70 results about "Osteoarthritic cartilage" patented technology

A method of determining the voltage and current output required for the application of specific and selective electric and electromagnetic signals to diseased articular cartilage in the treatment of osteoarthritis, cartilage defects due to trauma or sports injury, or used as an adjunct with other therapies (cell transplantation, tissue-engineered scaffolds, growth factors, etc.) for treating cartilage defects in the human knee joint and a device for delivering such signals to a patient's knee. An analytical model of the human knee is developed whereby the total tissue volume in the human knee may be determined for comparison to the total tissue volume of the diseased tissue in the animal model using electric field and current density histograms. The voltage and current output used in the animal model is scaled based on the ratio of the total tissue volume of the diseased tissue of the human to the total tissue volume of the diseased tissue in the animal model and the resulting field is applied to the diseased tissue of the human using at least two electrodes applied to the knee or a coil or solenoid placed around the knee. The voltage of the signal applied to the electrodes, coil or solenoid is varied based on the size of the knee joint; larger knee joints require larger voltages to generate the effective electric field.

The present invention provides nucleic acid arrays and methods of using the same for detecting gene expression in animal models of osteoarthritis or other inflammatory diseases. The nucleic acid arrays of the present invention comprise polynucleotide probes for genes that are differentially expressed in osteoarthritis-affected cartilage tissues as compared to non-osteoarthritic cartilage tissues. In one embodiment, a nucleic acid array of the present invention comprises a plurality of polynucleotide probe sets, each of which is capable of hybridizing under stringent or nucleic acid array hybridization conditions to a different respective tiling sequence selected from Table C, or the complement thereof.

Techniques and instruments for knee replacement surgery that allow for the removal of an oval oblong-shaped allograft bone and cartilage plug from a donor distal femur. The instruments include (i) sizing guides to match the recipient's femoral size and curvature to that of a donor femur (the sizing guides also acting as a wide pin placement template for the donor distal femur); (ii) osteotomes that cut the curved and straight portions of the implant shape (these may be disposable or reusable); and (iii) templates that fit over the guide pins and have openings to allow the osteotomes to cut the donor femur plug to the correct size, shape and depth. The instruments allow for a non-circular shape to be extracted from a donor femur for use in a bone-saving osteoarthritis distal femur resurfacing procedure.

Methods for identifying subjects having, or at risk for developing, osteoarthritis or other cartilage degenerative conditions by measuring levels of expression of F-spondin are provided. Assays, kits and methods for determining and assaying the presence of F-spondin in individual patients are disclosed. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods are disclosed for identifying candidate compounds that modulate F-spondin levels of expression and / or function or for determining and evaluating an individual's response to drugs and therapeutic agents, are provided. The invention further relates to the modulation of F-spondin, particularly the inhibition of F-spondin, for increasing or stimulating bone formation and / or growth and mediating the alleviation of bone disease, disorders or conditions. The use of F-spondin, an active fragment thereof, or a modulator thereof for enhancing cartilage repair or preventing or treating cartilage degeneration, degenerative diseases or arthritic conditions is also provided.

Disclosed therein is a big femoral head and femoral head surface replacement, which are used for hip osteoarthritis and vascular necrosis of femoral head. As a person get older and aged, the weight bearing hip joint is indispensably changed to osteoarthritis and sometimes showed avascular necrosis of the femoral head with unknown etiology. The deformed femoral head and hip joint should be replaced with the THA. Till now, the total hip replacement is performed in such a way that the necrosed femoral head and a healthy femoral neck are all removed and a femoral stem is inserted into the marrow cavity, and in this case, a small femoral head causes a reduction of a range of motion and dislocation of the hip joint occasionally, and osteolysis due to abrasion of plastic acetabular liner. In case of a conventional femoral head surface replacement (hereinafter, called “conventional FHSR”), a complication of femoral neck fracture and could not combined use with conventional THA. Recently, hard bearing system such as metal on metal THA or ceramic on ceramic THA without using plastic has been introduced to solve the problem of osteolysis due to abraded plastic particles generated when the THA is worn out as time goes. But there also have many problems as a limited range of motion, resected normal femoral neck and difficulties of rereplacement of the femoral stem. Because of the big femoral head or the FHSR can increase the range of motion and lower dislocation rate these devices are gradually widespread in young active person and Asian peoples. This invented design of the modularity gives the convenience to the surgeon and economically lower burden to patients to use of the FHSR and big femoral head system. The related accessory showed initial stability of the FHSR during operation and prevent from femoral neck fracture in follow-up periods.

The invention provides compositions useful for the treatment and / or prevention of damage to diarthrodial (synovial) joints and, in particular, traumatic synovitis, inflammation of the synovial membrane, and damage to the articular cartilage of the joint. Specifically, provided are compositions specially formulated for intra-articular and / or parenteral use in the treatment and / or prevention of traumaticsynovitis and / or damage to articular cartilage. Compositions adapted specifically for post surgical joint lavage or treatment and / or prevention of inflammatory arthritis, osteoarthritis (OA) and / or degenerative joint disease (DJD) are also provided. Compositions adapted for intra-articular and / or systemic administration comprised of therapeutic amounts of: chondroitin sulfate and hyaluronan (hyaluronic acid) are provided.

A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition.

An apparatus and related method for controlling a load on a human hip joint during normal gait while preserving motion. The approach is intended to treat osteoarthritis of the hip without substantially resisting an angular displacement associated with full mobility of the pelvis and femur bones.

The invention discloses a peptide (called BM23 peptide) which comprises 23 amino acids. The peptide derives from a BMP-2 amino acid sequence and is formed by mutation and modification. Compared with BMP-2, the peptide has remarkably improved stability and in-vivo effect duration, has activity for promoting differentiation of mesenchymal stem cells into cartilage cells and promoting cartilage cell proliferation, and can be used for repairing cartilage and / or treating osteoarthritis.

The invention discloses a KGN-carried collagen / chitosan / sodium hyaluronate composite scaffold. The scaffold is prepared from collagen, chitosan, sodium hyaluronate, KGN (kartogenin) and PLGA (poly(lactic-co-glycolic acid)). The preparation method comprises the following steps: preparing KGN-micromolecule-carried PLGA microspheres, mixing the PLGA microspheres, and preparing the collagen / chitosan / sodium hyaluronate composite scaffold. The composite scaffold has the characteristics of favorable biocompatibility, favorable biodegradability and the like, has the lubrication action of sodium hyaluronate and the marrow mesenchymal stem cell cartilage differentiation promotion action of KGN, is beneficial to cartilage defect repair of medium / early osteoarthritis, and is a favorable tissue regeneration material for osteoarthritis cartilage defects.

A garment made from three layers of flexible material dimensioned to surround respective joints, body parts or the complete body, except for the entire face, of a wearer. The garment alleviates or reduces pain from certain forms of arthritis, especially osteoarthritis and can delay the onset of such conditions. The garment also can prevent hypothermia and reduce adverse effects from exposure to reduced temperatures.

The invention provides a composition for preventing and treating bone arthritis. The composition is characterized by comprising non-denaturing type II collagen and cartilage collagen peptide accordingto a weight ratio of 1:(0.5 to 30), preferably 1:(1 to 20), more preferably 1:(1.5 to 10), and most preferably 1:(1.5 to 6). The invention also provides application of the composition in preparationof a product for preventing and treating the bone arthritis, wherein the product is a medicine or health-care food. The composition for preventing and treating bone arthritis has the advantages that the cartilage collagen peptide can be used as a raw material needed for synthesizing cartilage tissues, the degradation of joints is prevented, and the repair function is realized on the injured joints; the non-denaturing type II collagen can inhibit the generation of inflammation, so as to relieve and treat the arthritis; proved by experiment results, the combination of the cartilage collagen peptide and the non-denaturing type II collagen can achieve a synergistic effect on the preventing and treatment of arthritis.

