97 results about "Para position" patented technology

The invention discloses a tetranuclear ladder type organic tin carboxylate complex as well as a preparation method and application thereof, and belongs to the technical field of metal complexes, the tetranuclear ladder type organic tin carboxylate complex is prepared by taking para-position or ortho-position substituted benzoic acid as a ligand and taking organic tin dimethyl tin oxide as a substrate. The preparation method is simple to operate and mild in condition. The tetranuclear ladder type organic tin carboxylate complex can be used as a photocatalyst for photocatalytic production of H2O2, and the photocatalytic H2O2 production rate is as high as 5.12 * 10 < 3 > [mu] mol.g <-1 >. H <-1 > and is higher than the H2O2 production rate of a photocatalyst reported in the existing literature.

The invention discloses a COF (Covalent Organic Framework) photocatalyst based on accurate regulation and control of benzene ring nitrogen sites as well as a preparation method and application thereof, and belongs to the technical field of COF materials. According to the preparation method, toxic reagents are not needed, high repeatability of a COF structure is achieved by accurately controlling monomer substitution positions, photocatalytic activity and stability in an acid environment are remarkably improved by designing ortho-N-substituted, meta-N-substituted and para-N-substituted COF materials, especially the photocatalytic hydrogen peroxide production rate of ortho-N-substituted oN-COF reaches 3015 [mu] mol.g <-1 >. H <-1 >, and the photocatalytic activity and stability in the acid environment are remarkably improved. The activity is obviously higher than that in the prior art (1.8 mmol.g <-1 >. H <-1 >, namely 1800 mu mol.g <-1 >. H <-1 > reported by Zhang and the like), and the activity is kept 92% after five times of circulation. The process is green and environment-friendly, and is suitable for large-scale production.

The present invention relates to the technical field of supported metallocene catalysts, and particularly relates to a supported metallocene catalyst additive, a preparation method thereof and an application. The supported metallocene catalyst additive has the following structure: #imgabs0#, wherein R is selected from C1-C10 alkyl groups, R1 and R3 are selected from alkyl groups and adamantyl groups and are in the ortho and para positions of -OH, R2 is selected from C1-C10 alkyl groups and cycloalkyl groups, and R' is selected from alkyl groups. This additive can greatly retain the catalytic activity and copolymerization performance of the metallocene catalyst, increase the metal loading and catalytic activity, and reduce the dosage of the traditional cocatalyst MAO.

The invention relates to the field of chemical synthesis, in particular to an electrochemical synthesis method of a 4 '-N-methylbenzyl-3-indole derivative. According to the preparation method, selected electrons are traceless oxidizing agents, the energy conversion rate is high, no catalyst is needed in the reaction, the reaction steps are few, raw materials are easy to obtain, the reaction conditions are mild, operation is easy, convenient and safe, the substrate expansion range is wide, the compound functional group tolerance is high, the product yield can reach 80% or above, and the compound can be prepared in a gram level. N-methyl N-alkylaniline or N-methylaniline is used for carrying out electrochemical oxidation reaction on indole, N-methyl provides methylene to realize connection between benzene ring para-positions of the N-methyl N-alkylaniline and N-methylaniline and the C3 position of indole, and then the 3-arylmethylindole derivative is efficiently synthesized.

The application relates to a process for preparing a starting monomer by imidazolation of an aldehyde group in the para position of a substituted vinylphenyl starting material and to a starting monomer prepared by this method. The application further relates to a method for preparing a polymer from said starting monomer, to a polymer produced in this way, to a membrane consisting of said polymer, and to the use of the membrane for electrolysis, in fuel cells, in redox flow batteries or for dialysis.

