73 results about "Para position" patented technology

The application relates to a process for preparing a starting monomer by imidazolation of an aldehyde group in the para position of a substituted vinylphenyl starting material and to a starting monomer prepared by this method. The application further relates to a method for preparing a polymer from said starting monomer, to a polymer produced in this way, to a membrane consisting of said polymer, and to the use of the membrane for electrolysis, in fuel cells, in redox flow batteries or for dialysis.

The application relates to the technical field of photoelectric functional materials, in particular to an interface modification layer material and a synthesis method and application thereof. The interface modification layer material provided by the application increases the steric hindrance of the molecule by introducing a functional group at the para-position of the benzene ring in the BPhen molecular structure, and reduces the aggregation and crystallization of the molecule; the molecular weight of the synthesized phenanthroline derivative is large, the glass transition temperature is higher than that of BPhen, and the thermal stability of the material is better; the synthesized phenanthroline derivative exists in the form of ionized quaternary ammonium salt, the reactivity of the imine group in the molecular structure is weaker than that of BPhen or BCP, and the stability of the device is improved; and the synthesis method of the interface modification layer material provided by the application is simple, the yield is high, the purification is easy, the price is low, and the interface modification layer material can be prepared on a large scale. The interface modification layer material can be applied in a semiconductor photoelectric device, and is used as an electrode modification layer to reduce the electrode work function.

The present invention relates to the use as perfuming ingredient of a compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof, and wherein, when R 1 represents a C 1‑2 1-4 alkyl group, X represents a CHO group; or, when R 1 represents a hydrogen atom or a C 1‑2 1-4 alkyl group, X represents a CH(R 6 )CHO group; R 2 , R 3 , R 4 , R 5 and R 6 independently of one another represent a hydrogen atom or a C 1‑2 1-4 alkyl group, or R 3 and R 4 together represent an ethanediyl group; and, relative to position 1, the -C(R 3 )(R 4 )-CH(R 5 )-OH group is an ortho, meta, para substituent of the aromatic ring or a mixture thereof. Furthermore, the compound of formula (I) as part of a perfuming composition or of a perfumed consumer product is also part of the invention.

The present disclosure provides a tyrosine kinase inhibitor having the general formula (I).R1 is C1-C6 alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, mono-substituted phenyl, poly-substituted phenyl, trifluoromethyl, 2,2,2-trifluoroethyl, CH3O(CH2)n-,R being methyl, ethyl, isopropyl, trifluoromethyl, 2,2,2-trifluoroethyl, cyclopropyl, acetyl or acryloyl, and n being an integer from 1 to 6. R2 and R3 are respectively halogen, hydrogen, amino, substituted amino, cyano, hydroxyl, sulfonic acid group, sulfonamide, trifluoromethyl, 2,2,2-trifluoroethyl, methyl, methoxy or ethynyl. R2 and R3 are in an ortho, para or meta position. Y is NH, O, S or Z—N, where Z is methyl, ethyl, isopropyl, trifluoromethyl, 2,2,2-trifluoroethyl or cyclopropyl. X is Cl, Br or F.

The application discloses a kind of plane chiral [2.2] paracyclophanane monophosphine ligand pEPCP and preparation method and application thereof, it is related to chemical catalysis technical field, and its technical scheme main points are as follows: including racemate or enantiomer, the structural formula-I of the monophosphine ligand pEPCP of the application is as follows: [2.2] paracyclophanane skeleton containing monophosphine ligand pEPCP of the application, with two benzene rings in para position by two ethylene connection unique big steric hindrance, electron-rich rigid skeleton, different types ether substituent group is introduced in structure, change the electron cloud density and steric hindrance of aromatic ring directly connected by phosphine ligand.In addition, ether substituent group can also be used as weak coordination group, participate in adjusting ligand chelate dihedral angle.This makes metal, ligand and substrate form the most suitable coordination environment in catalytic process, so that corresponding catalytic reaction has the advantages such as high reactivity, good enantioselectivity, substrate universal range is wide, especially suitable for transition metal catalyzed asymmetric coupling reaction, with economic practicability and industrial application prospect.

