171 results about "Cross-resistance" patented technology

A mutant acetolactate synthase (ALS) enzyme that confers cross-resistance to all sulfonylurea, imidazolinone, pyrimidinyloxybenzoate, triazolopyrimidine and sulfonylamino-carbonyl-triazolinone herbicides is provided. The mutant enzyme contains an aspartic acid to glutamic acid substitution mutation at a newly identified conserved region of the ALS enzyme. A gene encoding the enzyme is also provided, as are transgenic plants that have been genetically engineered to contain and express the gene. The transgenic plants are cross-resistant to sulfonylurea, imidazolinone, pyrimidinyloxybenzoate, triazolopyrimidine and sulfonylamino-carbonyl-triazolinone herbicides.

The invention discloses a medicinal composite preparation containing quinolones, a preparation method thereof and an application thereof. The medicinal composite preparation containing quinolones comprises the following components, by mass, 0.5-95% of a quinolone medicine or a salt compound thereof, 1-97% of an organic acid or a salt compound thereof, 1-98.5% of a sweetener, 0-45% of a flavor enhancer, 0-10% of a flavoring agent, and the balance excipient. Finished products prepared from the medicinal composite preparation containing quinolones, which have the characteristics of stability, excellent dispersibility, good palatability and easy absorption, can be used as a broad-spectrum antiseptic, have the advantages of strong bactericidal activity, wide in vivo distribution and no cross drug resistance with other antibiotic medicines, and are effective to bacteria and mycoplasmas, can be used to treat various infectious diseases of the alimentary system, the respiratory system, the urinary system or the skin soft tissue of animals, wherein the diseases are caused by the sensitive bacterial or the mycoplasmas.

The invention discloses a pesticidal compound taking chlorantraniliprole and monosultap as active ingredients. The weight ratio of the chlorantraniliprole and the monosultap is 1:1 to 100, and the sum of the weight of the chlorantraniliprole and the monosultap is 10 to 50 percent of the total weight of the compound. The pesticidal compound is added with a solvent or a hydrotropy agent, an emulsifier, a dispersant, a sharing emulsifying agent, an antifreeze, a foam killer, a thickening agent, a stabilizing agent, an adhesive, etc. which are all different, and can be processed into different agent types such as an emulsion in water (EW), a microemulsion (ME), a suspending agent (SC), a wettable powder (WP), or a water dispersible grain agent (WDG), etc. The pesticidal compound can effectively prevent agricultural insects, in particular is applicable to prevent rice insect pests, has obviously synergized action for the poison function of insects, shows the characteristics of wide range of desinsection, high efficiency, rapid functional speed, low toxicity for mammals and natural enemy insects, low dosage and agricultural use cost, no cross resistance among medicaments, etc., and overcomes and defers the generation of the drug fastness of pests.

Disclosed is a method for the production of a woven belt band, especially for safety belts in vehicles, especially motor vehicles, consisting of warp threads and at least one weft thread, characterized in that a multifilament thread, made up of individual filaments, is used as a weft thread during weaving, said filaments consisting of a core surrounded by a meltable skin; also characterized in that the belt band is thermoset after weaving. The multifilament thread melts in an undulated form to form a monofilament spring-elastic single thread body, thereby increasing the cross-resistance of the belt, and is especially glued to the warp threads.

The invention belongs to the technical field of biological pharmacy, in particular to a bacterial strain green chromogenic streptomyces viridochromogenes SDSL1119 for producing antibiotic avilamycin special for an animal and a method for producing the avilamycin by the bacterial strain. The bacterial strain is collected in a CGMCC on July 21st, 2009 with the collection number of CGMCCNo.3198. Themethod comprises the steps of oblique plane culture, seed culture and fermentation culture. The invention has the advantages of environmental-friendly production process, high product bioactivity, favorable antibiosis effect and no residue and cross medicine resistance and can effectively prevent animal diseases and ensure the safety of animal source foods.

The invention relates to a composition containing picarbutrazox and a sterol-biosynthesis-inhibitor (SBIs) bactericide and a preparation thereof and applications of the composition and the preparation. The bactericidal composition comprises a bactericidal activity compound I and a bactericidal activity compound II, the bactericidal activity compound I is the picarbutrazox, and the bactericidal activity compound II is the sterol-biosynthesis-inhibitor (SBIs) bactericide. The bactericide composition has the advantages of being wide in control spectrum and free of cross resistance, the using quantity and the using number of the picarbutrazox and the sterol-biosynthesis-inhibitor (SBIs) bactericide can be obviously decreased, and the resistance is delayed. The invention also provides the preparation of the bactericidal composition, a preparation method suitable for the composition is designed, the effect of a medicament can be developed to a maximum degree, and the using quantity of the medicament is decreased. The invention also provides the applications of the bactericidal composition and the preparation, so that medicine is guided to be correctly used, and misusing of the medicament is reduced.

The invention relates to a bactericide composition containing pyraclostrobin and copper rosinate, containing pyraclostrobin and copper rosinate as effective components, wherein, the weight ratio of pyraclostrobin to copper rosinate is 1:2-3. The bactericide composition provided by the invention is characterized by that: 1, the composition has good synergism on a plurality of crop diseases within the range of certain proportion; 2, drug resistance caused by using pyraclostrobin or copper rosinate alone can be delayed greatly because pyraclostrobin and copper rosinate have different mechanisms of action and no cross-resistance between each other; and 3, pyraclostrobin is a novel bactericide with high price, while copper rosinate is cheaper, so that the combination of pyraclostrobin and copper rosinate can reduce the cost. The bactericide composition is a novel bactericide with high efficiency, low toxicity and broad-spectrum, with the advantages of long persistent period and being easy to use. Because the bactericide composition has a large number of reaction sites, the bactericide composition does not easily to generate drug resistance. Furthermore, the bactericide composition has dual functions of preventing and treating, and is capable of treating common plant diseases caused by a plurality of fungi and bacteria, such as downy mildew, epidemic disease, black spot disease, anthracnose, bacterial angular leaf spot, blight, tomato late blight of melons and fruits and the like.

The invention disclose an insecticidal composition using cyanogen insect amide and molosultap as effective components, prepared into aqueous emulsion (EW), micro emulsion (ME), suspending agent (SC), wettable powder (WP) or water dispersivity grain (WDG) by adding solvents and latent solvents, emulsifying agents, dispersing agents, antifreezing agents, defoaming agents, thickening agents, stabilizing agents or adhesives according to the method known by technicians in the technical field. The weight ratio of the cyanogen insect amide and the molosultap is 1:0.1-200, and the sum of the weights of the cyanogen insect amide and the molosultap is 2.2-70% of the total weight of the insecticidal composition. The composition has the remarkable synergized effect on the veneficium of insects, has the characteristics of broad insecticidal spectrum, high efficiency, quick effect, low poison to mammals and natural enemies, less insecticide amount, low agricultural cost, no cross resistance between insecticides and the like, and overcomes and defers the generation of the insecticide resistance of injurious insects. The composition effectively prevents and controls agricultural injurious insects and is particularly suitable for preventing and controlling rice injurious insects.

The invention discloses a capsule type compound pesticide formulation and a preparation method and application of the capsule type compound pesticide formulation. The compound pesticide microcapsule is composed of a shell, a pesticide A wrapped inside the shell and a pesticide B loaded in the shell. The shell is formed by a biodegradable high-molecular material. The pesticide A and the pesticide B do not have negative cross resistance or at least do not have cross resistance. According to the capsule type compound pesticide formulation, the manner that the kernel and the shell load pesticide is adopted to achieve compounding of the pesticides, and the ratio between the two compounded pesticides can be adjusted by adjustment of process parameters.