The present invention provides a preparation method of benzopyrone. The preparation method includes: step S1, using trifluoronitrobenzene as the first raw material, performing ortho-substitution reaction with nitromethane to obtain 1,2-difluoro-4-nitro-3-nitromethylenebenzene, and performing para-substitution reaction with alkoxide to obtain a first intermediate; step S2, subjecting the first intermediate to a Nef reaction, converting the nitromethyl group to a carboxyl group to obtain a second intermediate; step S3, subjecting the second intermediate to a reduction reaction, an oxidation reaction, and a denitrogenation rearrangement reaction to convert the nitro group to an aldehyde hydrazine to obtain an aldehyde hydrazine intermediate; step S4, under the action of a catalyst, subjecting the aldehyde hydrazine intermediate to a nucleophilic addition reaction with the second raw material to generate a secondary alcohol intermediate, and subjecting the secondary alcohol intermediate to a ring-closing reaction to obtain a target product. The above-mentioned method for preparing benzopyrone has a wide range of raw material sources, relatively mild reaction conditions, and a high overall reaction yield.

The application relates to the technical field of photoelectric functional materials, in particular to an interface modification layer material and a synthesis method and application thereof. The interface modification layer material provided by the application increases the steric hindrance of the molecule by introducing a functional group at the para-position of the benzene ring in the BPhen molecular structure, and reduces the aggregation and crystallization of the molecule; the molecular weight of the synthesized phenanthroline derivative is large, the glass transition temperature is higher than that of BPhen, and the thermal stability of the material is better; the synthesized phenanthroline derivative exists in the form of ionized quaternary ammonium salt, the reactivity of the imine group in the molecular structure is weaker than that of BPhen or BCP, and the stability of the device is improved; and the synthesis method of the interface modification layer material provided by the application is simple, the yield is high, the purification is easy, the price is low, and the interface modification layer material can be prepared on a large scale. The interface modification layer material can be applied in a semiconductor photoelectric device, and is used as an electrode modification layer to reduce the electrode work function.

The present invention relates to the use as perfuming ingredient of a compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof, and wherein, when R 1 represents a C 1‑2 1-4 alkyl group, X represents a CHO group; or, when R 1 represents a hydrogen atom or a C 1‑2 1-4 alkyl group, X represents a CH(R 6 )CHO group; R 2 , R 3 , R 4 , R 5 and R 6 independently of one another represent a hydrogen atom or a C 1‑2 1-4 alkyl group, or R 3 and R 4 together represent an ethanediyl group; and, relative to position 1, the -C(R 3 )(R 4 )-CH(R 5 )-OH group is an ortho, meta, para substituent of the aromatic ring or a mixture thereof. Furthermore, the compound of formula (I) as part of a perfuming composition or of a perfumed consumer product is also part of the invention.

The present disclosure provides a tyrosine kinase inhibitor having the general formula (I).R1 is C1-C6 alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, mono-substituted phenyl, poly-substituted phenyl, trifluoromethyl, 2,2,2-trifluoroethyl, CH3O(CH2)n-,R being methyl, ethyl, isopropyl, trifluoromethyl, 2,2,2-trifluoroethyl, cyclopropyl, acetyl or acryloyl, and n being an integer from 1 to 6. R2 and R3 are respectively halogen, hydrogen, amino, substituted amino, cyano, hydroxyl, sulfonic acid group, sulfonamide, trifluoromethyl, 2,2,2-trifluoroethyl, methyl, methoxy or ethynyl. R2 and R3 are in an ortho, para or meta position. Y is NH, O, S or Z—N, where Z is methyl, ethyl, isopropyl, trifluoromethyl, 2,2,2-trifluoroethyl or cyclopropyl. X is Cl, Br or F.

The application discloses a kind of plane chiral [2.2] paracyclophanane monophosphine ligand pEPCP and preparation method and application thereof, it is related to chemical catalysis technical field, and its technical scheme main points are as follows: including racemate or enantiomer, the structural formula-I of the monophosphine ligand pEPCP of the application is as follows: [2.2] paracyclophanane skeleton containing monophosphine ligand pEPCP of the application, with two benzene rings in para position by two ethylene connection unique big steric hindrance, electron-rich rigid skeleton, different types ether substituent group is introduced in structure, change the electron cloud density and steric hindrance of aromatic ring directly connected by phosphine ligand.In addition, ether substituent group can also be used as weak coordination group, participate in adjusting ligand chelate dihedral angle.This makes metal, ligand and substrate form the most suitable coordination environment in catalytic process, so that corresponding catalytic reaction has the advantages such as high reactivity, good enantioselectivity, substrate universal range is wide, especially suitable for transition metal catalyzed asymmetric coupling reaction, with economic practicability and industrial application prospect.

