Ciproflufen-containing retention spraying sanitary insecticidal composition and application thereof

Abstract

The invention discloses a cyprosulfuron-containing retention spraying sanitary insecticidal composition and application, the effective components of the compound insecticide are cyprosulfuron and an organophosphorus insecticide, and the organophosphorus insecticide is any one of dithiophosphos, fenthion, fenitrothion and pirimiphos-methyl. The total weight of the cyprosulfuron and the organophosphorus insecticide accounts for 2%-50% of the insecticidal composition, and the compounding weight ratio is (20: 1)-(1: 10). The binary composition solves the problem of resistance of sanitary pests to organophosphorus, improves the control effect, reduces the pesticide application amount, reduces the pesticide application irritation, and prolongs the persistence. The cyproflufen as a lethal agent has no cross resistance with organic phosphorus, has a good lethal effect, has no repellency to sanitary pests, is widely applied to places such as hotels, schools, factories, farms and the like, and has a special effect on prevention and treatment of the sanitary pests.

Description

Technical Field

[0001] The invention relates to a residual spraying hygienic insecticide composition containing ciprofloxacin and an application thereof. The invention relates to a hygienic insecticide composition containing an active component A and an active component B, wherein the active component A is selected from ciprofloxacin and the active component B is selected from any one of dimethoate, fenthion, fenitrothion and methyl pirimiphos, and belongs to the technical field of hygienic insecticide. Background Art

[0002] Cyprosulfuron is a new type of diamide insecticide with a molecular formula of C25H17BrF12N2O2. It is an allosteric modulator of γ-aminobutyric acid (GABA)-gated chloride ion channels, which causes insects to overexcite and twitch. It is mainly used to control lepidopteran and coleopteran pests of vegetables, perennial crops and grains, as well as sanitary pests such as termites, mosquitoes, flies and cockroaches. It has high larvicidal activity against lepidopteran pests such as Spodoptera litura and has a good control effect on thrips. It can effectively control pests that are resistant to other insecticides. Studies have shown that descyclopropylmethylene-cyclosulfuron produced by the metabolism of cyprosulfuron has competitive resistance to GABA receptor antagonists. The action site of descyclopropylmethylene-cyclosulfuron is different from that of organophosphorus insecticides. This type of agent can also control pests that are resistant to cyclopentadiene insecticides and fipronil.

[0003] For a long time, organophosphorus insecticides have been widely used in the prevention and control of public health pests. The long-term use of these agents will inevitably make health pests such as mosquitoes, flies, cockroaches, etc. resistant to some organophosphorus agents, which will greatly reduce the control effect of the agents. Especially in southern China, the resistance increases rapidly, which greatly reduces the control effect of health pests.

[0004] Dimethoate is a low-toxic organophosphorus insecticide, with acute oral LD50 of rats: 860mg / Kg (male), 13000mg / Kg (female), and acute percutaneous LD50>4000mg / Kg. Dimethoate mainly kills by contact, has no systemic activity, and has a wide spectrum of insecticidal effects. It can be used for public health to control midges, moths and houseflies, and can also control lice on humans, and fleas on dogs and cats.

[0005] Fenthion is a contact, stomach poison, wide spectrum, fast-acting, long-lasting, low-toxic organophosphorus insecticide for humans and animals. It is mainly used to control soybean borer, cotton, fruit trees, vegetable and rice pests, and can also control sanitary pests such as mosquitoes, flies, bedbugs, lice and cockroaches.

[0006] Fenitrothion is an organophosphorus insecticide. It is moderately toxic and low toxic to humans and animals. The acute oral LD50 of rats is 400-800 mg / Kg, and the acute percutaneous LD50 of rats is 1200 mg / Kg. Fenitrothion has contact and stomach poisoning effects, no systemic and fumigation effects, a medium residual effect period, a broad insecticide spectrum, and a persistent effect on Lepidoptera larvae. It can also control Diptera, Hemiptera, Coleoptera and other pests.

[0007] Methyl pirimiphos is a broad spectrum, fast-acting organophosphorus insecticide with stomach poison and fumigation effects. It has good efficacy against stored grain beetles, rice weevils, weevils, mealybugs, and moths. It can also control warehouse pests, household and public health pests (mosquitoes and flies).

[0008] In recent years, the field of residual spraying has seen pain points such as difficulty in completely killing mosquitoes and flies, short or no lasting effect of the pesticide, and other problems. When applying pesticides, the applicators can only increase the dosage and frequency of application, which leads to a significant increase in mosquito and fly resistance, a multiple increase in the cost of application, and an increase in the irritation of the pesticide to the applicators. Therefore, the market is in urgent need of a new generation of residual spraying agents to solve these pain points. Summary of the invention

[0009] The technical problem to be solved by the present invention is to provide a compound hygienic insecticide composition containing cyprodinil and organophosphorus, which has good insecticidal effect, low drug cost, synergistic effect, is not easy to produce drug resistance and has a long lasting effect, in view of the shortcomings of the prior art.

