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10 results about "Cross-resistance" patented technology

Cross-resistance is the tolerance to a usually toxic substance as a result of exposure to a similarly acting substance. It is a phenomenon affecting e.g. pesticides and antibiotics. As an example rifabutin and rifampin cross react in the treatment of tuberculosis. This sort of resistance is also seen against drugs involved with the treatment of HIV. Drugs ending with "- ine" and "-inavir" are the most common.

Bacillus flexus strain BJ699 and application thereof in strawberry production

The invention belongs to the technical field of agricultural microorganisms, and discloses a bacillus flexus strain BJ699 and application thereof in strawberry production. Specifically, the invention provides a novel bacillus flexus strain BJ699, and the preservation number of the strain BJ699 in the China Center for Type Culture Collection is CCTCC (China Center for Type Culture Collection) NO: M20252013. The invention also provides a microbial agent containing the strain BJ699 as an active component and application of the strain BJ699 in preparation of a microbial agent for prevention and control of strawberry root rot pathogenic bacteria and / or degradation of pyraclostrobin. The new strain or the microbial agent containing the strain comes from the natural environment, has no cross resistance to existing bactericides and insecticides, has the advantages of high efficiency, low toxicity, no environmental pollution, low possibility of drug resistance generation and the like, and has a wide application prospect.
Owner:INST OF AGRI RESOURCES & REGIONAL PLANNING CHINESE ACADEMY OF AGRI SCI +1

Eleven bactericide compositions mainly used for preventing and treating crop diseases caused by pyricularia oryzae and colletotrichum gloeosporioides

PendingCN122070814ABiocideFungicidesCross-resistancePyricularia
The invention belongs to the technical field of pesticides, and relates to 11 bactericide compositions for mainly preventing and treating crop diseases caused by pyricularia oryzae and colletotrichum gloeosporioides. The compound YJY-22 provided by the invention is novel in structure and unique in action mode, and has no cross resistance with isoprothiolane, fenoxanil, pyraclostrobin, tricyclazole, azoxystrobin, mancozeb, captan, difenoconazole, prochloraz, chlorothalonil and tebuconazole. As the action mechanism of the compound YJY-22 is different from that of the medicament, and the compound YJY-22 and the medicament have no cross resistance, the compound YJY-22 and the medicament are compounded, so that the sterilization range can be expanded, the sterilization effect can be enhanced, the drug resistance of phytopathogen can be delayed, the safety to crops is good, the prevention and control spectrum is expanded, and the requirements of pesticide reduction and synergism are met.
Owner:NANJING AGRICULTURAL UNIVERSITY +1

Plant-derived insecticide, its preparation method and application

ActiveCN117397687BBiocideAnimal repellantsPesticide residueCotton red
The plant source insecticide contains effective components of parathion and avermectin, the weight ratio of parathion and avermectin is 10-50:1, and is supplemented with an acceptable agricultural adjuvant to form one of emulsifiable concentrate, wettable powder, water dispersible granule, water emulsion or suspension agent suitable for agricultural use, and belongs to the field of pesticides. The plant source insecticide shows activity on peridroma saucia, aphid and cotton red spider, especially high acaricidal activity on red spider. The prevention and treatment effect on citrus red spider is obviously improved after parathion and avermectin are compounded, which shows that the combination of parathion and avermectin has significant synergistic effect on citrus red spider. Parathion is derived from Chinese herbal medicine plant, and there is no problem of pesticide residue, and the risk of drug damage is greatly reduced. At the same time, the two single agents of the composition have great difference in chemical structure and completely different action mechanism, and there is no cross resistance, which can delay the resistance problem caused by the use of the two single agents alone.
Owner:NANJING UNIV OF TRADITIONAL CHINESE MEDICINE

Molecular marker for interaction resistance of panonychus citri to insecticide as well as application and detection method of molecular marker

The invention discloses a molecular marker for interaction resistance of panonychus citri to insecticides as well as application and a detection method of the molecular marker. According to the molecular marker for the cross resistance of the panonychus citri to the multiple medicaments, the molecular marker is carboxylesterase genes PcCCE11 and / or PcCCE7, the nucleotide sequence of the PcCCE11 gene is as shown in SEQ ID NO.1, and the nucleotide sequence of the PcCCE7 gene is as shown in SEQ ID NO.2. The invention further discloses a preparation method of the molecular marker for the cross resistance of the panonychus citri to the multiple medicaments.
Owner:SOUTHWEST UNIV +2

Fungicidal compositions and uses thereof in prevention and treatment of fusarium diseases of crops

PendingUS20260026499A1BiocideFungicidesSuccinic acidCross-resistance
Disclosed are five fungicidal compositions and uses thereof in prevention and treatment of Fusarium diseases of crops, belonging to the technical field of plant disease prevention and treatment. The active ingredients of the compositions comprise a compound ZJS178 of formula (I) and a triazole fungicide, or a compound ZJS178 and a succinate dehydrogenase inhibitor fungicide, or a compound ZJS178 and a pyrrole fungicide, or a compound ZJS178 and an imidazole fungicide, or a compound ZJS178 and a strobilurin fungicide. The compositions of the present invention have a compounded synergistic effect and no cross-resistance, can significantly improve the fungicidal activity and efficacy, are beneficial for overcoming and delaying the resistance of pathogens, have good crop safety, and meet the requirements of pesticide quantity reduction and efficacy increase.
Owner:JIANGSU PESTICIDE RESEARCH INSTITUTE CO LTD +2

11 fungicide compositions mainly used for controlling crop diseases caused by pyricularia oryzae and colletotrichum spp.

