128 results about "Para position" patented technology

The invention discloses a tetranuclear ladder type organic tin carboxylate complex as well as a preparation method and application thereof, and belongs to the technical field of metal complexes, the tetranuclear ladder type organic tin carboxylate complex is prepared by taking para-position or ortho-position substituted benzoic acid as a ligand and taking organic tin dimethyl tin oxide as a substrate. The preparation method is simple to operate and mild in condition. The tetranuclear ladder type organic tin carboxylate complex can be used as a photocatalyst for photocatalytic production of H2O2, and the photocatalytic H2O2 production rate is as high as 5.12 * 10 < 3 > [mu] mol.g <-1 >. H <-1 > and is higher than the H2O2 production rate of a photocatalyst reported in the existing literature.

The invention relates to the technical field of supported metallocene catalysts, in particular to a supported metallocene catalyst additive as well as a preparation method and application thereof. The supported metallocene catalyst additive has the following structure: # imgabs0 #, R is selected from C1-C10 alkyl groups, R1 and R3 are selected from alkyl groups and adamantyl groups and are located at ortho-para positions of-OH, R2 is selected from C1-C10 alkyl groups and cycloalkyl groups, and R'is selected from alkyl groups. The additive can greatly retain the catalytic activity and copolymerization performance of a metallocene catalyst, improve the metal loading capacity and catalytic activity, and reduce the dosage of a traditional cocatalyst MAO.

The invention relates to a migration-resistant anti-aging agent as well as a preparation method and application thereof, the method comprises the following steps: taking a substance as shown in a formula I and nitric acid as reactants, condensing H in an amino para-position group-CH-H and nitryl to obtain a nitrated substance, and carrying out hydrogenation reduction on the nitryl of the nitrated substance under the action of a catalyst to obtain an intermediate product. And carrying out hydrogenation on the intermediate product and ketone under the action of a catalyst to obtain a final product, namely the migration-resistant anti-aging agent II. The raw materials are convenient to purchase and transport, the product yield is high, the cost is low, the operation is simple, and the environmental pollution is small, so that the method has an industrial development prospect. # imgabs0 #

The invention discloses a COF (Covalent Organic Framework) photocatalyst based on accurate regulation and control of benzene ring nitrogen sites as well as a preparation method and application thereof, and belongs to the technical field of COF materials. According to the preparation method, toxic reagents are not needed, high repeatability of a COF structure is achieved by accurately controlling monomer substitution positions, photocatalytic activity and stability in an acid environment are remarkably improved by designing ortho-N-substituted, meta-N-substituted and para-N-substituted COF materials, especially the photocatalytic hydrogen peroxide production rate of ortho-N-substituted oN-COF reaches 3015 [mu] mol.g <-1 >. H <-1 >, and the photocatalytic activity and stability in the acid environment are remarkably improved. The activity is obviously higher than that in the prior art (1.8 mmol.g <-1 >. H <-1 >, namely 1800 mu mol.g <-1 >. H <-1 > reported by Zhang and the like), and the activity is kept 92% after five times of circulation. The process is green and environment-friendly, and is suitable for large-scale production.

The present invention relates to the technical field of supported metallocene catalysts, and particularly relates to a supported metallocene catalyst additive, a preparation method thereof and an application. The supported metallocene catalyst additive has the following structure: #imgabs0#, wherein R is selected from C1-C10 alkyl groups, R1 and R3 are selected from alkyl groups and adamantyl groups and are in the ortho and para positions of -OH, R2 is selected from C1-C10 alkyl groups and cycloalkyl groups, and R' is selected from alkyl groups. This additive can greatly retain the catalytic activity and copolymerization performance of the metallocene catalyst, increase the metal loading and catalytic activity, and reduce the dosage of the traditional cocatalyst MAO.

The invention provides a preparation method of a chlorantraniliprole key intermediate 2-amino-5-cyano-N, 3-dimethyl benzamide, which comprises the following steps: taking cheap and easily available o-methylaniline as a raw material, acylating an aniline substrate through Boc anhydride, carrying out ortho-lithiation on n-butyllithium, introducing carbon dioxide gas, and carrying out acid hydrolysis to obtain 2-amino-3-methyl benzoic acid, thereby obtaining the chlorantraniliprole key intermediate 2-amino-5-cyano-N, 3-dimethyl benzamide. The preparation method comprises the following steps: firstly, preparing an isatoic anhydride intermediate, then carrying out triphosgene ring closing to obtain an isatoic anhydride intermediate, carrying out bromine para-position halogenation, carrying out cuprous cyanide high-temperature Rosenmn-von Braun reaction, and finally carrying out methylamine ring opening to obtain the target product 2-amino-5-cyano-N, 3-dimethylbenzamide, and although the route is long, the yield is high, the continuity is good, few industrial three wastes are generated, and the cost is lower, so that the preparation method has great industrial production value.