[0010] In order to achieve the above object, the present invention adopts the following technical solution:

[0011] The present invention first provides a residual spraying hygienic insecticide composition containing ciprofloxacin and its application, wherein the active ingredients are ciprofloxacin and an organophosphorus insecticide, and the total weight of the ciprofloxacin and the organophosphorus insecticide accounts for 2% to 50% of the total weight of the hygienic insecticide composition, and the remainder is auxiliary materials;

[0012] The organophosphorus insecticide is any one of dimethoate, fenthion, fenitrothion and methyl pirimiphos.

[0013] In the above technical solution, the weight ratio of cyflumizone and organophosphorus insecticide is 20:1 to 1:10, preferably 10:1 to 1:2; wherein:

[0014] The weight ratio of cyflumizone to dimethoate is preferably 1:1;

[0015] The weight ratio of cyfluthrin to fenthion is preferably 2:1;

[0016] The weight ratio of cyflumifenamid to methylpirimphos is preferably 6:1;

[0017] The weight ratio of cyfluthrin to fenitrothion is preferably 2:1.

[0018] In the above technical solution, the sanitary insecticide composition is in the form of wettable powder, water dispersible granules or suspension.

[0019] In the above technical solution, the auxiliary material is a mixture of any five or more of dispersant, wetting agent, defoamer, antifreeze agent, preservative, disintegrant, thickener, binder, attractant, stabilizer, filler and water in any proportion.

[0020] In the above technical scheme, the sanitary insecticide composition, when in the form of a wettable powder, comprises the following raw materials in weight percentage: 2%-50% of active ingredient, 1%-10% of dispersant, 1%-5% of wetting agent, 5%-10% of stabilizer, 5%-15% of attractant, and filler is supplemented to 100%.

[0021] In the above technical scheme, the sanitary insecticide composition, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 1%-10 disintegrant, 0.1%-1% binder, 5%-10% stabilizer, 5%-15% attractant, and filler is supplemented to 100%.

[0022] In the above technical scheme, the sanitary insecticide composition, when in the form of a suspension, comprises the following materials in weight percentage: 2%-50% of active ingredient, 1%-10% of dispersant, 1%-5% of wetting agent, 0.3%-0.5% of preservative, 0.5%-1.5% of thickener, 0.1-0.3% of defoaming agent, 3%-5% of antifreeze agent, 5%-10% of stabilizer, 5%-15% of attractant, and water is supplemented to 100%.

[0023] In the above scheme, the dispersant is selected from: any one of polycarboxylates (for example, TERSPERSE 2500, produced by Huntsman Corporation of the United States), lignin sulfonates, alkylbenzene sulfonates, naphthalenesulfonic acid formaldehyde condensate salts, alkylphenol polyoxyethylene ethers, fatty alcohol polyoxyethylene ethers, fatty amine polyoxyethylene ethers, fatty acid polyoxyethylene esters, and glycerol fatty acid ester polyoxyethylene ethers, or a mixture of two or more of them in any proportion.

[0024] In the above scheme, the wetting agent is selected from: alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylbenzene polyoxyethylene ether phosphate, phenethylphenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate (such as TERSPERSE 2425, Huntsman), naphthalene sulfonate (such as NNO), opening powder BX, wetting penetrant F, sodium dodecylbenzene sulfonate, detergent LS, any one of them, or a mixture of two or more in any proportion.

[0025] In the above scheme, the defoaming agent can be any one of polydimethylsiloxane, diethylene glycol ester, tributyl phosphate, and dipalmitoylethylenediamine, or a mixture of two or more of them in any proportion.

[0026] In the above scheme, the antifreeze agent can be any one of ethylene glycol, propylene glycol, glycerol, and urea, or a mixture of two or more of them in any proportion.

[0027] In the above scheme, the preservative is selected from any one of potassium sorbate and sodium benzoate or a mixture of the two in any proportion.

[0028] In the above scheme, the disintegrant is selected from: any one of ammonium sulfate, sodium sulfate, sodium bicarbonate, and sodium carbonate, or a mixture of two or more of them in any proportion.

[0029] In the above scheme, the thickener is selected from: any one of xanthan gum, hydroxyethyl cellulose, methyl cellulose, and magnesium aluminum silicate, or a mixture of two or more of them in any proportion.

[0030] In the above scheme, the binder is selected from: any one of dextrin, polyvinyl pyrrolidone, sodium alginate, or a mixture of two or more of them in any proportion.

[0031] In the above scheme, the attractant is selected from: any one of anisaldehyde, N-methylacetamide, furanone, dimethyl disulfide, brown sugar, fatty acid dimethyl disulfide ester, tilapia meal, maltose, honey, milk flavor, or a mixture of two or more in any proportion. After the attractant is added to the sanitary composition, the application area can be 20% to 40% of the conventional application area, and the application location is selected from the four corners of the indoor room wall, the top or bottom corner line.

[0032] In the above scheme, the stabilizer is selected from: any one of urea-formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate, tetramethyl piperidine amine, sodium alginate propylene glycol ester, methyl ethyl sulfonate, and a mixture of two or more of them in any proportion. After being added to the sanitary composition, the stabilizer can make its 30-day lethality on the semi-absorbent surface or the absorbent surface greater than 60%.

[0033] In the above scheme, the filler is selected from: any one of kaolin, clay, diatomaceous earth, bentonite, white carbon black, attapulgite, corn starch, and light calcium carbonate, or a mixture of two or more of them in any proportion.

[0034] In the above technical scheme, when the sanitary insecticide composition is in the form of wettable powder, water dispersible granules or suspension, it can be prepared according to conventional methods or existing methods in the art.

[0035] In the above technical solution, the sanitary insecticide composition can show good quick effect and long-lasting effect on the semi-absorbent surface or the absorbent surface.

[0036] The present invention also provides an application of the sanitary insecticide composition in preventing and controlling sanitary pests in application fields by local application.

[0037] In the above technical solution, the local application method refers to a residual spraying method or a brushing method.

[0038] In the above technical solution, the application fields include hotels, schools, factories, farms and other places.

[0039] In the above technical scheme, the sanitary pests include one or more of housefly, city fly, big-headed golden fly, silk-light green fly, copper green fly, bright green fly, summer toilet fly, original toilet fly, red-headed blowfly, and trap fly.

[0040] In the above technical scheme, when the sanitary insecticide composition is used to control sanitary pests, the insecticide composition is diluted 100-500 times with water and sprayed on the surfaces of walls, floors, doors and windows, ceilings and homes in the application area, so that the sanitary pests are knocked down and killed when they contact the surface.

[0041] Compared with the existing technology, it has the following characteristics:

[0042] (1) At present, the registered formulations of ciprofloxacin have not been used for sanitary pests. The present invention has found through experiments that the combination of ciprofloxacin and some organophosphorus insecticides has a synergistic effect. On the one hand, the environmental compatibility is good and the application amount is reduced. On the other hand, from the perspective of the mechanism of action, the mechanism of action of ciprofloxacin and organophosphorus sanitary insecticides is different, and there is no cross-resistance, which solves the problem of sanitary pests' resistance to organophosphorus and improves the control effect. The combination of insecticides with different mechanisms of action can also delay the development of pest resistance, which is beneficial to the control of pest resistance.

[0043] (2) Cyprodinil is less irritating, which improves the safety of the sprayers. Furthermore, research has found that the combination of the two can improve the control effect of sanitary pests, and is a combination drug application technology with good market prospects.

[0044] (3) In order to solve the problems of persistence and poor lethality to targets such as houseflies, we used formulation technology to solve the problem of persistence. By studying the feeding habits of houseflies and adding attractants, we increased the frequency of licking by houseflies and increased the amount of medicine ingested by the flies. DETAILED DESCRIPTION

[0045] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0046] The preparation method of the dosage form in each embodiment of the present invention is as follows:

[0047] The laboratory preparation method of wettable powder is: weigh the effective ingredient, wetting agent, dispersant, stabilizer, attractant and filler in proportion, add them into a mixer and mix them evenly, and then grind them with a jet mill to obtain the wettable powder.

[0048] The laboratory preparation method of water-dispersible granules is as follows: weigh the active ingredient, wetting agent, dispersant, attractant, disintegrant, stabilizer and filler in proportion, add them into a mixer and mix them evenly, grind them with a jet mill, use the mixer again, add water and a mixture of a binder, extrude and granulate them with a granulator, and dry them by boiling drying to obtain water-dispersible granules.

[0049] The laboratory preparation method of the suspension concentrate is as follows: weigh water, dispersant, wetting agent, antifreeze, thickener, preservative, attractant, defoaming agent, and stabilizer in proportion, mix them evenly, add the original drug, shear them with a high-speed shearing machine for 5 minutes, and then transfer them to a sand mill for sand grinding for 2-3 hours to control the particle size D90 below 5μm to obtain the suspension concentrate.

[0050] The present invention will be described below in conjunction with specific embodiments:

[0051] Formulation Example 1: 20% cyprodinil·dimethoate wettable powder

[0052] Cyprodinil 10g, dimethoate 10g, sodium dodecylbenzene sulfonate 5g, calcium lignin sulfonate 10g, dimethyl disulfide 15g, urea-formaldehyde resin 5g, kaolin is made up to 100%.

