80 results about "Arterial Sclerosis" patented technology

A dibenzylamine compound represented by the formula (1) wherein R1 and R2 are each a C1-6 alkyl group optionally substituted by halogen atoms and the like; R3, R4 and R5 are each a hydrogen atom, a halogen atom and the like, or R3 and R4 may form, together with carbon atoms bonded thereto, a homocyclic or heterocyclic ring optionally having substituent(s); A is —N(R7) (R8) and the like; ring B is an aryl group or a heterocyclic residue; R6 is a hydrogen atom, a halogen atom, a nitro group, a C1-6 alkyl group and the like; n is an integer of 1 to 3, a prodrug thereof and a pharmaceutically acceptable salt thereof show selective and potent CETP inhibitory activity, and therefore, they can be provided as therapeutic or prophylactic agents for hyperlipidemia or arteriosclerosis and the like.

The present invention is related to:(i) matrix metalloproteinase inhibitors containing sulfonylamino acid derivatives of the formula (Ia):wherein R1 is hydrogen, C1-4 alkyl; R is hydrogen, C1-8 alkyl etc.; E is -CONR3-, in which R3 is hydrogen, C1-4 alkyl etc., -NR3CO-, -CO-O-, -O-CO- etc.; A is hydrogen, C1-8 alkyl, C3-7 cycloalkyl, or Ar; J is bond, C2-4 alkylene etc.; G is -(CH2)m- in which m is 2, 3 or 4, orin which R6 and R7 is hydrogen, C1-8 alkyl etc.; and non-toxic salts thereof,(ii) novel sulfonylamino acid derivatives of the formula (Ib):wherein all the symbols are the same meaning as (i); and non-toxic salts thereof, and(iii) process for the preparation of the compound of the formula (Ib). The compounds of the formula (Ia) are useful for prevention and / or treatment of diseases induced by overexpression and excess activity of MMP. The diseases such as above, for example, are rheumatoid, arthrosteitis, unusual bone resorption, osteoporosis, periodontitis, interstitial nephritis, arteriosclerosis, pulmonary emphysema, cirrhosis, cornea injury, metastasis of, invasion of or growth of tumor cell, autoimmune disease (Crohn's disease, Sjogren's syndrome etc.), disease caused by vascular emigration or infiltration of leukocytes, arterialization.

This invention provides a method for assessing arterial stiffness noninvasively using photoplethysmography. The method of the invention for assessing arterial stiffness using photoplethysmography comprises: a user information input step, characteristic point extraction step, and arterial stiffness assessment step. In particular, the characteristic point extraction step includes the correction of the characteristic points, and the arterial stiffness assessment step includes the result of performing multiple linear regression analysis using the baPWV (brachial-ankle pulse wave velocity) value. In addition, according to this invention, arterial stiffness assessment, which was previously an expensive procedure which the user could only obtain at a specialized institution, can be carried out at low cost in the course of daily life, e.g. at home or at work, and can thus be applied in the u-healthcare and home health management service environments.

Specified phenylpropionic acid derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α 4 integrin, such as inflammatory diseases in which α 4 integrin-depending adhesion process participates in the pathology, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

Phenylalanine derivatives of the following formula, analogues thereof and pharmaceutically acceptable salts thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α4 integrin in which α4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.wherein R1 is a methyl group and R2 is a methoxy group.