The invention relates to the field of chemical synthesis, in particular to an electrochemical synthesis method of a 4 '-N-methylbenzyl-3-indole derivative. According to the preparation method, selected electrons are traceless oxidizing agents, the energy conversion rate is high, no catalyst is needed in the reaction, the reaction steps are few, raw materials are easy to obtain, the reaction conditions are mild, operation is easy, convenient and safe, the substrate expansion range is wide, the compound functional group tolerance is high, the product yield can reach 80% or above, and the compound can be prepared in a gram level. N-methyl N-alkylaniline or N-methylaniline is used for carrying out electrochemical oxidation reaction on indole, N-methyl provides methylene to realize connection between benzene ring para-positions of the N-methyl N-alkylaniline and N-methylaniline and the C3 position of indole, and then the 3-arylmethylindole derivative is efficiently synthesized.

The application relates to a process for preparing a starting monomer by imidazolation of an aldehyde group in the para position of a substituted vinylphenyl starting material and to a starting monomer prepared by this method. The application further relates to a method for preparing a polymer from said starting monomer, to a polymer produced in this way, to a membrane consisting of said polymer, and to the use of the membrane for electrolysis, in fuel cells, in redox flow batteries or for dialysis.

To provide a method for producing vinyl catechol compounds that enables the production of the vinyl catechol compounds without heavy metals.SOLUTION: A method for producing a vinyl catechol compound disclosed herein includes the step for reacting a vinylphenol compound represented by formula (I) with at least one selected from the group consisting of a first microbial cell containing 4-hydroxyphenylacetic acid-3-monooxygenase, a processed product of the first microbial cell, a second microbial cell containing phenol-2-monooxygenase, and a processed product of the second microbial cell. In formula (I), R represents hydrogen or a methyl group, and the position of the hydroxyl group is in the meta or para position relative to the -C(R)=CH2 group.SELECTED DRAWING: None

The invention discloses a long-acting antioxidant for polyamide and a preparation method thereof, and is characterized in that hindered phenol para-position in the structure is bonded with an aromatic carboxylic acid group through amide, and the structure is as follows: # imgabs0 # is obtained by performing acylating chlorination on 3, 5-di-tert-butyl-4-hydroxyphenylpropionic acid and then reacting with 5-aminoisophthalic acid, the operation process is simple, the cost is low, and the long-acting antioxidant is suitable for industrial production. The prepared antioxidant has an excellent long-acting antioxidant effect in polyamide, and has important significance on the service life of a polyamide material.

The present invention provides a preparation method of benzopyrone. The preparation method includes: step S1, using trifluoronitrobenzene as the first raw material, performing ortho-substitution reaction with nitromethane to obtain 1,2-difluoro-4-nitro-3-nitromethylenebenzene, and performing para-substitution reaction with alkoxide to obtain a first intermediate; step S2, subjecting the first intermediate to a Nef reaction, converting the nitromethyl group to a carboxyl group to obtain a second intermediate; step S3, subjecting the second intermediate to a reduction reaction, an oxidation reaction, and a denitrogenation rearrangement reaction to convert the nitro group to an aldehyde hydrazine to obtain an aldehyde hydrazine intermediate; step S4, under the action of a catalyst, subjecting the aldehyde hydrazine intermediate to a nucleophilic addition reaction with the second raw material to generate a secondary alcohol intermediate, and subjecting the secondary alcohol intermediate to a ring-closing reaction to obtain a target product. The above-mentioned method for preparing benzopyrone has a wide range of raw material sources, relatively mild reaction conditions, and a high overall reaction yield.

The invention discloses a method for quantitatively detecting hydroxyl radicals in a soil suspension. Benzoic acid is used as a trapping agent of hydroxyl radicals, is captured at a benzene ring para-position within extremely short reaction time and is stably stored in a benzene ring-OH form, and the concentration of the hydroxyl radicals in the soil suspension to be detected can be accurately quantified through a standard curve of a multi-point external standard method by detecting the peak integral area of a sample. Compared with the existing method, the method has the advantages that the result reproducibility is good, and the detection limit can be as low as 0.58 mu g / L. And the adopted HPLC-MS / MS is used for quantitative analysis of p-hydroxybenzoic acid, has high response and can improve the detection accuracy.