The invention provides a synthesis method and a modification method of a TS-1 catalyst and a method for preparing benzenediol. The TS-1 catalyst is obtained by taking tetraethyl orthosilicate as a silicon source, tetrabutyl titanate as a titanium source and quaternary ammonium salt of chitosan and tetrapropylammonium hydroxide as structure-directing agents, and the TS-1 catalyst is uniform in particle size and smooth in surface and has a short b-axis lamellar and mesoporous structure. According to the method, the TS-1 catalyst is modified by the silane coupling agent to obtain the modified TS-1 catalyst, and under the action of the modified TS-1 catalyst, phenol hydroxylation is performed to synthesize benzenediol by taking hydrogen peroxide as an oxidizing agent, so that the phenol conversion rate of hydroxylation reaction and the para-position content in the product are improved, the reaction economic value is increased, and the operation process is simple.

Provided are embodiments of para-substituted 1,1-dialkyl-4-phenylpiperazin-1-ium iodides advantageous for modulating inflammation that have been synthesized and their electrophysiology activities for α9, α9α10, and α7 nAChRs compared. The para position contained alkyl or aryl amides, or heterocyclic isosteres for the amide, and the alkyl groups were varied at the ammonium piperazine nitrogen to see if compensatory changes in size at this position of the molecule impacted function. The compounds were characterized with two-electrode voltage-clamp measurements on Xenopus oocytes expressing nAChRs. General, the compounds were more potent for α9-containing receptors than for α7, and the majority were either full or strong partial agonists for α9-containing nAChR.

This invention discloses a method for synthesizing nitrogen-containing heterocyclic compounds with a maleimide structural unit and a pyrazolone ring. The method includes the following steps: N-phenylmaleimide olefin and pyrazolone olefin are reacted with 4-dimethylaminopyridine in dichloromethane at a reflux temperature of dichloromethane. After the reaction, saturated brine is added to quench the reaction, followed by extraction with ethyl acetate, removal of the solvent by rotary evaporation under reduced pressure, and separation by forward silica gel column chromatography to obtain nitrogen-containing heterocyclic compounds with a maleimide structural unit and a pyrazolone ring. This invention utilizes optimal reaction conditions for substrate expansion, introducing methyl, methoxy, and chlorine atoms at the ortho, meta, and para positions on the benzene ring of N-phenylmaleimide olefin, constructing a series of nitrogen-containing heterocyclic compounds simultaneously containing a maleimide structural unit and a pyrazolone ring in yields up to 90%. The reaction method of this invention has a fast reaction rate and high yield.

The invention discloses a preparation method and a preparation system of p-chloro-o-cresol, and the preparation method comprises the following steps: 1) adding dichloroethane into molten o-cresol, and adding a catalyst; (2) controlling the temperature to be 5-15 DEG C, and adding sulfuryl chloride into the material in the step (1) at different feeding speeds according to the reaction time and the reaction stage; and (3) after the reaction is finished, rectifying and purifying liquid of reaction materials to obtain the p-chloro-o-cresol. According to the present invention, the process is simple, the reaction condition is mild, the reaction is controlled, the selectivity is high, the ortho-cresol is subjected to preferential para-position chlorination, the reaction is sufficient, the selectivity is high, the polychlorination phenomenon is avoided, the phenol content and the isomer content in the crude product are low, the yield is high, and the large-scale production is easily achieved.

