42 results about "Kaempferide" patented technology

The invention discloses a method for extracting flavone ingredients and extracting kaempferide from sophoricoside and relates to the medicine. The method comprises the following steps: de-ionized water is added into the raw material of the sophoricoside, and reflux extracting is carried out in heating condition; extracting liquid-purpose diatomite and filtering is carried out; the filter solution is put on a macroporous resin column, impurity is washed by water and the filter solution is eluted by high-concentration ethanol; concentrating and drying is carried out on the eluting solution, thus obtaining the sophoricoside flavone extract; hydrolysate is added into the sophoricoside flavone extract and hydrolyzing is carried out in heating condition; pH value is adjusted to neutral after hydrolysis; steaming and removing alcohol, filtering, washing repeatedly by water are carried out on filter residue; drying and extracting are carried out on the filter residue by an extracting agent of mixed solution of aether and ethanol, the extract solution is steamed and the high-purity kaempferide is obtained. The method can be used for producing high-purity kaempferide flavone extract and kaempferide and has the advantages of simple process, good product quality, high degree of comprehensive utilization, being suitable for industrial production and low cost.

Disclosed is a superficial venules dredging preparation for treating cerebral arteriosclerosis which comprises the constituents (by weight portion) of quercetin 2-6.35 g, kaempferide 1.5-4.6 g, isorhamnetin 0.35-1g, ginkgolides 1-3g, ginseng saponin 0.6-2g, and right amount of auxiliary materials.

The invention discloses a method for near-infrared online monitoring content change of total flavonol glycosides in a folium ginkgo extraction process. The method comprises the following steps: associating data of a quercetin content, a kaempferide content and an isorhamnetin content measured by high performance liquid chromatography with near infrared spectral information by using a partial least squares method, and establishing a multivariate quantitative calibration model of the quercetin content, the kaempferide content and the isorhamnetin content in the folium ginkgo extraction process; quickly detecting the quercetin content, the kaempferide content and the isorhamnetin content in the unknown folium ginkgo extraction process by using the established multivariate quantitative calibration model. The method disclosed by the invention can be used for sampling an extracting solution in the folium ginkgo extraction process in real time and monitoring the content change of total flavonol glycosides in the folium ginkgo extracting solution in real time; the result is accurate and reliable.

The invention discloses a method for transforming gingko pollen flavonoid glycoside employing microorganisms. By adopting the method, the gingko pollen flavonoid glycoside is transformed by using lactobacillus BL1. The bacterial strain is facultative anaerobic, simple in cultivation condition, quick to grow, strong in fertility, safe and efficient, can generate a plurality of complex enzymes, and can carry out growth and propagation by taking single gingko pollen as matrix. The gingko pollen does not need wall-breaking treatment in advance; the flavonoid glycoside in the gingko pollen does not need complicated extraction and purification, and is efficiently transformed into corresponding aglycone; the capability of directly taking the gingko pollen as the raw material to transform the flavonoid glycoside into corresponding aglycone is high. The conversion ratio of flavonoid glycoside kaempferide-3,4'-diosgenin-diglucoside, 3-O-[6-O(alpha-L-rhamnose base)-beta-D-glucosyl] kaempferide and kaempferol-3-glucoside is up to over 99 percent. The kaempferol which is over 100 times more than the former can be obtained from the gingko pollen by transformation. Thus, the bioavailability is greatly improved.

The invention discloses a method for detecting quality of niaolukang particles. The formula of the niaolukang particle is as follows: preparing 1000g of leonurus, 1000g of eclipta, 1000g of plantago asiatica, 300g of junci medulla, 1000g of desmodium, 200g of liquorice, 1000g of rhizoma polygonati and 500g of rhizoma dioscoreae into granular formulation. In the method, quercetin (C15H1107) and kaempferol (C15H10O6) in desmodium are taken as a quality control index, and compared with stachydrine in the leonurus, the ingredients are stable in property, and generate small detection error. In addition, the high performance liquid chromatography is utilized for measuring content, so that the resolution rate is higher than that of other chromatography, the speed is high, and the measurement can be completed in ten minutes to dozens of minutes; the repeatability is high; a high performance liquid chromatography column can be used repeatedly; and the automatic operation is conducted, and the analysis accuracy is high. Therefore, the accuracy, the specificity and the credibility of a detection result in the quality control process of products are improved.

