Method for performing interceptive treatment on osteoarthritis of knee joints through dental pulp stem cells
A technology of osteoarthritis and stem cells, applied in anti-inflammatory agents, bone diseases, pharmaceutical formulations, etc., can solve the problems of inability to apply in large quantities, low awareness, high cost, etc., and achieve the effect of reducing joint cavity exudate
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[0024] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.
[0025] like Figure 1 to Figure 3 Shown, a method for the blockade of dental pulp mesenchymal stem cells for the treatment of knee osteoarthritis, the method uses complete Freund's adjuvant (CFA) and sodium iodoacetate (MIA) through the joint cavity injection, after a period of 1 week The rat model of knee osteoarthritis was obtained by the induction of knee osteoarthritis; after 1 week, the rats in different groups were treated with intervention, and the treatment group was treated with DPSCs cell suspension in situ injection or intravenous injection to block the Treatment: After 4 weeks of treatment, samples were collected to analyze the treatment effect to evaluate the treatment effect of DPSCs on knee osteoarthritis.
[0026] 1. Experimental materials:
[0027] 1) Experimental animals: SD rats, female, 16, 8 weeks old, SPF grade.
[0028] ...
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