This invention discloses a novel molecular fingerprinting algorithm for assisting in the design of MOFs for acid gas separation, comprising the following steps: S1, using drawing software to draw 17 possible ortho, meta, and para positions of benzene rings, five-membered rings, and six-membered rings, obtaining their .mol ​​files; S2, converting the .mol ​​files to .smart format and writing a separate .py file for the new fingerprint; S3, calling the original fingerprint in the newly written .py file, adding the two results to obtain a new 184-bit fingerprint; S4, using the new fingerprint to test multiple CoRE-MOFs using various machine learning methods. This invention can determine whether the N-bond in a five-membered or six-membered ring of a macromolecule is ortho, meta, or para, which is beneficial for identifying differences in molecular structure between molecules with different performance characteristics, thereby accelerating the screening of high-performance materials, effectively saving time and costs, and shortening the development cycle.

The invention provides an aryl amide derivative containing a tertiary carbon center and a preparation method thereof. The preparation method comprises the following steps: in an inert atmosphere, adding aryl amide, a metal reducing agent, an iron catalyst and secondary chloralkane into an organic solvent, stirring at normal temperature for reaction, and quenching, separating and purifying after the reaction is completed to obtain the aryl amide derivative with the para-position being the tertiary carbon center. The method has the advantages of simple operation, easily available raw materials, mild reaction conditions and considerable yield.

A system for effecting conversion of hydrogen from an ortho-isomer to a para-isomer is disclosed. The system comprises at least one reactor (10) comprising at least one reaction chamber (11) filled with a catalytic bed comprising a metal organic framework (MOF), characterized in that the at least one reaction chamber (11) is surrounded by a housing (12) through which a flow of cooling fluid is susceptible to pass.

The invention discloses a synthesis method for para-acylation / migration of aromatic hydrocarbon under catalysis of carbene, which is characterized by comprising the following steps: reacting aldehyde, acrylamide, a fluorine source, a carbene catalyst, alkali and a solvent in N2 atmosphere under heating and stirring conditions, then adding water for quenching, extracting with ethyl acetate, removing the solvent in vacuum to obtain a coarse material, purifying the coarse material by silica gel column chromatography, and finally obtaining the para-acylation / migration of aromatic hydrocarbon under catalysis of carbene. The target compound beta-aryl-gamma-perfluoroalkyl amide derivative is obtained. The reaction is carried out under extremely mild conditions, the substrate range is wide, and the tolerance of functional groups is good. The method provided by the invention has selectivity on aromatic acylation positions, and is not influenced by electron and space effects of aromatic substrates. In addition, the research activity of the derivatives shows that the derivatives have the potential to be developed into effective fungicides for crop protection. The compound can be used as a potential candidate drug for inhibiting phytopathogen bacteria, and has good research and development values.

A polypropylene composition (PC) comprising: a. from 95.0 to 99.99 wt.-%, of a polypropylene (PP), preferably a propylene homopolymer (HPP); and b. from 0.01 to 5.0 wt.-%, of a compound according to Formula (I), wherein each R is independently selected from C1 to C6 alkylene, C2 to C6 alkenylene and a single bond, each R′ is independently selected from H and C1 to C6 alkyl, each R″ is independently selected from H and C1 to C22 alkyl, wherein each alkylene, alkenylene and alkyl group may optionally be substituted by deuterium or fluorine, and the two substituents on the central benzene ring may be either positioned in an ortho, meta or para relationship; wherein the polypropylene composition (PC) has an MFR2 of from 400 to 5000 g / 10 min and a melting temperature Tm of from 140 to 170° C.

The present invention relates to an aqueous adhesive composition comprising a thermosetting resin based on: - at least one aromatic hydrocarbon compound A1 comprising at least one aromatic hydrocarbon compound comprising at least two aromatic rings bearing a single hydroxyl function, it being understood that at least one of the ortho or para positions of each aromatic ring is unsubstituted; - at least one aromatic compound A2 comprising a single phenol which is unsubstituted or substituted by a single alkyl or a single alkenyl group; and - a formaldehyde compound A3. According to the invention, the aromatic compound A2 is present in a weight content of the dry extract of the adhesive composition of less than or equal to 0.18.

