3147 results about "High Blood Pressures" patented technology

Devices, systems and methods are disclosed for the formation of an arteriovenous fistula. Embodiments include catheter apparatus including an ablation element for creating and/or modifying the fistula. The devices, systems and methods can be used to treat patients with one or more numerous ailments including chronic obstructive pulmonary disease, congestive heart failure, hypertension, hypotension, respiratory failure, pulmonary arterial hypertension, lung fibrosis and adult respiratory distress syndrome.

The invention provides a method of treating obesity, diabetes, and/or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance) in a mammal by administering to the mammal a therapeutically effective amount of an irreversible MAO-B inhibitor.

The present invention is generally related to the discovery of the therapeutic benefit of administering gamma-tocopherol and gamma-tocopherol derivatives. More specifically, the use of gamma-tocopherol and racemic LLU-alpha, (S)-LLU-alpha, or gamma-tocopherol derivatives as antioxidants and nitrogen oxide scavengers which treat and prevent high blood pressure, thromboembolic disease, cardiovascular disease, cancer, natriuretic disease, the formation of neuropathological lesions, and a reduced immune system response are disclosed.

The object of the present invention is to provide PPAR (peroxisome proliferator-activated receptor) activity regulators, which can be widely used for improving insulin resistance and preventing/treating various diseases such as diabetes, metabolic syndromes, hyperlipemia, high-blood pressure, vascular disorders, inflammation, hepatitis, fatty liver, liver fibrosis, NASH (non-alcoholic steatohepatitis) and obesity.

The present invention provides PPAR activity regulators which comprise an acylamide compound having the specific structure, prodrugs thereof, or pharmaceutically acceptable salts thereof.

The invention discloses Chinese medicated liquor for treating hypertension and a preparation method thereof. The Chinese medicated liquor is prepared from sun-dried ginseng, Radix Astragali, bighead atractylodes rhizome, Tuckahoe, tuber fleeceflower root, dried rhizome of rehmannia, white paeony root, angelica, bupleurum, dried orange peel, sealwort, centipedes, pilose antler, stir-baked semen ziziphi spinosae, thinleaf milkwort root-bark, Indian bread with hostwood, licorice, walnut, raisins, white spirit and other raw materials. Combining the raw materials, the Chinese medicated liquor takes both qi and blood into consideration, coordinates defensive qi and nutritive qi, makes qi and blood circulating in the whole body, coordinates the relationship between yin and yan, combines deintoxication and nourishing, removing blood stasis without hurting human body, maintains normal upbearing and downbearing of qi and blood, thereby reducing blood pressure.

The present invention provides novel compounds of Formula I

and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells. Such disorders and diseases include, by way of example only, cardiac disorders and diseases, skeletal muscular disorders and diseases, cognitive disorders and diseases, malignant hyperthermia, diabetes, and sudden infant death syndrome. Cardiac disorder and diseases include, but are not limited to, irregular heartbeat disorders and diseases; exercise-induced irregular heartbeat disorders and diseases; sudden cardiac death; exercise-induced sudden cardiac death; congestive heart failure; chronic obstructive pulmonary disease; and high blood pressure. Irregular heartbeat disorders and diseases include and exercise-induced irregular heartbeat disorders and diseases include, but are not limited to, atrial and ventricular arrhythmia; atrial and ventricular fibrillation; atrial and ventricular tachyarrhythmia; atrial and ventricular tachycardia; catecholaminergic polymorphic ventricular tachycardia (CPVT); and exercise-induced variants thereof. Skeletal muscular disorder and diseases include, but are not limited to, skeletal muscle fatigue, exercise-induced skeletal muscle fatigue, muscular dystrophy, bladder disorders, and incontinence. Cognitive disorders and diseases include, but are not limited to, Alzheimer's Disease, forms of memory loss, and age-dependent memory loss.

The invention provides a sleep-improving and health-care drug pillow, relating to a health-care medical product, in particular to making materials and process of the sleep-improving and health-care drug pillow. A drug core of the pillow mainly comprises the following raw materials in parts by weight: 1000 parts of cottonseeds, 500 parts of buckwheat shell, 20 parts of tea, 30 parts of spina date seed, 30 parts of schisandra, 20 parts of lily, 20 parts of ganoderma lucidum, 30 parts of akebia stem, 30 parts of tuber fleeceflower root, 10 parts of cordyceps, 10 parts of Chinese angelica, 30 parts of rehmannia root, 10 parts of safflower, 30 parts of red-rooted salvia root, 10 parts of longan, 30 parts of common clubmoss herb, 30 parts of garden balsam stem, 10 parts of Chinese atractylode rhizome, 10 parts of clematis root, 30 parts of pawpaw, 30 parts of divaricate saposhnikovia root, 30 parts of dried orange peel, 20 parts of costustoot, 20 parts of polygala root, 30 parts of Szechwan lovage rhizome, 10 parts of honeysuckle, 20 parts of glossy privet fruit, 10 parts of wild chrysanthemum, 10 parts of lonicera chrysantha flower, 10 parts of amomum shell, 20 parts of mint, 30 parts of galanga, 20 parts of bergamot, 20 parts of coptis, 20 parts of amur corktree bark, 10 parts of tuber fleeceflower stem, 10 parts of dwarf lilytruf tuber, 10 parts of dandelion, 30 parts of radix astragali, 30 parts of nutgrass galingale rhizome, 2000 parts of millet mature vinegar, 30 parts of honey and 30 parts of yellow wine and is refined by adopting the processes of soaking, roasting, brewing, mixing and the like. The sleeping-improving and health-care pillow has the advantages of simple making process and strong drug efficacy and has special curative effects on long-term insomnia, high blood pressure, headache, tinnitus and cervical pain.

A multi-colored health care tofu containing fruit and vegetable comprises the following raw materials with the weight portions of 8 to 10 portions of soybean, 4 to 10 portions of fruits, 8 to 10 portions of vegetables and 0.3 to 1 portions of ecological coagulant, wherein, the fruit and the vegetable are the fruits and the vegetables with the pH of less than 7. The ecological coagulant is the mixture of glucose and plaster which is in the ratio of 1 to 3:22 to 28. The production process comprises screening and sorting soybean, soaking and removing peels, grinding for separation, mixing and coloring by adding the extracted natural vegetable juice and fruit juice, cooking and coagulating, squeezing and forming and packing the finished products. In the invention, algin, mannite, plant fiber, protein, a plurality of amino acids, a plurality of vitamins, a plurality of trace elements including calcium, iron and selenium which are the essential matter inside the body are added, which can effectively prevent a plurality of diseases including high blood pressure, obesity, cardiovascular genomic, biliary calculus and other diseases.

Compounds of the formula

wherein R₁, R₂, R₃, R₄, X and Y are as defined, which have a superior cGMP specific phosphodiesterase (PDE) inhibitory activity, and can be used as an agent for the treatment of cardiovascular diseases such as angina pectoris, heart failure, cardiac infarction, hypertension, arteriosclerosis, and the like; allergic diseases such as asthma, or disorders of male or female genital function and the like.

The invention discloses an agent box, which is characterized by the following: utilizing the relation between mononucleotide polymorphism site E112D genetype of important enzyme praline carboxypeptidase gene on vessel or esoderma regulating access and ACEI medical effect; forecasting ACEI medical effect; possessing good ACEI medical effect when genetype as 112EE pure wild-type; possessing bad effect when the genetype as 112ED heterozygous type or 112DD pure saltant; incorporating polymorphism parting oligonucleotide of E112D polymorphism site genetype with praline carboxypeptidase gene to test biological sample and related agent. This invention improves effectiveness and safety of clinic medicine, which provides criterion for new medicine of high blood pressure.