PCT designated stageWO2026108765A1BiocideFungicidesCross-resistancePyricularia
11 fungicide compositions mainly used for controlling crop diseases caused by Pyricularia oryzae and Colletotrichum spp.. Compound YJY-22 has a novel structure and a unique mode of action, and exhibits no cross-resistance with isoprothiolane, fenoxanil, pyraclostrobin, tricyclazole, azoxystrobin, mancozeb, captan, difenoconazole, prochloraz, chlorothalonil, or tebuconazole. Because compound YJY-22 and the described agents have different mechanisms of action and have no cross-resistance, combining compound YJY-22 and the described agents not only can broaden the antifungal spectrum and enhance antifungal efficacy, but also can delay fungicide resistance of plant pathogens, ensure high crop safety, expand the control spectrum, and meet the requirement of pesticide reduction with increased efficiency.
Owner:NANJING AGRICULTURAL UNIVERSITY +1

A pyrroline dione compound, a preparation method thereof and a bactericide application

ActiveCN119569636BBiocideOrganic chemistryAntibacterial activityCross-resistance
The application provides a pyrroline dione compound and a preparation method and fungicide application thereof. The pyrroline dione compound is named 1-(2,6-diethyl-4-methylphenyl)-1H-pyrrole-2,5-dione, and a structural formula is shown as formula I: the pyrroline dione compound and an agricultural fungicide with the compound as an effective component are used for preventing and treating various plant diseases caused by plant pathogenic fungi, oomycetes and bacteria. The compound is novel in structure and action mechanism, convenient in synthesis method, good in safety, has broad-spectrum and high-efficiency antibacterial activity, has no cross resistance with other existing fungicides, can be used for preventing and treating plant diseases of vegetables, fruits, food crops, oil crops, economic crops, garden crops and Chinese medicinal materials, and has good chemical protection and internal absorption treatment effects on resistant crop diseases.
Owner:NANJING JIXING BIOTECH DEV CO LTD +1

Benzimidazole salt compound with insecticidal activity, preparation method and application

PendingCN121554425ABiocideOrganic chemistryAedes aegyptiChemical compound
The invention discloses a benzimidazole salt compound with insecticidal activity as well as a preparation method and application thereof, and aims to solve the problem that an existing insecticide cannot give consideration to insecticidal activity and resistance at the same time. The salt compound containing the benzimidazole structure provided by the invention has good insecticidal activity on aedes aegypti, mythimna orientalis and plutella xylostella, has no cross resistance or obvious negative cross resistance on aedes aegypti pyrethroid-resistant strains, and has the control effect on the plutella xylostella equivalent to that of commercial insecticide permethrin sold in the market. A lead compound with application potential and an innovative research and development thought are provided for creating novel resistance treatment pesticides with negative cross resistance characteristics.
Owner:NORTHWEST A & F UNIV

Small-molecule inhibitor of targeted phytophthora sterol sensing receptor SSRK1 and application of small-molecule inhibitor

PendingCN122030416ABiocideFungicidesPhytophthora sp.Receptor
The invention discloses a small-molecule inhibitor of a targeted phytophthora sterol sensing receptor SSRK1 and application of the small-molecule inhibitor, and belongs to the technical field of pesticide biology. The inhibitor can specifically bind to a sterol binding site of SSRK1 and competitively block a natural sterol signal, so that comprehensive inhibition on growth, development and pathogenicity of phytophthora is realized. The compound shows remarkable bacteriostatic activity on various phytophthora (such as phytophthora sojae, phytophthora infestans and phytophthora capsici), and can effectively prevent and treat crop diseases such as soybean root rot, potato late blight and phytophthora capsici. The small-molecule inhibitor provided by the invention has the characteristics of novel target spot, unique action mechanism, broad spectrum, high efficiency, environmental friendliness and the like, is not easy to generate cross resistance with the traditional bactericide, and provides a new candidate molecule and preparation development approach for green prevention and control of phytophthora.
Owner:SANYA INSTITUTE OF NANJING AGRICULTURAL UNIVERSITY

Pyrrolinedione compound, and preparation method therefor and use thereof as microbicide

PCT designated stageWO2026086964A1BiocideOrganic chemistryBiotechnologyCross-resistance
Provided in the present application are a pyrrolinedione compound, and a preparation method therefor and the use thereof as a microbicide. The pyrrolinedione compound is 1-(2,6-diethyl-4-methylphenyl)-1H-pyrrole-2,5-dione. The pyrrolinedione compound and an agricultural microbicide using the pyrrolinedione compound as an active ingredient are used for controlling a variety of plant diseases caused by phytopathogenic fungi, oomycetes and bacteria. The pyrrolonedione compound has a novel structure and action mechanism, a convenient synthesis method and good safety, exhibits a broad-spectrum and high-efficiency antimicrobial activity, shows no cross resistance with other existing microbicides, can be used for controlling plant diseases in vegetables, fruits, grain crops, oil crops, economic crops, landscape crops and Chinese medicinal materials, and has a particularly good chemical protective effect and systemic therapeutic effect on diseases in drug-resistant crops.
Owner:NANJING JIXING BIOTECH DEV CO LTD +1