92 results about "Lesion group" patented technology

Methods for isolating polynucleotides encoding antibodies against lesional tissues are provided, wherein the methods comprise the steps of: (a) isolating a B cell(s) that infiltrates into a lesional tissue of interest; and (b) obtaining an antibody-encoding polynucleotide from the isolated B cell(s). The lesions may be a cancer tissue or such. Antibody genes can be obtained without depending on B cell cloning. Accordingly, it is also possible to obtain genes encoding human-derived antibodies which are difficult to clone. Genes that encode antibodies against cancer can be obtained using cancer tissues as the lesion.

A non-invasive tool for skin disease diagnosis would be a useful clinical adjunct. The purpose of this study was to determine whether visible/near-infrared spectroscopy can be used to non-invasively characterize skin diseases. In-vivo visible- and near-infrared spectra (400-2500 nm) of skin neoplasms (actinic keratoses, basal cell carcinomata, banal common acquired melanocytic nevi, dysplastic melanocytic nevi, actinic lentigines and seborrheic keratoses) were collected by placing a fiber optic probe on the skin. Paired t-tests, repeated measures analysis of variance and linear discriminant analysis were used to determine whether significant spectral differences existed and whether spectra could be classified according to lesion type. Paired t-tests showed significant differences (p<0.05) between normal skin and skin lesions in several areas of the visible/near-infrared spectrum. In addition, significant differences were found between the lesion groups by analysis of variance. Linear discriminant analysis classified spectra from benign lesions compared to pre-malignant or malignant lesions with high accuracy. Visible/near-infrared spectroscopy is a promising non-invasive technique for the screening of skin diseases.

The invention provides a method for preparing cartilage tissues from artificial in-vitro sources by the aid of human urine cells in an in-vitro manner. The method includes steps of (1), a), reprogramming the human urine cells to generate induced pluripotent stem cells and directionally differentiating the induced pluripotent stem cells to obtain mesenchymal stem cells, or b), carrying out transdifferentiation to generate the mesenchymal stem cells; (2), cultivating the mesenchymal stem cells obtained at the step (1) in cartilage induced differentiation media to obtain the cartilage tissues from the artificial in-vitro sources. The method has the advantages that the cartilage tissues are constructed in the in-vitro manner and can be used for replacing damaged or lesion tissue cells, so that the purpose of repairing cartilage can be achieved, and the effective method is provided for constructing the cartilage tissues in the in-vitro manner and has huge application value.

The invention discloses an automatic marking method for lesion area morphology in a breast ultrasound contrast video, and the method comprises the steps: designing an end-to-end network model structure, just transmitting to-be-recognized data to a model, enabling the model to automatically carry out the convolution operation of each frame of image, and extracting a discrimination feature of a classification basis. The focus area range does not need to be manually drawn in the whole identification process; certain lesion morphological characteristics describe contrast change under related normal tissues and contrast change of lesion tissues, such as enhanced intensity and enhanced time sequence, a convolutional neural network is used for automatically carrying out convolution calculation ona whole radiography video frame sequence, mapping data of normal tissues and lesion areas are shown through calculated characteristic values, and comparison is carried out according to network rulesto obtain a result. In addition, for morphological characteristics such as crab foot shape and enhancement sequence, the designed network is used to automatically calculate the characteristics corresponding to the morphological dynamic change for the spatial-temporal characteristics of the continuous frames of the video.

The invention discloses a visible-light and near-infrared fluorescent 3D co-imaging endoscope system based on a single detector, and belongs to the technical field of endoscope imaging systems, achieving simultaneous acquisition and display of visible-light and near-infrared fluorescent 3D images. The 3D co-imaging endoscope system comprises a visible-light near-infrared excitation light source, abinocular endoscope imaging system, an optical relay inversion system, an image sensor module, an image processing fusion module and a 3D image display system. The endoscope system has the advantagesthat two images with horizontal parallax are received by the RGB-NIR detector to achieve acquisition of the 3D images, so that the visible-light colored 3D image and the near-infrared fluorescent 3Dimage are acquired at the same time; the system structure is simple, and the size is small; operation interruption for status switching is not needed, and smooth operation processes are ensured; the position and size of lesion tissue can be sensed by doctors directly, and accordingly, the success rate of operations is greatly increased.