The invention discloses a preparation method for highly effective compound dietary cellulose. The method of the invention is characterized in that: the highly effective compound dietary cellulose is prepared with the following materials, insoluble dietary fiber, water-soluble dietary fiber, vitamin C and lactic acid bacteria powder, in definite proportions. The product of the invention is the highly effective compound dietary cellulose which is provided with dual characteristics of insoluble dietary fiber and water-soluble dietary fiber and the dosage form of the product can be capsules or granules. The long-term taking of the product of the invention can ensure obvious curative effects on high blood pressure, high blood fat, high cholesterol, diabetes, obesity, constipation, gastro-intestinal diseases, etc. If being added with different materials such as microcrystalline celluloses, magnesium stearate, maltodextrin, citric acid, sodium bicarbonate and PEG6000, according to different preparation forms, the product can also be prepared into tablets, chewable tablets and effervescent tablets. The highly effective compound dietary cellulose of the invention has simple, scientific and reasonable prescription, simple technology and stable quality, and is easy to be produced in large scale, thus being a safe and green health-care food product.

Dependent variables believed to contribute to a likelihood of falling are analyzed using a latent class analysis. The dependent variables are biomedical factors, which may include, for example, arthritis, high blood pressure, diabetes, foot disorders, Parkinson's Disease, stroke, eye disorder, limb disorder, or proprioceptive disorder. Data pertaining to the biomedical factors is gathered from a population of individuals at risk of falling. Covariate data, including for example age and the number of prescriptions taken, is further analyzed against latent class data. For a particular group of at risk individuals, a set of five classes produced useful results broadly corresponding to groups representing individuals who have: good health; a range of diseases; Parkinson's Disease; arthritis; and high blood pressure. A probability of falling is determined, relative to the group of individuals with good health.

Food products fortified with a therapeutically effective amount of milk mineral are administered for the treatment of high blood pressure, stroke, obesity, kidney stones, colon cancer, breast cancer, head and neck tumors, premenstrual syndrome, postpartum depression, hypertensive disorders of pregnancy, Type-2 diabetes, depression, asthma, inflammatory bowel disease, attention deficit disorder, migraine headaches, kidney disease, hypercholesterolaemia, congestive heart failure, or immune deficiency.

The invention relates to a traditional Chinese medicine for treating cardiac, cerebral and vascular diseases; the drug is composed of forty kinds of crude drugs by weight parts: milk veteh, salvia miltiorrhiza, root of common peony, ligusticum wallichii, lumbricus, sanguisuga, rhizoma acori graminei, polygala root, red ocher, oyster, angelica, the root of kudzu vine, arisaema cum bile and the like; the preparation method is that: (1) the crude drugs are prepared into water extract liquid; (2) the water extract liquid is prepared into oral liquid; (3)the water extract liquid obtained by the step (1) is dried, crushed, sieved, undersize material is extracted powder; (4) the extracted powder prepared by the step (3) is prepared into various dosage forms. The preparation method of crude powder is that: lime earth of the crude drugs is sieved, and then the crude drugs are crushed and sieved, the undersize material is taken out and is sterilized to be crude powder, and the crude powder is prepared into various dosage forms. The traditional Chinese medicine has the major functions of treating miocardial infarction and angina caused by coronary heart disease, high blood pressure and cerebral thrombosis, hemiplegia, cerebral infarction, cerebrovascular accident, sequel of apoplexy and other symptoms, and the medicine has obvious effect on headache, dizziness and heart cerebrovascular diseases caused by high blood pressure and cerebral circulation insufficiency.

The invention discloses a non-invasive central aortic blood pressure measuring method and device. The non-invasive central aortic blood pressure measuring method includes, according to a human artery network model based on viscous fluid mechanics, a method of calculating artery network model personalized parameters of a measured person through measured radial artery and brachial artery pulse wave signals and arm blood pressure values, a method of calculating an ascending aorta-radial artery transfer function and a method of calculating central arterial pressure waveforms through measured central arterial pressures. The non-invasive central aortic blood pressure continuous measuring device comprises a pulse wave signal processing and analysis unit and a radial artery and brachial artery pulse wave signal acquisition unit worn on a wrist. The method is different from an existing general transfer function method, the artery network model parameters of each person to be measured are measured and calculated and the artery network model parameters are numerical characteristics of the cardiovascular system states of the person to be measured with the calculated central arterial pressure waveforms, and the method and device has important meanings in prevention, curing and control of cardiovascular diseases, especially high-risk diseases, such as hypertensions and coronary heart diseases.