The invention belongs to the field of agriculture, and relates to a bactericidal activity compound composition, in particular to a composition containing picarbutrazox and a mitochondrion-cytochrome-enzyme-inhibitor bactericide and a preparation thereof and applications of the composition and the preparation. The bactericidal composition comprises a bactericidal activity compound I and a bactericidal activity compound II, the bactericidal activity compound I is the picarbutrazox, and the bactericidal activity compound II is the mitochondrion-cytochrome-enzyme-inhibitor bactericide. The bactericide composition has the advantages of being wide in control spectrum and free of cross resistance, the using quantity and the using number of the picarbutrazox and the mitochondrion-cytochrome-enzyme-inhibitor bactericide can be obviously decreased, and the resistance is delayed. The invention also provides the preparation of the bactericidal composition, a preparation method suitable for the composition is designed, the effect of a medicament can be developed to a maximum degree, and the using quantity of the medicament is decreased. The invention also provides the applications of the bactericidal composition and the preparation, so that medicine is guided to be correctly used, and misusing of the medicament is reduced.

The invention provides a breast cancer multidrug-resistant cell strain constructed by virtue of epirubicin induction, wherein the breast cancer multidrug-resistant cell strain has a collection number of CCTCC C201439. The invention further provides a method for constructing the breast cancer multidrug-resistant cell strain. According to the invention, an MDA-MB-231 / EPI drug-resistant strain is successfully established, wherein a drug-resistant index is 26.27 times, and obvious cross resistance is produced for taxol, etoposide and cis-platinum. A drug-resistant tumor cell model is provided for the following related researches so as to research drug-resistant tumor cell morphology and biological characteristics, research a tumor multidrug resistance mechanism, analyze sensitivity to chemotherapeutic drugs as well as screen chemotherapeutic drugs, develop tumor drug resistant reverse drugs and research and develop a more effective tumor therapeutic method, and the like.

The invention belongs to the field of agriculture, and relates to a bactericidal activity compound composition, in particular to a composition containing picarbutrazox and a succinate-dehydrogenase-inhibitor (SDHIs) bactericide and a preparation thereof and applications of the composition and the preparation. The bactericidal composition comprises a bactericidal activity compound I and a bactericidal activity compound II, the bactericidal activity compound I is the picarbutrazox, and the bactericidal activity compound II is the succinate-dehydrogenase-inhibitor (SDHIs) bactericide. The bactericide composition has the advantages of being wide in control spectrum and free of cross resistance, the using quantity and the using number of the SDHI can be obviously decreased, and the resistance is delayed. The invention also provides the preparation of the bactericidal composition, a preparation method suitable for the composition is designed, the effect of a medicament can be developed to a maximum degree, and the using quantity of the medicament is decreased. The invention also provides the applications of the bactericidal composition and the preparation, so that medicine is guided to be correctly used, and misusing of the medicament is reduced.

The invention provides a new bacterial strain that can prevent and control plant pathogenic fungi and kill acarids—streptomyces S1-5 and its application in resisting plant pathogenic fungi and killing acarids. Streptomyces sp.S1-5 (Streptomyces sp.S1-5), preserved in China Center for Type Culture Collection, date of preservation: May 24, 2007, preservation number CCTCC No: M 207073. The pesticide prepared by the present invention can achieve the effect of killing fungicides and killing acarids by using it once, greatly reducing agricultural costs and lightening the burden on farmers; and the duration of effect is as long as 30 days, and it is also safe for humans and animals, does not kill natural enemies and is beneficial Insects are not easy to produce resistance to control objects, do not pollute the environment, can be rapidly degraded by soil microorganisms without affecting soil fertility and microbial flora, have no bioaccumulation, and are very safe for ecology. They are a key enzyme inhibitor. Pesticides, no cross-resistance with other insecticides.

The present disclosure relates to a series of bis(hydroxymethyl) and its bis(carbamate) of 8H-3a-azacyclopenta[a]indene-1-yl and 5,10-dihydropyrrolo-[1,2-b]isoquinolines derivatives (Formula I-Formula IV) as DNA di-alkylating agents. The preliminary antitumor studies indicated that compounds disclosed herein could exhibit potent cytotoxicity in vitro and antitumor therapeutic efficacy in human tumor xenografts and could have little or no cross-resistance to either Taxol or Vinblastine. The results demonstrated that compounds disclosed herein possess potent antitumor therapeutic efficacy and are expected to have potential for clinical applications.

The invention discloses a preparation method for botanical pesticide pomegranate peel polyphenol raw powder. The preparation method includes a first step of smashing pomegranate peels, a second step of carrying out extraction on solvent or water of mixture from 0 DEG C to the boiling point of the solvent or the mixture, a third step of carrying out vacuum concentration on the extractive, and carrying out spray drying to form the botanical pesticide pomegranate peel polyphenol raw powder. The invention further discloses pomegranate peel polyphenol plant fungicide which comprises the pomegranate peel polyphenol raw powder and auxiliary ingredients, wherein the content of pomegranate peel polyphenol is 1%-7%. Through the adoption of the technical scheme, compared with the existing agentia, the pomegranate peel polyphenol plant fungicide and the application and the preparation method have the advantages that the preparation method turns waste into wealth, saves resources and enables the pomegranate peel to regenerate; the pomegranate peel polyphenol plant fungicide prepared through the method is safe, nontoxic, environment-friendly, free from pesticide residue, wide in prevention and treatment, remarkable in effects, unique in mechanism of action, and free from cross resistance with the existing agentia, and accords with the national industrial policy for replacing high-toxic high residual pesticides.

The invention discloses a complex biological fungicide for preventing and treating wheat scab. The complex biological fungicide comprises validamycin A and JS399-19, wherein the weight ratio of the validamycin A to the JS399-19 ranges from 1:20-20:1. The invention further discloses application of the complex biological fungicide in preventing and treating wheat scab. The validamycin A and the JS399-19 in the complex biological fungicide are fungicides with different functional mechanisms and do not have cross-resistance with carbendazim and triadimefon, wherein carbendazim and triadimefon are leading medicine for preventing and treating wheat scab in the past. The complex biological fungicide has the advantages of being wide in bacteriocidal spectrum, high in absorption, good in fast-acting property, long in preserving effect period, environmentally friendly, low in cost and easy to process.

The invention provides a quinoline derivative and an application of the quinoline derivative. The quinoline derivative has the structure shown in a general formula A which is shown in the specification. The quinoline derivative or the agriculture and garden acceptable acid addition salt of the quinoline derivative can be served as active components of insecticides in the agriculture and the garden to be used for killing insects of lepidoptera, homoptera, coleoptera and orthoptera, does not generate cross resistance and also has the stronger killing activity to pests which already have pesticide resistance.

The invention discloses a cross resistance welding process for heterogeneous wires. The process is as follows: various different combinations of current and pressure are adopted; in a first pulse, large electrode pressure and small welding current are adopted; contact resistance between a small electrode and a welded wire is reduced so as to reduce electrode adhesion; and the contact area is increased to reduce splashing. In a second pulse, small electrode pressure and large welding current are adopted; a heat production proportion of the contact resistance is increased, so that a non-equilibrium heat production phenomenon at a combined surface can be relieved, thereby generating plenty of molten metal on the combined surface, filling grooves generated because of structural factors, and increasing joint strength. The cross resistance welding process has the technical effects that: the process is suitable for cross resistance welding for heterogeneous wires, especially easy-to-melt materials can wet spread-out heterogeneous material combination on a difficult-to-melt material surface; and the process can realize efficient connection of heterogeneous wires, avoids a special tool required by other welding methods, reduces the welding cost and greatly improves the welding efficiency.

The invention relates to a pesticide composition taking chlorantraniliprole and thiocyclam as active ingredient, wherein the weight ratio of chlorantraniliprole and thiocyclam is 1-100: 100-1. The mass percentage of the active ingredient in the pesticide composition is 5 to 70%, wherein the mass percentage of chlorantraniliprole is 0.5 to 50%, and the mass percentage of thiocyclam is 0.5 to 50%; and the pesticide composition can be added with an assistant or an excipient to be manufactured into an aqueous emulsion or a suspending agent, wettable powder and water dispersible granules. The composition has a remarkable synergized action in poisoning insects, has the characteristics of wide insecticidal spectrum, high efficiency, high speed of action, durative efficacy, low toxicity, low pesticide consumption and agricultural cost, no cross resistance among the agents, and the like, and overcomes and suspends pesticide resistance of pests. The composition can effectively prevent and treatagricultural pests and is particularly suitable for preventing and treating rice pests.

The invention provides an insecticidal farm chemical composition and application thereof. The composition adopts one of diafenthiuron or lufenuron, and indoxacarb as active components. The composition has the advantages that: (1) compared with a mono agent, the composition has obvious synergism to lepidoptera pests and improves the control effect; (2) the action mechanisms of the active components and the conventional insecticides of organic phosphorus, pyrethroid and the like are different without cross resistance, and are different from using more methylamino avermectin benzoate, so that the field drug dosage is reduced greatly and the cost is reduced; (3) the difference of the action mechanisms of the active components in the composition is advantageous to overcome and retard the generation of pest drug resistance; and (4) the composition enlarges the controlling spectrum, and has double effects on treating various pests appearing simultaneously.

The invention relates to an herbicide, in particular to an herbicide composition containing pyriminobac methyl, pyribenzoxim and cyhalofop-butyl, a preparation and an appliance thereof. The herbicide composition containing the pyriminobac methyl, the pyribenzoxim and the cyhalofop-butyl comprises three effective components which are the pyriminobac methyl, the pyribenzoxim and the cyhalofop-butyl, wherein the quality radio of the pyriminobac methyl, the pyribenzoxim and the cyhalofop-butyl is 0.1-60:0.1-60:0.1-70. The pyriminobac methyl, the pyribenzoxim and the cyhalofop-butyl do not have cross resistance, can effectively enhance weeding effect of the herbicide by being mixed and matched, enlarge control spectrums of the herbicide, widely kill various weeds containing graminaceous, cyperaceae and broad leaves, improve fast-acting property and durable effect, reduce times for spraying in a growth period, and have greatly important significance for delaying drug resistance. Simultaneously, because the working concentration of single insecticide reduces, the occurrence risk of pesticide hazard is greatly reduced. The herbicide composition containing pyriminobac methyl, pyribenzoxim and cyhalofop-butyl, the preparation and the appliance thereof meet the demands that a drug is used for many times in agricultural production, the use times of the drug are reduced and the risk of the pesticide hazard is reduced.

The present invention relates to an insecticide containing flubendiamide, which belongs to technical field of pesticide. The insecticide contains 1% to 80% of active ingredients. Flubendiamide which belongs to an insecticide of phthalic acid diamides has broad-spectrum control efficiency on Lepidoptera pests. No cross resistance exists between the insecticide and the existing insecticide, so the insecticide is suitable for controlling pests with resistance to the existing insecticide.

The present invention relates to method of tackling Phytophthora parasitica var. nicotianae with resistance on metalaxyl, and belongs to the field of plant protection and agricultural chemical technology. The present invention screens out two kinds of germicides, including Junke and Xiuan, with negative cross resistance to metalaxyl for applying alternately to prevent and control Phytophthora parasitica var. nicotianae with resistance on metalaxyl. The present invention has simple operation, high effect, reduced agricultural chemical residue, raised tobacco safety and other advantages.

The invention relates to an emamectin benzoate indoxacarb suspending agent and a preparation method thereof. The suspending agent is characterized by comprising the following components in percentage by weight: 0.5-1.5 percent of emamectin benzoate, 2-10 percent of indoxacarb, 2-8 percent of emulsifier, 1-5 percent of dispersant, 0.1-1 percent of anti-sludging agent, 2-10 percent of antifreeze agent, 0.5-2 percent of antioxidant, 0.5-2 percent of wetting agent, 1-3 percent of defoaming agent, 5-10 percent of solvent, and the balance of water. Compared with the prior art, the suspending agent has the advantages of having the effects of contact killing and stomach toxicity, blocking sodium channels in nerve cells of pests so as to ensure that target pests have poor harmony and paralysis anddie finally, having no cross resistance with other insecticides, having higher biological activity to various lepidoptera and homoptera pests and mites, preventing various pests on crops of cereals, cottons, fruits, vegetables, and the like.

