10 results about "Chronic occlusion" patented technology

The present disclosure is a magnetically guided re-entry catheter system and method configured to direct subintimal crossing and re-entry into the artery true lumen of a guidewire during treatment of arterial chronic total occlusions. A magnet is affixed to a catheter, and the catheter is directed through the artery containing the chronic total occlusion via a guidewire. A second, ferromagnetic guidewire is directed through the artery to the opposite side of the chronic total occlusion, before crossing out of the true lumen into the subintimal. The magnetic attraction between the second guidewire and the magnet directs re-entry of the second guidewire into the true lumen once the second guidewire has passed the chronic total occlusion.

The invention provides an opening device for chronic internal carotid artery occlusion, and relates to the technical field of medical instruments. The opening device comprises a guide wire catheter and a guide wire body arranged in the guide wire catheter in a penetrating manner; the expansion and contraction assembly is arranged on the guide wire catheter, clamps the guide wire body in an expansion state and abuts against the inner wall of the blood vessel; the expansion and contraction assembly comprises a flow guide interlayer arranged in the side wall of the guide wire catheter, an outer-layer expansion and contraction film arranged on the outer side of the far end of the guide wire catheter and communicated with the flow guide interlayer, and an inner-layer expansion and contraction film arranged on the inner side of the far end of the guide wire catheter. A communicating hole communicating an inner cavity of the outer-layer expansion and contraction film with an inner cavity of the inner-layer expansion and contraction film is formed in the guide wire catheter. The outer swelling and shrinking film is tightly attached to the periphery of the blood vessel wall after being swelled, and clamping of the guide wire catheter is achieved; the inner-layer swelling and shrinking film abuts against the side wall of the guide wire body after being swelled, clamping of the guide wire body is achieved, the guide wire body is supported in the radial direction, the guide wire body is kept in the middle of a blood vessel, and the possibility that the guide wire enters a false cavity is reduced.

The present disclosure is a magnetically guided re-entry catheter system and method configured to direct subintimal crossing and re-entry into the artery true lumen of a guidewire during treatment of arterial chronic total occlusions. A magnet is affixed to a catheter, and the catheter is directed through the artery containing the chronic total occlusion via a guidewire. A second, ferromagnetic guidewire is directed through the artery to the opposite side of the chronic total occlusion, before crossing out of the true lumen into the subintimal. The magnetic attraction between the second guidewire and the magnet directs re-entry of the second guidewire into the true lumen once the second guidewire has passed the chronic total occlusion.

The present invention relates to the systems and methods of identifying compounds to treat or prevent chronic obstructive pulmonary disorders (COPD). The present invention also provides compositions to treat or prevent COPD comprising modulators of one or more selected from the group consisting of: AC AN, ACTN1, ADAMTS4, ADRB2, AGER, AN06, AP3B1, AP0A1, ARRB1, ATP1A1, BCL2L1, BDKRB1, BRAF, CALCRL, CCL11, CDH1, CEACAM8, CHRM3, CHRNA1, CLU, COL10A1, COL12A1, COL14A1, COL4A2, COL6A1, COL6A3, COLGATE 1, CRH, CSK, CTSD, CTTN, CXCR1, CXCR4, CXCR5, FBN1, FGA, FGG, FHL2, FTH1, GNB1, GPIHBP1, GPR84, GPR97, GRM8, HAPLN1, H2BFS, HBB, HSP90B1, ICAM1, IGF1R, IL6, ITGA1, ITGAV, LAMA2, LAMA4, LRP1, LTBP1, MAPK3, MGAM, MMP1, MMP13, MMP3, MMP9, MYBPH, MYH10, MYH9, NMU, NR3C1, P4HB, PLCB3, PLAG2G7, POU2AF1, PPIB, PROK2, RUNX2, RXFP1, S100A12, S100P, SAA1, SDC2, SLC2A5, SMAD3, SPARCL1, SPP1, SYT13, TBX1, TF, TGFB2, THBS1, TIMP1, TLN1, TPM1, TPM2, TPM4, TSPAN14, TEN, TWIST2, VIM, and WT1, and methods of use thereof.