The invention provides a detection method of persimmon leaf quality; which is characterized in that: the method comprises the following steps: sample solution preparation: the persimmon leaf powder to be detected is taken out and mixed with methyl alcohol to obtain a first mixed solution which carries out ultrasonic wave treatment to filter the first mixed solution, and the obtained filtrate is concentrated to obtain test article solution; kaempferide, quercetin and methanol are mixed to obtain a second mixed solution which is used as reference substance solution; detection: the sample solution is measured by thin layer chromatography, the chromatograph of the test article is observed weather to display the spots with same color with the reference substance at the same position of the chromatograph of the reference substance solution. If yes, the persimmon leaf powder to be detected is determined to contain the kaempferide and the quercetin; compared with the method that the persimmon leaf quality is determined by the characteristics in the prior art, the detection method can accurately determine the drug effective ingredients of the persimmon leaf to be detected.

The present invention discloses a detection method for a flavone component in clematis filamentosa dunn, and an application thereof. According to the present invention, a kaempferide-containing methanol solution is adopted as a reference substance solution; a high performance liquid chromatography method is adopted to carry out qualitative and/or quantitative analysis for the flavone component in a prepared clematis filamentosa dunn solution requiring detection. The method of the present invention can be applicable for detections of the flavone component in extracts, preparations, decoction pieces or medicinal materials, and no interference is generated to the negative result, wherein the extracts contain the clematis filamentosa dunn component, and the extracts are prepared by the same or the similar extraction methods. In addition, the method of the present invention has strong specificity and good reproducibility, such that the uniform, stable, effective and controllable preparation assortment of the clematis filamentosa dunn can be effectively ensured, and the process normalization, the quality stability and the quality uniformity are ensured.

The present invention provides novel compounds with radioprotective effects and pharmaceutically acceptable salts, prodrugs, and solvates thereof as shown in formula (I). Ar is selected from astaxanthin, anthocyanins, proanthocyanidins, resveratrol, VitaminA, VitaminC, VitaminE and flavonoids such as apigenin, luteolin, kaempferide, quercetin, glycyrrhizin, hesperidin, dihydroquercetin, Dihydromorin, (+) catechin, (-) epicatechin, ginkgetin, Ophiopogonone A, rubrofusarin, baicalein and the like, R1 is selected from the following groups shown in the specification, further, the present invention provides a preparation method and use of the compounds and the derivatives thereof in treatment of radiation injuries.

The invention discloses enzyme-rich blood replenishing four herbs decoction and a preparation method thereof. The four herbs decoction is mainly prepared from angelica sinensis extract, ligusticum chuanxiong hort extract, Chinese herbaceous peony extract, prepared rehmannia root extract, a plant enzyme magnetized solution, A-methyl ursolate, kaempferide, hydroxyethyl cellulose and chicken soup. The preparation method includes the following steps that 1, angelica sinensis extract, ligusticum chuanxiong hort extract, Chinese herbaceous peony extract, prepared rehmannia root extract, a plant enzyme magnetized solution, A-methyl ursolate, kaempferide, hydroxyethyl cellulose and chicken soup are selected according to the proportion for use; 2, all the extract are stirred and mixed evenly to obtain mixed liquid; 3, the mixed liquid, the adjuvants, the ingredients and the plant enzyme magnetized solution are sequentially added into the chicken soup to obtain blood replenishing four herbs decoction. The prepared blood replenishing four herbs decoction can replenish blood for women without causing blood stasis, the body recovery effects of the women are increased, and the absorption of theintestinal tracts of the women to nutrient components and various components of the blood replenishing four herbs decoction is improved.

The invention provides a medicinal preparation containing albizia flower total flavone and medical application. The albizia flower total flavone contains the following components in percentage by weight: 41-50 percent of quercitrin, 0.1-10 percent of quercetin, 0.1-5 percent of kaempferide, 0.1-2 percent of quercetin-3-0-alpha-L-arabinoside, and quercetin-3-0-alpha-L-arabinoside. The invention also discloses a method for preparing the albizia flower total flavone medicinal preparation with high dissolution rate, as well as application of the albizia flower total flavone and medical preparation thereof serving as basic active substances in preparing a medicine for treating depression.

