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Silver nano-chain meshed material, preparation method thereof and application in preparing medicine for curing tumor

A technology of mesh materials and tumor drugs, applied in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as the network structure of nano silver chains that have not been seen, and achieve strong near-infrared absorption characteristics, good stability, and inhibition. effect of growth

Inactive Publication Date: 2010-05-26
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is no literature report on the network structure of nano-silver chains

Method used

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  • Silver nano-chain meshed material, preparation method thereof and application in preparing medicine for curing tumor
  • Silver nano-chain meshed material, preparation method thereof and application in preparing medicine for curing tumor
  • Silver nano-chain meshed material, preparation method thereof and application in preparing medicine for curing tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1. Take 0.2mol / L 1mL silver nitrate (AgNO 3 ) aqueous solution, diluted to 10mL with deionized water;

[0040] 2. Take 0.2mol / L 1mL surfactant (citric acid) and drop into the solution in step 1, and stir well.

[0041] 3. Take 10mL of toluene, add it to the solution in step 2, and stir well.

[0042] 4. Take 0.01mol / L 0.3-2mL sodium borohydride aqueous solution dropwise into the mixture in step 3, stir continuously, and react at room temperature for 4 hours.

[0043] 5. The liquid after reacting for 4 hours was left to stand for more than 4 hours, and the toluene was separated and removed; the water layer product was centrifuged, and the precipitate was washed with water and redispersed in 10 mL of deionized water to obtain the present invention.

[0044] The scanning electron microscope image of its network structure is shown in figure 1 . The diameter is about 30nm, and the length distribution ranges from tens of nanometers to hundreds of nanometers. It is a face...

Embodiment 2

[0046] 1. Take 0.2mol / L 1mL silver nitrate (AgNO 3 ) aqueous solution, diluted to 10mL with deionized water;

[0047] 2. Take 0.2mol / L 1mL surfactant (polyvinylpyrrolidone) dropwise into the solution in step 1, and stir well.

[0048] 3. Take 10mL of toluene, add it to the solution in step 2, and stir well.

[0049]4. Take 0.01mol / L 0.3-2mL sodium borohydride aqueous solution dropwise into the mixture in step 3, stir continuously, and react at room temperature for 4 hours.

[0050] 5. The liquid after reacting for 4 hours was left to stand for more than 4 hours, and the toluene was separated and removed; the water layer product was centrifuged, and the precipitate was washed with water and redispersed in 10 mL of deionized water to obtain the present invention.

Embodiment 3

[0052] 1. Take 0.2mol / L 1mL silver nitrate (AgNO 3 ) aqueous solution, diluted to 10mL with deionized water;

[0053] 2. Take 0.2mol / L 1mL surfactant (polyethylene glycol) dropwise into the solution in step 1, and stir well.

[0054] 3. Take 10mL of toluene, add it to the solution in step 2, and stir well.

[0055] 4. Take 0.01mol / L 0.3-2mL sodium borohydride aqueous solution dropwise into the mixture in step 3, stir continuously, and react at room temperature for 4 hours.

[0056] 5. The liquid after reacting for 4 hours was left to stand for more than 4 hours, and the toluene was separated and removed; the water layer product was centrifuged, and the precipitate was washed with water and redispersed in 10 mL of deionized water to obtain the present invention.

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Abstract

The invention discloses a silver nano-chain meshed material and a preparation method thereof. The silver nano-chain meshed material is prepared by using a wet chemistry method, selecting silver as the research content and carrying out reaction through interfaces of an organic solution and an inorganic solution. The silver nano-chain meshed material of the invention can inhibit the growth of tumor tissues or can be used together with anti-tumor medicines to improve the medical effect and achieve the curing purpose, has low toxicity, sensing characteristic and elastic modulus which can approach normal natural biological tissue, can enable cells to grow on the surface of the silver nano-chain meshed material, has the function of repairing lesion tissues, and has strong near-infrared absorption characteristic and photothermal conversion characteristic. Compared with a developer which is clinically used at present, the stability of the silver nano-chain meshed material is better than the stability of organic dye, and the silver nano-chain meshed material can not be decomposed easily and has good light stability; the safety of the silver nano-chain meshed material is better than the safety of radioactive elements, and the injury to human bodies is smaller; and the silver nano-chain meshed material can be used as a thermal sensitizer to absorb infrared light, thereby reducing the injury to human bodies.

Description

technical field [0001] The invention provides a silver nano-chain mesh material and a preparation method, and also discloses the application of the material in the preparation of drugs for treating tumors, belonging to the field of metal nano-material technology and application. Background technique [0002] The basic physical properties of metal nanomaterials are closely related to their size, morphology and structure. Because one-dimensional metal nanomaterials have unique dimensional characteristics that the surface plasmon resonance absorption along the length direction moves to the near-infrared region, and the near-infrared region (800nm-1200nm is the transmission window of human tissue). Therefore, the characteristic of one-dimensional metal nanomaterials has attracted extensive attention from scientists in the fields of physics, chemistry, and biomedicine. In 2002, the Y.Xia research group of the Department of Chemistry, University of Washington reported the synthes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/34A61K47/32A61K47/18A61K47/12A61K47/02A61K49/00A61P35/00A61K47/10
Inventor 宋宏伟白雪董彪王宇
Owner JILIN UNIV
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