[0053] Formulation Example 2: 30% cyprodinil·dimethoate water dispersible granules

[0054] 20g of cyfluthrin, 10g of dimethoate, 0.5g of BX powder, 0.5g of sodium dodecyl sulfate, 1g of sodium naphthalenesulfonic acid formaldehyde condensate, 5g of dimethyl disulfide of fatty acid, 5g of ammonium sulfate, 1g of dextrin, 5g of polyalkylene glycol, and kaolin is made up to 100%.

[0055] Formulation Example 3: 15% cyprodinil·dimethoate suspension

[0056] 5g of cyprodinil, 10g of dimethoate, 0.5g of calcium salt of alkyl sulfonate, 0.5g of sodium lauryl sulfate, 1g of potassium salt of polycarboxylate, 4g of calcium salt of lignin sulfonate, 0.5g of potassium sorbate, 1g of magnesium aluminum silicate, 0.5g of xanthan gum, 0.3g of polydimethylsiloxane, 5g of propylene glycol, 5g of polyacrylic acid, 5g of tilapia meal, and make up to 100% with water.

[0057] Formulation Example 4: 50% cyprodinil·dimethoate water dispersible granules

[0058] Cyprodinil 30g, dimethoate 20g, Lakai powder BX2g, sodium lauryl sulfate 2g, alkylbenzene sulfonate calcium salt 2g, lignin sulfonate calcium salt 8g, brown sugar 12g, sodium sulfate 3g, ammonium sulfate 1g, polyvinyl pyrrolidone 1g, ethylene oxide-propylene oxide block polyether 6g, kaolin is supplemented to 100%.

[0059] Formulation Example 5: 2% cyprodinil·dimethoate suspension

[0060] 1g of cyprodinil, 1g of dimethoate, 0.5g of sodium lauryl sulfate, 0.5g of calcium alkyl sulfonate, 0.5g of potassium polycarboxylate, 0.5g of sodium naphthalenesulfonic acid formaldehyde condensate, 0.4g of potassium sorbate, 0.7g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of diethylene glycol ester, 4g of ethylene glycol, 6g of ethyl acrylate, 5g of tilapia meal, and make up to 100% with water.

[0061] Formulation Example 6: 14% cyprodinil·fenthion wettable powder

[0062] Cyprodinil 12g, fenthion 2g, sodium lauryl sulfate 2g, calcium lignin sulfonate 6g, brown sugar 10g, white carbon black 10g, vinyl acetate 6g, diatomaceous earth is supplemented to 100%.

[0063] Formulation Example 7: 22% cyprodinil·fenthion water dispersible granules

[0064] Cyprodinil fluazifop 20g, fenthion 2g, sodium lauryl sulfate 3g, lakai powder BX 2g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, N-methylacetamide 10g, sodium sulfate 5g, sodium bicarbonate 5g, polyvinylpyrrolidone 0.5g, dextrin 0.5g, tetramethylpiperidinamine 7g, white carbon black 6g, kaolin is supplemented to 100%.

[0065] Formulation Example 8: 12% cyprodinil·fenthion suspension

[0066] 10g of cyprodinil, 2g of fenthion, 2g of calcium salt of alkyl sulfonate, 1g of sodium lauryl sulfate, 4g of potassium salt of polycarboxylate, 6g of calcium salt of lignin sulfonate, 0.5g of potassium sorbate, 0.5g of xanthan gum, 0.3g of tributyl phosphate, 3g of glycerol, 7g of propylene glycol sodium alginate, 15g of maltose, and make up to 100% with water.

[0067] Formulation Example 9: 15% cyprodinil·fenthion suspension

[0068] 15g of cyprodinil, 5g of dimethoate, 3g of sodium lauryl sulfate, 1.5g of polyoxyethylene fatty acid ester, 4g of potassium polycarboxylate, 3g of sodium naphthalenesulfonic acid formaldehyde condensate, 0.4g of potassium sorbate, 0.7g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of tributyl phosphate, 0.1g of dipalmitoyl ethylenediamine, 4g of ethylene glycol, 8g of methyl ethyl sulfonate, 6g of honey, and make up to 100% with water.

[0069] Formulation Example 10: 18% cyprodinil·fenthion wettable powder

[0070] 6g of cyprodinil, 12g of fenthion, 5g of sodium salt of naphthalenesulfonate formaldehyde condensate, 2g of sodium salt of alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, 2g of sodium salt of naphthalenesulfonate, 1g of sodium dodecyl sulfate, 5g of dimethyl disulfide ester of fatty acids, 10g of attapulgite, 7g of n-acylated alkyl alcohol amine, and light calcium carbonate is supplemented to 100%.

