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1 results about "Carboxypeptidase" patented technology
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A carboxypeptidase (EC number 3.4.16 - 3.4.18) is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to a aminopeptidases, which cleave peptide bonds at the N-terminus of proteins. Humans, animals, bacteria and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation.
Regulation of delta-2 tubulin for treating chemotherapy-induced peripheral neuropathy
The subject matter provides methods and compositions for preventing or treating chemotherapy-induced peripheral neuropathy (CIPN) by modulating delta-2 tubulin accumulation in sensory neurons. The therapeutic approaches targeting enzymes that regulate delta-2 tubulin formation, such as cytosolic carboxypeptidases (CCP1 and CCP6), or enhancing tubulin re-tyrosination via tubulin tyrosine ligase (TTL).
Owner:THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK