9 results about "Kaempferide" patented technology

The invention discloses an application of kaempferide and 4, 7-dimethyl naringenin in inhibition of synthesis of deoxynivalenol, in particular to an application of kaempferide and 4, 7-dimethyl naringenin in prevention and treatment of wheat scab, and a pathogenic bacterium of the wheat scab is fusarium graminearum. The kaempferide and the 4, 7-dimethyl naringenin are used for preventing and treating the wheat scab by inhibiting the biosynthesis of deoxynivalenol and / or inhibiting the expression of a key gene for synthesizing deoxynivalenol. The kaempferide and the 4, 7-dimethyl naringenin involved in the invention are wheat endogenous secondary metabolites, are derived from plants, have low toxicity to crops, are easy to degrade in the environment, and do not have the problem of residual pollution of chemical bactericides. Meanwhile, as the action mechanism is different from that of the existing chemical bactericide, the bactericide has no cross resistance with the common bactericide, and is suitable for resistance treatment and a green agricultural production system.

The invention relates to a plant active ingredient for inhibiting synovial cell inflammatory response and a method for treating rheumatoid arthritis by using the plant active ingredient. The active ingredient is selected from one or more of kaempferide, quercetin, luteolin and alpinetin sesquiterpenoids, and is derived from medicinal plants such as alpinia pumila, glabrous sarcandra herb or herba epimedii and the like. The high-purity flavonoid monomer is obtained through a specific extraction process including ethanol reflux extraction, ethyl acetate extraction, macroporous resin enrichment and silica gel column chromatography separation. The composition can remarkably inhibit activation of NF-kappa B signal channels in synovial cells in vitro, reduce expression levels of inflammatory factors TNF-alpha, IL-1beta and IL-6 and reduce generation of reactive oxygen species (ROS) and nitric oxide (NO), and has a good anti-rheumatic arthritis effect. The active component can be prepared into various dosage forms such as capsules, granules, injections and the like, and is suitable for treatment or adjuvant treatment of rheumatic arthritis and related diseases thereof.

This invention discloses a method for constructing a fingerprint spectrum of a throat-clearing hard candy and a method for detecting its component content, belonging to the field of component detection technology. In this invention, the throat-clearing hard candy sample solution is analyzed by high-performance liquid chromatography (HPLC) to obtain a fingerprint spectrum of the candy; and the content information of the components is obtained through the external standard method, realizing qualitative and quantitative analysis of the components of the throat-clearing hard candy. Specifically, it involves the simultaneous qualitative and quantitative analysis of the following 10 components: gallic acid, neochlorogenic acid, chlorogenic acid, isorhamnetin-3-O-glucose-7-O-rhamnoside, rutin, luteolin, isochlorogenic acid B, isorhamnetin-3-O-glucose, glycyrrhizic acid, and kaempferol, providing a reliable and quantifiable standard for the quality assessment of throat-clearing hard candy. The chromatogram obtained by the method of this invention has the characteristics of stable baseline, high peak resolution, strong specificity, and good peak symmetry.

The invention belongs to the technical field of medicines, and particularly relates to application of kaempferide in preparation of anti-Seneca virus medicines. The invention also discloses an anti-Seneca virus pharmaceutical composition of the kaempferide. Experiments prove that the kaempferide can obviously inhibit the replication of Seneca virus in both BHK-21 cell and PK-15 cell models, and has no obvious toxicity to cells in an effective action concentration range. Through deep study on the antiviral mechanism, the kaempferide can enhance the antiviral reaction by regulating the innate immune pathway of host cells, and a new treatment strategy and drug choice are provided for infectious diseases caused by Seneca virus.

This invention relates to the use of kaempferol and / or its metabolites in the preparation of antiviral drugs, wherein the viruses include any one or a combination of at least two of influenza A virus, vesicular stomatitis virus, severe fever with thrombocytopenia syndrome virus, or Crimean-Congo hemorrhagic fever virus. This invention demonstrates that kaempferol and its metabolites can enhance and prolong the type I IFN-activated JAK / STAT pathway, enhance innate immunity, and possess broad-spectrum antiviral activity.

