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Application of seaweed polypeptide in preparing health-care product for reducing blood fat and blood sugar as well as beverage containing polypeptide for reducing blood fat and blood sugar

A hypolipidemic and hypoglycemic technology, applied in the fields of hypoglycemic beverages, hypolipidemic, and seaweed polypeptides, can solve the problems of lack of a reliable and satisfactory treatment method, changes in liver function, muscle lysis, etc., and achieve the effect of lowering blood pressure. Significant effect, high vitamin and mineral content, and wide source of raw materials

Inactive Publication Date: 2013-03-13
FISHERIES RES INST OF FUJIAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned various drugs have their limitations. For example, biguanide hypoglycemic drugs can cause greater damage to the stomach and cause indigestion; sulfonylureas may cause leukopenia; Intestinal reactions, specifically manifested as abdominal distension, stomach distension, burning pain in the upper abdomen, diarrhea or constipation; insulin sensitizers may cause water retention
[0006] The most commonly used hypolipidemic drugs are HMG-CoA reductase inhibitors, specifically lovastatin, simvastatin, pravastatin, mevastatin, fluvastatin, atorvastatin, cerivastatin and Rovastatin, etc. However, statins are likely to cause increased liver enzymes, which may cause changes in liver function, and some patients have symptoms of muscle pain after taking the drug, and some even cause muscle lysis
[0007] In summary, there is currently no reliable and satisfactory treatment for lowering blood sugar and blood lipids.

Method used

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  • Application of seaweed polypeptide in preparing health-care product for reducing blood fat and blood sugar as well as beverage containing polypeptide for reducing blood fat and blood sugar

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1) Raw materials: choose the first stubble dried laver;

[0028] 2) Add water to soak: add water in the ratio of 1:25 (Porphyra haitanensis: water) and soak for 30 min;

[0029] 3) Colloidal grinding and grinding: Pass the laver soaking mixture through colloid milling to form a finer laver slurry;

[0030] 4) Heating and heat preservation: heat the seaweed slurry to the center temperature of 50℃;

[0031] 5) Protease enzymolysis: use AS.1398 neutral protease at 50℃, pH7.5, and enzyme amount E / S 10000U.g -1 , Under the condition of substrate concentration 5% (w / v), enzymatically hydrolyze Porphyra haitanensis slurry for 10 hours to obtain enzymatic hydrolysate;

[0032] 6) Centrifugation: Put the enzyme hydrolysate at 8000r.min -1 Centrifuge for 10 min to remove laver residue and obtain the supernatant;

[0033] 7) Supernatant dilution: the supernatant collected by centrifugation is thicker, first dilute it with water at a ratio of 1:1;

[0034] 8) Ul...

Embodiment 2

[0036] 1) Raw material: The raw material is selected from the third crop of dried laver;

[0037] 2) Add water to soak: add water in the ratio of 1:25 (Porphyra haitanensis: water) and soak for 30 min;

[0038] 3) Colloidal grinding and grinding: Pass the laver soaking mixture through colloid milling to form a finer laver slurry;

[0039] 4) Heating and heat preservation: heat the seaweed slurry to the core temperature of 45℃;

[0040] 5) Protease enzymolysis: use AS.1398 neutral protease at 45℃, pH7.2, and add enzyme amount E / S 8000U.g -1 , Under the condition of 3% (w / v) substrate concentration, enzymatically hydrolyze Porphyra haitanensis slurry for 10 hours to obtain enzymatic hydrolysate;

[0041] 6) Centrifugation: Put the enzyme hydrolysate at 8000r.min -1 Centrifuge for 10 min to remove laver residue and obtain the supernatant;

[0042] 7) Supernatant dilution: the supernatant collected by centrifugation is thicker, first dilute it with water at a ratio of...

Embodiment 3

[0045] 1) Raw material: choose the last dried laver as raw material;

[0046] 2) Add water to soak: add water at the ratio of 1:30 (Porphyra haitanensis: water) and soak for 30 min;

[0047] 3) Colloidal grinding and grinding: Pass the laver soaking mixture through colloid milling to form a finer laver slurry;

[0048] 4) Heating and heat preservation: heat the seaweed slurry to the core temperature of 55℃;

[0049] 5) Protease enzymolysis: use AS.1398 neutral protease at 55℃, pH7.8, and add enzyme amount E / S 12000U.g -1 , Under the condition of substrate concentration of 7% (w / v), enzymatically hydrolyze Porphyra haitanensis slurry for 5 hours to obtain enzymatic hydrolysate;

[0050] 6) Centrifugation: Put the enzyme hydrolysate at 8000r.min -1 Centrifuge for 10 min to remove laver residue and obtain the supernatant;

[0051] 7) Supernatant dilution: the supernatant collected by centrifugation is thicker, first dilute it with water at a ratio of 1:1;

[0052]...

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Abstract

The invention relates to an application of a seaweed polypeptide in preparing a health-care product for reducing blood fat and blood sugar as well as a beverage containing the polypeptide for reducing the blood fat and the blood sugar. The seaweed polypeptide is prepared by the following steps of: milling a mixture of immersed porphyra haitanensis and water through a colloid mill to obtain porphyra haitanensis slurry; adopting AS.1398 neutral protease to carry out enzymolysis on the porphyra haitanensis slurry for 5-10 hours under the conditions that the temperature is 45-55 DEG C, the pH (Potential of Hydrogen) is 7.2-7.8, the enzyme adding amount E / S is 8000-12000 U / g and the weight / volume ratio concentration of a substrate is 3-7%, so as to obtain an enzymolysis solution; centrifuging the enzymolysis solution and collecting liquid supernatant; and carrying out ultra-filtering separation on the liquid supernatant to obtain an active component with the molecular weight of less than 10000 Da. An animal experiment shows that agars are subjected to biological enzymolysis to obtain the seaweed polypeptide which has the obvious effects of reducing the blood fat, the blood sugar and blood pressure; and after the seaweed polypeptide is taken for a long period, the weight can be prevented from too fast increase and the happening possibility of arteriosclerosis can be reduced.

Description

[0001] technical field [0002] The present invention relates to the medical use of the polypeptide and a beverage containing the polypeptide, in particular to a seaweed polypeptide with the function of lowering blood fat and blood sugar and a beverage containing the polypeptide for lowering blood fat and blood sugar. Background technique [0003] Seaweed belongs to lower plants and mainly grows in shallow sea areas. my country has a long coastline, a large area of ​​shallow seas, and a rich variety of seaweeds. Among them, seaweeds with economic value are mainly divided into three categories: green algae, brown algae and red algae. At present, the commercial seaweeds that have been artificially cultured mainly include: kelp, wakame and hijiki belonging to brown algae; algae, Porphyra variegata, asparagus, gracilaria, red cabbage and kylin belonging to red algae dishes etc. [0004] However, since the development of seaweed industry in my country is in its infancy, its util...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02C12P21/06A23L2/66A61P3/06A61P3/10
Inventor 吴成业王茵苏永昌刘淑集
Owner FISHERIES RES INST OF FUJIAN
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