The present invention is related to:(i) matrix metalloproteinase inhibitors containing sulfonylamino acid derivatives of the formula (Ia); wherein R1 is hydrogen, C1-4 alkyl; R2 is hydrogen, C1-8 alkyl etc.; E is -CONR3-, in which R3 is hydrogen, C1-4 alkyl etc., -NR3CO-, -CO-O-, -O-CO- etc.; A is hydrogen, C1-8 alkyl, C3-7 cycloalkyl, or Ar; J is bond, C2-4 alkylene etc.; G is -(CH2)m-, in which m is 2, 3 or 4, orin which R6 and R7 is hydrogen, C1-8 alkyl etc.; and non-toxic salts thereof,(ii) sulfonylamino acid derivatives of the formula (Ib):wherein all the symbols are the same meaning as (i); and non-toxic salts thereof, and(iii) process for the preparation of the compound of the formula (Ib).The compounds of the formula (Ia) are useful for prevention and / or treatment of diseases induced by overexpression and excess activity of MMP. The diseases such as above, for example, are rheumatoid, arthrosteitis, unusual bone resorption, osteoporosis, periodontitis, interstitial nephritis, arteriosclerosis, pulmonary emphysema, cirrhosis, cornea injury, metastasis of, invasion of or growth of tumor cell, autoimmune disease (Crohn's disease, Sjogren's syndrome etc.), disease caused by vascular emigration or infiltration of leukocytes, arterialization.

Vitamin K is effective in counteracting the reduction in arterial elasticity normally associated with the aging process. A pharmaceutical composition or nutritional formulation comprising vitamin K can be used to combat age-related stiffening of the arteries, and the consequences thereof, namely pulmonary congestion, hypertension, left ventricular hypertrophy, congestive (right sided) heart failure, left sided or left ventricular failure, chronic cardiac failure, angina pectoris, myocardial infarction, Mönckeberg's sclerosis and stroke.

The invention discloses a mashed shrimp ball and a preparation method of the mashed shrimp ball. The mashed shrimp ball is prepared from the following raw materials in part by weight: 60-65 parts of smashed shrimp meat, 20-25 parts of diced shrimp meat, 4-5 parts of rice wine, 4-5 parts of egg white, 3-5 parts of sugar, 1.5-2 parts of salt, 1.5-2 parts of cassava raw powder and 3-5 parts of monosodium glutamate, wherein the smashed shrimp meat and the diced shrimp meat are prepared from prawns, the weight ratio of the smashed shrimp meat to the diced shrimp meat in the prepared stuffing is 3 to 1, meat particles of the mashed shrimp ball are full, and the mouthfeel of the mashed shrimp ball is improved; the mashed shrimp ball is processed by the prawns, the prawn is rich in nutrition; the prawns per 100g contain 20% of protein, contain extremely low fat which is not more than 1% and is unsaturated fatty acid generally, also contain multiple mineral elements such as phosphorus and iron, contain the highest calcium content compared with the calcium contents of the other animals and plants, and are also rich in vitamin A and B vitamins; and particularly, magnesium contained in the prawn has the efficacies of protecting the cardiovascular system, reducing the content of cholesterol in blood, preventing arteriosclerosis and preventing and controlling hypertension.

With a measurement device attached to the upper arm as a master, a measurement device, which is a slave, attached to the ankle is controlled to measure a pulse wave in synchronization. The measurement device on the master side obtains a measurement result from the measurement device on the slave side, and detects the appearance time difference of the pulse wave waveforms by synchronizing the pulse waves measured in both measurement devices, thereby calculating a Pulse Wave Velocity as the index of arterial sclerosis.

The invention relates to an application of a seaweed polypeptide in preparing a health-care product for reducing blood fat and blood sugar as well as a beverage containing the polypeptide for reducing the blood fat and the blood sugar. The seaweed polypeptide is prepared by the following steps of: milling a mixture of immersed porphyra haitanensis and water through a colloid mill to obtain porphyra haitanensis slurry; adopting AS.1398 neutral protease to carry out enzymolysis on the porphyra haitanensis slurry for 5-10 hours under the conditions that the temperature is 45-55 DEG C, the pH (Potential of Hydrogen) is 7.2-7.8, the enzyme adding amount E / S is 8000-12000 U / g and the weight / volume ratio concentration of a substrate is 3-7%, so as to obtain an enzymolysis solution; centrifuging the enzymolysis solution and collecting liquid supernatant; and carrying out ultra-filtering separation on the liquid supernatant to obtain an active component with the molecular weight of less than 10000 Da. An animal experiment shows that agars are subjected to biological enzymolysis to obtain the seaweed polypeptide which has the obvious effects of reducing the blood fat, the blood sugar and blood pressure; and after the seaweed polypeptide is taken for a long period, the weight can be prevented from too fast increase and the happening possibility of arteriosclerosis can be reduced.