[0071] Formulation Example 11: 50% cyprodinil·fenthion wettable powder

[0072] 25g of cyprodinil, 25g of fenthion, 2g of fatty alcohol polyoxyethylene ether, 4g of lignin sulfonate calcium salt, 4g of naphthalenesulfonic acid formaldehyde condensate sodium salt, 2g of phenethylphenol polyoxyethylene ether phosphate, 5g of dimethyl disulfide, 10g of milk flavor, 3g of white carbon black, 4g of urea-formaldehyde resin, 4g of polyalkylene glycol, and diatomaceous earth is supplemented to 100%.

[0073] Formulation Example 12: 24% cyprodinil·pirimiphos-methyl wettable powder

[0074] 16g of cyprodinil, 8g of methyl pyrifos, 0.5g of sodium dodecyl sulfate, 0.5g of alkylbenzene polyoxyethylene ether phosphate, 6g of lignin sulfonate calcium salt, 10g of anisaldehyde, 5g of N-methylacetamide, 9g of n-acylated alkyl alcoholamine, and clay is supplemented to 100%.

[0075] Formulation Example 13: 40% cyprodinil·pirimifosyl water dispersible granules

[0076] Cyprodinil 30g, methyl pyrifos 10g, detergent LS 3g, sodium lauryl sulfate 2g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, lignin sulfonate calcium salt 6g, furanone 10g, sodium carbonate 5g, dextrin 1g, sodium alginate propylene glycol 8g, bentonite 20g, corn starch is supplemented to 100%.

[0077] Formulation Example 14: 50% cyprodinil·pirimifosyl suspension concentrate

[0078] 40g of cyprodinil, 10g of methyl pyrifos, 2g of calcium salt of alkyl sulfonate, 2g of wetting and penetrating agent F2g, 1g of polyoxyethylene glycerol fatty acid ester, 4g of potassium salt of polycarboxylate, 4g of calcium salt of lignin sulfonate, 0.3g of sodium benzoate, 0.2g of magnesium aluminum silicate, 0.3g of carboxymethyl cellulose, 0.1g of tributyl phosphate, 5g of propylene glycol, 9g of propylene glycol sodium alginate, 5g of milk flavor, and make up to 100% with water.

[0079] Formulation Example 15: 16% Compound·Methyl Pirimiphos Water Dispersible Granules

[0080] Cyprodinil fluazifop 8g, methyl pirimiphos 8g, pull open powder BX 2g, sodium dodecyl sulfate 3g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, lignin sulfonate calcium salt 5g, anisaldehyde 10g, sodium sulfate 8g, sodium bicarbonate 2g, polyvinyl pyrrolidone 0.3g, sodium alginate 0.5g, sodium alginate propylene glycol 9g, clay 10g, kaolin is supplemented to 100%.

[0081] Formulation Example 16: 12% cyprodinil·pirimifosyl suspension concentrate

[0082] 4g of cyprodinil, 8g of methyl pirimiphos, 2g of sodium lauryl sulfate, 2g of alkylbenzene polyvinyl ether phosphate, 3g of fatty amine polyoxyethylene ether, 4g of potassium polycarboxylate, 3g of naphthalenesulfonic acid formaldehyde condensate sodium salt, 0.4g of potassium sorbate, 0.3g of hydroxyethyl cellulose, 0.2g of xanthan gum, 0.3g of polydimethylsiloxane, 4g of propylene glycol, 5g of tetramethylpiperidinamine, 5g of propylene glycol sodium alginate, 5g of honey, and make up to 100% with water.

[0083] Formulation Example 17: 30% cyprodinil·pirimiphos-methyl wettable powder

[0084] Cyprodinil fluazifop 15g, methyl pirimiphos 15g, naphthalenesulfonic acid formaldehyde condensate sodium salt 6g, ligninsulfonic acid calcium salt 2g, detergent LS 3g, sodium dodecyl sulfate 1g, N-methylacetamide 12g, tetramethylpiperidinamine 5g, sodium alginate propylene glycol 5g, and clay is supplemented to 100%.

[0085] Formulation Example 18: 12% cyprodinil·fenthion wettable powder

[0086] 8g of cyfluthrin, 4g of chlorpyrifos, 2g of sodium lauryl sulfate, 1g of detergent LS, 5g of sodium naphthalenesulfonic acid formaldehyde condensate, 5g of calcium ligninsulfonate, 8g of N-methylacetamide, 7g of furanone, 5g of tetramethylpiperidinamine, and clay is added to make up to 100%.