The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and / or connective tissue damage. Also provided herein are biomaterials and methods for alleviating and / or reducing the risk for developing arthritis (e.g., osteoarthritis) associated with joint injury and / or joint surgery.

The invention provides a stem cell injection for treating osteoarthritis cartilage defect and preparation and application thereof. The injection comprises fifth-generation umbilical cord mesenchymal stem cells and a liquid solvent, wherein the fifth generation umbilical cord mesenchymal stem cells are suspended in the liquid solvent, and the concentration is (2.0-3.0)x10<7> cells / 4.5-5.0ml of the liquid solvent. The liquid solvent is normal saline, or autologous platelet-rich plasma, or a mixed solution of normal saline and human albumin, or a mixed solution of normal saline and autologous platelet-rich plasma. The human albumin accounts for 5-8% in volume by percentage. The normal saline accounts for 10% or below in volume by percentage. The injection is administered by intravenous injection or bone joint cavity local injection or the combination of the two, the cell injection amount of the intravenous injection is (1.0-1.5)x10<8> cells / one time, and the cell injection amount of the bone joint cavity injection is (2.0-3.0)x10<7> cells / one time / one knee. The effect of the stem cell injection for treating the integrity degree of osteoarthritis cartilage is obviously superior to that of a traditional hyaluronic acid (HA) method.

The present invention provides a method for treating at least one of the following: osteoarthritis, rheumatoid arthritis, cartilage injury, and a cartilage defect containing the following steps. First, a defective cartilage tissue is provided. Second, a solution containing ions for treating defective cartilage tissue is provided. Third, the solution containing ions is introduced about the defective cartilage tissue. Fourth, an electrical source generates electricity. Fifth, the solution containing ions and an area about the defective cartilage tissue is contacted with the electricity from the electrical source. Sixth, the electrical source is powered on to provide electricity, whereby the ions move from the solution and into the defective cartilage tissue.

Device for the treatment of arthritis and arthrosis of the extremities generally shaped as a case, in the form of a glove or a sock, which comprises: an inner layer made of a porous material (14); a second layer in the form of a paraffin-filled bladder (1) that covers the entire inner space; surrounding said inner paraffin layer (1), the following are placed: a teflon splint (2) equipped with means designed to straighten the fingers or toes (wires made of nitinol or a similar material); a very thin layer made of latex or an insulating material (4); and, finally, an outer cover (6); it may further be equipped with wires or coils (5) around each finger or parallel to the palm or the back of the hand. Moreover, it is equipped with a control unit (12) for turning on and for controlling the temperatures and currents to be applied.

The methods and devices described below provide for minimally invasive method of performing micro-fracture therapy for the treatment of osteoarthritis. The method entails use of a laser to ablate numerous holes into the bone and cartilage of a joint which is afflicted with osteoarthritis. Laser systems which are adapted to file several beams simultaneously to create several micro-fracture bores simultaneously to speed the creation of numerous micro-fracture bores in the cartilage and underlying bone.

The invention discloses a personalized load reducing type knee joint orthopedic brace. A middle connecting piece comprises an upper connecting plate, a middle connecting plate and a lower connecting plate which are sequentially connected; the middle connecting plate comprises a condyle contact plate, a double-shaft bottom disk and two limiting buckles; the double-shaft bottom disk is a double-layer plate of a hollow structure; the condyle contact plate, the double-shaft bottom disk and the limiting buckles are sequentially connected from inside to outside; the upper connecting plate and the lower connecting plate are both connected into the hollow structure of the double-shaft bottom disk; and the two limiting buckles coaxially rotate with the upper connecting plate and the lower connecting plate correspondingly. The personalized load reducing type knee joint orthopedic brace can effectively reduce squeezing to the opposite side mesooecium in the correcting process, personalized customization on the knee joint orthopedic brace of a patient is achieved, wearing is more comfortable, the brace is lighter in character, normal functions of knee joints are not affected, the structure is stable, design is reasonable, and the personalized load reducing type knee joint orthopedic brace is used for reliving and treating the knee osteoarthritis (on the inner side and the outer side), and postoperative external fixation of the knee joints.

The invention discloses a method for performing interceptive treatment on osteoarthritis of knee joints through dental pulp stem cells (DPSCs). The method comprises the following steps: injecting CFA(Complete Freund's Adjuvant) and MIA (Sodium Iodoacetate) through an articular cavity and performing induction for one week to obtain a rat model of the osteoarthritis of the knee joints; performing intervention and treatment on different groups of rats after one week, wherein a treatment group adopts interceptive treatment in a way of DPSCs cell suspension liquid articular cavity orthotopic injection or intravenous injection; taking materials after treatment for 4 weeks and analyzing a treatment effect, and evaluating the treatment effect of DPSCs on the osteoarthritis of the knee joints. According to the method disclosed by the invention, an experimental result proves that the DPSCs has a treatment effect on bone osteoarthritis induced by combination of CFA and MIA; after treatment for 4weeks, through DPSCs systematic or local injection, a knee joint bone structure induced by the combination of CFA and MIA can be recovered, and exudates of the articular cavity are reduced. Through the DPSCs systematic or local injection, a transparent cartilage arrangement structure and cell forms can be recovered.

The invention discloses a preparation method of bi-crosslinking stem cell sphere hydrogel for osteoarthritis, and belongs to the field of biological material preparation. The hydrogel can be used as a viscous substitute for synovial fluid after a cartilage operation, and is used for treating osteoarthritis, subchondral injury, osteoporosis, synovitis, tenosynovitis, tendinitis, tendon degeneration and interstitial cystitis. The hydrogel is injectable bi-crosslinking hydrogel and is prepared by modifying hyaluronic acid from an articular cavity matrix and chondroitin sulfate through hydroxyl groups and activating bi-crosslinking through EDC (Ethylene Dichloride). The bi-crosslinking stem cell sphere hydrogel obtained through reaction has good mechanical performance and controllable degradation rate, facilitates survival of 3D cell spheres, can moisturize, lubricate and slowly release biological factors for a long time, has high drug loading rate and light responsiveness, and has potential application value in the fields of injectable drug slow release carriers, minimally invasive therapy and the like.

A garment made from three layers of flexible material dimensioned to surround respective joints, body parts or the complete body, except for the entire face, of a wearer. The garment alleviates or reduces pain from certain forms of arthritis, especially osteoarthritis and can delay the onset of such conditions. The garment also can prevent hypothermia and reduce adverse effects from exposure to reduced temperatures.

This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) back-bones grafted with polyethylene glycol.

The invention relates to a domestic rabbit traumatic osteoarthritis model making device. An impact head is arranged at one end of an impact rod of an impact unit in a detachable mode, and a sleeve movably sleeves the outer side of the impact rod; a spring covers the outer side of the impact rod which is located in the sleeve; when the spring is at a natural length, a shielding sheet clings to a second baffle plate; when the domestic rabbit traumatic osteoarthritis model making device is used, the relative positions and included angles of the impact unit, a connecting unit and a leg wrapping unit are regulated and fixed, when the rear end of the impact rod is pulled by external force, the impact rod and the shielding sheet are integrally moved backwards and the spring becomes shrunk, and meanwhile, the shielding sheet and the second baffle plate are separated; the spring, after being released, can drive the impact head of the impact rod to impact upon an object in the front, so that a controllable operation over a cartilage injury degree can be achieved by regulating the strength of the exerted external force; various osteoarthritis models are comparable; and the domestic rabbit traumatic osteoarthritis model making device is good in experimental effect and high in experimental data reliability.