22 results about "Cross-resistance" patented technology

The invention belongs to the technical field of agricultural microorganisms, and discloses a bacillus flexus strain BJ699 and application thereof in strawberry production. Specifically, the invention provides a novel bacillus flexus strain BJ699, and the preservation number of the strain BJ699 in the China Center for Type Culture Collection is CCTCC (China Center for Type Culture Collection) NO: M20252013. The invention also provides a microbial agent containing the strain BJ699 as an active component and application of the strain BJ699 in preparation of a microbial agent for prevention and control of strawberry root rot pathogenic bacteria and / or degradation of pyraclostrobin. The new strain or the microbial agent containing the strain comes from the natural environment, has no cross resistance to existing bactericides and insecticides, has the advantages of high efficiency, low toxicity, no environmental pollution, low possibility of drug resistance generation and the like, and has a wide application prospect.

The invention relates to the technical field of medicines, and particularly discloses a screening target of an antibacterial drug, application and a screening method, and the screening method comprises the following steps: testing the interaction between a candidate drug and the target; functional verification of the target protein; testing the antibacterial activity of the candidate drugs; and carrying out an in-vitro antibacterial curve test, evaluating the sterilization or antibacterial effect of the candidate drug on different bacteria, and comparing the change of bacterial gene expression before and after the treatment of the candidate drug through omics analysis (transcriptome and proteome analysis). A new direction is provided for research and development of antibacterial drugs by discovering a new antibacterial target, such as Spx and SodA, of the ISP I except for acting on bacterial ribosomes, a new drug without cross resistance with traditional antibiotics can be developed according to the drug design of the new target, the antibacterial effect is improved, the new antibacterial target of the ISP I in the colimycin and the action mechanism of the new antibacterial target are disclosed, and the application of the ISP I in the colimycin in preparation of the antibacterial drugs is promoted. And a new thought and a new method are provided for research and development of antibacterial drugs.

The invention provides a compound as shown in a formula (I), a stereoisomer thereof, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a crystal form thereof, an isotope derivative thereof, a prodrug thereof and a metabolite thereof. The solvate or hydrate of the compound can be used for preparing a pharmaceutical composition for treating and / or preventing diseases related to mycobacterium tuberculosis and / or nontuberculous mycobacterium. The compound provided by the invention has an excellent bactericidal effect and strong specificity, has no cross resistance with the existing antituberculosis drugs, and provides a breakthrough direction for treatment of drug-resistant tuberculosis.

The invention relates to the field of chemical engineering and pesticides, in particular to an isoxazoline derivative containing dihydrazide as well as a preparation method and application of the isoxazoline derivative. The bishydrazide-containing isoxazoline derivative is a compound as shown in a formula (1). The novel isoxazoline derivative containing dihydrazide is obtained by combining an isoxazoline structure and a dihydrazide structure and carrying out special structural design, and the isoxazoline derivative containing dihydrazide has no cross resistance with existing insecticides, is relatively low in toxic and side effects, and can be applied to the field of pesticides. Meanwhile, the insecticidal composition has broad-spectrum insecticidal activity and an excellent insecticidal effect, and the problem that the pesticide resistance of pests such as spodoptera frugiperda and plutella xylostella is enhanced at present is effectively solved. Formula (1) # imgabs0 #

The invention provides a pyrroline diketone compound as well as a preparation method and a bactericide application thereof. The name of the pyrroline diketone compound is 1-(2, 6-diethyl-4-methylphenyl)-1H-pyrrole-2, 5-diketone, and the structural formula of the pyrroline diketone compound is shown as a formula I. The pyrroline diketone compound and an agricultural bactericide taking the compound as an effective component are used for preventing and treating various plant diseases caused by plant pathogenic fungi, oomycetes and bacteria. The compound is novel in structure and action mechanism, convenient in synthesis method and good in safety, has broad-spectrum and efficient antibacterial activity, does not have cross resistance with other existing bactericides, can be used for preventing and treating plant diseases of vegetables, fruits, food crops, oil crops, commercial crops, garden crops, traditional Chinese medicinal materials and the like, and has broad application prospects. And particularly, the composition has good chemical protection effect and systemic treatment effect on drug-resistant crop diseases.

The invention belongs to the technical field of pesticides, and relates to 11 bactericide compositions for mainly preventing and treating crop diseases caused by pyricularia oryzae and colletotrichum gloeosporioides. The compound YJY-22 provided by the invention is novel in structure and unique in action mode, and has no cross resistance with isoprothiolane, fenoxanil, pyraclostrobin, tricyclazole, azoxystrobin, mancozeb, captan, difenoconazole, prochloraz, chlorothalonil and tebuconazole. As the action mechanism of the compound YJY-22 is different from that of the medicament, and the compound YJY-22 and the medicament have no cross resistance, the compound YJY-22 and the medicament are compounded, so that the sterilization range can be expanded, the sterilization effect can be enhanced, the drug resistance of phytopathogen can be delayed, the safety to crops is good, the prevention and control spectrum is expanded, and the requirements of pesticide reduction and synergism are met.

The plant source insecticide contains effective components of parathion and avermectin, the weight ratio of parathion and avermectin is 10-50:1, and is supplemented with an acceptable agricultural adjuvant to form one of emulsifiable concentrate, wettable powder, water dispersible granule, water emulsion or suspension agent suitable for agricultural use, and belongs to the field of pesticides. The plant source insecticide shows activity on peridroma saucia, aphid and cotton red spider, especially high acaricidal activity on red spider. The prevention and treatment effect on citrus red spider is obviously improved after parathion and avermectin are compounded, which shows that the combination of parathion and avermectin has significant synergistic effect on citrus red spider. Parathion is derived from Chinese herbal medicine plant, and there is no problem of pesticide residue, and the risk of drug damage is greatly reduced. At the same time, the two single agents of the composition have great difference in chemical structure and completely different action mechanism, and there is no cross resistance, which can delay the resistance problem caused by the use of the two single agents alone.

The invention discloses a molecular marker for interaction resistance of panonychus citri to insecticides as well as application and a detection method of the molecular marker. According to the molecular marker for the cross resistance of the panonychus citri to the multiple medicaments, the molecular marker is carboxylesterase genes PcCCE11 and / or PcCCE7, the nucleotide sequence of the PcCCE11 gene is as shown in SEQ ID NO.1, and the nucleotide sequence of the PcCCE7 gene is as shown in SEQ ID NO.2. The invention further discloses a preparation method of the molecular marker for the cross resistance of the panonychus citri to the multiple medicaments.

Disclosed are five fungicidal compositions and uses thereof in prevention and treatment of Fusarium diseases of crops, belonging to the technical field of plant disease prevention and treatment. The active ingredients of the compositions comprise a compound ZJS178 of formula (I) and a triazole fungicide, or a compound ZJS178 and a succinate dehydrogenase inhibitor fungicide, or a compound ZJS178 and a pyrrole fungicide, or a compound ZJS178 and an imidazole fungicide, or a compound ZJS178 and a strobilurin fungicide. The compositions of the present invention have a compounded synergistic effect and no cross-resistance, can significantly improve the fungicidal activity and efficacy, are beneficial for overcoming and delaying the resistance of pathogens, have good crop safety, and meet the requirements of pesticide quantity reduction and efficacy increase.

11 fungicide compositions mainly used for controlling crop diseases caused by Pyricularia oryzae and Colletotrichum spp.. Compound YJY-22 has a novel structure and a unique mode of action, and exhibits no cross-resistance with isoprothiolane, fenoxanil, pyraclostrobin, tricyclazole, azoxystrobin, mancozeb, captan, difenoconazole, prochloraz, chlorothalonil, or tebuconazole. Because compound YJY-22 and the described agents have different mechanisms of action and have no cross-resistance, combining compound YJY-22 and the described agents not only can broaden the antifungal spectrum and enhance antifungal efficacy, but also can delay fungicide resistance of plant pathogens, ensure high crop safety, expand the control spectrum, and meet the requirement of pesticide reduction with increased efficiency.

The invention provides an aryl isoxazoline compound as well as an isomer or pharmaceutically acceptable salt thereof and application thereof, the structure of the aryl isoxazoline compound is shown as a formula (I), in the formula (I), R1, R2, R3, R4 and R5 are respectively and independently selected from hydrogen atoms, halogen atoms, cyano groups and other groups, and R1, R2, R3, R4 and R5 are independently selected from hydrogen atoms, halogen atoms, cyano groups and other groups; l1 is an alkylene group of a C1-C6 straight chain or branched chain; and R6 is selected from a substituted or unsubstituted C2-C8 alkenyl group, a substituted or unsubstituted C2-C8 alkynyl group, a substituted or unsubstituted C3-C6 cycloalkyl group, a substituted or unsubstituted C1-C4 alkylene group, a C3-C6 cycloalkyl group or C (= O) R7. The aryl isoxazoline compound has no cross resistance with existing insecticides, has an efficient control effect on pests, and particularly has an excellent pesticide effect on rice-stem borers. In addition, the compound is low in toxicity, environment-friendly and suitable for large-scale application.

