The invention belongs to the technical field of medical hydrogel, and particularly relates to a preparation method and application of antibacterial, anti-inflammatory and repair-promoting long-
residence hydrogel, the method comprises the following steps: step 1, preparation of modified
konjac mannan: performing oxidation reaction on
konjac mannan and an
oxidizing agent in the presence of a
solvent to obtain modified
konjac mannan; the oxidized konjac
mannan is obtained; carrying out
acylation reaction on the oxidized konjac
mannan and an
acylation reagent in the presence of a catalyst to obtain modified konjac
mannan; step 2, preparing modified
gelatin: reacting
gelatin with a compound containing a
boric acid group and an
aldehyde group, and then reacting with an acylating agent containing a carbon-carbon
double bond to obtain the modified
gelatin; step three, preparation of long-retention hydrogel: preparing a solution A from the modified konjac mannan obtained in the step one and
tannic acid; preparing an
antibacterial agent, a
photoinitiator and the modified gelatin obtained in the step 2 into a solution B; and mixing the solution A and the solution B, and initiating curing through
light irradiation to form the long-
residence hydrogel. Compared with the prior art, the hydrogel has the advantages that through the synergistic effect of
aldehyde covalent bonding of the modified konjac
polysaccharide and multi-element
hydrogen bonds of the
tannic acid, the
uterine cavity adhesion force and the long-acting
residence capacity are remarkably enhanced,
uterine cavity contraction can be effectively resisted, the positive effect is achieved in the aspect of
uterine cavity adhesion prevention, and the application prospect is wide. Particularly, the antibacterial, anti-inflammatory and repair-promoting effects are good.