The invention discloses a bactericidal composite of a rice sheath blight disease and an application of the bactericidal composite. The most appropriate proportion is sought for preventing and treating the rice sheath blight disease according to different mechanisms of action of various agents, and in combination of a traditional Chinese medicine agent with bactericidal and insect expelling effects. Compared with the traditional agent, the composite has the following advantages: a) the composite is efficient, low in toxicity and residual, good in quick action, long in lasting period and environmentally friendly; b) the composite has no cross resistance to the traditional mainstream agent for preventing and treating the rice sheath blight disease; c) the various agents are compatible and have a significant synergistic action, the bactericidal activity is improved, the administration dosage of a single bactericide is reduced, and the pesticide use cost is reduced; d) a risk level of resistance of pathogenic bacteria to the chemical agent can be reduced, the sensitivity of the pathogenic bacteria is kept, and the resistance of the bacteria to the single agent in a formula can be retarded at the same time when the traditional Chinese medicine agent is added; e) the composite has a significant bactericidal effect, reduces harm of the disease to crop production and increases and improves the yield and quality of agricultural products.

The invention provides a resistance strain type weighing sensor simulator which comprises a Wheatstone full bridge type bridge circuit and a crossed resistance network, wherein bridge arms of the Wheatstone full bridge type bridge circuit are internally and respectively connected with fixed resistors R1, R2, R4 and R3 in sequence; the fixed resistor R4 of at least one bridge arm is connected with an adjustable resistor W1 in series; one arm of the crossed resistance network is connected with two resistors R7 and R8 in sequence; two ends of the arm are voltage input ends and respectively connected between the R1 and the R3 as well as between the R2 and the R4; the other arm of the crossed resistance network is connected with four resistors R6, R10, R9 and R5 in sequence; two ends of the other arm are respectively connected between the R1 and the R2 and connected with a mobile contact of the adjustable resistor W1; and two ends of an output signal of the resistance strain type weighing sensor simulator are respectively between the R6 and the R10 as well as between the R9 and the R5. According to the resistance strain type weighing sensor simulator, high-precision simulation signals can be generated.

The invention provides a compound bactericide of prochloraz and hexaconazole. The compound preparation has no cross resistance with current major medicaments, i.e., carbendazim and triadimefon for preventing and treating the fusarium head blight of wheat, and can be used for effectively treating the pesticide resistance of the fusarium head blight of the wheat to the carbendazim and the triadimefon. The invention provides an optimal synergistic proportion range between the two medicaments and a processing process of the compound preparation. The compound preparation has the advantages of wide bactericidal spectrum, high systemic property, good quick response and long lasting period. A field test result proves that the compound preparation has an extremely obvious prevention and treatment effect on the fusarium head blight of the wheat and low cost compared with a single dose.

The invention provides a tildipirosin-containing medicinal composition. The dosage form of the medicinal composition is an injection, the composition comprises, by mass / volume, 1-20% of tildipirosin, 10-25% of polyvinylpyrrolidone, an acid, and the balance of water, and the use amount of the acid makes the pH value of the composition be 5.5-6.5; and the tildipirosin is tildipirosin or a pharmaceutically acceptable salt thereof. Tildipirosin in above raw materials is a special antibiotic for livestock and poultry, does not bring a cross drug resistance problem for people, is a first selected medicine for treating animal respiratory tract diseases, and has a very good treatment effect on Streptococcus suis, Pasteurella multocida, Haemophilus parasuis, Actinobacillus pleuropneumoniae and mycoplasma.

The invention discloses a separated streptomyce NBF715 and an application thereof in crop disease control. The separated streptomyce NBF715 is preserved in the China type culture collection center, and the preservation number is CCTCC NO: M2017414. It is firstly reported that the bacterial strain can be used for preventing and treating tobacco black shank, preventing and treating bacterial wilt oftomatoes, eggplants, peppers and gingers, preventing and treating citrus blue mold, preventing and treating tea target spot, and preventing and treating pepper anthracnose and potato late blight, andhas no cross resistance with a current bactericide and a pesticide. Compared with the current prevention and treatment of using a chemical synthesis pesticide, because the bacterial strain is from anatural environment, the bacterial strain has the advantages of high efficiency, low toxicity, environment-friendliness and difficult generation of resistance and the like, and has the extensive application prospect.