39 results about "Para position" patented technology

The application discloses a kind of plane chiral [2.2] paracyclophanane monophosphine ligand pEPCP and preparation method and application thereof, it is related to chemical catalysis technical field, and its technical scheme main points are as follows: including racemate or enantiomer, the structural formula-I of the monophosphine ligand pEPCP of the application is as follows: [2.2] paracyclophanane skeleton containing monophosphine ligand pEPCP of the application, with two benzene rings in para position by two ethylene connection unique big steric hindrance, electron-rich rigid skeleton, different types ether substituent group is introduced in structure, change the electron cloud density and steric hindrance of aromatic ring directly connected by phosphine ligand.In addition, ether substituent group can also be used as weak coordination group, participate in adjusting ligand chelate dihedral angle.This makes metal, ligand and substrate form the most suitable coordination environment in catalytic process, so that corresponding catalytic reaction has the advantages such as high reactivity, good enantioselectivity, substrate universal range is wide, especially suitable for transition metal catalyzed asymmetric coupling reaction, with economic practicability and industrial application prospect.

This invention discloses a method for synthesizing nitrogen-containing heterocyclic compounds with a maleimide structural unit and a pyrazolone ring. The method includes the following steps: N-phenylmaleimide olefin and pyrazolone olefin are reacted with 4-dimethylaminopyridine in dichloromethane at a reflux temperature of dichloromethane. After the reaction, saturated brine is added to quench the reaction, followed by extraction with ethyl acetate, removal of the solvent by rotary evaporation under reduced pressure, and separation by forward silica gel column chromatography to obtain nitrogen-containing heterocyclic compounds with a maleimide structural unit and a pyrazolone ring. This invention utilizes optimal reaction conditions for substrate expansion, introducing methyl, methoxy, and chlorine atoms at the ortho, meta, and para positions on the benzene ring of N-phenylmaleimide olefin, constructing a series of nitrogen-containing heterocyclic compounds simultaneously containing a maleimide structural unit and a pyrazolone ring in yields up to 90%. The reaction method of this invention has a fast reaction rate and high yield.

The invention discloses a preparation method and a preparation system of p-chloro-o-cresol, and the preparation method comprises the following steps: 1) adding dichloroethane into molten o-cresol, and adding a catalyst; (2) controlling the temperature to be 5-15 DEG C, and adding sulfuryl chloride into the material in the step (1) at different feeding speeds according to the reaction time and the reaction stage; and (3) after the reaction is finished, rectifying and purifying liquid of reaction materials to obtain the p-chloro-o-cresol. According to the present invention, the process is simple, the reaction condition is mild, the reaction is controlled, the selectivity is high, the ortho-cresol is subjected to preferential para-position chlorination, the reaction is sufficient, the selectivity is high, the polychlorination phenomenon is avoided, the phenol content and the isomer content in the crude product are low, the yield is high, and the large-scale production is easily achieved.

This invention discloses a novel molecular fingerprinting algorithm for assisting in the design of MOFs for acid gas separation, comprising the following steps: S1, using drawing software to draw 17 possible ortho, meta, and para positions of benzene rings, five-membered rings, and six-membered rings, obtaining their .mol ​​files; S2, converting the .mol ​​files to .smart format and writing a separate .py file for the new fingerprint; S3, calling the original fingerprint in the newly written .py file, adding the two results to obtain a new 184-bit fingerprint; S4, using the new fingerprint to test multiple CoRE-MOFs using various machine learning methods. This invention can determine whether the N-bond in a five-membered or six-membered ring of a macromolecule is ortho, meta, or para, which is beneficial for identifying differences in molecular structure between molecules with different performance characteristics, thereby accelerating the screening of high-performance materials, effectively saving time and costs, and shortening the development cycle.

A system for effecting conversion of hydrogen from an ortho-isomer to a para-isomer is disclosed. The system comprises at least one reactor (10) comprising at least one reaction chamber (11) filled with a catalytic bed comprising a metal organic framework (MOF), characterized in that the at least one reaction chamber (11) is surrounded by a housing (12) through which a flow of cooling fluid is susceptible to pass.

A polypropylene composition (PC) comprising: a. from 95.0 to 99.99 wt.-%, of a polypropylene (PP), preferably a propylene homopolymer (HPP); and b. from 0.01 to 5.0 wt.-%, of a compound according to Formula (I), wherein each R is independently selected from C1 to C6 alkylene, C2 to C6 alkenylene and a single bond, each R′ is independently selected from H and C1 to C6 alkyl, each R″ is independently selected from H and C1 to C22 alkyl, wherein each alkylene, alkenylene and alkyl group may optionally be substituted by deuterium or fluorine, and the two substituents on the central benzene ring may be either positioned in an ortho, meta or para relationship; wherein the polypropylene composition (PC) has an MFR2 of from 400 to 5000 g / 10 min and a melting temperature Tm of from 140 to 170° C.

The present invention relates to an aqueous adhesive composition comprising a thermosetting resin based on: - at least one aromatic hydrocarbon compound A1 comprising at least one aromatic hydrocarbon compound comprising at least two aromatic rings bearing a single hydroxyl function, it being understood that at least one of the ortho or para positions of each aromatic ring is unsubstituted; - at least one aromatic compound A2 comprising a single phenol which is unsubstituted or substituted by a single alkyl or a single alkenyl group; and - a formaldehyde compound A3. According to the invention, the aromatic compound A2 is present in a weight content of the dry extract of the adhesive composition of less than or equal to 0.18.

The invention relates to the technical field of organic synthesis, and discloses a preparation method of dialkyl substituted biphenyl, which comprises the following steps: (1) in the presence of hydrogen and a hydroalkylation catalyst, contacting alkylbenzene with benzene, and carrying out hydroalkylation reaction to obtain a product mixture containing cyclohexyl alkylbenzene isomers; wherein on the basis of the total amount of the cyclohexyl alkylbenzene isomers in the product mixture, the total amount of the p-cyclohexyl alkylbenzene and / or the m-cyclohexyl alkylbenzene is not less than 90wt%; (2) separating and purifying the product mixture to separate unreacted benzene, alkylbenzene and optional cyclohexylbenzene, so as to obtain a cyclohexylalkylbenzene isomer mixture; (3) contacting the cyclohexylalkylbenzene isomer mixture with a dehydrogenation catalyst for dehydrogenation reaction; and (4) contacting a product of the dehydrogenation reaction with olefin, and carrying out an alkylation reaction. The method has higher total yield of para-position and meta-position dialkyl substituted biphenyl.

The invention provides an improved preparation method of a benzoyl sulfamoyl benzoic acid compound, which is characterized in that a benzoic acid compound as shown in a formula I and p-carboxybenzenesulfonamide are directly condensed by using phosphorus pentoxide as a condensing agent to generate the benzoyl sulfamoyl benzoic acid compound as shown in a formula II, r1 is hydrogen, halogen, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-6 cycloalkyl group or a C3-6 cycloalkyloxy group, preferably hydrogen, a C1-6 alkyl group or a C1-6 alkoxy group, more preferably a C1-6 alkoxy group, and further preferably a methoxy group; the number of R1 is 1-2, when two R1 exist, the R1 can be the same or different, and the R1 is in the ortho-position or para-position, preferably in the ortho-position; in particular, R1 is preferably an ortho-substituted methoxy group. Formula I and formula II.

The present application relates to a kind of small molecule probes and its preparation method and application, the chemical structure of the probe is as shown in the following formula: Wherein, R1 is 1-propyl sulfonic acid or 1-butyl sulfonic acid;R2 independently selected from trifluoromethyl or sulfur pentafluoride group, the substitution position of R2 is the ortho, para or meta of hydroxyl on benzene ring;Preparation method is by the condensation reaction of salicylaldehyde containing fluorine substituent group and indoline, directly introduce containing fluorine substituent group into the spiro-pyran molecule structure with pH response, prepared with 19 F MRI and fluorescence imaging pH-responsive bimodal imaging small molecule probe.Compared with the prior art, the small molecule probe of the present application exhibits significantly different 19 F NMR chemical shift and fluorescence intensity, high-resolution 19 F MRI imaging and fluorescence imaging, greatly improve the sensitivity and accuracy of imaging, has important application prospect in the field of biosensing, cell imaging, medical diagnosis etc.

The invention provides a preparation method of cyproterone acetate. The preparation method comprises the following steps: a) converting a compound as shown in a formula (1) into a compound as shown in a formula (2); and b) converting the compound shown in the formula (2) into cyproterone acetate. According to the invention, 1alpha, 2alpha-methylene-4, 6-diene pregna-3, 20-diketone-17-acetate is taken as a raw material, epoxy reaction is firstly carried out on the 6 site and the 7 site to obtain a compound shown in a formula (2), and then epoxy ring-opening elimination is carried out on the 6 site and the 7 site to obtain cyproterone acetate. The reaction route provided by the invention is short in synthesis path, short in reaction time, few in by-products, high in conversion rate and high in finished product quality. Experimental results show that the chromatographic purity of the prepared cyproterone acetate is 99.86% or above, and the cyproterone acetate does not contain more than 0.1% of impurities.

The invention relates to a preparation method of 3-bromobenzotrifluoride, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: taking benzotrifluoride as a raw material, and reacting with liquid bromine under the action of a catalyst and a complexing agent to obtain 3-bromobenzotrifluoride; the catalyst is iron powder, ferric trichloride or ferric tribromide; the complexing agent is at least one of methanol, ethanol, methyl tertiary butyl ether, tetrahydrofuran, 2-methyltetrahydrofuran, acetone or sodium acetate. The compound containing lone pair electrons is added into the reaction liquid to form a complex with ferric iron, so that the activity of the ferric iron catalyst is reduced, and the situation that the bromine substitution selectivity is reduced due to too high activity is avoided; the selectivity of aromatic ring bromine meta-substitution is improved, the generation of para-bromine substituted isomers and polysubstituted impurities is reduced, and the purity and yield of the product are improved.

The present invention relates to a composition of matter comprising: a) at least one compound of formula (I), in the form of any one of its isomers or a mixture of these isomers; wherein R 1 represents a hydrogen atom or a C 1‑2 alkyl group; and R represents a group of formula -CH2C(Me)2OH; said R being a meta or para substituent of the aromatic ring with respect to position 1 or a mixture thereof; and b) at least one compound of formula (II), in the form of any one of its isomers or a mixture of these isomers; wherein R 1 and R have the same meaning as defined in formula (I); said R being an ortho, meta or para substituent of the aromatic ring with respect to position 1 or a mixture thereof; as well as their use as perfuming ingredient, as well as compositions and consumer products comprising such composition of matter and a process for the preparation thereof.

This invention belongs to the field of catalytic materials technology, specifically relating to a pyridinediimide cobalt complex and its preparation method, as well as a method for preparing 1-hexene. A pyridinediimide cobalt complex has the structural formula: ; wherein, R... 1 Selected from fluorine, chlorine, bromine, ester, cyano, benzyl, and hydrogen; R 2 Selected from methyl, ethyl, isopropyl, fluorine, hydrogen, trifluoromethyl, methoxy, R 2 The positions are ortho, para, and meta of aniline; R 3 Selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and hydrogen. This cobalt pyridine diimine complex, under the co-catalysis of methylaluminoxane (MAO), can catalyze the selective oligomerization of propylene to prepare 1-hexene. The oligomerization reaction conditions are mild, and the resulting polyethylene significantly reduces the symmetry and regularity of the polymer chain segments, thereby weakening its crystallinity. While maintaining mechanical strength, it also exhibits excellent flexibility, resistance to environmental stress cracking, and low-temperature impact resistance.

The application relates to the field of medicine synthesis, in particular to a three-step preparation method of a ketoprofen general compound. The ketoprofen general compound is prepared through three-step reactions of deamination, deesterification and acid hydrolysis from a prepared compound of formula IV, wherein R1 is -CONR4R5, -COX1, -COOR2 or -CN at the ortho position or the para position of an amine group, R2, R3, R4 and R5 are the same or different and are H or C1-C6 alkyl, and X1 is F, Cl, Br or I. The reaction is suitable for industrial production.