The invention belongs to the technical field of image processing, and discloses an image processing system in orthopedic anesthesia based on optimized sedation management and regional blocking. The image processing system comprises an ultrasonic image obtaining module, an operation state detection module, a main control module, an image processing module, a three-dimensional navigation module, a storage module and a display module. Through the image processing module, a doctor is prevented from manually identifying lesion tissue, the image identifying efficiency is improved, the doctor does not need to have a high lesion identification ability, and the labor cost is reduced. Through the three-dimensional navigation module, a virtual bone image of a surgical spot of a user and a three-dimensional image of the specific location, where a surgical instrument enters, in the user body are overlaid on a real vision of the doctor, in the surgical process, real-time navigation is conducted, thesurgical operation efficiency of the doctor is greatly improved, and a surgery is more safely, accurately and efficiently implemented.

The invention discloses an anastomosis clamp and an anastomosis set containing the anastomosis clamp. The anastomosis clamp comprises a carrier transparent cap, a pushing rod and a fixing clamp, wherein the carrier transparent cap is arranged at the front end of an endoscope; the front end of the carrier transparent cap is provided with a fixing clamp containing cavity, and the rear end of the carrier transparent cap is provided with a pushing cavity; the pushing cavity is communicated with the fixing clamp containing cavity; the fixing clamp is arranged in the fixing clamp containing cavity;one end of the pushing rod extends into the pushing cavity; the pushing cavity is located outside the endoscope; when the pushing rod is pushed forwards, the fixing clamp stretches out of the fixing clamp containing cavity, and the front end of the fixing clamp is tightened in the direction of the center axis. The anastomosis set comprises a traction clamp and the above anastomosis clamp, and thetraction clamp pulls the lesion tissues, so that the lesion tissues get close to the carrier transparent cap or enter the carrier transparent cap. The device is simple in structure, is not affected byhuman tissue peristalsis after entering a human body, cannot generate structural deformation and winding phenomena, and improves the success rate of an operation.

The invention discloses a nasopharyngeal carcinoma positioning segmentation method and system based on an image segmentation convolutional neural network, and the method comprises the steps: obtaining an electronic nose endoscopic image through employing a WLI mode and an NBI mode, inputting the electronic nose endoscopic image into a nasopharyngeal carcinoma diagnosis model based on the image segmentation convolutional neural network, obtaining a malignant tumor region marked by the diagnosis model, and carrying out the positioning segmentation of the nasopharyngeal carcinoma. The diagnosis system can judge the captured image in real time, mark the malignant tumor part in the nasopharyngeal carcinoma image, export the diagnosis result, intuitively judge whether the target lesion is the malignant tumor tissue or not and determine the boundary range of the malignant tumor lesion according to the malignant tumor lesion as long as the lens is focused on the suspicious lesion tissue in the nasopharyngeal cavity. Suspicious diseased regions are quickly selected for biopsy, so that the accuracy of nasopharyngeal carcinoma detection under a nasal endoscope is effectively improved, and the detection rate of biopsy is increased.

The invention relates to biopsy forceps. The biopsy forceps comprise a handle, sliding handles, a drag line, an insulating sleeve and a drag line rotating device. The sliding sleeves are slidably connected with the handle. One end of the drag line is fixedly connected to the sliding handles. A sling is arranged at the other end of the drag line. The insulating sleeve, namely a hollow sleeve, sleeves the drag line. One end of the insulating sleeve is connected with the handle fixedly. The drag line is divided into two sections, one section is a fixing section fixedly connected with the slidinghandles, and the other section is a rotatable rotating section. The drag line rotating device comprises a shell and a rotating shaft for allowing the rotating section to pass through. The rotating shaft is connected with the shell rotationally. The rotating section of the drag line and the rotating shaft rotate synchronously. The biopsy forceps have the advantages that the sling at the end of thedrag line can rotate at 360 degrees optionally, so that the sling can get in easily from the angle of a lesion tissue during acquiring the lesion tissue, labor and time are saved during acquisition, and operation is simple.

The invention discloses a radiotherapy system and a treatment plan generation method thereof. The radiotherapy system comprises a beam irradiation device, a treatment plan module and a control module. The beam irradiation device generates a treatment beam and irradiates an irradiated body to form an irradiated part, the treatment plan module generates a treatment plan according to parameters of the treatment beam and medical image data of the irradiated part, and the control module calls the treatment plan corresponding to the irradiated body from the treatment plan module, and controls the beam irradiation device to sequentially irradiate the irradiated body according to the at least two irradiation angles determined by the treatment plan generation method and the irradiation time corresponding to each irradiation angle. According to the radiotherapy system and the treatment plan generation method thereof, the radiation quantity of the shallow part of the irradiated part can be dispersed, and the radiation quantity of the deep part of a lesion tissue can be increased, so that the maximum dose of a normal tissue can be reduced, the minimum dose of the lesion tissue can be increased, and uniform distribution of the dose in the lesion tissue can be ensured.

The invention relates to a disposable anorectal visual mucous membrane protection fixing device which can enlarge operation view to the greatest extent in a clinic anorectal operation, effectively protect mucous membrane tissues of the back wall of a rectum, and ensure the safety and the quality of the operation. The disposable anorectal visual mucous membrane protection fixing device includes a fixing retractor and a peep sleeve; the peep sleeve can be inserted into the fixing retractor and can freely rotate in the fixing retractor; the fixing retractor is transparent and can enlarge the clinic operation view to the greatest extent; the fixing retractor can isolate a lesion tissue from the mucous membrane tissues of the back wall of a rectum and protect the mucous membrane tissues, and then the safety of the operation can be ensured; the peep sleeve is provided with an opening and can freely rotate in the fixing retractor; the peep sleeve can be used at any time as needed before the operation, during the operation or after the operation, the tissues and wounds can be checked one-by-one through the opening of the peep sleeve; and the defects of a poor operation view and postoperative bleeding can be overcome, and the safety and the quality of the operation can be ensured.

The invention discloses an elastic loop anus loop ligature instrument which comprises an inner sleeve, an outer sleeve and at least one group of thread push tube components, wherein the inner sleeve is provided with a vacuum pipe; an inner launching sleeve which communicates with the vacuum pipe to suck lesion tissue is fixedly arranged at the front end of the inner sleeve; at least one containinggroove which is distributed along an axial direction to contain elastic loops is formed in the outer periphery of the inner launching sleeve; the outer periphery of the inner sleeve is sleeved by theouter sleeve; the outer sleeve is propped against a wrench which is rotationally mounted on a shell to move relative to the inner sleeve under the action of the wrench; an outer launching sleeve which is arranged at the outer periphery of the inner launching sleeve in a sleeving manner to push all elastic loops to move forwards in a direction close to lesion tissue till sucked lesion tissue is sleeved by elastic loops in containing grooves close to the lesion tissue is fixedly arranged at the front end of the outer sleeve; and the thread push tube components are detachably and fixedly arranged at the outer circumference of the outer sleeve, are correspondingly connected with the elastic loops sleeved by the containing grooves, and are used for withdrawing corresponding elastic loops to tie and bundle the lesion tissue after the lesion tissue is sleeved by the elastic loops. The elastic loop anus loop ligature instrument is convenient to operate since only the wrench needs to be shifted in an operation.

The invention relates to a biopsy forceps convenient to adjust and a using method thereof, the biopsy forceps comprise a clamping mechanism and a storage mechanism, the clamping mechanism comprises afirst forceps handle, a second forceps handle, a first rotating plate and a second rotating plate, the first forceps handle and the second forceps handle are rotationally connected through a pin shaft, and the first forceps handle and the second forceps handle are symmetrical to each other; wherein one side of the first rotating plate is rotatably connected with the first forceps handle through apin shaft, one side of the second rotating plate is rotatably connected with the second forceps handle through a pin shaft, the first rotating plate is rotatably connected with the second rotating plate through the pin shaft, and when the first forceps handle and the second forceps handle are closed, the edges of a first storage shell and a second storage shell can clamp part of lesion tissue forsampling, and during sampling of the first storage shell and the second storage shell, a clamping plate and a cutting edge can cut the lesion tissue to prevent tearing of the lesion tissue, so that infection of a lesion part is reduced.

The invention provides an automatic sealing switching-free mechanism of a puncture outfit. The automatic sealing switching-free mechanism is mainly composed of a bracket assembly and a puncture casingpipe assembly. When a clinic operative instrument enters a puncture casing pipe, the instruction is firstly in contact with a protective gasket, the damage of the operative instrument to a protectivesealing valve is effectively avoided, and the sealing valve and the protective gasket are formed by two or more pieces in an annular assembly mode. When the clinic operative instrument enters the puncture casing pipe, the sealing valve can effectively seal the periphery of the operative instrument according to the appearances of different operative instruments and provide good air impermeabilityfor a clinic operation, the bracket assembly and the puncture casing pipe assembly can be separated at any time through a designed fastener and a connecting switch, and a clinic doctor can conveniently take out the lesion tissue through the puncture casing pipe and meanwhile does not need to replace adapters different in diameter when using different diameters of operative instrument. Therefore, the operation time of the clinic doctor is greatly shortened, and the operation safety is greatly improved.

A positioning device used for a digestive tract lesion endoscope comprises a positioning assembly used for marking inside a digestive tract and a detection assembly used for positioning outside the digestive track, wherein the positioning assembly used for marking inside the digestive track comprises a vertical pipe, a semispherical shell with a convex surface facing upwards is fixedly installed at the upper end of the vertical pipe, a liquid inlet hole is formed in the top of the semispherical shell, a motor installation plate is fixedly installed at the lower end of the vertical pipe, a battery is fixedly installed at the top of the motor installation plate, and a second round plate is disposed on the lower side of the motor installation plate. The positioning device determines a digestive tract lesion position through swallowing of the endoscope, an output shaft of a driving motor is controlled to rotate forwards and thus a rack pushes a rectangular elastic skin to make contact withthe inner wall of the digestive tract, so that the positioning assembly is stopped, the lesion position can be further determined, a medical worker can find the accurate lesion position on the outerside of the digestive tract through the detection assembly, and the rack pushes a piston block to continuously push out a medicine liquid to lesion tissue so as to treat a patient.

The invention discloses a fundus retina image segmentation method based on a deep convolutional neural network. The method employs the deep convolutional neural network to map features of a vascular tissue, an optic disc optic cup tissue and a lesion tissue in a medical image, and employs the convolutional network to segment the image. In addition, in order to increase segmentation accuracy, a new data preprocessing method of the fundus retina image is used for enhancing the image; an end-to-end deep convolutional network is used for solving a problem of small blood vessel segmentation, and deep significant features of a lesion area are obtained and visualized; a series of problems caused by large pixels of various medical images are solved by using a method of combining multiple deep neural networks.

A medical device and a method for diagnosing a diseased condition of tissue of a subject using a plurality of laterally spaced apart electrodes, the method including initiating an impedance measurement session including passing an electrical current through the electrodes to obtain values of skin impedance of a target tissue region, and applying a trained evaluation procedure for diagnosis of the diseased condition in the target tissue region on the basis of the measured data set of impedance values. The trained evaluation procedure extracts impedance data from the impedance spectra from obtained data sets of impedance values reflecting tissue characteristics of a lesion; evaluates the obtained data set of impedance to provide a first outcome indicating a probability of a diseased condition; and re-evaluates the first outcome based on the extracted impedance data and data related to underlying structure to provide a second outcome indicating a probability of a diseased condition.

The embodiment of the invention provides an ablation device and a pulse ablation system. According to the ablation device provided by the embodiment of the invention, a needle tube and a needle core of an ablation assembly are connected in a relative movement manner, a linkage assembly is switched between the state of fixing the needle tube and the state of fixing the needle core, the linkage assembly is driven to move through an adjusting assembly, then the needle core or the needle tube clamped by the linkage assembly is driven to move, and therefore, the length of a working area of the ablation assembly is adjusted. Therefore, the ablation assembly can be suitable for lesion tissues with different depths and/or sizes, and the application scene of the ablation device is widened; and moreover, after the needle core is in contact with the diseased tissue, the needle core does not need to be moved again, so that discomfort of a patient due to the fact that the needle core punctures the diseased tissue for many times is avoided.

The invention discloses an efficient lesion tissue collecting device for thoracic surgery department. The device comprises a shell, four mounting grooves which are symmetrically distributed in a cross shape are formed in the inner wall of the shell, disinfection mechanisms are arranged in the two opposite mounting grooves, freezing mechanisms are arranged in the other two mounting grooves, a rotating cylinder is arranged in the shell, the rotating cylinder is connected with the shell, two symmetrically distributed through grooves are formed in the inner wall of the rotating cylinder , the through grooves are matched with the mounting grooves, a rotating mechanism is arranged at the top of the rotating cylinder, the disinfection mechanisms comprise a plurality of ultraviolet disinfection lamps, and the ultraviolet disinfection lamps are vertically mounted in the mounting grooves. The disinfection mechanisms and the freezing mechanisms are arranged in the shell, the two functions are integrated in the shell at the same time, a large amount of space is saved, and the situation that a large amount of operating room space is occupied and medical staff are hindered is avoided.

The invention discloses a special laparoscope aspirator with gripping tongs for the hepatobiliary surgery department. The special laparoscope aspirator comprises an outer tube and an inner tube movably sleeved with the outer tube, wherein gripping tong main bodies which are symmetrically arranged are rotationally connected to the left end of the outer tube, an aspiration head is arranged at the left end of the inner tube, the aspiration head is located on the inner sides of the two gripping tong main bodies, a connector is fixedly connected to the right end of the outer tube, and a movable hole is formed in the connector. For the special laparoscope aspirator with the gripping tongs for the hepatobiliary surgery department, the volume liquid and waste gas in the affected part can be drained and discharged, meanwhile, the lesion tissue can be conveniently clamped, meanwhile, the lesion tissue can be sampled and cut, in addition, during the cutting process, the tissue needing to be cut is clamped and positioned through the two gripping tong main bodies, so that the lesion tissue can be thoroughly cut off easily during cutting, the cutting difficulty is reduced, and as a result, the working efficiency of cutting and sampling is guaranteed, the smooth operation of the operation is facilitated, the risk of injury to the abdominal viscera of a patient is also reduced, meanwhile, theintegral structure is simple, and the operation and use by people are facilitated.

The invention belongs to the technical field of molecular biomedicine, and particularly relates to a high-mobility protein HMGB3 and a gene thereof as molecular markers for screening and diagnosing early stage of cervical lesion and application of the molecular markers. According to the molecular markers and the application thereof, the differential genes in each progress stage of the cervical lesion are screened out from a GEO database, then statistics is carried out according to the expression conditions of the differential genes in the lesion tissue, so that the gene HMGB3 with higher priority is screened out for subsequent verification. Verification experiments prove that the expression positive rate of HMGB3 is far higher than the positive rate of an existing diagnosis method in the cervical epithelium CIN1 level, namely cervical primary lesion, it is indicated that the sensitivity of HMGB3 serving as the marker has obvious advantages compared with the existing diagnosis method, and HMGB3 can be used for early detection, screening and diagnosis of cervical lesion.

The invention discloses a photoelectric combined instrument and a photodynamic therapy instrument. The photoelectric combined instrument comprises a laser device and an electrolyzer; an electrode of the electrolyzer and an optical fiber of the laser device can simultaneously act on lesion tissue in which a photosensitive drug is preset; the laser device emits a laser to activate the photosensitivedrug preset in the lesion tissue; the electrolyzer can electrolyze tissue fluid in the lesion tissue to generate sufficient oxygen, so that the photosensitive drug can be activated and fully has a photoreaction with the oxygen to generate singlet oxygen to kill pathological cells, so that the effect of photodynamic therapy is improved. According to the photoelectric combined instrument, continuous photodynamic therapy is realized, the pathological cells are effectively killed, and the problem that the therapy effect is severely weakened due to environment hypoxia of the photodynamic therapy is solved.