The application relates to the technical field of photoelectric functional materials, in particular to an interface modification layer material and a synthesis method and application thereof. The interface modification layer material provided by the application increases the steric hindrance of the molecule by introducing a functional group at the para-position of the benzene ring in the BPhen molecular structure, and reduces the aggregation and crystallization of the molecule; the molecular weight of the synthesized phenanthroline derivative is large, the glass transition temperature is higher than that of BPhen, and the thermal stability of the material is better; the synthesized phenanthroline derivative exists in the form of ionized quaternary ammonium salt, the reactivity of the imine group in the molecular structure is weaker than that of BPhen or BCP, and the stability of the device is improved; and the synthesis method of the interface modification layer material provided by the application is simple, the yield is high, the purification is easy, the price is low, and the interface modification layer material can be prepared on a large scale. The interface modification layer material can be applied in a semiconductor photoelectric device, and is used as an electrode modification layer to reduce the electrode work function.

The present invention relates to the use as perfuming ingredient of a compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof, and wherein, when R 1 represents a C 1‑2 1-4 alkyl group, X represents a CHO group; or, when R 1 represents a hydrogen atom or a C 1‑2 1-4 alkyl group, X represents a CH(R 6 )CHO group; R 2 , R 3 , R 4 , R 5 and R 6 independently of one another represent a hydrogen atom or a C 1‑2 1-4 alkyl group, or R 3 and R 4 together represent an ethanediyl group; and, relative to position 1, the -C(R 3 )(R 4 )-CH(R 5 )-OH group is an ortho, meta, para substituent of the aromatic ring or a mixture thereof. Furthermore, the compound of formula (I) as part of a perfuming composition or of a perfumed consumer product is also part of the invention.

The invention provides a polyamide lubricating grease thickening agent. The polyamide lubricating grease thickening agent has a structure according to a formula I: (MCA-DA-) (PCA-DA) y-PCA-(DA-PCA) y (-DA-MCA) (I). In formula I, at each occurrence, PCA is independently a reacted polycarboxylate, at each occurrence, MCA is independently a reacted monocarboxylate, at each occurrence, DA is independently a reacted n-alkyl diamine, and y is a 0 or a non-zero integer. In addition, in Formula I, the polyamide grease thickener has a weight average molecular weight in the range of from about 450 g / mol to about 2600 g / mol. Further, in Formula I, the structure comprises at least 4 amide bonds and at least two internal aromatic moieties are disubstituted in the para-position.

The present disclosure provides a tyrosine kinase inhibitor having the general formula (I).R1 is C1-C6 alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, mono-substituted phenyl, poly-substituted phenyl, trifluoromethyl, 2,2,2-trifluoroethyl, CH3O(CH2)n-,R being methyl, ethyl, isopropyl, trifluoromethyl, 2,2,2-trifluoroethyl, cyclopropyl, acetyl or acryloyl, and n being an integer from 1 to 6. R2 and R3 are respectively halogen, hydrogen, amino, substituted amino, cyano, hydroxyl, sulfonic acid group, sulfonamide, trifluoromethyl, 2,2,2-trifluoroethyl, methyl, methoxy or ethynyl. R2 and R3 are in an ortho, para or meta position. Y is NH, O, S or Z—N, where Z is methyl, ethyl, isopropyl, trifluoromethyl, 2,2,2-trifluoroethyl or cyclopropyl. X is Cl, Br or F.

The invention discloses a planar chiral [2.2] paracyclophane alkane monophosphine ligand pEPCP as well as a preparation method and application thereof, and relates to the technical field of chemical catalysis, the planar chiral [2.2] paracyclophane alkane monophosphine ligand pEPCP is characterized by comprising a racemate or an enantiomer, and the structural formula I of the monophosphine ligand pEPCP is as follows: # imgabs0 #. Different types of ether substituents are introduced into the structure of a unique large-steric-hindrance electron-rich rigid skeleton formed by connecting two benzene rings at para-positions through two ethylidene groups, so that the electron cloud density and steric hindrance of aromatic rings directly connected with phosphine ligands are changed. In addition, the ether substituent can also be used as a weak coordination group and participates in adjusting a dihedral angle of ligand chelation. The metal, the ligand and the substrate form the most appropriate coordination environment in the catalysis process, so that the corresponding catalytic reaction has the advantages of high reaction activity, good enantioselectivity, wide substrate universal application range and the like, is particularly suitable for asymmetric coupling reaction catalyzed by transition metal, and has economic practicability and industrial application prospects.

