The invention discloses a medicine for treating lumbar disc herniation with syndrome of blood stasis and a preparation method of the medicine, wherein the medicine consists of the following medicinal raw materials: heterophyllous eupatorium herb, lycopodium clavatum, beautiful spotflower herb, lamiophlomis rotate, hedera helix, herba pyrolae, amber, herba lycopi, motherwort, ground beetles, nude fern herb, radix achyranthis bidentatae, tall monkshood root, herba scutellariae barbatae, fruticose breynia juvenile, herba salviae chinensis, cattail pollen, cortex moutan radicis, radix zanthoxyli, orpiment, lysimachia capillipes hemsl, phaseolus calcaratus, flos citri sarcodactyli, camphor root, radix chimonanthus, lindernia ruellioides, fructus piperis longi, rhizoma homalomenae, angelica sinensis, folium et cacumen murryvae and borneol. The medicine disclosed by the invention has functions of promoting blood circulation and removing stasis, regulating qi and relieving pain, and the medicine is mainly used for treating the symptom of blood stasis due to lumbar disc herniation. On the basis of the theory of traditional Chinese medicine, the medicine, from a holistic view, takes effects of improving a relation between protrusion and nerves, relaxing muscles in waist and back, recovering the normal alignment of lumbar vertebra, relieving pain, improving fibrous cartilage and the like by regulating blood circulation in whole body and by promoting blood circulation and removing stasis; and the medicine is safe and effective, convenient in administration, easy to be accepted in patients and applicable to clinical market development.