The invention relates to the technical field of traditional Chinese medicines, in particular to a method for extracting hydroxysafflor yellow, kaempferol and 6-methyl kaempferol in safflower and formula granules thereof, which specifically comprises the following steps: (1) adding 4-24 times of drinking water into a multifunctional extraction tank, heating to 40-100 DEG C, putting the safflower into the multifunctional extraction tank while the safflower is hot, extracting for 1-3 times by using hot water at 40-100 DEG C, extracting for 20-120 minutes each time, filtering, and concentrating to obtain filtrate; collecting an extracting solution; (2) adding 6-20 times of water into safflower dregs extracted with hot water, decocting and extracting for 1-2 times, 20-120 minutes each time, filtering and collecting an extracting solution, and (3) adding 6-20 times of water into safflower dregs extracted with hot water, extracting for 1-3 times, 0.5-2 hours each time, filtering and collecting an extracting solution, merging the three extracting solutions, and spray-drying to obtain the traditional Chinese medicine composition. According to the preparation method, a hot water feeding and warm water decoction extraction mode is adopted, so that the content of hydroxysafflor yellow and kaempferide in the safflower formula granules can continuously and stably reach a relatively high level, the transfer rate of active ingredients in the safflower formula granules is ensured to be consistent with the standard of the safflower formula granules, and the product quality of the safflower formula granules is improved.

The invention discloses a Ganhai Weikang capsule specific chromatogram based on a multi-component material basis as well as a construction method and application thereof, and belongs to the technical field of quality control and evaluation of Chinese patent medicines. A high performance liquid chromatography-high resolution mass spectrometry method is adopted for detection, and glycyrrhizic acid, liquiritin, liquiritigenin, apiose liquiritin, naringenin, chlorogenic acid, syringic acid, protocatechuic acid, hesperidin, narirutin, p-coumaric acid and kaempferide are taken as reference substances; the specific chromatogram is successfully constructed by detecting different batches of Ganhai Weikang capsules. The method for detecting the specific chromatogram of the Ganhai Weikang capsule, established by the invention, is simple and convenient to operate, high in precision and rapid in analysis, can realize efficient and synchronous detection of 12 characteristic components, and has good stability, accuracy and reproducibility. According to the method, synchronous and rapid analysis of multiple components is realized, the detection efficiency is remarkably improved, and reliable scientific basis and technical support are provided for quality control and clinical curative effect guarantee of the Ganhai Weikang capsules.

The invention discloses a traditional Chinese medicine composition for treating burns and scalds and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 10-20 parts of rheum officinale, 4-12 parts of musk, 5-15 parts of frankincense, 5-15 parts of catechu, 10-20 parts of liquorice, 8-16 parts of sanguisorba officinalis and 10-40 parts of sesame oil. The formula is easy to prepare, convenient to take, rapid in pain relieving, rapid in wound drying, rapid in scabbing, short in treatment course, relatively low in treatment cost, free of skin grafting and wide in application range; traditional Chinese medicine compositions such as rheum officinale, musk, frankincense, catechu, liquorice, sanguisorba officinalis and sesame oil are jointly used in the traditional Chinese medicine compound preparation for treating burns and scalds, sanguisorba officinalis and catechu contain flavanol substances such as catechin and epicatechin and flavone components such as quercetin and kaempferide, recovery of burns and scalds is facilitated, and wound healing is accelerated; the liquorice inhibits platelet aggregation and prevents thrombosis, and the rhubarb has an obvious inhibiting effect on staphylococcus aureus and pseudomonas aeruginosa and relieves various inflammatory reactions.

The application discloses a kind of pharmaceutical composition and preparation method thereof.It is made of the following weight parts raw material components: quercetin 2-5 parts, kaempferol 1-3 parts, isorhamnetin 3-8 parts, isoginkgetin 3-8 parts, ginsenoside Rg1 1-3 parts, ginsenoside Rb1 3-8 parts, ginsenoside Rf 3-8 parts, starch 15-50 parts, calcium carbonate 10-30 parts, water 30-120 parts.The pharmaceutical composition of the application directly uses the main active components in ginseng extract and ginkgo biloba leaf extract.It is found through experimental research that the combination of isorhamnetin and isoginkgetin in the component, the combination of ginsenoside Rb1 and ginsenoside Rf has synergistic effect.