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Compound emulsifiable paste for treating acne and preparation method thereof

A compound cream and acne technology, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, ointment delivery, etc., and can solve problems such as long treatment period, skin oxidation, and dull skin

Inactive Publication Date: 2010-11-17
哈尔滨乐泰生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention provides a compound cream for treating acne and its preparation method in order to solve the problems of long course of treatment, skin oxidation during the healing process, dull skin and formation of stains in existing medicines for treating acne.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0007] Specific embodiment one: a kind of compound cream for treating acne in this embodiment is composed of 0.5%~5% clindamycin hydrochloride, 0.5%~3% metronidazole, 0.1%~5% clindamycin Vitamin A, 0.2%-5% vitamin C, 2%-5% emulsifier, 20%-30% stearic acid, 7.3%-11.0% white petrolatum, 3.6%-5.4% monostearic acid Glyceride, 3.6%-5.4% lanolin, 4.5%-5.7% glycerin and 19.5%-57.7% purified water.

[0008] The compound cream for treating acne in this embodiment is an oil-in-water type off-white cream, which can accelerate the healing of ulcers through the joint action of vitamin A, clindamycin hydrochloride, metronidazole and vitamin C, and this implementation The products of this method have the advantages of good properties, easy absorption and release. During the treatment process, it can avoid the adverse reactions of skin oxidation, dullness, peeling and cracking, promote skin growth, accelerate the healing of ulcers, and shorten the treatment time. The treatment cycle is 14 da...

specific Embodiment approach 2

[0009] Specific embodiment two: the difference between this embodiment and specific embodiment one is that a compound cream for treating acne is composed of 1% to 4% clindamycin hydrochloride and 1% to 2.5% metronidazole by mass percentage. Azole, 0.5%-4% vitamin A, 0.5%-4% vitamin C, 2.5%-4% emulsifier, 22%-28% stearic acid, 7.5%-10.0% white petrolatum, 3.8% ~5.0% glycerol monostearate, 3.8%~5.0% lanolin, 4.8%~5.5% glycerin and 32.0%~52.6% purified water.

specific Embodiment approach 3

[0010] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that a compound cream for treating acne is composed of 2% clindamycin hydrochloride, 1.8% metronidazole, 2% vitamin A, 2% vitamin C, 3% emulsifier, 25% stearic acid, 8% white petrolatum, 4.5% glycerol monostearate, 4.5% lanolin, 5.0% glycerin and Made with 42.2% purified water.

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Abstract

The invention relates to compound emulsifiable paste for treating acne and a preparation method thereof, in particular to a medicament for treating acne and a preparation method thereof. The compound emulsifiable paste solves the problems of long treatment course and skin oxidation, dim skin and formation of color spots in the healing process in the conventional medicament for treating the acne. The compound emulsifiable paste is prepared from clindamycin hydrochloride, metronidazole, vitamin A, vitamin C, an emulsifying agent, stearic acid, albolene, glycerol monostearate, lanolinum, glycerol and purifying water. The preparation method comprises the following steps of: adding the vitamin A into uniform solution prepared from the stearic acid, the albolene, the glycerol monostearate and the lanolinum to obtain an oil phase; dissolving the glycerol and the emulsifying agent into the purifying water, adding the clindamycin hydrochloride, the metronidazole and the vitamin C, and stirring uniformly to obtain a aqueous phase; and adding the oil phase into the aqueous phase, stirring, homogenizing and standing the mixture to obtain the compound emulsifiable paste for treating the acne. The treatment period of the compound emulsifiable paste is between 14 and 24 days, skin is bright and clean after healing, and the compound emulsifiable paste can treat the acne, seborrheic dermatitis, acne rosacea and folliculitis.

Description

technical field [0001] The invention relates to a medicine for treating acne and a preparation method thereof. Background technique [0002] Acne is a chronic inflammation of the pilosebaceous glands caused by the combined action of multiple factors. It is generally caused by the accumulation of sebum in the hair follicle. The accumulation of sebum in the hair follicle leads to the proliferation of Propionibacterium acnes in the hair follicle. The enzyme produced by P. acnes can decompose Free fatty acids are produced from sebum, which stimulates hair follicles and causes inflammation. At present, there are many methods for treating acne clinically. Among them, liniment and ointment made by combining clindamycin and metronidazole, because clindamycin and metronidazole only play a bactericidal and bacteriostatic effect , for the skin ulcer formed after acne, it can only be healed by the skin itself. The treatment course is 60-90 days, the treatment course is long, and at the...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K31/4164A61K31/07A61K31/375A61K47/48A61K47/44A61K47/12A61K47/14A61K9/06A61P17/10A61P17/08A61P17/00A61K47/10A61K47/26A61K47/42
Inventor 郎伟君
Owner 哈尔滨乐泰生物科技有限公司
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