Hydroxyl carthamus tinctorius yellow colour A, preparation method and application thereof

A technology of hydroxysafflower and yellow pigment, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of no practical application value, small yield, unfavorable large-scale production, etc., and achieve shortening Production cycle, improved purity, grainy and crispy effect

Active Publication Date: 2008-06-11
山西德元堂药业有限公司
View PDF3 Cites 29 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such a small yield is not conducive to large-scale industrial production and has no practical application value
[0007] Visible, there is no preparation method b

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hydroxyl carthamus tinctorius yellow colour A, preparation method and application thereof
  • Hydroxyl carthamus tinctorius yellow colour A, preparation method and application thereof
  • Hydroxyl carthamus tinctorius yellow colour A, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0035] [Example 1] Preparation of hydroxysafflor yellow A

[0036] 1) Extraction: Take 100g of safflower medicinal materials, add 1200g of water and extract 3 times at 80°C for 1.5 hours each time. Combine the extracts and concentrate to a relative density of 1.12 at 60°C. After standing for 24 hours, centrifuge to obtain the supernatant. ;

[0037] 2) Separation: Take the supernatant liquid and add it to the treated D101 macroporous adsorption resin column with the column bed diameter ratio of 1:10 according to the ratio of the supernatant volume to the column bed volume of 1:10. Elute with water at a flow rate of 20ml / min until the Molisch reaction and ninhydrin reaction of the eluent are negative, and then elution with 5 column volumes of 5% ethanol solution at a flow rate of 20ml / min, collect 5% ethanol for elution The solution is concentrated to a relative density of 1.2 at 50°C to obtain concentrated solution A;

[0038] 3) Purification: Take the concentrated solution A and ...

Example

[0049] [Formulation Example 1] Hydroxysafflor yellow A freeze-dried powder injection

[0050] Hydroxysafflor yellow A 25g

[0051] Mannitol 25g

[0052] Add water for injection to 400ml

[0053] Weigh the dry powder of hydroxysafflor yellow A and mannitol respectively, add water for injection to dissolve and add water for injection to the full amount, stir well, sterile filter, and divide the filtrate into vials, 0.4ml each, and freeze dry in vacuum , Press plug, sealing aluminum cover. The hydroxysafflor yellow A freeze-dried powder injection was prepared.

Example

[0054] [Formulation Example 2] Hydroxysafflor yellow A freeze-dried powder injection

[0055] Hydroxysafflor yellow A 25g

[0056] Mannitol 50g

[0057] Add water for injection to 800ml

[0058] Weigh the dry powder of hydroxysafflor yellow A and mannitol respectively, add water for injection to dissolve and add water for injection to the full amount, stir well, sterile filter, and divide the filtrate into vials of 0.8ml each, and freeze dry in vacuum , Press plug, sealing aluminum cover. The hydroxysafflor yellow A freeze-dried powder injection was prepared.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a hydroxysaffloryellow A extracted from Chinese medicinal material safflower, a relative preparation method and application thereof. The inventive extraction method of hydroxysaffloryellow A is stuffed into chromatography column according to different diameter-height ratios, the invention uses the upper sample to process column chromatography according to different ratios between upper sample volumes and bed volumes, to separate and purify safflower extract. The invention has simple process, few steps, low cost, high yield, no environment pollution and suitability for industrialized and large-scale production. The yield of extracted hydroxysaffloryellow A is higher than 50%, while the hydroxysaffloryellow A content tested by high-effect liquid hydroxysaffloryellow A reaches 99.5%. The drug prepared from the hydroxysaffloryellow A can effectively prevent and treat cerebrovascular diseases as cerebral infraction and hypertensive cerebral hemorrhage or the like.

Description

technical field [0001] The invention relates to hydroxysafflower yellow A extracted from traditional Chinese medicine safflower, its preparation method and application. Background technique [0002] Safflower is the dried flower of Carthamus tinctorius L., a plant in the Compositae family. It has a pungent and warm nature, enters the heart and liver meridians, and has the effect of removing blood stasis and relieving pain. It is the king drug of various prescriptions for promoting blood circulation and removing blood stasis. The extraction of active ingredients in safflower has attracted more and more attention from relevant people. Previous studies have shown that the active ingredients of safflower for promoting blood circulation are mainly concentrated in water-soluble safflower yellow pigment. Safflower yellow is a chalcone compound, which has various pharmacological effects such as expanding coronary artery, anti-oxidation, protecting myocardium, lowering blood pressure...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07H15/20A61K31/7034A61K36/286A61P9/00
Inventor 杨炜
Owner 山西德元堂药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap