The present invention relates to a method for preparing a
cell-derived ECM
scaffold to which chondrocytes or stem cells are attached, a method for
cartilage regeneration by
tissue engineering, which comprises using the
cell-derived ECM
scaffold, and a therapeutic composition for treating
cartilage disorder, which contains the ECM
scaffold as an effective component. More specifically, the present invention relates to a method for
cartilage regeneration by
tissue engineering, which comprises
transplanting ECM scaffold, having chondrocytes or stem cells attached thereto, into cartilage defects, and a therapeutic composition for treating
cartilage disorder, which contains the ECM scaffold, having chondrocytes or stem cells attached thereto, as an effective component. According to the present invention, when the inventive ECM scaffold having chondrocytes or stem cells attached thereto is transplanted into a cartilage defect, mature
articular cartilage having the same appearance and characteristics as those of natural cartilage tissue, can be regenerated without side effects such as inflammatory responses.