87 results about "Chronic occlusion" patented technology

Methods, systems, devices and kits for performing lung volume reduction in patients suffering from chronic obstructive pulmonary disease or other conditions using and comprising minimally invasive instruments introduced through the mouth (endotracheally) to isolate a target lung tissue segment from other regions of the lung and reduce lung volume. Isolation is achieved by deploying an obstructive device in a lung passageway leading to the target lung tissue segment. Once the obstructive device is anchored in place, the segment can be aspirated through the device. This may be achieved by a number of methods, including coupling an aspiration catheter to an inlet port on the obstruction device and aspirating through the port. Or, providing the port with a valve which allows outflow of gas from the isolated lung tissue segment during expiration of the respiratory cycle but prevents inflow of air during inspiration. In addition, a number of other methods may be used. The obstructive device may remain as an implant, to maintain isolation and optionally allow subsequent aspiration, or the device maybe removed at any time.

Devices, systems and methods are disclosed for the formation of an arteriovenous fistula. Embodiments include catheter apparatus including an ablation element for creating and/or modifying the fistula. The devices, systems and methods can be used to treat patients with one or more numerous ailments including chronic obstructive pulmonary disease, congestive heart failure, hypertension, hypotension, respiratory failure, pulmonary arterial hypertension, lung fibrosis and adult respiratory distress syndrome.

Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.

A device and method is provided for electrically stimulating the diaphragm to control breathing while inhibiting respiratory drive. A stimulation phase is identified. The stimulation phase is a period of time within the breathing cycle in which stimulation will inhibit respiratory drive. The respiratory drive inhibition may be used in a number of applications including but not limited to: improving or remodeling the heart in heart failure patients, treating apnea, chronic obstructive pulmonary disorder (COPD), and hypertension.

The methods and devices disclosed altering gaseous flow within a lung to improve the expiration cycle of individuals having Chronic Obstructive Pulmonary Disease.

This is directed to methods and devices suited for maintaining an opening in a wall of a body organ for an extended period. More particularly devices and methods are directed maintaining patency of channels that alter gaseous flow within a lung to improve the expiration cycle of, for instance, an individual having chronic obstructive pulmonary disease.

A long term oxygen therapy system having an oxygen supply directly linked with a patient's lung or lungs may be utilized to more efficiently treat hypoxia caused by chronic obstructive pulmonary disease such as emphysema and chronic bronchitis. The system includes an oxygen source, one or more valves and fluid carrying conduits. The fluid carrying conduits link the oxygen source to diseased sites within the patient's lungs.

The invention generally relates to method and apparatus for crossing an obstruction in a tubular member, and more particularly to a medical device method for crossing of a chronic occlusion in a subintimal or interstitial space of an artery.

Devices, systems and instructing methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease. The instructing method for treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.

A percutaneous single-phase surgical procedure is disclosed for creating a pneumostoma to treat chronic obstructive pulmonary disease. A pneumostomy instrument is introduced percutaneously through the thoracic wall, parietal membrane, visceral membrane and into the parenchymal tissue of the lung. The pneumostomy instrument crosses the pleural cavity between the parietal membrane and visceral membrane there being no pleurodesis between the membranes prior to passage of the pneumostomy instrument. A pneumoplasty device at the distal end of the pneumostomy instrument displaces and engages the parenchymal tissue of the lung and the pneumostomy instrument is used to secure the lung and visceral membrane in contact with the parietal membrane and chest wall. The pneumostomy instrument is left in place while a pneumostoma tract heals and pleurodesis occurs between the pleural membranes surrounding the pneumostomy instrument.

The invention generally relates to method and apparatus for crossing an obstruction in a tubular member, and more particularly to a medical device method for crossing of a chronic occlusion in a subintimal or interstitial space of an artery.

The invention discloses an auxiliary system and method for diagnosing the chronic obstructive pulmonary disease based on a support vector machine. The system comprises a multi-feature input unit and aprocessor, and the processor is provided with a multi-dimensional feature selection module, a support vector machine establishment module and a support vector machine model testing module; the multi-dimensional feature selection module establishes a first sample, the first sample is subjected to feature dimension reduction through a maximum dependence degree algorithm based on a rough set, multiple main feature sub-sets are obtained, and a sample set composed of the main feature sub-sets is established and used as a second sample; the support vector machine establishment module establishes asupport vector machine model; the support vector machine model testing module divides the second sample into a training set and a prediction set randomly, a trainer is generated, and whether or not the second sample obtained through dimension reduction expresses into the chronic obstructive pulmonary disease is predicted according to the support vector machine model. According to the auxiliary system and method, based on the support vector machine model, the relation between the chronic obstructive pulmonary disease and all physiological indexes of a patient is established, and the testing accuracy degree is high.

The present invention relates to methods for the treatment of exacerbation periods of pulmonary diseases, particularly chronic obstructive pulmonary diseases, by administering alpha-1 antitrypsin (AAT) to a subject in need thereof. Particularly, the present invention discloses the efficient treatment of exacerbation periods of pulmonary diseases by administering AAT via inhalation.