PROBLEMS TO BE SOLVED: A finger arterial elasticity measuring program, a finger arterial elasticity measuring device and a finger arterial elasticity measuring method are provided for making it possible to measure an elasticity index of a finger artery in accordance with a pulse wave of a finger artery without measuring a blood pressure in evaluating the elasticity of the finger artery related to the degree of arterial sclerosis in an easy and least expensive manner.MEANS FOR SOLVING THE PROBLEMS: A computer functioning by a finger arterial elasticity measuring program includes a pulse wave data memory unit 42, a cuff pressure data memory unit 43, a normalized pulse volume (NPV) calculating unit 52 for dividing an amplitude (ΔI) of an alternate component of a pulse wave by an average value of direct components (I) to calculate NPV, a relative cuff pressure (Pr) calculating unit 53 for calculating a difference between a cuff pressure at the maximum amplitude of the pulse wave and each cuff pressure as Pr, an FEI calculating unit 54 for calculating a linear regression slope (n) of the following expression (1) as an elasticity index of a finger artery: ln(NPV)=ln(bn)−n·Pr . . . (1) where b is a constant.

The present invention relates to an inhibitor of matrix metalloprotease (MMP) production and tumor necrosis factor (TNF) production, and medicines for the treatment of diseases such as chronic rheumatoid arthritis, osteoarthritis, allergic diseases, psoriasis, transplant rejection, arterial sclerosis, ischemic re-perfusion disorder, diabetic nephritic and ocular diseases, cancer, autoimmune glomerulonephritis, infectious diseases, Crohn's disease, inflammatory intestinal diseases and autoimmune hepatitis, each comprising certain polyazanaphthalene compounds or pharmaceutically acceptable salts thereof as active ingredients.

The present invention provides methods for treating subjects having or at risk of having a neuropathological disorder or brain inflammatory diseases with and without vascular involvement, and systemic inflammatory vascular disease by administering a therapeutically effective amount of Activated Protein C (APC) to the subject. Brain disorders and brain inflammatory vascular diseases that can be treated by the invention method include all neurodegenerative diseases with different types of neuronal dysfunction, including stroke, Alzheimer's disease, Parkinson's disease, Huntington disease, neuroimmunological disorders such as multiple scelrosis and Gullian-Barre, encephalitis, meningitis, as well as other peripheral vascular diseases, such as diabetes, hypertension, artheriosclerosis. Also included are methods of treatment using APC in combination with a co-factor, such as Protein S.

Phenylalanine derivatives of the following formula, analogues thereof and pharmaceutically acceptable salts thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α4 integrin in which α4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.wherein R1 is a methyl group and R2 is a methoxy group.

The present invention relates to a medicine composition for curing angiocardiopathy and cerebrovascular disease. Said medicine composition contains ginsenoside and breviscapine.

Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the α4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which α4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

A blood circulation and channel invigorating soup is an obviously effective medicine for curing thromboangitis obliterans, arteriosclerosis occlusive diseases, arteritis, phlebeurysma, vein valve insufficiency, deep venous thrombus, shallow venous thrombus, peripheral neuritis, Raynaud's disease, diabetic gangrene, carotid sclerosis plaque formation, cerebral arteriosclerosis thrombosis, cerebral circulation insufficiency, and various artery and vein blood stasis syndromes. The soup is composed of ginseng, hairy deerhorn, pangolin, leech, earthworm, scorpio, female ground beetle, red sage root, resina draconis, pseudo-ginseng, angelica, cortex moutan, safflower, forsythia, centipede and licorice. The soup has the functions of promoting blood circulation by removing blood stasis, reducing swelling and stopping pain, reducing blood viscosity, dissolving thrombus, dredging blood vessel, and repairing vein valve, and the functions of improving blood circulation, promoting healing abscess and the like, and is used for curing thromboangitis obliterans, arteriosclerosis occlusive diseases, arteritis, phlebeurysma, vein valve insufficiency, deep venous thrombus, shallow venous thrombus, peripheral neuritis, Raynaud's disease, diabetic gangrene, carotid sclerosis plaque formation, cerebral arteriosclerosis thrombosis, cerebral circulation insufficiency, and various artery and vein blood stasis syndromes, can achieve the effect of curing both symptoms and root causes, can achieve the aim of no relapse after recovery; approved by clinic tests, the soup can effectively release the pain of a plurality of patients and receive positive comments from the patients.

