1203 results about "High Blood Pressures" patented technology

The invention provides a pharmaceutical composition for use in the prevention or therapy of glaucoma, increased intraocular pressure, ocular hypertension and / or a symptom associated therewith, wherein the composition comprises tafluprost and a semifluorinated alkane.

The present invention relates to a smart wearable wristband with electrical electrodes for non-invasive neurostimulation, comprising: a main unit for fitting around a wrist and measuring user's vital signs; and a stimulation portion for stimulating median nerve or ulnar nerve located below Neiguan PC 6 or JianShi PC 5. According to the present invention, hypertension or stress can be effectively alleviated.

The invention relates to an intelligent blood pressure measuring method and system based on a pulse wave method, and belongs to the technical field of medical detection. The blood pressure measuring method comprises the steps that pulse wave signals collected by a pulse wave signal collecting device from the body surface of a subject are obtained in real time; filtering and de-noising the pulse wave signal to obtain a pre-processed pulse wave signal; extracting a plurality of characteristic parameters from the preprocessed pulse wave signals to obtain a characteristic parameter data set; analyzing the correlation between the characteristic parameters in the characteristic parameter data set and the blood pressure based on a characteristic value method, and extracting to obtain a sensitive characteristic value data set; based on a pre-established proportional relation model, calculating according to the sensitive characteristic value data set to obtain a preliminary blood pressure value; inputting the preliminary blood pressure value and the sensitive characteristic value data set into a pre-trained neural network model to obtain an optimized final blood pressure value; and outputting and displaying the final blood pressure value through a display module. The precision and stability of blood pressure measurement can be improved.

Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspension of one or more ingredients. In embodiments of the present invention, amounts of the formulation and / or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

The invention relates to the technical field of microorganisms, in particular to application of pediococcus acidilactici. The pediococcus acidilactici TG005 is preserved in the China Center for Type Culture Collection on June 24, 2024, the preservation number is CCTCC NO: M 20241349, and the preservation address is Wuhan University, Wuhan, China. The pediococcus acidilactici TG005 provided by the invention is a multifunctional probiotic strain, is obtained by screening from domestic healthy human excrement samples, and has good application safety and functional adaptability; the strain can reduce the cholesterol level and prevent cardiovascular diseases; uric acid precursor substances are degraded, uric acid generation is reduced, and hyperuricemia and related diseases are prevented; pathogenic bacteria with fusobacterium nucleatum and bacteroides fragilis can be inhibited, and colorectal cancer is prevented; when being used as a probiotic additive for preparing medicines for degrading cholesterol, preventing cardiovascular diseases caused by high cholesterol, preventing hyperuricemia, colorectal cancer and the like, the lactobacillus plantarum has a wide application prospect.

To provide formulations for treatment of hypertension, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pains, asthma, pulmonary arterial hypertension, and chronic obstructive pulmonary disease.SOLUTION: The invention provides a chemical formulation for use in a method of treating a disease, the method comprising: inserting a delivery catheter into a vascular lumen adjacent to nerves, where the vascular lumen includes a pulmonary artery; infusing the chemical formulation into the vascular lumen through the delivery catheter, where the amount of the chemical formulation is an amount effective to injure or damage the nerves and provide benefits in alleviating the symptoms of the disease; and withdrawing the delivery catheter from the blood vessel. The chemical formulation is at least one of 10-100 wt.% of ethanol, and 1-100 wt.% of acetic acid. The disease includes pulmonary arterial hypertension.SELECTED DRAWING: None

The invention relates to the technical field of lung perfusion, in particular to an AI-based lung perfusion evaluation system, which comprises an image quality screening module, a blood vessel positioning analysis module, a blood flow velocity measurement module, a blood vessel anomaly analysis module and an anomaly response module, and is characterized in that the image quality screening module monitors the pixel density of an image and the variation amplitude of color gradient. According to the method, through real-time image definition evaluation and screening, the image selection process is optimized, it is ensured that all the images used for analysis reach the high-quality standard, the gray level change and the edge contour of the blood vessel are automatically calculated, the potential lesion area is accurately positioned and marked, more detailed blood vessel structure analysis is provided, and the accuracy of blood vessel analysis is improved. In addition, the system can rapidly analyze the speed deviation of the blood vessel segment, timely identify the abnormal blood flow, effectively improve the judgment speed of diseases such as pulmonary embolism or pulmonary hypertension, enhance the efficiency of coping with emergency medical conditions through automatic abnormal detection and recording, improve the accuracy and speed of judgment, and support more effective clinical decisions.