The application provides a pyrroline dione compound and a preparation method and fungicide application thereof. The pyrroline dione compound is named 1-(2,6-diethyl-4-methylphenyl)-1H-pyrrole-2,5-dione, and a structural formula is shown as formula I: the pyrroline dione compound and an agricultural fungicide with the compound as an effective component are used for preventing and treating various plant diseases caused by plant pathogenic fungi, oomycetes and bacteria. The compound is novel in structure and action mechanism, convenient in synthesis method, good in safety, has broad-spectrum and high-efficiency antibacterial activity, has no cross resistance with other existing fungicides, can be used for preventing and treating plant diseases of vegetables, fruits, food crops, oil crops, economic crops, garden crops and Chinese medicinal materials, and has good chemical protection and internal absorption treatment effects on resistant crop diseases.

The invention belongs to the technical field of crop control, and particularly relates to saline-alkaline tolerant bacillus velezensis capable of colonizing trichosanthes kirilowii maxim and application of the bacillus velezensis. The bacillus velezensis is bacillus velezensis MH24, the preservation number of the bacillus velezensis MH24 is CCTCC (China Center For Type Culture Collection) NO: M20221680, and the bacillus velezensis MH24 can be used for preventing and controlling diseases such as trichosanthes kirilowii maxim anthracnose, bacterial angular leaf spot, virus diseases, root rot and root-knot nematode. And the composition has no cross resistance with existing bactericides and insecticides. The strain has saline-alkaline tolerance and can be used for prevention and control and yield increase of soil-borne diseases of trichosanthes kirilowii maxim in salinized soil. Compared with the existing chemical synthetic pesticide for prevention and treatment, the compound is from the natural environment, has the advantages of high efficiency, low toxicity, no environmental pollution, low possibility of generating drug resistance and the like, and has a wide application prospect.

The invention discloses a benzimidazole salt compound with insecticidal activity as well as a preparation method and application thereof, and aims to solve the problem that an existing insecticide cannot give consideration to insecticidal activity and resistance at the same time. The salt compound containing the benzimidazole structure provided by the invention has good insecticidal activity on aedes aegypti, mythimna orientalis and plutella xylostella, has no cross resistance or obvious negative cross resistance on aedes aegypti pyrethroid-resistant strains, and has the control effect on the plutella xylostella equivalent to that of commercial insecticide permethrin sold in the market. A lead compound with application potential and an innovative research and development thought are provided for creating novel resistance treatment pesticides with negative cross resistance characteristics.

The invention belongs to the field of biological medicines, and particularly relates to a Psammulin A and podophyllotoxin spliced compound and application thereof in preparation of a medicine for treating tumors. The compound is a compound as shown in a formula (I), a derivative, and pharmaceutically acceptable salt or hydrate thereof. The spliced compound is applied to the fields of preparation and tumor resistance; the invention also relates to application of the compound in preparation of drugs for resisting paclitaxel-resistant tumors. The invention also relates to application of the compound in anti-osimertinib drug-resistant tumors. The intracellular activity of the spliced compound disclosed by the invention is superior to that of Psammulin A and etoposide, and the spliced compound has no cross resistance with paclitaxel and osimertinib.

The invention discloses a small-molecule inhibitor of a targeted phytophthora sterol sensing receptor SSRK1 and application of the small-molecule inhibitor, and belongs to the technical field of pesticide biology. The inhibitor can specifically bind to a sterol binding site of SSRK1 and competitively block a natural sterol signal, so that comprehensive inhibition on growth, development and pathogenicity of phytophthora is realized. The compound shows remarkable bacteriostatic activity on various phytophthora (such as phytophthora sojae, phytophthora infestans and phytophthora capsici), and can effectively prevent and treat crop diseases such as soybean root rot, potato late blight and phytophthora capsici. The small-molecule inhibitor provided by the invention has the characteristics of novel target spot, unique action mechanism, broad spectrum, high efficiency, environmental friendliness and the like, is not easy to generate cross resistance with the traditional bactericide, and provides a new candidate molecule and preparation development approach for green prevention and control of phytophthora.