This invention discloses a method for synthesizing nitrogen-containing heterocyclic compounds with a maleimide structural unit and a pyrazolone ring. The method includes the following steps: N-phenylmaleimide olefin and pyrazolone olefin are reacted with 4-dimethylaminopyridine in dichloromethane at a reflux temperature of dichloromethane. After the reaction, saturated brine is added to quench the reaction, followed by extraction with ethyl acetate, removal of the solvent by rotary evaporation under reduced pressure, and separation by forward silica gel column chromatography to obtain nitrogen-containing heterocyclic compounds with a maleimide structural unit and a pyrazolone ring. This invention utilizes optimal reaction conditions for substrate expansion, introducing methyl, methoxy, and chlorine atoms at the ortho, meta, and para positions on the benzene ring of N-phenylmaleimide olefin, constructing a series of nitrogen-containing heterocyclic compounds simultaneously containing a maleimide structural unit and a pyrazolone ring in yields up to 90%. The reaction method of this invention has a fast reaction rate and high yield.

The invention discloses a preparation method and a preparation system of p-chloro-o-cresol, and the preparation method comprises the following steps: 1) adding dichloroethane into molten o-cresol, and adding a catalyst; (2) controlling the temperature to be 5-15 DEG C, and adding sulfuryl chloride into the material in the step (1) at different feeding speeds according to the reaction time and the reaction stage; and (3) after the reaction is finished, rectifying and purifying liquid of reaction materials to obtain the p-chloro-o-cresol. According to the present invention, the process is simple, the reaction condition is mild, the reaction is controlled, the selectivity is high, the ortho-cresol is subjected to preferential para-position chlorination, the reaction is sufficient, the selectivity is high, the polychlorination phenomenon is avoided, the phenol content and the isomer content in the crude product are low, the yield is high, and the large-scale production is easily achieved.

This invention discloses a novel molecular fingerprinting algorithm for assisting in the design of MOFs for acid gas separation, comprising the following steps: S1, using drawing software to draw 17 possible ortho, meta, and para positions of benzene rings, five-membered rings, and six-membered rings, obtaining their .mol ​​files; S2, converting the .mol ​​files to .smart format and writing a separate .py file for the new fingerprint; S3, calling the original fingerprint in the newly written .py file, adding the two results to obtain a new 184-bit fingerprint; S4, using the new fingerprint to test multiple CoRE-MOFs using various machine learning methods. This invention can determine whether the N-bond in a five-membered or six-membered ring of a macromolecule is ortho, meta, or para, which is beneficial for identifying differences in molecular structure between molecules with different performance characteristics, thereby accelerating the screening of high-performance materials, effectively saving time and costs, and shortening the development cycle.

A system for effecting conversion of hydrogen from an ortho-isomer to a para-isomer is disclosed. The system comprises at least one reactor (10) comprising at least one reaction chamber (11) filled with a catalytic bed comprising a metal organic framework (MOF), characterized in that the at least one reaction chamber (11) is surrounded by a housing (12) through which a flow of cooling fluid is susceptible to pass.

A polypropylene composition (PC) comprising: a. from 95.0 to 99.99 wt.-%, of a polypropylene (PP), preferably a propylene homopolymer (HPP); and b. from 0.01 to 5.0 wt.-%, of a compound according to Formula (I), wherein each R is independently selected from C1 to C6 alkylene, C2 to C6 alkenylene and a single bond, each R′ is independently selected from H and C1 to C6 alkyl, each R″ is independently selected from H and C1 to C22 alkyl, wherein each alkylene, alkenylene and alkyl group may optionally be substituted by deuterium or fluorine, and the two substituents on the central benzene ring may be either positioned in an ortho, meta or para relationship; wherein the polypropylene composition (PC) has an MFR2 of from 400 to 5000 g / 10 min and a melting temperature Tm of from 140 to 170° C.

The present invention relates to an aqueous adhesive composition comprising a thermosetting resin based on: - at least one aromatic hydrocarbon compound A1 comprising at least one aromatic hydrocarbon compound comprising at least two aromatic rings bearing a single hydroxyl function, it being understood that at least one of the ortho or para positions of each aromatic ring is unsubstituted; - at least one aromatic compound A2 comprising a single phenol which is unsubstituted or substituted by a single alkyl or a single alkenyl group; and - a formaldehyde compound A3. According to the invention, the aromatic compound A2 is present in a weight content of the dry extract of the adhesive composition of less than or equal to 0.18.

The invention relates to the technical field of organic synthesis, and discloses a preparation method of dialkyl substituted biphenyl, which comprises the following steps: (1) in the presence of hydrogen and a hydroalkylation catalyst, contacting alkylbenzene with benzene, and carrying out hydroalkylation reaction to obtain a product mixture containing cyclohexyl alkylbenzene isomers; wherein on the basis of the total amount of the cyclohexyl alkylbenzene isomers in the product mixture, the total amount of the p-cyclohexyl alkylbenzene and / or the m-cyclohexyl alkylbenzene is not less than 90wt%; (2) separating and purifying the product mixture to separate unreacted benzene, alkylbenzene and optional cyclohexylbenzene, so as to obtain a cyclohexylalkylbenzene isomer mixture; (3) contacting the cyclohexylalkylbenzene isomer mixture with a dehydrogenation catalyst for dehydrogenation reaction; and (4) contacting a product of the dehydrogenation reaction with olefin, and carrying out an alkylation reaction. The method has higher total yield of para-position and meta-position dialkyl substituted biphenyl.

The invention provides an improved preparation method of a benzoyl sulfamoyl benzoic acid compound, which is characterized in that a benzoic acid compound as shown in a formula I and p-carboxybenzenesulfonamide are directly condensed by using phosphorus pentoxide as a condensing agent to generate the benzoyl sulfamoyl benzoic acid compound as shown in a formula II, r1 is hydrogen, halogen, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-6 cycloalkyl group or a C3-6 cycloalkyloxy group, preferably hydrogen, a C1-6 alkyl group or a C1-6 alkoxy group, more preferably a C1-6 alkoxy group, and further preferably a methoxy group; the number of R1 is 1-2, when two R1 exist, the R1 can be the same or different, and the R1 is in the ortho-position or para-position, preferably in the ortho-position; in particular, R1 is preferably an ortho-substituted methoxy group. Formula I and formula II.

The present application relates to a kind of small molecule probes and its preparation method and application, the chemical structure of the probe is as shown in the following formula: Wherein, R1 is 1-propyl sulfonic acid or 1-butyl sulfonic acid;R2 independently selected from trifluoromethyl or sulfur pentafluoride group, the substitution position of R2 is the ortho, para or meta of hydroxyl on benzene ring;Preparation method is by the condensation reaction of salicylaldehyde containing fluorine substituent group and indoline, directly introduce containing fluorine substituent group into the spiro-pyran molecule structure with pH response, prepared with 19 F MRI and fluorescence imaging pH-responsive bimodal imaging small molecule probe.Compared with the prior art, the small molecule probe of the present application exhibits significantly different 19 F NMR chemical shift and fluorescence intensity, high-resolution 19 F MRI imaging and fluorescence imaging, greatly improve the sensitivity and accuracy of imaging, has important application prospect in the field of biosensing, cell imaging, medical diagnosis etc.

The present invention proposes a process for preparing high-purity estetrol, which uses (17β)-3-(phenylmethoxy)-estra-1,3,5(10),15-tetraen-17-ol acetate as a raw material, introduces hydroxyl groups at positions 15 and 16 through a dihydroxylation reaction, protects the hydroxyl groups at positions 15 and 16 through a ketal reaction, separates isomers, and then sequentially removes the benzyl protecting group, the acyl group, and the ketal protecting group. Finally, the process is purified to obtain a compound of formula (I) #imgabs0#. The present invention uses a ketal method to protect the hydroxyl groups at positions 15 and 16, and then separates the isomers, thereby achieving a satisfactory isomer removal effect and refining yield. Moreover, the process is convenient, and the ketal reaction only requires the use of an organic ketone reagent and a catalytic amount of acid. The organic ketone reagent can be completely recovered and reused, and almost no waste is generated.

The invention provides a preparation method of cyproterone acetate. The preparation method comprises the following steps: a) converting a compound as shown in a formula (1) into a compound as shown in a formula (2); and b) converting the compound shown in the formula (2) into cyproterone acetate. According to the invention, 1alpha, 2alpha-methylene-4, 6-diene pregna-3, 20-diketone-17-acetate is taken as a raw material, epoxy reaction is firstly carried out on the 6 site and the 7 site to obtain a compound shown in a formula (2), and then epoxy ring-opening elimination is carried out on the 6 site and the 7 site to obtain cyproterone acetate. The reaction route provided by the invention is short in synthesis path, short in reaction time, few in by-products, high in conversion rate and high in finished product quality. Experimental results show that the chromatographic purity of the prepared cyproterone acetate is 99.86% or above, and the cyproterone acetate does not contain more than 0.1% of impurities.