The invention belongs to the technical field of medical treatment and public health, and particularly relates to a hypertension group knowledge recommendation method and system based on a large language model multi-agent. Hypertension knowledge question-answer pair information, medical short video information and user personal health portraits are finely extracted by constructing a hypertension knowledge question-answer pair library; according to the method, video content quality evaluation and matching degree evaluation are performed, and user platform interaction data adjustment is combined, so that personalized and accurate knowledge recommendation services can be provided for hypertension users, the requirements of hypertension patients for health knowledge are met, the accuracy and effectiveness of knowledge recommendation are improved, and self-health management of the patients is facilitated.

A wearable device to measure a user's physiological parameters comprising one or more biosensors, as well as a light source comprising light emitting diodes, lenses for directing light towards tissue of the user comprising blood vessels, and a detection system receiving reflected tissue light. The physiological parameters, for example hypertension, are measured with a differential measurement. For example, the physiological parameters may be associated with pulse rate and blood flow. The output signal is associated with the physiological parameters, and artificial intelligence may be used in making decisions regarding the output signal. Signal-to-noise ratio of the output signal may be improved by synchronizing the detection system to the light source, increasing light intensity, and detecting a change. The wearable device is configured to determine that is being worn by the user and may be configured to communicate with a smartphone or tablet.

The invention discloses a tree shrew hypertension model making method. The method comprises the following steps: (1) solvent preparation: dissolving palmitic acid in absolute ethyl alcohol to prepare 24mg / ml storage liquid for later use; and (2) diluting the stock solution in the step (1) with 10% BSA (Bovine Serum Albumin) into a solution with the concentration of 6mg / ml, and injecting the solution into the abdominal cavity of the tree shrew according to the dosage of 20mg / kg for 21d to finish modeling. The model preparation method is simple, and the model forming rate is high.

The invention provides an intelligent blood pressure measuring method and system based on an electronic Korotkoff sound method, and relates to the technical field of medical instruments.The method comprises the steps that in the process that a cuff wound around the upper arm of a person to be measured is deflated, multiple Korotkoff sound signals from a brachial artery and the air pressure, corresponding to the Korotkoff sound signals, in the cuff are obtained; determining the initial systolic pressure of the to-be-tested person according to the first air pressure in the cuff when the Korotkoff sound signal appears for the first time, and determining the initial diastolic pressure of the to-be-tested person according to the second air pressure in the cuff when the Korotkoff sound signal appears for the last time; performing feature value extraction on the plurality of Korotkoff sound signals to obtain a plurality of feature parameters; and inputting the plurality of characteristic parameters, the initial systolic pressure and the initial diastolic pressure into a preset neural network model to obtain target systolic pressure and target diastolic pressure of the to-be-measured person, and taking the target systolic pressure and the target diastolic pressure as blood pressure measurement results of the to-be-measured person. The method has the technical effect that the accuracy of blood pressure measurement is improved.

A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart. Pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.

The invention discloses preparation and application of lotus seed protein peptide with ACE (angiotensin converting enzyme) inhibitory activity, and belongs to the technical field of food-borne active peptide development. According to the ACE inhibitory peptide WVPRYFPF and the preparation method thereof, the ACE inhibitory peptide is rapidly screened by utilizing a polypeptiomics and molecular docking technology, the defects of time consumption and labor consumption caused by step-by-step separation and purification are avoided, the obtained ACE inhibitory peptide WVPRYFPF has extremely high ACE inhibitory activity, IC50 of the ACE inhibitory peptide WVPRYFPF is 16.7 mu M, and the ACE inhibitory peptide WVPRYFPF can be used for assisting or replacing hypertension drugs. The lotus seed protein peptide disclosed by the invention has the characteristic of inhibiting ACE enzyme activity in vitro, and animal experiments prove that the protein peptide can also play a role in lowering blood pressure in a spontaneous hypertension rat (SHR).

The invention features polypeptides that include an extracellular ActRIIB variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIB variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and / or pulmonary hypertension.