The invention discloses a quinolone compound as well as a preparation method and application thereof, and belongs to the technical field of medicines. The invention provides a novel quinolone compound, which comprises a pharmaceutical salt, a hydrate, a solvate, a polycrystal or a co-crystal of the quinolone compound, and a pharmaceutical prodrug or derivative of the quinolone compound. The quinolone compound and the derivative thereof provided by the invention can be used for preparing related medicines for treating bacterial infection, and the compound has remarkable anti-MRSA activity and has no cross resistance with the existing fluoroquinolone medicines.

Provided in the present application are a pyrrolinedione compound, and a preparation method therefor and the use thereof as a microbicide. The pyrrolinedione compound is 1-(2,6-diethyl-4-methylphenyl)-1H-pyrrole-2,5-dione. The pyrrolinedione compound and an agricultural microbicide using the pyrrolinedione compound as an active ingredient are used for controlling a variety of plant diseases caused by phytopathogenic fungi, oomycetes and bacteria. The pyrrolonedione compound has a novel structure and action mechanism, a convenient synthesis method and good safety, exhibits a broad-spectrum and high-efficiency antimicrobial activity, shows no cross resistance with other existing microbicides, can be used for controlling plant diseases in vegetables, fruits, grain crops, oil crops, economic crops, landscape crops and Chinese medicinal materials, and has a particularly good chemical protective effect and systemic therapeutic effect on diseases in drug-resistant crops.

The invention discloses a cyprosulfuron-containing retention spraying sanitary insecticidal composition and application, the effective components of the compound insecticide are cyprosulfuron and an organophosphorus insecticide, and the organophosphorus insecticide is any one of dithiophosphos, fenthion, fenitrothion and pirimiphos-methyl. The total weight of the cyprosulfuron and the organophosphorus insecticide accounts for 2%-50% of the insecticidal composition, and the compounding weight ratio is (20: 1)-(1: 10). The binary composition solves the problem of resistance of sanitary pests to organophosphorus, improves the control effect, reduces the pesticide application amount, reduces the pesticide application irritation, and prolongs the persistence. The cyproflufen as a lethal agent has no cross resistance with organic phosphorus, has a good lethal effect, has no repellency to sanitary pests, is widely applied to places such as hotels, schools, factories, farms and the like, and has a special effect on prevention and treatment of the sanitary pests.

The invention belongs to the technical field of sanitary insecticidal, and relates to a sanitary insecticidal compound composition and application thereof. The composition comprises a component A and a component B in a mass ratio of (20: 1)-(1: 10), the component A is a methoxy acrylate compound as shown in a formula I, and the component B is an organophosphorus insecticide. The binary composition provided by the invention solves the problem of resistance of sanitary pests to organophosphorus, improves the control effect, reduces the pesticide application amount, reduces the pesticide application irritation, and prolongs the persistence. The active component A is used as a lethal agent, has no cross resistance with organic phosphorus, has a good lethal effect, has no repellency to sanitary pests, is widely applied to places such as hotels, schools, factories and farms, and has a special effect on prevention and treatment of the sanitary pests.

The invention provides an anti-drug-resistant mycobacterium tuberculosis cinnamon extract I and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine extracts.Cinnamon is used as a raw material, and the cinnamon extract I with the anti-drug-resistant mycobacterium tuberculosis effect is obtained through moving bed extraction, countercurrent chromatography separation and distillation. The cinnamon extract I disclosed by the invention has obvious anti-mycobacterium tuberculosis activity, and has a good inhibition effect on mycobacterium tuberculosis and various drug-resistant mycobacterium tuberculosis; the cinnamon extract I has no synergistic effect with common anti-tuberculosis drugs such as rifampicin, isoniazide, ethambutol, streptomycin and levofloxacin, and has no cross resistance with rifampicin, isoniazide and levofloxacin, so that the cinnamon extract I possibly has a unique antibacterial mechanism for mycobacterium tuberculosis, and a new thought and a new method can be provided for prevention and treatment of tuberculosis.

The invention relates to the technical field of summer black grape planting, and particularly provides a summer black grape fruit expanding method. The gibberellin and the forchlorfenuron are combined and compounded into the summer black grape fruit swelling agent, the action mechanisms of the gibberellin and the forchlorfenuron in the summer black grape fruit swelling aspect are different, cross resistance does not exist, and the gibberellin and the forchlorfenuron are combined and compounded into liquid medicine to have an obvious synergistic interaction effect; and the fruit swelling effect on summer black grapes is obviously better than that of gibberellin and forchlorfenuron single agents. According to the method, gibberellin and forchlorfenuron of different concentrations are applied after the full-bloom stage, the time interval between two times of pesticide application is 12-15 days, and fruit retention and expansion of summer black grape clusters are achieved in the mode.