The invention belongs to the technical field of catalysts, and particularly discloses a method for preparing cresol by catalyzing xylenol and phenol in the presence of a pyridine acidic ionic liquid in the presence of hydrogen, and the cresol (ortho-position, meta-position and para-position mixed cresol) is prepared by taking the xylenol and the phenol as raw materials and taking the pyridine acidic ionic liquid as a solvent and a catalyst in the presence of the hydrogen. According to the reaction process conditions, the hydrogen pressure ranges from 1 MPa to 3 MPa, the reaction time ranges from 2 h to 8 h, the reaction temperature ranges from 250 DEG C to 350 DEG C, the ratio of phenol to xylenol (mole) is 1-4, the ratio of pyridine acidic ionic liquid to raw materials (phenol and xylenol) is 10 / 90-30 / 70 (wt), the conversion rate of the xylenol in the reaction can reach 75.68%, and the selectivity of the xylenol can reach 87.58%. The pyridine acidic ionic liquid can be recycled.

The present invention discloses a near-infrared fluoroboron dipyrrole compound for bioimaging and sonodynamic therapy and a preparation method thereof. The chemical structural formula of the compound is shown in Formula 4; the preparation method is: first, para-substituted benzaldehyde, 2,4-dimethylpyrrole and boron trifluoride ether are prepared under acid catalysis by the fluoroboron dipyrrole compound; then the obtained fluoroboron dipyrrole compound and the para-substituted benzaldehyde are dehydrated and condensed under the catalysis of acid and base to obtain a target product. The near-infrared difluoroboron pyrrole compound disclosed in the present invention has mild synthesis conditions, short reaction time, high yield, simple post-processing and a wide range of structural applications. The present invention connects thiomethylbenzaldehyde and aniline derivatives to the fluoroboron dipyrrole skeleton, and the prepared compound has absorption and fluorescence emission in the near-infrared region, and has good bioimaging effect; in addition, it can also efficiently generate reactive oxygen species under ultrasound, and can produce excellent sonodynamic effect.

The application discloses a kind of probe with terpyridine as recognition group and containing three electron donors and a preparation method and application thereof.The para position of the three pyridine nitrogens of the compound simultaneously contains a carbazole, 3,6-di-tert-butyl carbazole, diphenylamine, 4,4'-dimethoxytriphenylamine or 10-phenylphenothiazine electron donor;In the preparation method, with tris(dibenzylideneacetone) dipalladium, palladium catalyst such as tetra(triphenylphosphine) palladium or cuprous iodide as catalyst, with 4,4',4"-tribromo-2,2':6',2"-terpyridine or 4,4"-dibromo-[2,2':6',2"-terpyridine]-4'-yl trifluoromethanesulfonate as intermediate, the probe is prepared.The application realizes rapid visual sensitive detection of copper ions.

The invention relates to a preparation method of 3-bromobenzotrifluoride, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: taking benzotrifluoride as a raw material, and reacting with liquid bromine under the action of a catalyst and a complexing agent to obtain 3-bromobenzotrifluoride; the catalyst is iron powder, ferric trichloride or ferric tribromide; the complexing agent is at least one of methanol, ethanol, methyl tertiary butyl ether, tetrahydrofuran, 2-methyltetrahydrofuran, acetone or sodium acetate. The compound containing lone pair electrons is added into the reaction liquid to form a complex with ferric iron, so that the activity of the ferric iron catalyst is reduced, and the situation that the bromine substitution selectivity is reduced due to too high activity is avoided; the selectivity of aromatic ring bromine meta-substitution is improved, the generation of para-bromine substituted isomers and polysubstituted impurities is reduced, and the purity and yield of the product are improved.

The present invention discloses a 1-(substituted phenyl)oxy-2,4-pentanedione compound or a salt thereof and its use as a PVC stabilizer. The 1-(substituted phenyl)oxy-2,4-pentanedione compound has the structure represented by formula (I): #imgabs0#, wherein R is H or an electron-donating group, and R is connected to the benzene ring in an ortho-, meta-, or para-substituted manner or in a benzo-binding manner. When used as a PVC stabilizer, the 1-(substituted phenyl)oxy-2,4-pentanedione compound or a salt thereof of the present invention exhibits outstanding thermal stability and weather resistance, effectively improving the weather resistance of PVC products and the thermal stability during processing.

The present invention relates to a composition of matter comprising: a) at least one compound of formula (I), in the form of any one of its isomers or a mixture of these isomers; wherein R 1 represents a hydrogen atom or a C 1‑2 alkyl group; and R represents a group of formula -CH2C(Me)2OH; said R being a meta or para substituent of the aromatic ring with respect to position 1 or a mixture thereof; and b) at least one compound of formula (II), in the form of any one of its isomers or a mixture of these isomers; wherein R 1 and R have the same meaning as defined in formula (I); said R being an ortho, meta or para substituent of the aromatic ring with respect to position 1 or a mixture thereof; as well as their use as perfuming ingredient, as well as compositions and consumer products comprising such composition of matter and a process for the preparation thereof.

This invention belongs to the field of catalytic materials technology, specifically relating to a pyridinediimide cobalt complex and its preparation method, as well as a method for preparing 1-hexene. A pyridinediimide cobalt complex has the structural formula: ; wherein, R... 1 Selected from fluorine, chlorine, bromine, ester, cyano, benzyl, and hydrogen; R 2 Selected from methyl, ethyl, isopropyl, fluorine, hydrogen, trifluoromethyl, methoxy, R 2 The positions are ortho, para, and meta of aniline; R 3 Selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and hydrogen. This cobalt pyridine diimine complex, under the co-catalysis of methylaluminoxane (MAO), can catalyze the selective oligomerization of propylene to prepare 1-hexene. The oligomerization reaction conditions are mild, and the resulting polyethylene significantly reduces the symmetry and regularity of the polymer chain segments, thereby weakening its crystallinity. While maintaining mechanical strength, it also exhibits excellent flexibility, resistance to environmental stress cracking, and low-temperature impact resistance.

The application relates to the field of medicine synthesis, in particular to a three-step preparation method of a ketoprofen general compound. The ketoprofen general compound is prepared through three-step reactions of deamination, deesterification and acid hydrolysis from a prepared compound of formula IV, wherein R1 is -CONR4R5, -COX1, -COOR2 or -CN at the ortho position or the para position of an amine group, R2, R3, R4 and R5 are the same or different and are H or C1-C6 alkyl, and X1 is F, Cl, Br or I. The reaction is suitable for industrial production.

A polypropylene composition (PC) comprising: a. 95.0 to 99.99 wt.-% of a polypropylene (PP), preferably a propylene homopolymer (HPP); and b. 0.01 to 5.0 wt.-% of a compound according to formula (I) wherein each R is independently selected from C1 to C6 alkylene, C2 to C6 alkenylene and a single bond, each R' is independently selected from H and C1 to C6 alkyl, each R" is independently selected from H and C1 to C 22 alkyl, wherein each alkylene, alkenylene and alkyl can optionally be substituted with deuterium or fluorine, and the two substituents on the central phenyl ring can be positioned in ortho, meta or para relationship; wherein the polypropylene composition (PC) has a MFR2 of 400 to 5000 g / 10min and a melting temperature Tm of 140 to 170 °C.

The invention discloses an intrinsic low-flammability organic phase change material as well as a preparation method and application thereof. The intrinsic low-combustibility organic phase-change material has the following structural general formula: R1 and R4 both comprise long chains with a main chain containing 10 or more carbon or oxygen or substitutes thereof, unsaturated compounds, carboxylic acid compounds or ether compounds, R2 comprises H or-OCH3, and R3 comprises-CH2-CH2-or-CH2 = CH2-. The preparation method comprises the following steps: taking a para-carboxyl substituted phenolic compound, a long-chain amine compound and paraformaldehyde as raw materials, and carrying out amidation reaction and Mannich condensation reaction to obtain an amido-containing benzoxazine monomer, namely the intrinsic low-flame organic phase change material. The benzoxazine unit contained in the intrinsic low-flammability organic phase change material can be subjected to ring opening polymerization in a high-temperature or open fire environment to form polybenzoxazine with certain flame retardance, and the material also well integrates the heat storage density and the flame retardance and has wide application prospects.