A polypropylene composition (PC) comprising: a. 95.0 to 99.99 wt.-% of a polypropylene (PP), preferably a propylene homopolymer (HPP); and b. 0.01 to 5.0 wt.-% of a compound according to formula (I) wherein each R is independently selected from C1 to C6 alkylene, C2 to C6 alkenylene and a single bond, each R' is independently selected from H and C1 to C6 alkyl, each R" is independently selected from H and C1 to C 22 alkyl, wherein each alkylene, alkenylene and alkyl can optionally be substituted with deuterium or fluorine, and the two substituents on the central phenyl ring can be positioned in ortho, meta or para relationship; wherein the polypropylene composition (PC) has a MFR2 of 400 to 5000 g / 10min and a melting temperature Tm of 140 to 170 °C.

This invention discloses an amino compound with a benzophenanthrene furan group and an organic light-emitting device, selected from compounds of formula 1: Al-A 10 One of the groups is derived from Formula 2, where * represents a bond connected to the basic skeleton in Formula 1. When A2 is derived from a group in Formula 2, L1 is a para-phenylene group, R1 and R2 are derived from single bonds, substituted or unsubstituted C5-C24 aromatic hydrocarbon groups, substituted or unsubstituted C5-C24 heteroaromatic hydrocarbon groups, and Ar1 and Ar2 are derived from C5-C30 aromatic hydrocarbon groups, substituted or unsubstituted C5-C30 heteroaromatic hydrocarbon groups. In this invention, the triarylamine is para-linked to a transition benzene ring with benzo[a]phenanthrenefuran. This benzene ring linkage enhances the overall stability of the target molecule, strengthens the conjugation of the molecule, and increases the stacking property of the molecule in organic light-emitting materials. This invention also sets phenanthrene, naphthyl, or dibenzothiophene groups on the other two substituents of the triarylamine, affecting the electron affinity and electron transport properties of the triarylamine and further extending its lifespan.

The invention belongs to the field of lubricating oil additives, and particularly relates to an antioxidant as well as a preparation method and application thereof. The antioxidant at least comprises one of the following structures: R1, R2, R5 and R7 are all phenyl-containing alkyl groups and are positioned at para-position, ortho-position or two positions of amino groups; and R3, R4, R6 and R8 are all alkyl groups and are respectively connected to R1, R2, R5 and R7. The antioxidant disclosed by the invention has excellent oxidation resistance, and compared with a single amine antioxidant containing benzene ring olefin substituent, the antioxidant disclosed by the invention has better solubility; and compared with a single non-phenyl substituent amine type antioxidant, the amine type antioxidant has higher thermal stability.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to phenyl sulfanilamide para-triazole derivatives, a preparation method and application of the phenyl sulfanilamide para-triazole derivatives in resisting carbonic anhydrase. The structural general formula of the derivative is as shown in formula I, the invention provides a brand-new phenyl sulfanilamide para-triazole derivative and pharmaceutically acceptable salt, the inhibition activity of the derivative on human carbonic anhydrase is obviously superior to that of traditional inhibitors acetazolamide and methazolamide, and the derivative has selective binding capacity on different human carbonic anhydrase subtypes and has the potential to be developed into a novel carbonic anhydrase inhibition drug.

The application discloses a molecular sieve catalyst and a preparation method and application thereof. The catalyst comprises a passivation substance, a molecular sieve and a binder. The passivation substance comprises silicon dioxide and a passivation element, the passivation element is selected from at least one of Fe, Mg, Co, Cu, Zn, Ga, Ni, V, Cr, W, Pt or Pd, and the mass ratio of the passivation element to the silicon dioxide is 0.01-6.00. The catalyst is used in an aromatic hydrocarbon disproportionation or aromatic hydrocarbon alkylation reaction, and can significantly improve an aromatic hydrocarbon conversion rate and a para-position selectivity of a para-position alkyl aromatic hydrocarbon product.