This application provides a blood pressure measurement method for a wearable device and a wearable device, so as to improve measurement accuracy of a blood pressure value. The wearable device includes a pressure transducer (PT) and a photoplethysmography (PPG) module. The PT and the PPG module are deployed at a target position of the wearable device. The target position includes a position for contacting a wearer when the wearable device is in a worn state. The method includes: obtaining a pressure value collected by the PT; obtaining a PPG signal collected by the PPG module; and determining a blood pressure value of the wearer based on the pressure value and the PPG signal.

The invention relates to the technical field of blood pressure dynamic monitoring systems, and provides an artificial intelligence-based blood pressure dynamic monitoring and risk assessment system, which comprises a patient terminal, a doctor terminal, a data center terminal, a local anomaly detection terminal and a strategy generation terminal, the patient terminal is used for collecting blood pressure, body position change and endocrine hormone fluctuation data of a patient in real time; the data center terminal is used for fusing, storing and processing the data uploaded by the patient terminal and performing overall risk assessment; the local anomaly detection terminal is used for collecting local blood flow rate and pulse wave conduction velocity data and carrying out local anomaly detection index analysis; the strategy generation terminal is used for generating strategy information according to the overall risk assessment result and the local anomaly detection index; and the doctor terminal is used for receiving and displaying the overall risk assessment result and the local anomaly detection index, and receiving and executing the strategy information. According to the invention, the comprehensiveness and timeliness of hypertension risk prediction and intervention are improved.

Implant devices for hypertension and methods of treatment are provided. Implant devices are configured for placement in a target region of an aortic arch of the patient, thereby engaging arterial walls in the target region sufficiently to stretch and / or tension arterial walls, thereby inducing the baroreflex response. Such implants can include one or more expandable structures configured to engage an elongated target region in the aortic arch. The target region can extend along a majority of the aortic arch including a cylindrical segment of aortic arch between the left common carotid artery and the left subclavian artery. An elongated target zone can further extend at least between the brachiocephalic artery takeoff and the left subclavian artery takeoff. Such embodiments can utilize one or more expandable structures with a non-circular cross-section that stretch and reshape the arterial walls to induce tension in the arterial walls, thereby generating a robust baroreflex response.

The invention relates to the field of medical health, and provides a blood pressure data management method and system for a face recognition blood pressure meter, and the method comprises the steps: firstly obtaining and detecting a face image of a user, recognizing features, matching the features with a user face database to obtain identity data, extracting detailed physical sign parameters, calculating a health index, and measuring blood pressure based on the health index. Comprising the following steps: calculating a dynamic blood pressure change value and a resting blood pressure value, calculating a pulse pressure value, performing state analysis and risk detection on a detected user, determining a blood pressure index by grouping data, searching an index range to find abnormal blood pressure data, marking an abnormal blood pressure label, triggering a signal device to generate a blood pressure alarm signal, and sending the blood pressure alarm signal to a remote monitoring terminal. The analysis unit analyzes the abnormal blood pressure data to generate a blood pressure data report. According to the invention, the coordination management of blood pressure data can be improved.

The invention relates to the technical field of medicines, and particularly discloses a compound antihypertensive pharmaceutical composition. The pharmaceutical composition provided by the invention selects sacubitril valsartan sodium and indapamide as active ingredients, and within a prescription dosage range limited by the application, the two medicines can fully realize an antihypertensive effect through a synergistic effect, and the renal function of a patient is effectively improved. Through cooperation of the two components, the hypertension symptom of a patient can be effectively controlled, the adverse reaction is not obvious, and the compliance of the patient can be improved by adopting the compound preparation, so that the control on the blood pressure of the patient is enhanced.

Provided is a long-acting kinin or a derivative thereof, for use in fundamentally solving the problem that the kinin is undruggable. On the one hand, the half-life period of the kinin or the derivative thereof is prolonged by means of long-acting technology, preventing the kinin or the derivative thereof from being rapidly degraded and inactivated in vivo; and on the other hand, action sites of the kinin and a receptor are covered or partially covered by means of long-acting modification, effectively avoiding rapid decrease of blood pressure in a short time, hypotension, and other adverse reactions. The long-acting kinin or the derivative thereof well retains receptor binding activity and signal conduction activity in an in-vitro cell experiment, and can effectively treat hypertension and prevent or treat hypertension complications in in-vivo experiments, and thus a novel method for treating hypertension and hypertension complications is provided.

