Preparation method for medicament compound brasilein and use thereof

A pharmaceutical compound, hematoxylin technology, applied in the direction of drug combination, pharmaceutical formula, organic chemistry, etc., can solve the problems of poor operation safety and high extraction cost, and achieve the effect of low extraction cost, simple operation and high operation safety

Inactive Publication Date: 2008-02-20
TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The technical effect of this new process described by our company compared to previous methods has been that it can be done easily without harming health or causing environmental concerns during its production processes. This makes them safer for use around industrial sites where they are used frequently.

Problems solved by technology

This patented method involves extracting certain components from plants called berry pulp or red coffee beans that are used for medications like sanguisorba root or guaiacum nitidol. However, this process requires expensive equipment such as vacuums at different locations around China, making it difficult to operate safely while also being dangerous due to its use of harmful substances found within traditional methods.

Method used

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  • Preparation method for medicament compound brasilein and use thereof

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preparation example Construction

[0025] The method for preparing the medicinal compound Brazilian hematoxylin provided by the present invention has the following specific process steps:

[0026] 1) First, heat and extract 5-15 times the weight of the medicinal material with an alkaline water solvent to obtain an extract. The temperature used for heating extraction is 30°C to 100°C, and the number of extractions is generally 1 to 3 times, and each time is 30 minutes to 5 hours. The concentration of the aqueous alkali used is 0.01 to 6%.

[0027] 2) Add acid to the extract at room temperature to make the pH value 2-6, centrifuge or filter statically, discard the supernatant, take the precipitate, and then dry to obtain a dried product;

[0028] 3) Dissolve the dried product with alcohol and perform chromatographic separation to obtain brazil hematoxylin.

preparation Embodiment 1

[0031] Hematoxylin heartwood (500g) is extracted with 5 times the weight of 0.01% sodium hydroxide aqueous solution, heated (100°C) for 3 times, each time for 5 hours, the extract is placed at room temperature and then used in acid to make the pH value 2 , Let stand, take the precipitate, discard the supernatant, and dry. The dried product is dissolved in ethanol, mixed with 200-300 mesh silica gel, separated by silica gel column chromatography, eluted with a petroleum ether: acetone gradient, the column chromatography solution is concentrated, purified by dextran gel, and finally Brazil hematoxylin is obtained. .

preparation Embodiment 2

[0033] Hematoxylin heartwood (500g) is extracted with 10 times the weight of 2% sodium hydroxide aqueous solution, heated (80℃) for 2 times, 3 hours each time, the extract is placed at room temperature and neutralized with acid to make the pH value 5. Let stand, discard the supernatant, take the precipitate, and dry the precipitate. The dried product is dissolved in ethanol, mixed with 60-80 mesh polyamide, separated by polyamide column chromatography, and eluted with water and ethanol respectively. The ethanol eluate is collected and concentrated, purified by dextran gel, and finally Brazilian hematoxylin is obtained. Vegetarian.

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Abstract

A medicine compound Brazilian haematein prime and a preparation method and function thereof relate to the preparation method of a medicine compound that is separated from lignum sappan heartwood. Aqueous alkaline solution extraction is adopted in the method, and no organic solvent is involved, therefore, the extraction cost is low and the operation is safe. Experiments with animals also prove that the produced Brazilian haematein prime is suitable for medicine preparation or curing diseases that are caused by blood pressure elevation in human body, such as various high blood pressures, arterial sclerosis of porridge type, coronary heart disease, cerebral thrombosis and cerebral hemorrhage, etc.

Description

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Claims

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Application Information

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Owner TSINGHUA UNIV
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