution, recycling the methanol, feeding the distillation residues into a hazardous waste treatment center, merging the foul condensate produced by multiple-effect evaporation and crystallization mother liquor produced by centrifugal separation, homogenizing, and performing anaerobic and aerobic biological treatment and advanced treatment. The method provided by the invention is an integrated method for combining multiple-effect evaporation, methanol rectification and biological treatment and has the characteristics of reasonable resource utilization, low cost, simplicity and convenience in operation, stable operation and the like.

A dispersing tablet of clindamycin hydrochloride palmitate and its preparing process are disclosed.

The invention provides a clindamycin palmitate hydrochloride particle and a preparation method thereof. The clindamycin palmitate hydrochloride particle provided by the invention consists of a drug pill core and a coating layer covering the outside of the drug pill core, wherein the drug pill core comprises clindamycin palmitate hydrochloride, a carrier and a water-soluble pore-forming agent; andthe coating layer comprises a pH-dependent coating material. According to the clindamycin palmitate hydrochloride particle provided by the invention, a soft material is prepared by virtue of a wet process/the drug pill core is prepared by virtue of an extrusion-spheronisation process firstly, and then the soft material or the drug pill core is coated by coating liquid by virtue of a spray coatingprocess. The clindamycin palmitate hydrochloride particle provided by the invention is applicable to children; the integrity of the particle can be kept before the particle is taken, and the particle,after entering human bodies, can be slowly released, so that a stable and lasting blood concentration can be provided, and clinical demands of reducing the times of administration, reducing dose-related toxicity and improving patient compliance can be satisfied; and meanwhile, the bad taste of the medicine (the particle) can be masked without adding a great amount of flavoring agents.

The present invention relates to a clindamicin palmitate masticatory tablet and its preparation method. It is characterized by that it adopts dry granulation process so as to maximally retain the activity of clindamicin palmitate, it is easy to implement industrial production and its preparation process is simple.

The invention discloses compound shuanghuanglian oral solution used for controlling the cold of a dog and a preparation method thereof, and aims to provide compound shuanghuanglian oral solution used for treating the cold of a dog, which has the advantages of convenient use, high cure rate, quick response and treatment of both principal and secondary aspect of disease, and a preparation method thereof, which has the advantages of simple process and easy implementation. Each 100L of oral solution comprises 0.05 to 5kg of baicalin, 0.5 to 10kg of honey suckle and weeping forsythia extract, 0.1 to 5kg of clindamycin hydrochloride, 5 to 20kg of glucose, 0.2 to 5kg of analginum, 0.005 to 0.05kg of chlortrimeton, 0.1 to 5kg of ribavirin, 0.1kg of sodium glutamate and 0.1kg of sodium hydroxide. The compound shuanghuanglian oral solution is a compound preparation; the honey suckle and weeping forsythia extract, the baicalin, the ribavirin, and the clindamycin hydrochloride have the effect of inhibiting viruses and bacteria so as to control the cold; and by combining the glucose for supplementing energy, the antipyretic and anti-inflammatory analginum, the anti-allergic chlortrimeton and the sodium glutamate for improving the taste and smell of the oral solution, the cold of the dog is multilaterally treated.

The present invention discloses a preparation method of clindamycin hydrochloride powder injection. Said preparation method includes the following steps: (1) adding solvent to dissolve clindamycin hydrochloride; (2), decoloring the dissolved solution and filtering; (3), fine filtering the above-mentioned filtrate under the condition of sterile environment to obtain fine filtrate; (4), adding acetone into the fine filtrate, heating, dissolving, adding active carbon and filtering; (5), standing still to obtain clindamycin crystal; and (6), drying, pulverizing and filling so as to obtain the invented product.

The invention relates to a method for purifying clindamycin hydrochloride. The process comprises process steps as follows: clindamycin hydrochloride adduct reaction liquid is subjected to macroporous resin adsorption and methyl alcohol desorption; obtained desorbed solution is subjected to reduced pressure distillation and concentration, then is dissolved by butyl acetate solvent, and is subjected to alkaline hydrolysis, alkaline extraction and activated carbon decoloration, and clindamycin alkali decolored solution is obtained; a clindamycin hydrochloride product is obtained after acetone crystallization conversion. According to the method, the macroporous resin is utilized in the clindamycin hydrochloride adduct reaction liquid, so as to facilitate alkaline hydrolysis and alkaline extraction and separation processes, reduce an emulsification effect, improve the clindamycin hydrochloride synthesis yield by more than 6%, reduce a solvent loss, lower production costs, and increase economic benefits; the DMF recovery is facilitated, the cost for raw materials is saved, the influence of DMF on the environment is reduced, and the ecological environment is preserved.

The industrial production process of palmitate of clindamycin hydrochloride includes the following main steps: the reaction of isopropylylidene clindamycin hydrochloride and palmitoyl chloride in the presence of acid-binding agent to prepare palmitate of isopropylylidene clindamycin hydrochloride; eliminating protecting radical to obtain coarse palmitate of clindamycin hydrochloride; and final re-crystallization and separation to obtain palmitate of clindamycin hydrochloride product. The present invention has the advantages of facile materials, simple and mild technological process and low power consumption, can obtain white product with HPLC content up to 97.1 %, and is suitable for industrial production.

The invention relates to the technical field of intelligent measurement and control of trichloromethyl carbonate residues, in particular to an intelligent detection method for trichloromethyl carbonate residues in clindamycin hydrochloride. The method is completed by adopting a gas chromatography-mass spectrometer convenient for automatically leveling a column head of a chromatographic column in a matching manner. The detection method comprises the following steps: 1) preparing a raw material solution of a test sample; 2) preparing a test sample preparation solution; 3) preparing a reference substance solution; and 4) respectively and independently putting the prepared test sample raw material solution, the test sample preparation solution and the reference substance solution into a gas chromatography-mass spectrometer for detection. According to the invention, through the arranged cutting and leveling structure, the chromatographic column head can be automatically cut and leveled when the chromatographic column head of the chromatographic mass spectrometer body is replaced, and compared with manual leveling, the leveling efficiency and the leveling quality are greatly improved.

The invention discloses a specific clindamycin hydrochloride superfine powdered lyophilized preparation and a preparation method thereof. The preparation method uses clindamycin hydrochloride and triphosgene as raw materials, and comprises the following steps: performing chlorination reaction in the system of trichloromethane, N,N-dimethylformamide and antioxidant; hydrolyzing and alcoholizing to obtain clindamycin hydrochloride ethylate; decoloring and dealcoholizing to obtain high-purity clindamycin hydrochloride; and performing air-jet superfine crushing, and lyophilizing to obtain the specific clindamycin hydrochloride superfine powdered lyophilized preparation. The specific clindamycin hydrochloride superfine powdered lyophilized preparation has the advantages of good clarity, high stability, high purity, few impurities, small particles, large specific surface area, good solubility, small toxic and side effect, allergy prevention and the like.

This invention relates to a pharmaceutical composition made of a clindamycin salt complexed with strongly acidic non-spherical resin particles, wherein predominantly all of the resin particles are less than 75 microns in diameter, to form clindamycin-resin complex, wherein in the clindamycin-resin complex provides for immediate release of the clindamycin in a target environment and at least one non-ionic excipient. In one embodiment, the inventive subject matter is an oral liquid pharmaceutical formulation made of a complex of clindamycin hydrochloride, a fractionated resin and excipients to stabilize the complex. The pharmaceutical formulation remains stable in deionized water until the dosage form reaches an ion-rich environment (stomach or intestine), there which the active ingredient clindamycin hydrochloride is released.

The invention relates to a compound emulsifiable paste for treating acne and a preparation method thereof. The compound emulsifiable paste comprises the following ingredients by weight percent: 1% of clindamycin hydrochloride, 0.8% of metronidazole, 7%-16% of albolene, 4%-12% of glycerol, 1%-3% of liquid paraffin, 4%-6% of simethicone, 3%-8% of emulsifying agent, 4%-6% of penetration enhancer and the balance of distilled water. The compound emulsifiable paste solves the difficulties that indissolvable drug can not be distributed uniformly, the drug with heat instability is decomposed and subjected to color change when being heated, the possibility of paste preparation in normal temperature can be realized, and the paste is ideal in appearance and is stable. Meanwhile, according to the compound emulsifiable paste, the permeability of corneum of the skin is improved, the effective dose of the drug achieving the wound part is ensured, the bioavailability of effective ingredients of the drug can be improved, the effective dose is reduced, and the toxicity and the skin irritation are low.

The invention relates to a material control device for tableting clindamycin hydrochloride palmitate. The material control device comprises a feed pipe body and a motor, wherein a feed hole is formed in the feed pipe body; a material baffle is arranged in the feed hole; a rotating shaft is arranged at the left end of the material baffle; a base is arranged at the lower end of the motor; a signal sensor is arranged at the upper end of the motor; a frequency modulation controller is arranged at the left upper end of the signal sensor; the frequency modulation controller and the signal sensor exchange signals through a connecting line; a control panel is arranged on a casing of the frequency modulation controller; and a power plug is arranged at the upper end of the frequency modulation controller. According to the material control device, the material baffle is arranged in the feed hole, the other end of the material baffle is fixedly connected with the rotating shaft of the motor, and the frequency modulation controller controls the time that the motor spends in rotating once and the rotation frequency of the motor to further control the weight of medicine powder which enters a middle mold hole through the feed hole; and the material control device has very high accuracy and improves yield of medicines.