The invention relates to traditional Chinese medicine particles for treating the syndrome of insufficiency of lung and kidney qi caused by chronic obstructive disease of lung, which can effectively solve the problem of treatment medication for the syndrome of insufficiency of lung and kidney qi caused by chronic obstructive disease of lung. The traditional Chinese medicine particles are prepared from 6-12g of ginseng, 15-30g of radix astragali, 9-15g of cornel, 9-15g of wolfberry fruit, 6-12g of magnolia vine fruit, 6-12g of epimedium, 9-15g of thunberg fritillary bulb, 9-15g of red peony root, 9-15g of earthworm, 9-15g of perilla fruit, 15-30g of Japanese ardisia and 9-15g of dried orange peel. The traditional Chinese medicine particles have abundant raw materials and a scientific and advanced preparation method, have the efficacies of supplementing qi, benefiting lung and kidney, resolving phlegm and promoting blood circulation, and are innovations in the traditional Chinese medicine.

The invention provides a method for estimating if a patient suffering from Chronic Obstructive Pulmonary Disease (COPD) is approaching an exacerbation. Data with connected data indicative of levels of blood oxygen saturation obtained from the patient and their respective time of measurements are received, and a processor executes an algorithm involving: 1) calculating a statistical measure, e.g. a regression, of the level of blood oxygen saturation data taking into account available data within a time window with a limited length back in time, e.g. 30 days back in time, and 2) estimating if the patient is approaching an exacerbation by comparing a value obtained from said statistical measure to a reference value. Finally, an output indicative of a result of said estimation is generated. The method can ensure that COPD patients, e.g. in tele homecare, are properly treated before suffering from a severe exacerbation that could necessitate hospitalization. The COPD patient can easily measure blood oxygen saturation with an oxygen meter, and the algorithm can be executed on a mobile phone, a PC, on a server in contact with the patient via the interne, or on a dedicated oxygen meter device.

A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising a glucocorticosteroid for the treatment of asthma, chronic obstructive pulmonary disease, allergic rhinitis, or any other respiratory disease. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease.

The invention relates to a kit used for diagnosing the acute exacerbation period of chronic obstructive pulmonary disease. The kit comprises a cell factor and an enzyme labeled antibody thereof and is characterized in that the cell factor is interleukin 9, interleukin 18 binding protein A, C-C sequence ligand 28, a human skin T cell capture chemokine, a Beta cytokine, a monocyte chemoattractant protein-3, a monocyte chemoattractant protein-4, a lymphotoxin induced protein entering the T cell, a macrophage-derived chemokine, a human bone marrow suppression factor 1, a human macrophage stimulating protein, an osteopontin and a human thymus expressed chemokine. The invention firstly proposes that the cell factor can be used as a leading indicator for diagnosis of the acute exacerbation period of the chronic obstructive pulmonary disease.

An in vitro method aiding in the assessment of chronic obstructive pulmonary disease (COPD). The disclosure further relates to a method for assessing COPD from a sample, derived from an individual, by measuring the protein ASC in said sample in vitro.

The present invention discloses a Chinese medicine for effectively curing and preventing chronic obstructive disease of lung with obvious therapeutic effect. It is made up by using (by weight portion) 1-30 portions of astragalus root, 1-20 portions of pilose asiabell root, 1-15 portions of bile-processed arisaema root and 1-15 portions of silkworm through a certain preparation process.

The invention discloses an application of manufacturing statins gas spray in airway inflammation disease. The aerosol refers to a non-chlorofluorocarbon (CFC) solution formula. The fine subfraction (FPF) of the formula is high. The result display of a gas spray inhalant thermodynamic experience is quick and the effect is high so as to be used for treating bronchial asthma and a chronic obstructive pulmonary disease (COPD). The aerosol inhalant has the advantages of being good in anti-inflammation of airway and reducing adverse reaction caused by oral large doses.

The invention belongs to the field of biomedicine, relating to a method for establishing a chronic obstructive pulmonary disease superposition asthma model. By adopting a combined method of Drip endotoxin and smoke in trachea and egg albumin sensitization inspiration, the invention has reliable evaluation on aspects of lung tissue pathology, bronchial reactivity, serum cytokine, hypothalamus-hypophysis-adrenal axis and the like. The result of comparison with the pure chronic obstructive pulmonary disease or asthma model shows that the chronic obstructive pulmonary disease superposition asthma model has the characteristic change of the chronic obstructive pulmonary disease or asthma and weakens or intensifies the charateristic pathologic physiological changes. The invention has the advantages of simple preparation and good reliability and repetitiveness, and meets the disease pathologic physiological characteristics of the chronic obstructive pulmonary disease merger asthma, and can be used for the research of pathogenic mechanisms, prevention and treatment, and the like of the chronic obstructive pulmonary disease merger asthma.

The invention discloses a smoke exposure device used for establishing a chronic obstructive pulmonary disease model. The smoke exposure device mainly comprises a flow regulating device, a peristaltic pump and a closed box, wherein the flow regulating device comprises a smoke inlet pipe, an air inlet pipe, a smoke outlet pipe, an air outlet pipe, a smoke flow regulator and an air flow regulator; the smoke flow regulator is communicated with the smoke inlet pipe and the smoke outlet pipe respectively; the air flow regulator is communicated with the air inlet pipe and the air outlet pipe respectively; the smoke outlet pipe, the air outlet pipe and an air duct are communicated with one another; and the air duct is communicated with the closed box and is arranged inside a pump bed of the peristaltic pump. The smoke exposure device has the advantages of precisely regulating the smoke flow and the ratio of the smoke flow to air, facilitating quantitative analysis, improving the stability, reliability and repeatability of an experiment, and effectively avoiding the suffocation death of experimental animals, the cigarette smoke inhalation of experiment operators and atmospheric pollution, along with simple structure, convenient manufacturing and low cost.