The invention relates to the technical field of organic synthesis, and discloses a preparation method of dialkyl substituted biphenyl, which comprises the following steps: (1) in the presence of hydrogen and a hydroalkylation catalyst, contacting alkylbenzene with benzene, and carrying out hydroalkylation reaction to obtain a product mixture containing cyclohexyl alkylbenzene isomers; wherein on the basis of the total amount of the cyclohexyl alkylbenzene isomers in the product mixture, the total amount of the p-cyclohexyl alkylbenzene and / or the m-cyclohexyl alkylbenzene is not less than 90wt%; (2) separating and purifying the product mixture to separate unreacted benzene, alkylbenzene and optional cyclohexylbenzene, so as to obtain a cyclohexylalkylbenzene isomer mixture; (3) contacting the cyclohexylalkylbenzene isomer mixture with a dehydrogenation catalyst for dehydrogenation reaction; and (4) contacting a product of the dehydrogenation reaction with olefin, and carrying out an alkylation reaction. The method has higher total yield of para-position and meta-position dialkyl substituted biphenyl.

The invention relates to a composition containing a novolak and water. In one embodiment, a composition is provided comprising novolak and water with the percentage of ortho linkages of the phenol rings of the novolak is greater than that of para linkages, the novolak having a phenolic compound and an aldehyde molar ratio of from 1:0.2 to 1:0.45 and the composition having from 2% to 20% by weight of water based on the weight of the sum of the novolak and the water.

The invention provides an improved preparation method of a benzoyl sulfamoyl benzoic acid compound, which is characterized in that a benzoic acid compound as shown in a formula I and p-carboxybenzenesulfonamide are directly condensed by using phosphorus pentoxide as a condensing agent to generate the benzoyl sulfamoyl benzoic acid compound as shown in a formula II, r1 is hydrogen, halogen, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-6 cycloalkyl group or a C3-6 cycloalkyloxy group, preferably hydrogen, a C1-6 alkyl group or a C1-6 alkoxy group, more preferably a C1-6 alkoxy group, and further preferably a methoxy group; the number of R1 is 1-2, when two R1 exist, the R1 can be the same or different, and the R1 is in the ortho-position or para-position, preferably in the ortho-position; in particular, R1 is preferably an ortho-substituted methoxy group. Formula I and formula II.

The present application relates to a kind of small molecule probes and its preparation method and application, the chemical structure of the probe is as shown in the following formula: Wherein, R1 is 1-propyl sulfonic acid or 1-butyl sulfonic acid;R2 independently selected from trifluoromethyl or sulfur pentafluoride group, the substitution position of R2 is the ortho, para or meta of hydroxyl on benzene ring;Preparation method is by the condensation reaction of salicylaldehyde containing fluorine substituent group and indoline, directly introduce containing fluorine substituent group into the spiro-pyran molecule structure with pH response, prepared with 19 F MRI and fluorescence imaging pH-responsive bimodal imaging small molecule probe.Compared with the prior art, the small molecule probe of the present application exhibits significantly different 19 F NMR chemical shift and fluorescence intensity, high-resolution 19 F MRI imaging and fluorescence imaging, greatly improve the sensitivity and accuracy of imaging, has important application prospect in the field of biosensing, cell imaging, medical diagnosis etc.

The present invention proposes a process for preparing high-purity estetrol, which uses (17β)-3-(phenylmethoxy)-estra-1,3,5(10),15-tetraen-17-ol acetate as a raw material, introduces hydroxyl groups at positions 15 and 16 through a dihydroxylation reaction, protects the hydroxyl groups at positions 15 and 16 through a ketal reaction, separates isomers, and then sequentially removes the benzyl protecting group, the acyl group, and the ketal protecting group. Finally, the process is purified to obtain a compound of formula (I) #imgabs0#. The present invention uses a ketal method to protect the hydroxyl groups at positions 15 and 16, and then separates the isomers, thereby achieving a satisfactory isomer removal effect and refining yield. Moreover, the process is convenient, and the ketal reaction only requires the use of an organic ketone reagent and a catalytic amount of acid. The organic ketone reagent can be completely recovered and reused, and almost no waste is generated.