The invention discloses a preparation method and application of a fluoroalkylated MIL-101 (Cr) material for enhanced adsorption of short-chain perfluorinated compounds, relates to the technical field of metal organic framework (MOF) materials, and aims to solve the problem that the conventional MOF material has insufficient adsorption performance on short-chain PFASs. According to the MIL-101 (Cr)-TF structure, a pair of trifluoromethyl is connected to each benzene ring of original MIL-101 (Cr) in a para-position mode, and the average pore size of the MIL-101 (Cr)-TF structure is three times or above that of an MIL-101 (Cr) material; the removal rates of the MIL-101 (Cr)-TF on PFBA and PFHxA belonging to short-chain PFAS in the simulated wastewater are not lower than 94% and 99% respectively, and the total removal rate of PFOA, PFOS, PFBA, PFHxA and 6: 2 FTS is not lower than 96%; the preparation method comprises the following steps: taking 2, 5-bis (trifluoromethyl) terephthalic acid as an organic ligand, and preparing with chromium nitrate nonahydrate through a hydrothermal method; the preparation method disclosed by the invention is simple and relatively low in cost, and the prepared MIL-101 (Cr)-TF has excellent adsorption performance on short-chain PFASs and is not easily influenced by environmental factors.

This invention discloses an amino compound with a benzophenanthrene furan group and an organic light-emitting device, selected from compounds of formula 1: Al-A 10 One of the groups is derived from Formula 2, where * represents a bond connected to the basic skeleton in Formula 1. When A2 is derived from a group in Formula 2, L1 is a para-phenylene group, R1 and R2 are derived from single bonds, substituted or unsubstituted C5-C24 aromatic hydrocarbon groups, substituted or unsubstituted C5-C24 heteroaromatic hydrocarbon groups, and Ar1 and Ar2 are derived from C5-C30 aromatic hydrocarbon groups, substituted or unsubstituted C5-C30 heteroaromatic hydrocarbon groups. In this invention, the triarylamine is para-linked to a transition benzene ring with benzo[a]phenanthrenefuran. This benzene ring linkage enhances the overall stability of the target molecule, strengthens the conjugation of the molecule, and increases the stacking property of the molecule in organic light-emitting materials. This invention also sets phenanthrene, naphthyl, or dibenzothiophene groups on the other two substituents of the triarylamine, affecting the electron affinity and electron transport properties of the triarylamine and further extending its lifespan.

The invention belongs to the field of lubricating oil additives, and particularly relates to an antioxidant as well as a preparation method and application thereof. The antioxidant at least comprises one of the following structures: R1, R2, R5 and R7 are all phenyl-containing alkyl groups and are positioned at para-position, ortho-position or two positions of amino groups; and R3, R4, R6 and R8 are all alkyl groups and are respectively connected to R1, R2, R5 and R7. The antioxidant disclosed by the invention has excellent oxidation resistance, and compared with a single amine antioxidant containing benzene ring olefin substituent, the antioxidant disclosed by the invention has better solubility; and compared with a single non-phenyl substituent amine type antioxidant, the amine type antioxidant has higher thermal stability.

This invention discloses a COF photocatalyst based on precise regulation of benzene ring nitrogen sites, as well as its preparation method and application, belonging to the technical field of covalent organic framework (COF) materials. The preparation method of the present invention does not require toxic reagents and achieves high reproducibility of the COF structure by precisely controlling the monomer substitution position. By designing COF materials with ortho-, meta-, and para-N substitutions, the photocatalytic activity and stability in acidic environments are significantly improved. In particular, the photocatalytic hydrogen peroxide production rate of oN-COF substituted with ortho-N reaches 3015 μmol·g ‑1 ·h ‑1 , which is significantly higher than the existing technology (such as 1.8 mmol·g reported by Zhang et al. ‑1 ·h ‑1 That is 1800 μmol·g ‑1 ·h ‑1 ), after 5 cycles, the activity remained at 92%. The process of the present invention is green and environmentally friendly and suitable for large-scale production.