The application discloses a kind of plane chiral [2.2] paracyclophanane monophosphine ligand pEPCP and preparation method and application thereof, it is related to chemical catalysis technical field, and its technical scheme main points are as follows: including racemate or enantiomer, the structural formula-I of the monophosphine ligand pEPCP of the application is as follows: [2.2] paracyclophanane skeleton containing monophosphine ligand pEPCP of the application, with two benzene rings in para position by two ethylene connection unique big steric hindrance, electron-rich rigid skeleton, different types ether substituent group is introduced in structure, change the electron cloud density and steric hindrance of aromatic ring directly connected by phosphine ligand.In addition, ether substituent group can also be used as weak coordination group, participate in adjusting ligand chelate dihedral angle.This makes metal, ligand and substrate form the most suitable coordination environment in catalytic process, so that corresponding catalytic reaction has the advantages such as high reactivity, good enantioselectivity, substrate universal range is wide, especially suitable for transition metal catalyzed asymmetric coupling reaction, with economic practicability and industrial application prospect.

A material having the following structure: # imgabs0 # wherein R and R1 may be the same or different and each independently represents an alkyl group or an aryl group, X may be hydrogen or may be a branched or linear C1-C20 alkyl group, and wherein the aromatic ring substituent attached to polymer B is located meta-or para-position to the aromatic ring substituent attached to polymer A, and wherein polymer A is a non-polar polymer and polymer B is a polymer formed from at least two polar monomers for improving the adhesion of coatings such as paints, inks and adhesives to polyolefin substrates.

The invention provides a synthesis method and a modification method of a TS-1 catalyst and a method for preparing benzenediol. The TS-1 catalyst is obtained by taking tetraethyl orthosilicate as a silicon source, tetrabutyl titanate as a titanium source and quaternary ammonium salt of chitosan and tetrapropylammonium hydroxide as structure-directing agents, and the TS-1 catalyst is uniform in particle size and smooth in surface and has a short b-axis lamellar and mesoporous structure. According to the method, the TS-1 catalyst is modified by the silane coupling agent to obtain the modified TS-1 catalyst, and under the action of the modified TS-1 catalyst, phenol hydroxylation is performed to synthesize benzenediol by taking hydrogen peroxide as an oxidizing agent, so that the phenol conversion rate of hydroxylation reaction and the para-position content in the product are improved, the reaction economic value is increased, and the operation process is simple.

Provided are embodiments of para-substituted 1,1-dialkyl-4-phenylpiperazin-1-ium iodides advantageous for modulating inflammation that have been synthesized and their electrophysiology activities for α9, α9α10, and α7 nAChRs compared. The para position contained alkyl or aryl amides, or heterocyclic isosteres for the amide, and the alkyl groups were varied at the ammonium piperazine nitrogen to see if compensatory changes in size at this position of the molecule impacted function. The compounds were characterized with two-electrode voltage-clamp measurements on Xenopus oocytes expressing nAChRs. General, the compounds were more potent for α9-containing receptors than for α7, and the majority were either full or strong partial agonists for α9-containing nAChR.

This invention discloses a method for synthesizing nitrogen-containing heterocyclic compounds with a maleimide structural unit and a pyrazolone ring. The method includes the following steps: N-phenylmaleimide olefin and pyrazolone olefin are reacted with 4-dimethylaminopyridine in dichloromethane at a reflux temperature of dichloromethane. After the reaction, saturated brine is added to quench the reaction, followed by extraction with ethyl acetate, removal of the solvent by rotary evaporation under reduced pressure, and separation by forward silica gel column chromatography to obtain nitrogen-containing heterocyclic compounds with a maleimide structural unit and a pyrazolone ring. This invention utilizes optimal reaction conditions for substrate expansion, introducing methyl, methoxy, and chlorine atoms at the ortho, meta, and para positions on the benzene ring of N-phenylmaleimide olefin, constructing a series of nitrogen-containing heterocyclic compounds simultaneously containing a maleimide structural unit and a pyrazolone ring in yields up to 90%. The reaction method of this invention has a fast reaction rate and high yield.

The invention discloses a preparation method and a preparation system of p-chloro-o-cresol, and the preparation method comprises the following steps: 1) adding dichloroethane into molten o-cresol, and adding a catalyst; (2) controlling the temperature to be 5-15 DEG C, and adding sulfuryl chloride into the material in the step (1) at different feeding speeds according to the reaction time and the reaction stage; and (3) after the reaction is finished, rectifying and purifying liquid of reaction materials to obtain the p-chloro-o-cresol. According to the present invention, the process is simple, the reaction condition is mild, the reaction is controlled, the selectivity is high, the ortho-cresol is subjected to preferential para-position chlorination, the reaction is sufficient, the selectivity is high, the polychlorination phenomenon is avoided, the phenol content and the isomer content in the crude product are low, the yield is high, and the large-scale production is easily achieved.