The invention discloses a far-infrared functional photobiotin composite material, an acupoint patch prepared from the far-infrared functional photobiotin composite material and application of the acupoint patch, and belongs to the technical field of far-infrared medical materials. The photobiotin composite material is prepared from the following components in parts by weight: 25 to 45 parts of modified stone needle, 20 to 30 parts of medical stone, 10 to 20 parts of germanite, 5 to 10 parts of silicon dioxide and 5 to 10 parts of aluminum oxide. The modified stone needle is prepared by processes of bentonite interlayer chambering, LaFe perovskite / TiO2 quantum dot intercalation, Prussian blue analogue loading and the like. The composite material has a far infrared emission characteristic and can generate resonance absorption with human tissues, negative oxygen ions are released through quantum dot photocatalysis, and a porous structure adsorbs inflammatory factors, namely LaFe perovskite / TiO2 quantum dot photocatalysis and cooperates with stone needle far infrared radiation to destroy bacterial cell membranes; and the medical stone releases trace elements to inhibit bacterial activity. The prepared acupoint patch is compounded with a medical pressure-sensitive adhesive through a compression molding process to generate micro-current to stimulate a TRPV1 ion channel, so that the treatment of facial paralysis, hypertension and diabetes mellitus is realized.

The invention provides a hypertension VR intervention method based on dynamic biofeedback and individualized modeling, and provides a hypertension VR intervention system based on dynamic biofeedback and individualized modeling. The method comprises the following steps: performing state analysis on dynamic biological feedback indexes of a hypertensive patient, namely a predicted pressure index (SPI) and an exercise intensity index (EII), deciding a hypertension VR intervention decision matched with the state of the dynamic biological feedback indexes, activating a VR scene of the corresponding decision in a system, and actively enabling the hypertensive patient to perform adaptive intervention training through VR equipment. Therefore, dynamic biological feedback intervention is realized by utilizing an intelligent decision training mode of the intelligent model. According to the method, training mode recommendation can be accurately carried out according to the patient state, state reward can be carried out according to the blood pressure change amplitude and the patient compliance score, so that the patient training mode is optimized, intelligent training is achieved, and the method has high guiding significance.

System and method for measuring hypertension conditions of a subject is disclosed. The disclosed system and method includes thermal sensors for capturing thermal images and / or videos of a body part; and a processing engine to detect a predefined region of the body part in each frame of the captured images and / or videos. The processing engine segments one or more portions from the detected predefined region in each frame of the captured images and / or videos to identify a region of interest comprising arteries in the one or more segmented portions. Based on the identified region of interest, the engine extracts pixel values from each frame of the captured images and / or videos to determine parameters associated with a blood flow velocity and a blood pressure of the subject. Further a type of hypertension and a risk score for the hypertension condition based on the determined parameters using computational models are measured.

The invention provides a theaflavin composition for treating hypertension as well as a preparation method and application thereof, and relates to the technical field of medicines. The theaflavin composition comprises theaflavin, a celery seed extract, a gastrodia elata extract, a parasitic loranthus extract, a centella asiatica extract, a lotus leaf extract and a licorice extract. Wherein the theaflavin can regulate blood fat, inhibit atherosclerosis and improve the vascular endothelial function; the celery seed extract inhibits the activity of angiotensin converting enzyme, and cooperates with theaflavin to regulate blood pressure; the gastrodia elata extract can calm liver wind and improve cerebral circulation; the loranthus parasiticus extract has the effects of tonifying liver and kidney and regulating water sodium metabolism; the centella asiatica extract can resist inflammation and repair vascular endothelium; the lotus leaf extract can clear heat, promote diuresis, calm the liver and suppress yang; and the licorice extract harmonizes the medicines and resists oxidation. According to the invention, theaflavin is taken as a core, multi-dimensional effects of reducing blood pressure, protecting blood vessels and resisting inflammation and oxidation are realized, and a natural and comprehensive health management scheme is provided for hypertensive patients.

The provided long-acting kinin or the derivative thereof fundamentally solves the problem that kinin has no druggability, on one hand, the half-life period of kinin or the derivative thereof is prolonged through a long-acting technology, and it is prevented that kinin or the derivative thereof is rapidly degraded and inactivated in vivo; on the other hand, the action site of the kinin and the receptor is covered or partially covered through long-acting modification, so that the adverse reactions such as rapid blood pressure reduction and hypotension in a short time are effectively avoided. The long-acting kinin or the derivative thereof well retains receptor binding activity and signal transduction activity in an in-vitro cell experiment, can effectively treat hypertension and prevent or treat hypertension complications in an in-vivo experiment, and provides a new method for treating hypertension and hypertension complications.