The present invention relates to an aqueous adhesive composition, comprising a thermosetting resin based on: - at least one hydrocarbon aromatic compound A1 comprising at least one hydrocarbon aromatic compound comprising at least two aromatic rings bearing a single hydroxyl function, it being understood that at least one of the ortho or para positions of each aromatic ring is unsubstituted; and - a formaldehyde compound A3; in which an aromatic compound A2 comprising a single phenol substituted or not by a single alkyl group or by a single alkenyl group is at a mass percentage of dry extract of the adhesive composition of at most 0.23.

The invention provides a preparation method and application of p-tert-butyltoluene. By adopting the hierarchical porous SAPO-5 molecular sieve catalyst with the microporous-mesoporous composite structure, a meta-position product can be promoted to be converted into a para-position product, the isomerization reaction performance is effectively improved, the side chain cracking reaction is reduced, and the yield of para-tert-butyltoluene is further improved, so that the economical efficiency of the reaction is remarkably improved, and the method has relatively great industrial application potential.

The invention provides a preparation method of cyproterone acetate. The preparation method comprises the following steps: a) converting a compound as shown in a formula (1) into a compound as shown in a formula (2); and b) converting the compound shown in the formula (2) into cyproterone acetate. According to the invention, 1alpha, 2alpha-methylene-4, 6-diene pregna-3, 20-diketone-17-acetate is taken as a raw material, epoxy reaction is firstly carried out on the 6 site and the 7 site to obtain a compound shown in a formula (2), and then epoxy ring-opening elimination is carried out on the 6 site and the 7 site to obtain cyproterone acetate. The reaction route provided by the invention is short in synthesis path, short in reaction time, few in by-products, high in conversion rate and high in finished product quality. Experimental results show that the chromatographic purity of the prepared cyproterone acetate is 99.86% or above, and the cyproterone acetate does not contain more than 0.1% of impurities.

The invention belongs to the technical field of catalysts, and particularly discloses a method for preparing cresol by catalyzing xylenol and phenol in the presence of a pyridine acidic ionic liquid in the presence of hydrogen, and the cresol (ortho-position, meta-position and para-position mixed cresol) is prepared by taking the xylenol and the phenol as raw materials and taking the pyridine acidic ionic liquid as a solvent and a catalyst in the presence of the hydrogen. According to the reaction process conditions, the hydrogen pressure ranges from 1 MPa to 3 MPa, the reaction time ranges from 2 h to 8 h, the reaction temperature ranges from 250 DEG C to 350 DEG C, the ratio of phenol to xylenol (mole) is 1-4, the ratio of pyridine acidic ionic liquid to raw materials (phenol and xylenol) is 10 / 90-30 / 70 (wt), the conversion rate of the xylenol in the reaction can reach 75.68%, and the selectivity of the xylenol can reach 87.58%. The pyridine acidic ionic liquid can be recycled.

The present invention discloses a near-infrared fluoroboron dipyrrole compound for bioimaging and sonodynamic therapy and a preparation method thereof. The chemical structural formula of the compound is shown in Formula 4; the preparation method is: first, para-substituted benzaldehyde, 2,4-dimethylpyrrole and boron trifluoride ether are prepared under acid catalysis by the fluoroboron dipyrrole compound; then the obtained fluoroboron dipyrrole compound and the para-substituted benzaldehyde are dehydrated and condensed under the catalysis of acid and base to obtain a target product. The near-infrared difluoroboron pyrrole compound disclosed in the present invention has mild synthesis conditions, short reaction time, high yield, simple post-processing and a wide range of structural applications. The present invention connects thiomethylbenzaldehyde and aniline derivatives to the fluoroboron dipyrrole skeleton, and the prepared compound has absorption and fluorescence emission in the near-infrared region, and has good bioimaging effect; in addition, it can also efficiently generate reactive oxygen species under ultrasound, and can produce excellent sonodynamic effect.