The invention relates to a system for measuring the conduction time of pulse waves between cerebral arteries and cerebral veins. The system comprises a signal acquisition device, a signal processing device and a display device, wherein the signal acquisition device is connected with the signal processing device through a communication interface module; and the output end of the signal processing device is connected with the display device. The cerebral blood flow signal acquisition method comprises the following steps: 1) arranging a fixed probe device with two cerebral blood flow signal acquisition devices; 2) synchronously acquiring cerebral blood flow signals; and 3) exchanging the positions of the two cerebral blood flow signal acquisition devices. The medicinal uses of the system are as follows: 1) synchronously acquiring the cerebral blood flow signals of ipsilateral encephalic large arteries (aorta) and encephalic deep veins of a person to be tested at a resting state; and 2) measuring the time difference of the two cerebral blood flow signals. Through the system provided by the invention, noninvasive detection is realized on the conduction time of pulse waves between the cerebral arteries and the cerebral veins; and the clinical practicality is strong, the stiffness of cerebral arteriolae can be accurately and directly reflected, and the risk of apoplexy is estimated, thus being beneficial for early discovering and preventing cerebral arteriosclerosis of patients.

Disclosed is a superficial venules dredging preparation for treating cerebral arteriosclerosis which comprises the constituents (by weight portion) of quercetin 2-6.35 g, kaempferide 1.5-4.6 g, isorhamnetin 0.35-1g, ginkgolides 1-3g, ginseng saponin 0.6-2g, and right amount of auxiliary materials.

Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the α 4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which α 4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

The invention discloses three-flavor nutrient healthcare bean curd and a preparation process thereof. The three-flavor nutrient healthcare bean curd comprises three main materials, namely soybeans, fish and eggs; the auxiliary materials include 20 kinds of natural plant perfume and mixed vegetable juice; and the coagulant is a composite coagulant. The raw material comprises the following components in parts by weight: 100-300 parts of soybeans, 50-200 parts of fish, 100-200 parts of eggs, 50-200 parts of cinnamon peel, 10-50 parts of fennel, 10-40 parts of pepper, 20-100 parts of anise, 10-30 parts of chilli, 10-60 parts of rhizoma kaempferiae, 20-100 parts of radix angelicae dahuricae, 10-80 parts of clove, 20-60 parts of semen myristicae, 5-30 parts of laurel, 2-20 parts of rosemary, 10-50 parts of black pepper, 10-80 parts of fructus amomi, 3-20 parts of thyme, 10-40 parts of cumin, 10-30 parts of leaf mustard, 5-50 parts of tonka bean, 10-60 parts of caraway seed, 5-30 parts of fructus tsaoko, 6-40 parts of basil, 30-200 parts of celery juice, 10-100 parts of spinach juice, 20-200 parts of rape juice, 20-100 parts of fresh cucumber juice, 10-80 parts of delta-glucolactone, 20-60 parts of gypsum and 10-50 parts of calcium acetate. The three-flavor nutrient healthcare bean curd disclosed by the invention reduces blood fat, prevents and controls coronary heart disease, prevents arteriosclerosis, regulates body immunity and improves memory.