The invention belongs to the field of natural compound extraction, and particularly relates to a method for extracting and detecting flavonoids from galangal. In the prior art, subcritical extractionof the flavonoids in galangal mostly adopts an organic solvent as an extraction reagent or is combined with ultrasonic extraction. The method only adopts subcritical water as the extraction reagent, and studies the optimum preparation conditions for extraction of seven substances of quercetin, pinocembrin, isorhamnetin, kaempferol, kaempferide, galangin and curcumin. A galangal extract obtained bythe preparation method can be directly applied to an oral preparation due to the fact that an organic reagent is not introduced during the preparation process. In addition, a high-performance liquidphase detection condition for the galangal extract is provided, and can simultaneously detect flavonoid compounds, and the repeatability is good. The extract and the method are applied to the preparation of cardiovascular drugs and have important production significance.

The invention discloses a method for making a pot-stewed chicken having the health-care function. Before being marinated, a washed chicken is soaked in a Chongcha tea solution for 1-5 hours, and then the surface of the chicken is drained after soaking is completed. Chongcha tea components are added in the method for making the pot-stewed chicken having the health-care function, and according to scientific research, it is confirmed that the Chongcha tea is rich in more than ten kinds of amino acids and trace elements, such as calcium, magnesium, zinc, selenium, flavone, tea polyphenols, catechins, glycosides, quercetin, rhamnose, glutamic acid, kaempferide, myricetin, alanine, biological fungi and apione, necessary for the human body. The chicken is tasty, delicious, attractive and refreshing and has the pharmaceutical functions of whetting the appetite, tonifying the spleen, refreshing, dispelling the effects of alcohol, removing toxins, clearing away heat, reducing blood pressure and the like. The made chicken is bright in color, dense, solid, salty and spicy in taste and tender in meat and has an unique health-care effect.

The invention discloses an application of methoxy flavonoid compound in preparation of anti-vitiligo medicine. According to the application of the methoxy flavonoid compound in preparation of the anti-vitiligo medicine, the methoxy flavonoid compound with 2-phenylchromone mother nucleus has an anti-vitiligo effect and represents compounds including kaempferide, isorhamnetin and kaempferol 3, 4 '-dimethyl ether. The methoxyflavone compound promotes regeneration and neogenesis of melanocytes and induces accumulation of melanin by promoting expression of key genes in a melanogenesis pathway, and maintains melanin steady state and reduces decomposition of original melanin cytochrome by up-regulating expression of melanin steady state related protein adcy6; meanwhile, the increase of active oxygen under physiological dose is induced, the expression of glutathione synthesized gclm, gclc and other related genes is down-regulated, melanin metabolism is reduced, so that the effect of treating vitiligo is achieved, and the methoxy flavonoid compound has important value and development prospect in the research and development of vitiligo treatment medicine.

The invention discloses a polyvinyl chloride cable material with excellent flame resistance. The polyvinyl chloride cable material is prepared from the following raw materials in parts by weight: 110to 115 parts of polyvinyl chloride resin, 4 to 8 parts of acetylene carbon black, 1 to 2 parts of an anti-aging agent, 5 to 9 parts of a flame retardant, 0.7 to 1.0 part of kaempferide, 2 to 5 parts of triaryl phosphate, 3 to 6 parts of chlorinated paraffin, 2 to 5 parts of epoxidized soybean oil, 1 to 2 parts of barium stearate, 1 to 3 parts of toner, 6 to 10 parts of a rare earth stabilizer, 11to 16 parts of calcium carbonate, and 17 to 21 parts of dioctyl terephthalate. The invention further discloses a preparation method of the polyvinyl chloride cable material with excellent flame resistance. The cable material has flame resistance and excellent mechanical property, can meet the market demand, is beneficial to the improvement of safety performance of wires and cables, and has a widemarket prospect.

The invention provides a preparation method of herba lysimachiae granules. The preparation method comprises the steps of adopting herba lysimachiae as a raw material; adopting water (90 to 95 DEG C) for forcedly and dynamically recycling extracting for three times; vacuum concentrating an extracting solution to obtain a herba lysimachiae extract; adding appropriate pharmaceutic adjuvant and appropriate amount of flavoring agent for highly dispersing, and then preparing to form mixed dry extract powder through a vacuum low-temperature continuous drying technology; adding ethyl alcohol for stirring and mixing to obtain the granules. According to the preparation method adopted by the invention, the contents of quercetin and kaempferide in the herba lysimachiae granules can be remarkably improved, and the increased range achieves 250 percent; the dosage of the commercially available herba lysimachiae granules for every time can be reduced by not less than 70 percent, so that the patient adaptability is greatly improved; the operation cost can be reduced by not less than 1/3, the energy consumption can be reduced by not less than 40 percent, and the modernization of a traditional Chinese medicine can be fully reflected.