[0087] Formulation Example 19: 30% cyfluthrin-cyfluthrin water dispersible granules

[0088] 25g of cyfluthrin, 5g of chlorpyrifos, 2g of phenethylphenol polyoxyethylene ether phosphate, 3g of sodium lauryl sulfate, 3g of naphthalenesulfonic acid formaldehyde condensate sodium salt, 5g of ligninsulfonic acid calcium salt, 8g of dimethyl disulfide, 3g of sodium sulfate, 0.5g of sodium alginate, 5g of tetramethylpiperidinamine, 5g of sodium alginate propylene glycol ester, and kaolin is made up to 100%.

[0089] Formulation Example 20: 2% cyprodinil·pirimiphos-methyl wettable powder

[0090] Cyprodinil fluazifop 1g, methyl pyrifos 1g, naphthalenesulfonic acid formaldehyde condensate sodium salt 6g, lignin sulfonate calcium salt 2g, detergent LS 3g, sodium dodecyl sulfate 1g, N-methylacetamide 12g, sodium alginate propylene glycol 4g, tetramethylpiperidinamine 4g, clay is supplemented to 100%.

[0091] Formulation Example 21: 16% cyprodinil·fenthion suspension

[0092] 8g of cyfluthrin, 8g of chlorpyrifos, 4g of wetting and penetrating agent F, 1g of fatty alcohol polyoxyethylene ether, 4g of potassium salt of polycarboxylate, 4g of calcium salt of lignin sulfonate, 0.5g of sodium benzoate, 0.5g of methyl cellulose, 0.3g of polydimethylsiloxane, 4g of urea, 5g of sodium alginate propylene glycol, 5g of N-methylacetamide, and make up to 100% with water.

[0093] Formulation Example 22: 45% cyprodinil·fenthion water dispersible granules

[0094] Cyprodinil fluazifop 30g, cypermethrin 15g, detergent LS 3g, sodium lauryl sulfate 1g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, lignin sulfonate calcium salt 6g, dimethyl disulfide 5g, sodium sulfate 5g, polyvinyl pyrrolidone 0.1g, sodium alginate propylene glycol 5g, kaolin is made up to 100%.

[0095] Formulation Example 23: 18% cyprodinil·fenthion suspension

[0096] 6g of cyfluthrin, 12g of chlorpyrifos, 2g of sodium lauryl sulfate, 4g of potassium polycarboxylate, 2g of sodium naphthalenesulfonate formaldehyde condensate, 0.5g of potassium sorbate, 1.2g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.3g of diethylene glycol ester, 5g of propylene glycol, 5g of sodium alginate propylene glycol ester, 5g of n-acylated alkyl alcoholamine, 5g of milk flavor, and make up to 100% with water.

[0097] Formulation Example 24: 2% cyprodinil·fenthion water dispersible granules

[0098] Cyprodinil fluazifop 1g, fenthion 1g, sodium lauryl sulfate 2g, lakai powder BX 3g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, N-methylacetamide 5g, sodium sulfate 1g, sodium bicarbonate 2g, polyvinyl pyrrolidone 0.5g, dextrin 0.5g, n-acylated alkyl alcoholamine 5g, tetramethylpiperidinamine 5g, white carbon black 6g, kaolin is supplemented to 100%.

[0099] Formulation Example 25: 5% cyprodinil·dimethoate suspension

[0100] 4g of cyprodinil, 1g of dimethoate, 3g of sodium lauryl sulfate, 1.5g of alkylphenol polyoxyethylene ether, 4g of potassium polycarboxylate, 3g of sodium naphthalenesulfonic acid formaldehyde condensate, 0.4g of potassium sorbate, 0.7g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of diethylene glycol ester, 2g of ethylene glycol, 3g of propylene glycol, 5g of sodium alginate propylene glycol, 6g of tilapia meal, and make up to 100% with water.

[0101] Application Example 1: Determination of the co-toxicity coefficient of cyprodinil and organophosphorus

[0102] Test target: Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0103] Test method: Refer to GB / T26350-2010 "Methods for detecting insecticide resistance in flies - Housefly bioassay" and NY / T1154.7-2006 "Guidelines for indoor bioassay of pesticides - Insecticides - Part 7: Determination of combined effects of mixtures" for test insects;

[0104] Table 1 Determination of the co-toxicity coefficient of cyprodinil and bispyribac (for houseflies)

[0105]

[0106] As shown in Table 1, when the ratio of ciprofloxacin to bispyribac is 20:1 to 1:10, the co-toxicity coefficient against houseflies is greater than 120, and there is a synergistic effect, especially when the ratio is 1:1, the synergistic effect is most obvious.

[0107] Table 2 Determination of the co-toxicity coefficient of cyprodinil and fenthion (for houseflies)

[0108]

[0109]

[0110] As shown in Table 2, when the ratio of ciprofloxacin to fenthion was 20:1 to 1:10, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the ratio was 2:1, the synergistic effect was most obvious.