The invention provides a chronic occlusion opening guide wire, and belongs to the technical field of interventional medical instruments. The opening guide wire comprises a guide wire body, the guide wire body is provided with an equal-diameter core, a supporting layer and a lubricating coating are sequentially arranged on the outer side of the core, the lubricating coating is used for reducing friction force generated when the guide wire body advances in a blood vessel, and the supporting layer is sequentially provided with a pushing section and a hardness adjusting section from the near end to the far end. The hardness adjusting section is configured to have high flexibility when the guide wire body advances along a blood vessel, and the hardness of the hardness adjusting section is increased to meet the penetration requirement when a blocked part needs to be penetrated; the guide wire is mainly used for solving the technical problems that in the prior art, the far end of a guide wire cannot give consideration to flexibility and occlusion penetrating capacity at the same time, and the far-end supporting force conduction effect is poor.

The invention provides an electrode-adjustable pulse ablation device and a control method, and relates to the technical field of medical instruments, and the electrode-adjustable pulse ablation device comprises an ablation catheter module and a control module which are connected in sequence. The ablation catheter module comprises a catheter assembly and an electrode assembly, the catheter assembly comprises a catheter, a catheter flexible part and an electrode wire, the electrode assembly comprises an electrode, a mandrel and an electrode fixing head, and the control module comprises a shell structure set, a pulse input assembly, an electrode adjusting mechanism and an unfolding and contracting driving mechanism. The problems that in the prior art, a catheter is insufficient in flexibility, the electrode size is fixed, the adjusting function is deficient, and the mandrel pushing deviation is large are solved, and an accurate, safe and efficient technical solution is provided for bronchial interventional therapy of the chronic obstructive pulmonary disease.

To provide apparatuses and methods of use for treating a subject in need of assistance with breathing, where, in some embodiments, the subject suffers from airflow obstruction or the subject suffers from chronic obstructive pulmonary disease.SOLUTION: A method of treating a subject comprising: (a) sensing when a subject is exhaling; and (b) delivering a stimulus to the subject's thorax or abdomen during at least part of the expiratory phase of breathing in response to said sensing, so as to assist the subject with exhalation. The method includes decreasing the subject's end expiratory lung volume (EELV) as compared with the subject's EELV when unassisted.SELECTED DRAWING: Figure 3

The invention provides an establishment method and application of an intracranial chronic artery occlusion ischemic stroke risk prediction model based on multi-phase CT imaging characteristics. The establishment method comprises the following steps: S1, acquiring a multi-phase CT image of a patient with chronic intracranial artery occlusion; s2, extracting a plurality of groups of CT image layers covering key brain regions from the CT images of different phases; s3, preprocessing the screened key brain region CT image layer; and S4, establishing a neural network model and performing network parameter optimization to obtain an intracranial chronic artery occlusion ischemic stroke prediction model. In the process of predicting the intracranial chronic artery occlusion ischemic stroke, quantitative reference can be provided for doctors to make clinical decisions, and the stability of evaluation and prediction is enhanced, so that the medical efficiency is improved, and the doctors are assisted in accurately making clinical evaluation.

The utility model provides a hypoperfusion stent for chronic internal carotid artery occlusion, and relates to the technical field of medical instruments, the hypoperfusion stent comprises a first stent and a flow limiting assembly which are mechanically connected, the flow limiting assembly is connected to the far end of the first stent, and the first stent is used for opening a vascular occlusion area; the first support and the flow limiting assembly have a pressing and holding state and an expansion state, and when the flow limiting assembly is in the expansion state, the flow of blood flowing to the far end of the flow limiting assembly can be limited. The flow limiting assembly is arranged at the far end of the first support playing a supporting role, when the first support opens a vascular occlusion position, the blood flow is controlled through the flow limiting assembly, the blood flow after recanalization can be gradually increased, the phenomenon of high perfusion caused by instantaneous increase of the blood flow is avoided, the surgical risk is reduced, and the surgical efficiency is improved. The flow limiting assembly is made of biodegradable materials and does not need to be taken out after operation, and the problem of high perfusion after recanalization of a blocked area can be solved.