Metal-organic framework material (MOF), comprising at least one metal center and at least one organic compound selected among the compounds according to formula (I):wherein n is from 1 to 2,R is —(CH2—CH2—O)m—CH3 with m from 1 to 7;preferably when n=1, the two —COOH groups are located in the para position relatively to the aryl substituted by the two RO groups; andpreferably when n=2, the four —COOH groups are located in the meta position relatively to the aryl substituted by the two RO groups.

This invention discloses a novel molecular fingerprinting algorithm for assisting in the design of MOFs for acid gas separation, comprising the following steps: S1, using drawing software to draw 17 possible ortho, meta, and para positions of benzene rings, five-membered rings, and six-membered rings, obtaining their .mol ​​files; S2, converting the .mol ​​files to .smart format and writing a separate .py file for the new fingerprint; S3, calling the original fingerprint in the newly written .py file, adding the two results to obtain a new 184-bit fingerprint; S4, using the new fingerprint to test multiple CoRE-MOFs using various machine learning methods. This invention can determine whether the N-bond in a five-membered or six-membered ring of a macromolecule is ortho, meta, or para, which is beneficial for identifying differences in molecular structure between molecules with different performance characteristics, thereby accelerating the screening of high-performance materials, effectively saving time and costs, and shortening the development cycle.

The invention provides an aryl amide derivative containing a tertiary carbon center and a preparation method thereof. The preparation method comprises the following steps: in an inert atmosphere, adding aryl amide, a metal reducing agent, an iron catalyst and secondary chloralkane into an organic solvent, stirring at normal temperature for reaction, and quenching, separating and purifying after the reaction is completed to obtain the aryl amide derivative with the para-position being the tertiary carbon center. The method has the advantages of simple operation, easily available raw materials, mild reaction conditions and considerable yield.

A system for effecting conversion of hydrogen from an ortho-isomer to a para-isomer is disclosed. The system comprises at least one reactor (10) comprising at least one reaction chamber (11) filled with a catalytic bed comprising a metal organic framework (MOF), characterized in that the at least one reaction chamber (11) is surrounded by a housing (12) through which a flow of cooling fluid is susceptible to pass.

The invention discloses a synthesis method for para-acylation / migration of aromatic hydrocarbon under catalysis of carbene, which is characterized by comprising the following steps: reacting aldehyde, acrylamide, a fluorine source, a carbene catalyst, alkali and a solvent in N2 atmosphere under heating and stirring conditions, then adding water for quenching, extracting with ethyl acetate, removing the solvent in vacuum to obtain a coarse material, purifying the coarse material by silica gel column chromatography, and finally obtaining the para-acylation / migration of aromatic hydrocarbon under catalysis of carbene. The target compound beta-aryl-gamma-perfluoroalkyl amide derivative is obtained. The reaction is carried out under extremely mild conditions, the substrate range is wide, and the tolerance of functional groups is good. The method provided by the invention has selectivity on aromatic acylation positions, and is not influenced by electron and space effects of aromatic substrates. In addition, the research activity of the derivatives shows that the derivatives have the potential to be developed into effective fungicides for crop protection. The compound can be used as a potential candidate drug for inhibiting phytopathogen bacteria, and has good research and development values.

A polypropylene composition (PC) comprising: a. from 95.0 to 99.99 wt.-%, of a polypropylene (PP), preferably a propylene homopolymer (HPP); and b. from 0.01 to 5.0 wt.-%, of a compound according to Formula (I), wherein each R is independently selected from C1 to C6 alkylene, C2 to C6 alkenylene and a single bond, each R′ is independently selected from H and C1 to C6 alkyl, each R″ is independently selected from H and C1 to C22 alkyl, wherein each alkylene, alkenylene and alkyl group may optionally be substituted by deuterium or fluorine, and the two substituents on the central benzene ring may be either positioned in an ortho, meta or para relationship; wherein the polypropylene composition (PC) has an MFR2 of from 400 to 5000 g / 10 min and a melting temperature Tm of from 140 to 170° C.

The present invention relates to an aqueous adhesive composition comprising a thermosetting resin based on: - at least one aromatic hydrocarbon compound A1 comprising at least one aromatic hydrocarbon compound comprising at least two aromatic rings bearing a single hydroxyl function, it being understood that at least one of the ortho or para positions of each aromatic ring is unsubstituted; - at least one aromatic compound A2 comprising a single phenol which is unsubstituted or substituted by a single alkyl or a single alkenyl group; and - a formaldehyde compound A3. According to the invention, the aromatic compound A2 is present in a weight content of the dry extract of the adhesive composition of less than or equal to 0.18.