The invention discloses a catalytic synthesis process of an empagliflozin intermediate compound, which comprises the following steps: dissolving a compound I in an organic solution, adding a catalyst, stirring and mixing at low temperature for 1-2 hours, then adding a compound II, reacting at low temperature, monitoring the reaction by HPLC (High Performance Liquid Chromatography), and separating a product after the reaction is finished to obtain a compound III. The preparation method has the beneficial effects that TMPMgCl.LiCl is used for carrying out oriented metallization on para-position of chlorine atoms and meta-position of benzyl to generate an aryl magnesium reagent, and then the aryl magnesium reagent and hydroxyl-protected glucolactone are subjected to nucleophilic addition reaction to obtain an intermediate compound; a huge TMP (2, 2, 6, 6-tetramethylpiperidyl) group ensures that deprotonation only occurs on a specific C-H bond which is accessible in space and strongest in acidity, extremely high regioselectivity is achieved, and compared with traditional strong bases such as n-butyllithium, the regioselectivity of the method is improved; and diastereoselectivity; therefore, the reaction selectivity is high, and the specificity is strong.

The invention belongs to the technical field of organic synthesis, and particularly discloses a preparation method and application of a polyiodo tetraphenylethylene derivative. Iodine atoms are introduced into para-positions of a plurality of benzene rings of a tetraphenyl ethylene skeleton, and at least one active group (carboxyl, nitryl, aldehyde group, hydroxyl, sulfydryl or amino) is accurately reserved. The preparation method comprises the following steps: by taking tetraphenylethylene with active group benzene ring para-substitution as a starting raw material, carrying out selective multi-site iodination reaction by adopting an iodination reagent under the catalysis of Lewis acid; and carrying out amidation reaction to realize derivatization of active groups. The technical contradiction that multi-site iodination and functional group retention are difficult to realize synchronously in the prior art is solved, and the obtained derivative has the characteristics of aggregation-induced emission, heavy atom effect, biological coupling activity and the like, and can be applied to the fields of biomedical imaging, medicine, chemical and biological sensing, organic synthesis, radiation detection, scintillation materials and the like. Wide application prospects are realized.

The present invention provides a method for obtaining a dealkoxyphenylated product in high yield from a substrate such as a sugar bonded via an oxygen atom to an alkoxyphenyl group. By reacting a lambda 3 -iodide with a substrate bonded via an oxygen atom to a phenyl group substituted with a C1-C5 alkoxy group in the para or ortho position in a fluorine-containing alcohol and water, a dealkoxyphenylated product can be obtained in high yield under mild conditions.

The application discloses a hydroxylase DmpAB, a coding gene and a preparation method and application thereof, a recombinant expression vector and a recombinant strain, relates to the technical field of genetic engineering, and the hydroxylase DmpAB comprises a first component and a second component, the amino acid sequence of the first component DmpA is shown in SEQ ID NO. 1, and the amino acid sequence of the second component DmpB is shown in SEQ ID NO. 2. The hydroxylase DmpAB provided in the application can effectively catalyze a substrate into an aromatic ring compound with a hydroxyl substituent, especially selectively catalyze hydroxylation of a hydroxyl substituent ortho position, in addition, the hydroxylase DmpAB also has good catalytic activity on a substrate with a carboxyl or methyl substituent para position and meta position of the hydroxyl substituent, the catalytic substrate range is wide, the action site is accurate, and the catalytic activity is not easily affected by the substituent.

Provided is a divinylbenzylfluorene compound that can achieve both solubility in methyl ethyl ketone and a high melting point. The divinylbenzylfluorene compound according to the present invention is a compound represented by the following general formula (1), in which R 1 , R 2 and R 3 each independently represents a hydrocarbon group having 1 to 5 carbon atoms, a, b, and c each independently represent an integer of 0 to 4, and the ratio of p,p-isomers in which the two vinylbenzyl groups in formula (1) are both para isomers is 20 to 50%. [Formula 1] JPEG0007795668000016.jpg48161