This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation and / or electroporation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation and / or electroporation is delivered in differing areas in and / or around the pulmonary vein in coordination with each other for enhanced efficacy.

The invention provides a blood pressure measurement system and method based on oscillatory wave and PPG signal collaborative learning, and relates to the technical field of wearable medical health monitoring. According to the method, the advantages of the CNN in local feature extraction, the Transform in time sequence modeling and the PPG signal in assisting blood pressure prediction are brought into full play, and the accuracy of blood pressure estimation can be remarkably improved. Complex features are automatically extracted through deep learning, dependence on manual feature engineering is reduced, traditional machine learning is adopted, model interpretation is enhanced, and the precision and robustness of blood pressure estimation are improved by combining the advantages of the two. The method is wide in applicability, can be applied to various scenes such as family health monitoring, clinical monitoring and wearable equipment, adopts multi-task learning, can predict systolic pressure and diastolic pressure at the same time, and shares a feature extraction network. Moreover, the algorithm is a lightweight algorithm, can be deployed on wearable equipment to realize low-power-consumption and high-efficiency real-time blood pressure estimation, and provides powerful support for health monitoring.

The utility model provides a blood vessel puncture sheath. The blood vessel puncture sheath comprises an outer sheath tube, a hemostasis valve, a three-way valve, a connecting tube, a thread hanging device and a dilator. The hemostasis valve is fixedly connected with the near end of the outer sheath tube; the dilator penetrates through the hemostasis valve and enters the outer sheath tube; the three-way valve is communicated with the hemostasis valve through a connecting pipe; the outer sheath tube is sleeved with the suture hanging device, the suture hanging device is close to the far end of the outer sheath tube, the far end of the outer sheath tube penetrates through the suture hanging device to be exposed, and a suture hanging hole and / or a suture hanging groove used for fixing a suture line are / is formed in the suture hanging device. The situation that the outer sheath tube is inserted too deep and makes contact with the opposite side blood vessel wall, and blood vessel injuries are caused is avoided. And the condition that the whole blood vessel puncture sheath is pushed out by blood pressure due to high blood pressure of the main artery is prevented. The situation that the whole blood vessel puncture sheath falls off due to the fact that the whole blood vessel puncture sheath is touched carelessly is avoided. In addition, the utility model further provides a blood vessel sheath set.

The invention relates to nutritional wet noodles rich in mixed beans and a preparation method of the nutritional wet noodles. The nutritional wet noodles comprise the following raw materials in parts by weight: 80-100 parts of flour, 5-10 parts of red beans, 5-10 parts of kidney beans, 5-10 parts of mung beans, 5-10 parts of peas, 5-10 parts of broad beans, 2-5 parts of starch acetate and 10-15 parts of an additive, the additive is in a micro-capsule shape, an internal profile is a composite extract, the composite extract comprises a scutellaria baicalensis extract and lecithin, the scutellaria baicalensis extract has good blood fat and blood pressure reducing effects and has a good dietary therapy effect on people suffering from hypertension, hyperlipidemia and hyperglycemia, and meanwhile the lecithin can reduce cholesterol in serum, so that the blood fat and the blood pressure can be reduced. The wall material is prepared by blending an intermediate 6, deionized water and a gelatin solution, and a coating solution contains chitosan and phosphate structures, so that browning of wet noodles can be effectively inhibited, the product quality is ensured, and the wet noodles can be placed for a longer time.

The invention discloses an optimal management method and device for hypertension medication, a medium and equipment. The method comprises the following steps: acquiring initial medication data of a target object for a target blood pressure drug; collecting and analyzing physiological data of the target object in a preset time range, and generating a physiological cycle curve of the target object; adjusting a blood pressure reference curve based on the physiological cycle curve to generate a blood pressure change target curve of the target object; and optimizing the initial medication data according to a blood pressure change target curve to generate a medication optimization scheme. According to the method, the actual blood pressure state of regular change of the patient is measured according to the physiological data change condition of the patient within a certain time range, so that the actual blood pressure state serves as supplement of sphygmomanometer measurement data, when 24-hour sphygmomanometer monitoring data of the patient is difficult to obtain, targeted medicine taking suggestions can be provided for the patient, the medicine taking accuracy of the patient is improved, and the patient experience is improved. And the hypertension management individuation level of the patient is improved.