The invention discloses a nutritional health-care bean paste and a preparation method thereof. The nutritional health-care bean paste is prepared from the following raw materials in parts by weight: 80-90 parts of yellow beans, 8-12 parts of aralia elata seem, 5-10 parts of Chinese artichoke, 3-5 parts of bolete, 3-4 parts of pumpkin seed powder, 2-3 parts of lotus leaf powder, 1-2 parts of Chinese hawthorn seed powder, 1-3 parts of bunge pricklyash leaves, 1-2 parts of humulus lupulus, 2-3 parts of semen arecae peel, 1-2 parts of fenugreek, 1-2 parts of hairy grape stems, 0.5-1.5 parts of angelica dahurica, 2-3 parts of waxgourd peel, 2-3 parts of cinnamomum cassia, 1-2 parts of snakegourd fruit peel, 30-40 parts of groundnut oil, 1.5-2.5 parts of soy sauce koji essences, 2-3 parts of bruised ginger, 3-5 parts of chopped green onion, 8-12 parts of capsicum, 2-3 parts of monosodium glutamate, 10-15 parts of iodized salt and 1-2 parts of five spice powder. The nutritional health-care bean paste prepared through the method disclosed by the invention has the health-care effects of loosening bowel to relieve constipation, improving the constipation, reducing blood fat, reducing cholesterol, softening blood vessels, preventing hypertension and arteriosclerosis, enhancing memory, protecting liver, beautifying, prolonging aging, strengthening stomach, promoting digestion, and the like, is unique in taste and rich in nutrition and is suitable for being eaten by various people.

The invention discloses a preparation method of a traditional Chinese medicine compound and application in prevention and treatment of Alzheimer disease. The traditional Chinese medicine compound is composed of 180 parts of Ginkgo leaf, 180 parts of Radix Polygonum Multiflorum Preparata, 90 parts of glossy privet fruit, 90 parts of Salvia miltiorrhiza, 90 parts of in Eucommia ulmoides, 90 parts of Cyathula officinalis, and 60 parts of Uncaria tomentosa. The traditional Chinese medicine compound is prepared by the method of: subjecting the Ginkgo leaf, glossy privet fruit, Salvia miltiorrhiza and Uncaria tomentosa to heating reflux extraction by 30-95% ethanol 1-4 times, recovering ethanol from the extracted solution and conducting concentration to obtain an extract A; adding water into the Radix Polygonum Multiflorum Preparata, Eucommia ulmoides, and Cyathula officinalis to conduct decoction and extraction 1-4 times, concentrating the decocted solution and then performing alcohol precipitation, recovering ethanol from the alcohol precipitated solution and conducting concentration, thus obtaining an extract B; and drying the extract A and the extract B, taking the dry extracts, and adding appropriate auxiliary materials to prepare hard capsules, soft capsules, tablets and granules. The traditional Chinese medicine compound prepared by the method provided by the invention can significantly improve the treatment effect on various diseases caused by cerebral arteriosclerosis, and has preventive and therapeutic effects on Alzheimer disease.

An antihypertensive Chinese medicine for reducing blood thickness, blood viscosity and blood fat, lowering blood pressure, and preventing cerebral thrombus and cerebral hemorrhage is prepared from 12Chinese-medicinal materials including Antelope's horn, scorpion, astragalus root, red sage root, etc. Its advantages are high curative effect (100% for effective rate) and no toxic by-effect.

