4 results about "Chronic occlusion" patented technology

The present invention relates to the systems and methods of identifying compounds to treat or prevent chronic obstructive pulmonary disorders (COPD). The present invention also provides compositions to treat or prevent COPD comprising modulators of one or more selected from the group consisting of: AC AN, ACTN1, ADAMTS4, ADRB2, AGER, AN06, AP3B1, AP0A1, ARRB1, ATP1A1, BCL2L1, BDKRB1, BRAF, CALCRL, CCL11, CDH1, CEACAM8, CHRM3, CHRNA1, CLU, COL10A1, COL12A1, COL14A1, COL4A2, COL6A1, COL6A3, COLGATE 1, CRH, CSK, CTSD, CTTN, CXCR1, CXCR4, CXCR5, FBN1, FGA, FGG, FHL2, FTH1, GNB1, GPIHBP1, GPR84, GPR97, GRM8, HAPLN1, H2BFS, HBB, HSP90B1, ICAM1, IGF1R, IL6, ITGA1, ITGAV, LAMA2, LAMA4, LRP1, LTBP1, MAPK3, MGAM, MMP1, MMP13, MMP3, MMP9, MYBPH, MYH10, MYH9, NMU, NR3C1, P4HB, PLCB3, PLAG2G7, POU2AF1, PPIB, PROK2, RUNX2, RXFP1, S100A12, S100P, SAA1, SDC2, SLC2A5, SMAD3, SPARCL1, SPP1, SYT13, TBX1, TF, TGFB2, THBS1, TIMP1, TLN1, TPM1, TPM2, TPM4, TSPAN14, TEN, TWIST2, VIM, and WT1, and methods of use thereof.

The invention provides a chronic occlusion opening guide wire, and belongs to the technical field of interventional medical instruments. The opening guide wire comprises a guide wire body, the guide wire body is provided with an equal-diameter core, a supporting layer and a lubricating coating are sequentially arranged on the outer side of the core, the lubricating coating is used for reducing friction force generated when the guide wire body advances in a blood vessel, and the supporting layer is sequentially provided with a pushing section and a hardness adjusting section from the near end to the far end. The hardness adjusting section is configured to have high flexibility when the guide wire body advances along a blood vessel, and the hardness of the hardness adjusting section is increased to meet the penetration requirement when a blocked part needs to be penetrated; the guide wire is mainly used for solving the technical problems that in the prior art, the far end of a guide wire cannot give consideration to flexibility and occlusion penetrating capacity at the same time, and the far-end supporting force conduction effect is poor.

The invention provides an establishment method and application of an intracranial chronic artery occlusion ischemic stroke risk prediction model based on multi-phase CT imaging characteristics. The establishment method comprises the following steps: S1, acquiring a multi-phase CT image of a patient with chronic intracranial artery occlusion; s2, extracting a plurality of groups of CT image layers covering key brain regions from the CT images of different phases; s3, preprocessing the screened key brain region CT image layer; and S4, establishing a neural network model and performing network parameter optimization to obtain an intracranial chronic artery occlusion ischemic stroke prediction model. In the process of predicting the intracranial chronic artery occlusion ischemic stroke, quantitative reference can be provided for doctors to make clinical decisions, and the stability of evaluation and prediction is enhanced, so that the medical efficiency is improved, and the doctors are assisted in accurately making clinical evaluation.