[0111] Table 3 Optimal co-toxicity coefficients of cyprodinil and other organophosphates (for houseflies)

[0112]

[0113] As can be seen from Table 3, the optimal ratio of ciprofloxacin and other organophosphorus compounds is in the range of 2:1 to 1:2, which has a significant synergistic effect.

[0114] Application Example 2: Indoor efficacy test for controlling mosquitoes and flies

[0115] Test targets: Culex pipiens pallens (a local resistant mosquito species in Yangzhou), female adults that have not sucked blood on the 3rd to 5th day after emergence;

[0116] Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0117] Test method: Refer to GB / T 13917.1-2009, forced contact method;

[0118] Test surface: glass board, varnished wood board, gypsum board;

[0119] Dosage setting: The total concentration of active ingredients in the preparation examples is diluted to 200 mg / L (usually 400 mg / L in actual use);

[0120] Control sample 1: 50% dimethoate EC (Jiangsu Gongcheng Biotechnology Co., Ltd.) diluted to 200 mg / l;

[0121] Control sample 2: 500 g / L pirimiphos-methyl emulsifiable concentrate (Syngenta Ltd., UK) diluted to 200 mg / L;

[0122] Test results:

[0123] Table 4: Efficacy test of formulation examples against mosquitoes and flies (glass plate)

[0124]

[0125]

[0126] Table 5: Efficacy test of formulation examples against mosquitoes and flies (varnished wooden board)

[0127]

[0128]

[0129] Table 6: Efficacy test of formulation examples against mosquitoes and flies (gypsum board)

[0130]

[0131] The test results show that when the dosage is reduced by half, the difference in efficacy between the drugs can be clearly seen on the glass surface. The efficacy of formulation examples 1, 4, 8, 11, 14, 17, and 20 are better than that of control samples 1 and 2 (see Table 4);

[0132] On semi-absorbent surface varnished wood board and absorbent surface gypsum board, the efficacy of the preparation examples decreased, mainly because part of the agent was absorbed by the material, resulting in less surface agent components. However, from the efficacy data, the preparation examples have good persistence, and the efficacy lethality of the varnish surface can reach more than 75% after 30 days, and the efficacy lethality of the gypsum surface can reach more than 60% after 30 days, which is better than the control sample 1 and the control sample 2. (See Table 5 and Table 6).

[0133] Application Example 3: Application of Appetite Inducing Agent in Preparation Example for Drug Efficacy Determination

[0134] Test target: Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0135] Test method: Use a 1.2m*1.2**1.2m glass box, dilute the agent, soak it with 20cm*20cm filter paper, dry it and spread it on the glass box, put 30 houseflies in it, and observe the longest stay time and contact frequency of houseflies on the filter paper surface;

[0136] Test agents: Preparation Example 10, Preparation Example 10 (removal of milk flavor), Preparation Example 20, Preparation Example 20 (removal of N-methylacetamide);

[0137] Dosage setting: The total concentration of active ingredients is diluted to 200 mg / L (usually 400 mg / L in actual use);

[0138] Table 7 Effect of attractants on the efficacy of houseflies

[0139]

[0140] The test results show that the addition of milk flavor to Preparation Example 11 increases the frequency of houseflies contacting the agent, and the efficacy is relatively good; the addition of N-methylacetamide to Preparation Example 20 increases the residence time of houseflies on the filter paper surface, increases the frequency of houseflies licking, and causes the houseflies to ingest more agents, so the final efficacy performance is better (see Table 7).

[0141] Application Example 4: Comparative Test on the Efficacy of Houseflies

[0142] Target: Housefly

[0143] Experimental method: Select the walls of the breeding farm building as the test objects and divide them into areas, spray the pesticide on the wall surface, and record the fly density reduction rate of each treatment group after 1 day, 2 days, and 3 days; the area of ​​the breeding farm room is about 50m2, and the area of ​​each wall is about 20m2.

[0144] Test treatment: Preparation examples 2, 9, 17, and 24 were diluted 100 times and sprayed on the four corners of the wall and the ground, 40% of the total area, with a dosage of 20 mg active ingredient / m2;

[0145] Control sample 3: Prepared according to the formulation of Preparation Example 2 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0146] Control sample 4: Prepared according to the formulation of Preparation Example 9 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0147] Control sample 5: Prepared according to the formulation of Preparation Example 17 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0148] Control sample 6: Prepared according to the formulation of Preparation Example 24, the attractant component was removed and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0149] When applying the control samples 3, 4, 5, and 6, the pesticide was sprayed on the entire surface of the wall and the ground;