The present invention provides an agent for improving mental disorders due to cerebral dysfunction and an agent for inhibiting vascular hyperpermeability each containing a hepatocyte growth factor. The agent for improving mental disorders according to the present invention is useful in improving mental disorders, particularly decline in learning and memory function, due to cerebral dysfunction occurred in blood circulation disorders in the brain (for example, cerebral infarction, cerebral hemorrhage, lacunar stroke, Biswanger's disease, cerebral thrombosis, subarachnoid hemorrhage, cerebrovascular moyamoya disease, carotid cerebral arterial fibrous muscular plasia, cerebral arterial sclerosis, internal carotid artery occlusion, hypertensive encephalopathy, cerebral edema, etc.) and neurodegenerative disorders (for example, multiple sclerosis, Parkinson's disease, Parkinson'syndrome, Huntington's chorea, cerebrovascular dementia and Alzheimer dementia), epilepsy, head injury, etc. The agent for inhibiting vascular hyperpermeability according to the present invention is efficacious to blood hyperpermeability in the brain due to blood circulation disorders in the brain (for example, cerebral infarction, cerebral hemorrhage, lacunar stroke, Biswanger's disease, cerebral thrombosis, subarachnoid hemorrhage, cerebrovascular moyamoya disease, carotid cerebral arterial fibrous muscular plasia, cerebral arterial sclerosis, internal carotid artery occlusion, hypertensive encephalopathy, cerebral edema, etc.), blood leakage, edema, subcutaneous hemorrhage and bleeding tendency due to vascular hyperpermeability in various tissues (including internal organs).

The invention discloses healthcare soybean milk with a kalium supplementing effect, which is prepared from the following raw materials in parts by weight: 80-90 parts of rice, 60-70 parts of kidney beans, 1-2 parts of cumin, 1-3 parts of roughhaired holly root, 1-2 parts of radix paeoniae alba, 2-3 parts of fructus amomi, 1-2 parts of radix glycyrrhizae, 20-30 parts of yogurt, 15-20 parts of soft white sugar, 15-20 parts of pulp of cornus, 8-12 parts of roses, 20-25 parts of lotus seeds, 22-24 parts of balsam pears, 20-30 parts of avocado, 1-2 parts of a soybean milk additive and a proper amount of water. The soybean milk disclosed by the invention adopts the rice and the kidney beans as the main raw materials, the kidney bean is a scarce food with high kalium and magnesium content and low sodium content, has functions of improving immunocompetence of human blood bodies, enhancing disease resistance, activating lymph T cells, boosting the synthesis of deoxyribonucleic acid, meanwhile has an effect on resisting the development of tumor cells, and can ameliorate patients suffering from heart disease, arteriosclerosis, hyperlipidemia, hypokalemia, salt contraindication and the like. In addition, the added avocado is rich in various vitamins, various mineral elements, edible plant fibers, and fat with 80 percent of unsaturated fatty acid, is a high-energy and low-sugar fruit, and has important physiological functions of lowering cholesterol and blood lipid, protecting heart vessels, eyes and liver system and the like.

A biological information displaying apparatus includes: a calculator which is configured to calculate measurement values of parameters based on a plurality of biological signals obtained by an acquiring unit, the parameters including: sclerosis parameters relating to arterial sclerosis; and stenosis and / or occlusion parameters relating to arterial stenosis and / or occlusion; a display which is configured to display information; and a display controller which is configured to produce different radar charts of the sclerosis parameters and the stenosis and / or occlusion parameters, and which is configured to display the measurement values of the parameters on the display, on respective one of line segments that radially extend from a center in each of the radar charts, while plotting each of the measurement values of corresponding parameters at a position that is remoter from the center as a clinical value is worse.

The invention discloses a useful and novel factor (polypeptide) which plays an important role for morbid vascular smooth muscle in restenosis after percutaneous transluminal coronany angioplasty (PTCA) and arterial sclerosis in the field of cardiovascular system.

The invention discloses a Chinese medicinal composition for treating cardiovascular and cerebrovascular atherosclerosis and its preparing process, wherein the composition is prepared from astragalus root, corktree bark, haw, dried ginger, job's tears, sarcodactylis swinple, root of herbaceous peony, Ligusticum wallichii, cyperus tuber, kudzu vine root, thunberg fritillary bulb, bitter orange, medicated leaven, pericarpium trichosanthis, atractylodes rhizome, root of red rooted saliva, chicken's gizzard-skin, pseudo-ginseng and Chinese trichosannthe powder through steps of boiling, extracting volatile oil, air-drying, disintegrating and proportioning.