The invention relates to a fluorinated trifunctional aromatic amine monomer, and a preparation method and application thereof. Monomer molecules are in triple rotational symmetry along the normal direction of a central benzene ring,-NH2 of three outer aromatic rings is located at meta-position or para-position of carbon connected with the central ring, each outer aromatic ring can independently carry 0-4 fluorine-containing substituents such as F, CF3, OCF3 or CF2CF3, and the total fluorine content is adjustable in a range of 14-49 wt%. The high-symmetry polyphenyl skeleton guarantees the molecular rigidity and purification convenience, the fluorine-containing substitution reduces the molecular polarizability, and the high-symmetry polyphenyl skeleton can be used as a rigid fluorine-containing building unit precursor of high-temperature-resistant, low-refractive-index and low-dielectric aromatic polymers. The preparation method comprises the following steps: firstly, preparing arylboronic acid ester from (fluorinated) bromo-aniline and a diboron reagent, and then carrying out triple cross-coupling on the arylboronic acid ester and (fluorinated) 1, 3, 5-tribromobenzene at one time under an alkaline condition, so as to finally prepare a high-purity target product. The route has the advantages of no strong corrosive fluorinating agent, short steps and high atom economy, is suitable for large-scale preparation, and provides greater degree of freedom for follow-up material balance refractive index, dielectric constant and thermal dimensional stability.

The invention provides synthesis and application of a boron-nitrogen-doped dark red / near-infrared narrow-band luminescent material, and solves the problems that existing boron-nitrogen-doped polycyclic aromatic hydrocarbon is difficult to cover near-infrared requirements, the synthesis route is complex and the half-peak width is relatively wide. The material comprises a boron-nitrogen coordination center; the boron-nitrogen coordination center is composed of a boron atom and three nitrogen atoms; the boron atom and one nitrogen atom form a boron-nitrogen coordination bond, the nitrogen atom participates in ring formation to form a substituted or unsubstituted ring A, and the ring A is selected from pyridine or pyridine derivatives; the boron atom and the other two nitrogen atoms form two boron-nitrogen covalent bonds, and the two nitrogen atoms are two secondary nitrogen atoms of indolocarbazole respectively; a ring A is connected with a benzene ring between the two indolocarbazoles, and the para-position of the ring A is substituted by an R group; r groups independently exist or form a ring C with similar nitrogen atoms.

The invention relates to a method for synthesizing high-carbon phenolic resin and extracting ortho-position and para-position alkylphenol, which is applied to the technical field of organic synthesis and separation and comprises the following steps: taking phenol or phenol and ortho-cresol-containing mixed phenol as a first component and at least one of various alkylphenols selected from coal chemical industry crude phenol rectification products as a second component, carrying out segmented polymerization reaction with aldehyde and a catalyst; controlling the reaction until the content of meta-position phenol is less than or equal to 1% and the content of free phenol is 5-30%, and steaming out unreacted phenol; carrying out secondary polymerization and solvent extraction on the distillate, and rectifying to obtain a product containing high-purity phenol and a plurality of ortho-position and para-position alkylphenols; and dehydrating the resin phase to obtain the high-carbon-content phenolic resin. According to the method, petrochemical phenol is partially replaced with cheap coal-based phenol, various high-added-value alkylphenols are co-produced while high-performance phenolic resin is synthesized, and high-value utilization of resources and cost reduction and efficiency improvement of the process are achieved.

This invention discloses a method for synthesizing 2,4-bis(4-biphenyl)-6-(2',4'-dihydroxy)phenyl-1,3,5-triazine, belonging to the field of ultraviolet absorber synthesis; the synthesis steps of this invention for preparing 2,4-bis(4-biphenyl)-6-(2',4'-dihydroxy)phenyl-1,3,5-triazine are as follows: (1) Under inert gas protection, biphenyl and 2-amino-4,6-dichlorotriazine are used as raw materials, and para-alkylation reaction is carried out under the first reaction conditions to obtain an intermediate mixture; (2) Intermediate A and intermediate B are separated from the intermediate mixture, and intermediate A continues to carry out the reaction in step (1); (3) Intermediate B is reacted with metal hydroxide to obtain intermediate C; (4) Intermediate C is iodinated to obtain intermediate D; (5) Intermediate D is reacted with resorcinol under the action of a second catalyst to carry out an ortho-alkylation reaction to obtain the product.