[0150] Table 8 Treatment of Formulation Examples 2, 9, 17, 24

[0151] deal with Application location Application method Formulation Example 2 Four corners of the wall, 20% of the area Residual spraying Preparation Example 9 Four corners of the wall, 40% area Residual spraying Preparation Example 17 Four corners of the wall, 20% of the area Residual spraying Preparation Example 24 Four corners of the wall, 40% area Residual spraying Control sample 1 The whole wall is sprayed Residual spraying Control sample 2 The whole wall is sprayed Residual spraying Control sample 3 The whole wall is sprayed Residual spraying Control sample 4 The whole wall is sprayed Residual spraying

[0152] Test results:

[0153] Table 9 Comparative test of the efficacy of formulation examples 2, 9, 17, and 24 against flies

[0154]

[0155]

[0156] As shown in Table 9, the present invention has strong attractant properties by adding attractant components, and converts conventional passive control into active attractant attraction. The application area is 20% and 40% of the conventional application area, and the application location is selected at the four corners of the wall. Formulation examples 2, 9, 17, and 24 have obvious fly control effects, with a 1-day density reduction rate of more than 80%, and a 3-day density reduction rate of more than 94%, which are better than control samples 3, 4, 5, and 6. Formulation examples 2, 9, 17, and 24 add attractant components, and flies are killed after gathering around the attractant components and contacting the liquid; it can be seen that the fly control effect of the compound of cyprosulfuron and organophosphorus insecticide with the addition of attractant components is better than that of the compound of cyprosulfuron and organophosphorus insecticide without the addition of attractant components, and the dosage is less than that of the composition without the addition of attractant components.

[0157] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. A residual spraying sanitary insecticide composition containing cyprodinil, characterized in that: The active ingredients are cyprosulfuron and organophosphorus insecticide, and the total weight of cyprosulfuron and organophosphorus insecticide accounts for 2% to 50% of the total weight of the sanitary insecticide composition, and the remainder is auxiliary materials; The organophosphorus insecticide is any one of dimethoate, fenthion, fenitrothion and methyl pirimiphos.

2. The sanitary insecticidal composition according to claim 1, characterized in that: The compounding weight ratio of cyfluthrin and organophosphorus insecticide is 20:1-1:

10.

3. The sanitary insecticidal composition according to claim 1, characterized in that: The sanitary insecticide composition is in the form of wettable powder, water-dispersible granules, and suspension; the auxiliary materials are a mixture of any five or more of dispersant, wetting agent, defoamer, antifreeze, preservative, disintegrant, thickener, binder, attractant, stabilizer, filler, and water in any proportion.

4. The sanitary insecticidal composition according to claim 3, characterized in that: The sanitary insecticide composition, when in the form of a wettable powder, comprises the following raw materials in weight percentage: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 5%-10% stabilizer, 5%-15% attractant, and filler to make up to 100%.

5. The sanitary insecticidal composition according to claim 3, characterized in that: The sanitary insecticide composition, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 1%-10 disintegrant, 0.1%-1% binder, 5%-10% stabilizer, 5%-15% attractant, and filler to make up to 100%.

6. The sanitary insecticidal composition according to claim 3, characterized in that: The sanitary insecticide composition, when in the form of a suspension, comprises the following materials in weight percentage: 2%-50% of active ingredients, 1%-10% of dispersants, 1%-5% of wetting agents, 0.3%-0.5% of preservatives, 0.5%-1.5% of thickeners, 0.1-0.3% of defoaming agents, 3%-5% of antifreeze agents, 5%-10% of stabilizers, 5%-15% of attractants, and water is added to 100%.

7. The sanitary insecticidal composition according to any one of claims 4 to 6, characterized in that: The attractant is selected from: any one of anisaldehyde, N-methylacetamide, furanone, dimethyl disulfide, brown sugar, fatty acid dimethyl disulfide ester, tilapia meal, maltose, honey, and milk flavor, or a mixture of two or more of them in any proportion.

8. The sanitary insecticide composition according to any one of claims 4 to 6, characterized in that: The stabilizer is selected from: any one of urea-formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate, tetramethyl piperidine amine, sodium alginate propylene glycol ester, methyl ethyl sulfonate, and a mixture of two or more of them in any proportion.

9. Use of the sanitary insecticide composition according to any one of claims 4 to 6 in controlling sanitary pests in an application field by topical application, characterized in that: The local application method refers to a residual spraying method or a brushing method; the application fields include hotels, schools, factories, and farms; the sanitary pests include one or more of houseflies, city flies, big-headed golden flies, silky green flies, copper green flies, bright green flies, summer toilet flies, toilet flies, red-headed blowflies, and ground flies.

10. The use according to claim 9, characterized in that: When the sanitary insecticide composition is used to control sanitary pests, the insecticide composition is diluted 100-500 times with water and sprayed on the walls, floors, doors and windows, ceilings and home surfaces in the application area, so that the sanitary pests are knocked down and killed when they contact the surface.

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