The invention discloses a method for identifying cyclocarya paliurus. The method comprises the following steps: (1) preparing a test solution; and (3) respectively preparing a methanol solution of kaempferide and a methanol solution of quercetin as reference substance solutions, respectively dripping the two reference substance solutions and the test solution on the same silica gel G thin-layer plate, developing by using dichloromethane-ethyl acetate-formic acid as a developing solvent, taking out, airing, spraying an ethanol solution of aluminum trichloride, heating the sample solution in the environment of 105 +/-5 DEG C until the spots are clearly developed, placing the sample solution under an ultraviolet lamp for inspection, and when the fluorescent spots in the chromatogram of the sample solution can find the corresponding fluorescent spots in the corresponding position of the chromatogram of one of the two reference substance solutions, determining that the powder to be detected is cyclocarya paliurus powder. The method is high in cyclocarya paliurus identification accuracy, meanwhile, the content of kaempferide in cyclocarya paliurus can be measured, the quality grade of cyclocarya paliurus can be evaluated, operation is easy, reaction is fast, and rapid detection and evaluation of the quality of cyclocarya paliurus are achieved.

The invention provides a sliced noodle seasoning, a sliced noodle seasoning packet and a preparation method, and relates to the technical field of foods and ingredients thereof. The sliced noodle seasoning is prepared from the following components in parts by weight: 0.5-1.5 parts of kaempferide, 0.05-0.15 part of clove, 0.4-0.8 part of fennel, 0.4-0.8 part of Amomum tsao-ko, 0.3-0.7 part of cinnamon, 0.3-0.5 part of angelica dahurica, 0.4-0.8 part of Chinese prickly ash, 0.3-0.5 part of pepper, 1.0-2.0 parts of star anise, 0.2-0.4 part of costus root, 0.3-0.5 part of rhizoma nardostachyos, 0.1-0.3 part of hay, 0.4-0.6 part of Pictocarpus heterophyllus, 0.5-0.9 part of dried orange peel, 0.5-0.9 part of katsumade galangal seed and 0.3-0.7 part of Amomum Kravanh Pierre ex Gagnep. In addition, the invention also provides the sliced noodle seasoning packet and the preparation method thereof. According to the seasoning for the sliced noodles, the spices in a specific ratio are selected forclearing damp, tonifying spleen, warming middle warmer and nourishing stomach, so that the finally prepared sliced noodles are extremely good in flavor, sufficient in fragrance, stable in taste and suitable for being used in families, the taste of the prepared sliced noodles is not inferior to that of sliced noodles eaten outside, and the operation is simple and convenient. The sliced noodle seasoning packet provided by the invention is more convenient than the sliced noodle seasoning.

The invention discloses a gingko general flavone sublingual tablet and a preparation method thereof.The sublingual tablet is prepared from, by weight, 1-260 parts of gingko general flavone, 2-25 parts of disintegrating agent and 35-245 parts of filler.Gingko general flavone is prepared from, by weight, 35-50% of quercetin, 6-16% of kaempferide and 15-25% of isorhamnetin.The gingko general flavone sublingual tablet is prepared by organically combining disintegrating agent with filler, and the tablet is put under a tongue when taken and can be rapidly disintegrated and absorbed by sublingual mucosal and directly enter blood circulation through jugular veins and superior vena cava to rapidly act so as to rapidly relieve migraine symptoms.Meanwhile, the tablet is particularly suitable for the aged and other patients having difficulty in swallowing and patients having difficulty in taking water in special environments such as battlefields, outdoor environments and tourist environments.

The invention relates to a quantitative analysis method of kaempferide in a Shuxuening injection, and belongs to the technical field of pharmaceutical analysis. The quantitative analysis method of the kaempferide in the Shuxuening injection comprises the following steps: preparation of a reference solution, preparation of a test solution and determination. The quantitative analysis method is simple, convenient and accurate, good in specificity and good in repeatability, the content of the kaempferide in the Shuxuening injection can be accurately measured by adopting high performance liquid chromatography, and a basis is provided for material basic research of the Shuxuening injection.